PROCESS FOR THE PREPARATION OF 3-[(1R,2R)-3-(DIMETHYLAMINO)-1-ETHYL-2-METHYLPROPYL]-PHENOL
    4.
    发明申请
    PROCESS FOR THE PREPARATION OF 3-[(1R,2R)-3-(DIMETHYLAMINO)-1-ETHYL-2-METHYLPROPYL]-PHENOL 审中-公开
    制备3 - [(1R,2R)-3-(二甲基氨基)-1-乙基-2-甲基丙烯酸] - 苯酚的方法

    公开(公告)号:WO2016023913A1

    公开(公告)日:2016-02-18

    申请号:PCT/EP2015/068488

    申请日:2015-08-11

    申请人: SANDOZ AG

    摘要: A process for the preparation of a compound of formula (I) and of a acid salt (T) wherein R 1 is selected from the group consisting of alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, R 2 and R 3 , are, independently of each other, selected from the group consisting of alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, R 4 , R 5 , R 6 and R 7 , are independently of each other, selected from the group consisting of H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, and wherein the acid salt is a 2,3-Ditoluoyl tartaric acid salt, 2,3-Dibenzoyl tartaric acid salt, 2,3-Dianisoyl tartaric acid salt, 2,3-Dibenzoyl tartaric acid mono(dimethylamide) salt or a mixture of two or more thereof, wherein the tartaric acid salt (T) of the compound of formula (I) contains at least 90 % by weight of the tartaric salt of the compound of formula (Ia) based on the total weight of the acid salt of the compound of formula (I).

    摘要翻译: 制备式(I)化合物和酸式盐(T)的方法,其中R 1选自烷基,芳基,环烷基,杂烷基,杂芳基和杂环烷基,R 2和R 3独立地为 彼此,选自烷基,芳基,环烷基,杂烷基,杂芳基和杂环烷基,R4,R5,R6和R7彼此独立地选自H,烷基,芳基,环烷基,杂烷基 ,杂芳基和杂环烷基,并且其中酸盐是2,3-二甲酰基酒石酸盐,2,3-二苯甲酰酒石酸盐,2,3-狄尼索酰酒石酸盐,2,3-二苯甲酰酒石酸单(二甲基酰胺) 盐或其两种或多种的混合物,其中式(I)化合物的酒石酸盐(T)含有至少90重量%的式(Ia)化合物的酒石酸盐,基于总重量 的式(I)化合物的酸式盐。

    AMINE PRECURSORS FOR DEPOSITING GRAPHENE
    5.
    发明申请
    AMINE PRECURSORS FOR DEPOSITING GRAPHENE 审中-公开
    用于沉积石墨的胺前体

    公开(公告)号:WO2015049624A1

    公开(公告)日:2015-04-09

    申请号:PCT/IB2014/064919

    申请日:2014-09-29

    摘要: The present invention relates to the use of an amine precursor of formula I (X 1 -R 1 ) n -NH (3-n) (I) or its ammonium salts for depositing a graphene film having a nitrogen content of from 0 to 65% by weight on a substrate S1 by chemical vapor deposition (CVD), wherein R 1 is selected from (a) C 1 to C 10 alkanediyl, which may all optionally be interrupted by at least one of O, NH and NR 2 , (b) alkenediyl, which may all optionally be interrupted by at least one of O, NH and NR 2 , (c) alkynediyl, which may all optionally be interrupted by at least one of O, NH and NR 2 , (d) C 6 to C 20 aromatic divalent moiety, and (e) CO and CH 2 CO, X 1 is selected from H, OH, OR 2 , NH 2 , NHR 2 , or NR 2 2 , wherein two groups X 1 may together form a bivalent group X 2 being selected from a chemical bond, O, NH, or NR 2 , R 2 is selected from C 1 to C 10 alkyl and a C 6 to C 20 aromatic moiety which may optionally be substituted by one or more substituents X 1 , n is 1, 2, or 3.

    摘要翻译: 本发明涉及式I(X 1 -R 1)n -NH(3-n)(I)的胺前体或其铵盐用于通过以下方式沉积氮含量为0至65%的石墨烯膜的用途: 通过化学气相沉积(CVD)在基底S1上的重量,其中R1选自(a)C1至C10链烷二基,其可全部任选地被O,NH和NR2中的至少一个中断,(b)亚烯二基,其可以 全部可选地被O,NH和NR2中的至少一个中断,(c)炔二基,其全部可选地被O,NH和NR2,(d)C6〜C20芳族二价部分中的至少一个中断,(e )CO和CH 2 CO,X 1选自H,OH,OR 2,NH 2,NHR 2或NR 2 2,其中两个基团X 1可以一起形成二价基团X 2,其选自化学键,O,NH或NR 2,R 2 选自C1至C10烷基和可任选被一个或多个取代基X1取代的C 6至C 20芳族部分,n为1,2或3。

    METHOD FOR THE CO-PRODUCTION OF NON-CYCLIC CARBONATES AND FATTY NITRILES AND/OR AMINES
    9.
    发明申请
    METHOD FOR THE CO-PRODUCTION OF NON-CYCLIC CARBONATES AND FATTY NITRILES AND/OR AMINES 审中-公开
    合成非循环碳酸盐和脂肪硝酸盐和/或氨基酸的方法

    公开(公告)号:WO2008145940A3

    公开(公告)日:2009-02-05

    申请号:PCT/FR2008050868

    申请日:2008-05-20

    摘要: The invention relates to a joint method of producing fatty nitriles and/or amines and dialkyl carbonates of formula R1O-CO-OR1 in which R1 comprises from 1 to 4 carbon atoms, starting from an ester of a saturated or unsaturated fatty acid derived from natural oils comprising the following zones: I) a zone for synthesis of a nitrile/amine comprising the following steps: a) optional conversion firstly by hydrolysis of the fatty acid ester derived from an oil of natural origin, to fatty acid simultaneously producing the alcohol R1OH which is recovered and sent to zone III, followed by b) ammoniation with ammonia of the fatty acid resulting from step a) and/or of the fatty acid ester to a nitrile respectively producing an ammonia/water mixture and/or an alcohol/ammonia/water mixture which are sent to zone IV, then by c) hydrogenation of the nitrile resulting from step b), optionally in the presence of ammonia, converting the nitrile to the corresponding amine, II) zone for synthesis of a carbonate of a monoalcohol by reaction of urea with the alcohol R1OH, the reaction of said alcohol with urea also producing ammonia, III) zone for recovery and purification of the alcohol R1OH which is used to supply zone II, IV) zone for recovery of the ammonia from zones I and II in order to be used as a supply for the ammoniation of step b) and optionally the hydrogenation of step c) in zone I.

    摘要翻译: 本发明涉及一种制备式R1O-CO-OR1的脂肪腈和/或胺和碳酸二烷基酯的方法,其中R 1包含1至4个碳原子,由衍生自天然的饱和或不饱和脂肪酸的酯开始 包含以下区域的油:I)腈/胺的合成区域,其包括以下步骤:a)首先通过将由天然来源的油衍生的脂肪酸酯水解成脂肪酸,同时制备醇R1OH 将其回收并送至区域III,然后b)将由步骤a)和/或脂肪酸酯得到的脂肪酸的氨氨化至分别产生氨/水混合物和/或醇/氨的腈 /水混合物,然后通过c)氢化来自步骤b)的腈,任选地在氨的存在下,将腈转化成相应的胺,II)用于合成ac的区域 通过脲与醇R 1 OH的反应,一元醇的碳酸酯,所述醇与尿素的反应也产生氨,III)用于回收和纯化用于提供II,IV区的醇的区域,用于回收 用于区域I和II中的氨,以便用作步骤b)的氨化供应和任选的区域I中步骤c)的氢化。

    PROCEDE DE CO-PRODUCTION DE CARBONATES NON CYCLIQUES ET DE NITRILES ET/OU D'AMINES GRAS
    10.
    发明申请
    PROCEDE DE CO-PRODUCTION DE CARBONATES NON CYCLIQUES ET DE NITRILES ET/OU D'AMINES GRAS 审中-公开
    合成非循环碳酸盐和脂肪硝酸盐和/或氨基酸的方法

    公开(公告)号:WO2008145940A2

    公开(公告)日:2008-12-04

    申请号:PCT/FR2008/050868

    申请日:2008-05-20

    摘要: L'invention vise un procédé conjugué de production de nitriles et/ou d'aminés gras et de dialkylcarbonates de formule R 1 O-CO-OR 1 dans laquelle R 1 comporte de 1 à 4 atomes de carbone, à partir d'un ester d'un acide gras insaturé ou non issu d'huiles naturelles comportant les zones suivantes : I) zone de synthèse d'un nitrile/amine comportant les étapes suivantes : a) transformation optionnelle tout d'abord par hydrolyse de l'ester de l'acide gras issu d'une huile d'origine naturelle, en acide gras produisant simultanément l'alcool R 1 OH qui est récupéré et adressé à la zone III, suivie en b) d'une ammoniation avec de l'ammoniac de l'acide gras issu de l'étape la et/ou de l'ester de l'acide gras en nitrile produisant respectivement un mélange ammoniac/eau et/ou un mélange alcool/ammoniac/eau qui sont envoyés à la zone IV, puis en c) d'une hydrogénation du nitrile issu de l'étape b), éventuellement en présence d'ammoniac, transformant le nitrile en aminé correspondante, II) zone de synthèse d'un carbonate de mono-alcool par réaction de l'urée sur l'alcool R 1 OH, la réaction dudit alcool avec l'urée produisant également de l'ammoniac, III) zone de récupération et de purification de l'alcool R 1 OH qui sert d'alimentation pour la zone II, IV) zone de récupération de l'ammoniac issue des zones I et II pour servir d'alimentation pour l'ammoniation de l'étape b et éventuellement l'hydrogénation de l'étape c dans la zone I.

    摘要翻译: 本发明涉及一种制备式R1O-CO-OR1的脂肪腈和/或胺和碳酸二烷基酯的方法,其中R 1包含1至4个碳原子,由衍生自天然的饱和或不饱和脂肪酸的酯开始 包含以下区域的油:I)腈/胺的合成区域,其包括以下步骤:a)首先通过将由天然来源的油衍生的脂肪酸酯水解成脂肪酸,同时制备醇R1OH 将其回收并送至区域III,然后b)将由步骤a)和/或脂肪酸酯得到的脂肪酸的氨氨化至分别产生氨/水混合物和/或醇/氨的腈 /水混合物,然后通过c)氢化来自步骤b)的腈,任选地在氨的存在下,将腈转化成相应的胺,II)用于合成ac的区域 通过脲与醇R 1 OH的反应,一元醇的碳酸酯,所述醇与尿素的反应也产生氨,III)用于回收和纯化用于提供II,IV区的醇的区域,用于回收 用于区域I和II中的氨,以便用作步骤b)的氨化供应和任选的区域I中步骤c)的氢化。