摘要:
A process for the preparation of polyfluoroalkylamines wherein polyfluoroalkylalcohols are reacted with an imide in the presence of SO2F2 and an acid scavenger in a first step and the compound obtained is then reacted with an acid, base or hydrazine in a second step.
摘要:
The present invention provides an improved process for the manufacture ( R )-6- hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethyl-ethylamino-ethyl]-2H-1,4- benzoxazin-3(4H)-one, in high purity and high yield, through the use of 1,1-dimethyl-2- (4-methoxyphenyl)ethyl amine L-tartrate salt, 1,1-dimethyl-2-(4-methoxyphenyl)ethyl amine maletate salt or the camphorsulfonate salt of intermediate (4). The invention also relates to sais salts, to processes for preparing them and to their use for the manufacture of ( R )-6-hydroxy-8-[1-hydroxy-2-[2-(4-methoxyphenyl)-1,1-dimethyl- ethylamino-ethyl]-2H-1,4-benzoxazin-3(4H)-one or a pharmaceutically acceptable salt thereof.
摘要:
The present invention relates to a method of reducing, cleaving and/or coupling at least one C=O, C-O, C=C or C=N bond of a compound, using a reagent comprising a stannyl cation.
摘要:
A process for the preparation of a compound of formula (I) and of a acid salt (T) wherein R 1 is selected from the group consisting of alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, R 2 and R 3 , are, independently of each other, selected from the group consisting of alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, R 4 , R 5 , R 6 and R 7 , are independently of each other, selected from the group consisting of H, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, and wherein the acid salt is a 2,3-Ditoluoyl tartaric acid salt, 2,3-Dibenzoyl tartaric acid salt, 2,3-Dianisoyl tartaric acid salt, 2,3-Dibenzoyl tartaric acid mono(dimethylamide) salt or a mixture of two or more thereof, wherein the tartaric acid salt (T) of the compound of formula (I) contains at least 90 % by weight of the tartaric salt of the compound of formula (Ia) based on the total weight of the acid salt of the compound of formula (I).
摘要:
The present invention relates to the use of an amine precursor of formula I (X 1 -R 1 ) n -NH (3-n) (I) or its ammonium salts for depositing a graphene film having a nitrogen content of from 0 to 65% by weight on a substrate S1 by chemical vapor deposition (CVD), wherein R 1 is selected from (a) C 1 to C 10 alkanediyl, which may all optionally be interrupted by at least one of O, NH and NR 2 , (b) alkenediyl, which may all optionally be interrupted by at least one of O, NH and NR 2 , (c) alkynediyl, which may all optionally be interrupted by at least one of O, NH and NR 2 , (d) C 6 to C 20 aromatic divalent moiety, and (e) CO and CH 2 CO, X 1 is selected from H, OH, OR 2 , NH 2 , NHR 2 , or NR 2 2 , wherein two groups X 1 may together form a bivalent group X 2 being selected from a chemical bond, O, NH, or NR 2 , R 2 is selected from C 1 to C 10 alkyl and a C 6 to C 20 aromatic moiety which may optionally be substituted by one or more substituents X 1 , n is 1, 2, or 3.
摘要:
Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of virological diseases or disorders and cancer.
摘要:
Verfahren zur Direktaminierung von Kohlenwasserstoffen zu Aminokohlenwasserstoffen umfassend die Schritte: a) Umsetzen eines Eduktstroms E, der mindestens einen Kohlenwasserstoff und mindestens ein Aminierungsreagenz enthält, zu einem Reaktionsgemisch R enthaltend Aminokohlenwasserstoffe und Wasserstoff, und b) elektrochemische Abtrennung mindestens eines Teils des bei der Umsetzung entstandenen Wasserstoffs aus dem Reaktionsgemisch R mittels einer gasdichten Membran-Elektroden-Assembly, die mindestens eine selektiv protonleitende Membran und auf jeder Seite der Membran mindestens einen Elektrodenkatalysator aufweist, wobei auf der Retenatseite der Membran mindestens ein Teil des Wasserstoffs an dem Anodenkatalysator zu Protonen oxidiert wird und die Protonen nach Durchqueren der Membran auf der Permeatseite an dem Kathodenkatalysator gemäß b1 ) zu Wasserstoff reduziert werden und/oder b2) mit Sauerstoff zu Wasser umgesetzt werden, wobei der Sauerstoff aus einem Sauerstoff enthaltenden Strom O stammt, der mit der Permeatseite der Membran in Kontakt gebracht wird.
摘要:
The invention relates to a joint method of producing fatty nitriles and/or amines and dialkyl carbonates of formula R1O-CO-OR1 in which R1 comprises from 1 to 4 carbon atoms, starting from an ester of a saturated or unsaturated fatty acid derived from natural oils comprising the following zones: I) a zone for synthesis of a nitrile/amine comprising the following steps: a) optional conversion firstly by hydrolysis of the fatty acid ester derived from an oil of natural origin, to fatty acid simultaneously producing the alcohol R1OH which is recovered and sent to zone III, followed by b) ammoniation with ammonia of the fatty acid resulting from step a) and/or of the fatty acid ester to a nitrile respectively producing an ammonia/water mixture and/or an alcohol/ammonia/water mixture which are sent to zone IV, then by c) hydrogenation of the nitrile resulting from step b), optionally in the presence of ammonia, converting the nitrile to the corresponding amine, II) zone for synthesis of a carbonate of a monoalcohol by reaction of urea with the alcohol R1OH, the reaction of said alcohol with urea also producing ammonia, III) zone for recovery and purification of the alcohol R1OH which is used to supply zone II, IV) zone for recovery of the ammonia from zones I and II in order to be used as a supply for the ammoniation of step b) and optionally the hydrogenation of step c) in zone I.
摘要:
L'invention vise un procédé conjugué de production de nitriles et/ou d'aminés gras et de dialkylcarbonates de formule R 1 O-CO-OR 1 dans laquelle R 1 comporte de 1 à 4 atomes de carbone, à partir d'un ester d'un acide gras insaturé ou non issu d'huiles naturelles comportant les zones suivantes : I) zone de synthèse d'un nitrile/amine comportant les étapes suivantes : a) transformation optionnelle tout d'abord par hydrolyse de l'ester de l'acide gras issu d'une huile d'origine naturelle, en acide gras produisant simultanément l'alcool R 1 OH qui est récupéré et adressé à la zone III, suivie en b) d'une ammoniation avec de l'ammoniac de l'acide gras issu de l'étape la et/ou de l'ester de l'acide gras en nitrile produisant respectivement un mélange ammoniac/eau et/ou un mélange alcool/ammoniac/eau qui sont envoyés à la zone IV, puis en c) d'une hydrogénation du nitrile issu de l'étape b), éventuellement en présence d'ammoniac, transformant le nitrile en aminé correspondante, II) zone de synthèse d'un carbonate de mono-alcool par réaction de l'urée sur l'alcool R 1 OH, la réaction dudit alcool avec l'urée produisant également de l'ammoniac, III) zone de récupération et de purification de l'alcool R 1 OH qui sert d'alimentation pour la zone II, IV) zone de récupération de l'ammoniac issue des zones I et II pour servir d'alimentation pour l'ammoniation de l'étape b et éventuellement l'hydrogénation de l'étape c dans la zone I.