公开(公告)号：WO2009035347A1

公开(公告)日：2009-03-19

申请号：PCT/NZ2008/000239

申请日：2008-09-11

Applicant: WEINBERG, Cristina-Simona ,  BOVIN, Nicolai ,  HENRY, Stephen, Micheal

Inventor： WEINBERG, Cristina-Simona ,  BOVIN, Nicolai ,  HENRY, Stephen, Micheal

IPC: G01N33/539 ,  C07K1/04 ,  G01N33/536 ,  A61K39/385 ,  C07K17/08 ,  G01N33/564 ,  C07F9/10 ,  G01N33/53 ,  G01N33/68 ,  C07K1/02 ,  G01N33/531 ,  G01N33/92

CPC classification number: G01N33/92 ,  A61K47/543 ,  A61K47/544 ,  C07F9/091 ,  C07F9/5721 ,  C07K5/1008 ,  C07K14/47 ,  C07K17/08 ,  C12N5/0006 ,  C12N5/0641 ,  C12N2503/00 ,  G01N33/5304 ,  G01N33/554 ,  G01N33/555 ,  G01N33/6854 ,  G01N33/80 ,  G01N2405/00

Abstract: Peptide-lipid constructs of the structure L-S-F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glycerolipid (including glycerophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of agglutination of the cells.

Abstract translation: 公开了结构L-S-F的肽 - 脂质构建体，其中F是肽，S是通过乙二醇的低聚物共价连接F与L的间隔基，L是二酰基或二烷基 - 甘油脂（包括甘油磷脂）。 间隔物理想地具有6至14个乙二醇重复，对应于分子量为约250至600的PEG。还公开了通过使血清与修饰以掺入肽 - 脂质构建体的细胞接触来检测血清中的反应性抗体的方法，其中 肽是抗体的表位，并确定细胞的凝集程度。

公开(公告)号：WO2009012595A1

公开(公告)日：2009-01-29

申请号：PCT/CA2008/001366

申请日：2008-07-25

Applicant: PHENOMENOME DISCOVERIES INC. ,  GOODENOWE, Dayan

Inventor： GOODENOWE, Dayan

IPC: G01N33/48 ,  G01N33/483 ,  G01N33/49 ,  G01N33/92

CPC classification number: G01N33/6848 ,  G01N33/6893 ,  G01N33/92 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2800/30 ,  G01N2800/38 ,  Y10T436/24

Abstract: Methods for the diagnosis, risk assessment, and monitoring of Autism Spectrum Disorder (ASD) are disclosed. More specifically the present invention relates to the measurement of small molecules (metabolites) in human plasma that are found to have different abundances between persons with a clinical manifestation of ASD and subjects not expressing symptoms of ASD. Further, this invention relates to the monitoring of putative therapeutic strategies designed to ameliorate the biochemical abnormalities associated with ASD.

Abstract translation: 披露了自闭症谱系障碍（ASD）的诊断，风险评估和监测方法。 更具体地说，本发明涉及人类血浆中的小分子（代谢物）的测量，其发现具有ASD的临床表现的人与未表达ASD的症状的受试者之间具有不同的丰度。 此外，本发明涉及监测旨在改善与ASD相关的生化异常的推定治疗策略。

公开(公告)号：WO0208760A8

公开(公告)日：2002-04-18

申请号：PCT/AU0100877

申请日：2001-07-19

Applicant: BIOTRON LTD ,  PARISH CHRISTOPHER RICHARD ,  CABALDA CRANE VIVIAN MAE

Inventor： PARISH CHRISTOPHER RICHARD ,  CABALDA-CRANE VIVIAN MAE

IPC: G01N27/62 ,  G01N27/64 ,  G01N33/483 ,  G01N33/574 ,  G01N30/72 ,  G01N33/50 ,  G01N33/66 ,  G01N33/92 ,  H01J49/40

CPC classification number: G01N33/574 ,  G01N2400/10 ,  G01N2405/00 ,  G01N2405/10

Abstract: The present invention provides a mass spectrometry-based method of identifying a cancer marker in sera and uses of said cancer marker in diagnosing cancer in human and non-human subjects. The invention further provides isolated cancer markers.

Abstract translation: 本发明提供一种鉴定血清中的癌症标志物的质谱法和用于诊断人类和非人类受试者的癌症的所述癌症标志物的用途。 本发明还提供了分离的癌症标志物。

公开(公告)号：WO01016602A1

公开(公告)日：2001-03-08

申请号：PCT/GB2000/003311

申请日：2000-08-30

IPC: G01N33/569 ,  G01N33/68

CPC classification number: G01N33/569 ,  G01N33/6854 ,  G01N2333/31 ,  G01N2333/34 ,  G01N2405/00

Abstract: Disclosed is a method of diagnosing a neuralgic or neuritic condition in a subject, the method comprising the steps of : obtaining a sample of body fluid from the subject having a suspected neuralgic or neuritic condition; and testing the sample for the presence of antibodies reactive with a bacterial antigen; diagnosis of a neuralgic or neuritic condition being made where the sample from the patient contains a concentration of said antibodies above a pre-determined level.

Abstract translation: 公开了一种诊断受试者的神经痛或神经炎状况的方法，所述方法包括以下步骤：从具有疑似神经痛或神经炎状况的受试者获得体液样品; 并测试样品中是否存在与细菌抗原反应的抗体; 在来自患者的样品含有高于预定水平的所述抗体的浓度的情况下，进行神经痛或神经炎状态的诊断。

公开(公告)号：WO2019091952A1

公开(公告)日：2019-05-16

申请号：PCT/EP2018/080259

申请日：2018-11-06

Applicant: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA ,  FONDAZIONE SANTA LUCIA

Inventor： ARMIROTTI, Andrea ,  REGGIANI, Angelo ,  SPALLETTA, Gianfranco

IPC: G01N33/68

CPC classification number: G01N33/6896 ,  G01N33/92 ,  G01N2405/00 ,  G01N2800/50 ,  G01N2800/52

Abstract: Disclosed is a method for detecting the presence, progression or risk of onset of neurodegenerative disease, based on determination of the concentration of lipid markers in an individual's serum or plasma sample.

公开(公告)号：WO2018213372A1

公开(公告)日：2018-11-22

申请号：PCT/US2018/032862

申请日：2018-05-16

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  DANA-FARBER CANCER INSTITUTE, INC.

Inventor： NASR, Mahmoud, L. ,  SHIH, William, M. ,  ZHAO, Zhao ,  WAGNER, Gerhard

IPC: G01N33/543 ,  C12Q1/68

CPC classification number: G01N33/54353 ,  G01N2405/00

Abstract: Provided herein, in some embodiments, are nucleic acid-lined nanodiscs and methods and kits for producing the nucleic acid-lined nanodiscs.

公开(公告)号：WO2017041037A1

公开(公告)日：2017-03-09

申请号：PCT/US2016/050265

申请日：2016-09-02

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： MCINTIRE, Laura

IPC: G01N33/92 ,  A61P25/16 ,  A61K35/00 ,  A61K45/06 ,  C07K14/47

CPC classification number: C07K14/4711 ,  A61B6/037 ,  A61K9/0043 ,  A61K31/202 ,  A61K38/00 ,  A61K45/06 ,  A61K47/24 ,  A61K47/38 ,  A61P25/16 ,  A61P25/28 ,  C07K14/775 ,  C07K16/28 ,  G01N33/6896 ,  G01N33/92 ,  G01N2333/4709 ,  G01N2405/00 ,  G01N2500/02 ,  G01N2800/2814 ,  G01N2800/2821

Abstract: The present invention relates to methods of treating neurodegenerative disorders associated with Alzheimer's disease (AD), Parkinson's disease (PD) and synucleinopathies, such as dementia with Lewy bodies, Down Syndrome (DS) and associated cognitive disorders, multiple system atrophy, and rare neuroaxonal dystrophies, such as Niemann-Pick type C disease (NPC) and Gaucher' s disease comprising administering an inhibitor to disrupt the interaction between Αβ or aS and neuronal lipids. The invention further relates to assays for identifying agents that reduce interaction between Αβ or aS and neuronal lipids. Lastly, the invention relates to methods and compositions for intranasal administration of fatty acids or lipids containing fatty acid acyl chains of dietary lipids for promoting central nervous system health and/or prevention or treatment of neurodegenerative disorders.

Abstract translation: 本发明涉及治疗与阿尔茨海默氏病（AD），帕金森病（PD）和突触核蛋白病相关的神经变性疾病的方法，例如路易体痴呆，唐氏综合征（DS）和相关的认知障碍，多系统萎缩和罕见的神经元 营养不良，例如尼曼 - 皮克型C型疾病（NPC）和戈谢氏病，包括施用抑制剂以破坏Aβ或aS与神经元脂质之间的相互作用。 本发明还涉及用于鉴定减少Aβ或aS与神经元脂质之间相互作用的试剂。 最后，本发明涉及用于鼻内施用脂肪酸或脂质的方法和组合物，其包含用于促进中枢神经系统健康和/或预防或治疗神经变性疾病的膳食脂质的脂肪酸酰基链。

公开(公告)号：WO2017005374A1

公开(公告)日：2017-01-12

申请号：PCT/EP2016/001182

申请日：2016-07-08

Applicant: CENTOGENE AG

Inventor： ROLFS, Arndt ,  COZMA, Claudia

IPC: G01N33/92

CPC classification number: G01N33/92 ,  A61K48/005 ,  A61P3/00 ,  C12Y305/01023 ,  G01N33/6851 ,  G01N33/6893 ,  G01N2405/00 ,  G01N2800/04 ,  G01N2800/52 ,  G01N2800/60

Abstract: The present invention is related to a method for diagnosing Farber's disease in a subject, wherein the method comprises detecting C26 ceramide in a sample from the subject.

Abstract translation: 本发明涉及一种用于诊断受试者中Farber氏病的方法，其中该方法包括检测来自受试者的样品中的C26神经酰胺。

公开(公告)号：WO2016196743A1

公开(公告)日：2016-12-08

申请号：PCT/US2016/035442

申请日：2016-06-02

Applicant: THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

Inventor： GRAVENSTEIN, Nikolaus ,  SHAW, Christiana, M. ,  COSTANZO, Michael, T. ,  YOST, Rick ,  ULMER, Candice, Z. ,  SEARCY, Louis

IPC: G01N33/574 ,  G01N33/50

CPC classification number: G01N33/5743 ,  G01N2405/00 ,  G01N2560/00

Abstract: The present disclosure provides methods and systems for detecting melanoma in a host. The methods include non-invasive methods of detecting melanoma and methods and systems for providing a molecular signature and/or melanoma biomarker signature for a host.

Abstract translation: 本公开提供了用于检测宿主中黑素瘤的方法和系统。 所述方法包括检测黑素瘤的非侵入性方法以及用于为宿主提供分子标记和/或黑素瘤生物标志物签名的方法和系统。

公开(公告)号：WO2016142679A1

公开(公告)日：2016-09-15

申请号：PCT/GB2016/050608

申请日：2016-03-07

Applicant: MICROMASS UK LIMITED

Inventor： PRINGLE, Steven Derek ,  JONES, Emrys ,  MORRIS, Michael Raymond ,  BALOG, Júlia ,  LANGRIDGE, James Ian ,  RICHARDSON, Keith ,  SIMON, Dániel ,  GÖDÖRHÁZY, Lajos ,  SZALAY, Dániel ,  TAKÁTS, Zoltán

IPC: G01N33/68 ,  A61B17/00 ,  G01N3/00 ,  G01N9/00 ,  H01J49/00 ,  A61B18/00 ,  G01N27/62

CPC classification number: H01J49/049 ,  A61B1/00013 ,  A61B1/041 ,  A61B1/31 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/055 ,  A61B5/14542 ,  A61B6/032 ,  A61B6/037 ,  A61B8/13 ,  A61B10/00 ,  A61B10/0041 ,  A61B10/0233 ,  A61B10/0283 ,  A61B17/00 ,  A61B17/320068 ,  A61B18/00 ,  A61B18/042 ,  A61B18/14 ,  A61B18/1445 ,  A61B18/1815 ,  A61B18/20 ,  A61B90/13 ,  A61B2010/0083 ,  A61B2017/320069 ,  A61B2018/00577 ,  A61B2218/008 ,  A61F13/38 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/24 ,  G01N1/2202 ,  G01N3/00 ,  G01N9/00 ,  G01N27/622 ,  G01N27/624 ,  G01N30/724 ,  G01N33/487 ,  G01N33/48735 ,  G01N33/6848 ,  G01N33/6851 ,  G01N33/92 ,  G01N2001/2223 ,  G01N2333/195 ,  G01N2405/00 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2570/00 ,  G01N2800/26 ,  G06F19/18 ,  G06F19/324 ,  G06F19/3481 ,  G16H50/20 ,  H01J49/0004 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0422 ,  H01J49/0445 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/0468 ,  H01J49/061 ,  H01J49/068 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/164 ,  H01J49/24 ,  H01J49/26

Abstract: A method is disclosed comprising obtaining or acquiring chemical or other non- mass spectrometric data from one or more regions of a target (2) using a chemical sensor (20). The chemical or other non-mass spectrometric data may be used to determine one or more regions of interest of the target (2). An ambient ionisation ion source 1 may then be used to generate aerosol, smoke or vapour (5) from one or more regions of the target (2).

Abstract translation: 公开了一种方法，其包括使用化学传感器（20）从目标（2）的一个或多个区域获得或获取化学或其他非质谱数据。 化学或其他非质谱数据可用于确定目标（2）的一个或多个感兴趣区域。 然后可以使用环境离子源1从目标（2）的一个或多个区域产生气溶胶，烟雾或蒸汽（5）。