Abstract:
This invention is directed to a fluorophenyl resin compound, to methods of its preparation; and to its use in the solid phase synthesis of amides, peptides, hydroxamic acids, amines, urethanes, carbonates carbamates, sulfonamides and alpha -substituted carbonyl compounds.
Abstract:
This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.
Abstract:
A method of crosslinking polystyrene polymers and co-polymers for the formation of macroplegmatic materials of an Mc 30,000 to 50,000 is described. The materials forming an insoluble gel which is shaped in an extruder to 3 to 5 cm pieces and is subject to sulphonation with dense sulphuric acid, with oleum sulphuric acid with sulphur trioxide and with chlorosulphonic acid, and the introduction of sulphonic groups to a high density and with the introduction of nitric group and with the introduction of carboxylic group with the copolymer styrene-acrylonitrile. The chlorosulfonic group promotes sulphonation and crosslinking with the formation of bridges with the sulfone group which is controlled with a 10-20 % of acetic acid present as regulator and an insoluble volume of gel is formed which following drainage of the solvent and after remaining to ripen for 4-7 hours it is treated with ethanol or propanol to extract the unreacted chlorosulphonic acid then is neutralised with sodium or potassium hydroxide subjected to an extruder for the preparation of 3-5 cm products. Following neutralisation and shrinkage to a 10 % water content and the products produced are deodorised at a temperature of 160 DEG C under vacuum and are converted to materials which absorb water inside their molecules up to 300 times their weight; having an inorganic content of 72-75 % they exhibit a high degree of stability in the ground, they do not degrade and can be used indefinitely for water absorption-release so that they operate as fertility promoters to any type of soil leading to an increase of green growth, and to the planting of trees and forests and to advance food production.
Abstract:
Fluorine containing terminal olefins may be grafted onto polymers containing hydrogen bound to carbon in the presence of free radicals. The olefins may also contain other functional groups. The resulting novel grafted polymers are useful as molding resins, for coating and as catalysts.
Abstract:
The invention relates to a process for producing polymer-polypeptide conjugates with reduced immunogenicity comprising the steps of: a) generating a polymer halogen formiate; and b) conjugating at least one polymer-halogen formiate to at least one attachment group on the polypeptide (Pep). The invention also relates to a polymer-polypeptide conjugate with reduced immunogenicity, an activated polymer for conjugating polypeptides (Pep), and the use of said process for reducing the immunogenicity of polypeptides used for pharmaceutical and/or industrial applications. Finally it is the object of the invention to provide the use of said polymer-polypeptide conjugate for a number of therapeutic and industrial purposes, such as the use in pharmaceuticals, personal care products and detergent compositions.
Abstract:
A method for the preparation of a labelled chemical library which method comprises synthesizing the library on a plurality of solid supports each of which is provided with at least one inert label which label remains attached to the solid phase and is unaffected by library synthesis, so as to provide a chemical library comprising a plurality of solid supports to each of which is attached at least one inert label and at least one member of the chemical library.
Abstract:
A process for producing a polyolefin having a terminal functional group in an industrially advantageous manner, comprising the step (A) of producing a terminally modified polyolefin of the general formula P-AlR R (wherein P represents a polymer chain, and R and R represent each a C1-C10 hydrocarbon group, etc.) in the presence of an olefin polymerization catalyst prepared from a solid titanium catalyst component (a), an organoaluminum compound (b), and optionally an organosilicon compound (c) and the step (B) of either conducting a substitution reaction between the -AlR R group of the polyolefin obtained in the step (A) and a compound having a functional structure, or conducting a substitution reaction between the -AlR R group of the polyolefin obtained in the step (A) and a compound having a structure capable of forming a functional group by solvolysis, followed by the solvolysis of the reaction product to yield a polyolefin of the general formula P-X (wherein P is as defined above, and X represents a functional group). The obtained polyolefin is useful as, for example, a compatibilizer for polymer blends and a starting material for molecular design.
Abstract translation:一种以工业上有利的方式制备具有末端官能团的聚烯烃的方法,包括制备通式为P-AlR 1 R 2的末端改性聚烯烃的步骤(A)(其中P表示聚合物链 在由固体钛催化剂组分(a),有机铝化合物(b)制备的烯烃聚合催化剂存在下,R 1和R 2各自代表C1-C10烃基等) 任选的有机硅化合物(c)和在步骤(A)中获得的聚烯烃的-AlR 1 R 2基团与具有官能结构的化合物之间进行取代反应的步骤(B),或 在步骤(A)中获得的聚烯烃的-AlR 1 R 2基团与通过溶剂分解形成官能团的结构的化合物之间进行取代反应,然后将反应产物溶解分解成 得到通式PX的聚烯烃(其中P i s,X表示官能团)。 所得聚烯烃可用作例如聚合物共混物的增容剂和用于分子设计的原料。