公开(公告)号：WO2010051295A1

公开(公告)日：2010-05-06

申请号：PCT/US2009/062299

申请日：2009-10-28

Applicant: WATERS TECHNOLOGIES CORPORATION ,  OEHRLE, Stuart, A.

Inventor： OEHRLE, Stuart, A.

IPC: C08H1/00

CPC classification number: C12Q1/04 ,  B01J39/07 ,  B01J41/07 ,  G01N1/40 ,  G01N30/08 ,  G01N30/96 ,  G01N33/50 ,  G01N33/6848 ,  G01N2333/195 ,  Y10T436/17 ,  B01J39/046 ,  B01J41/046

Abstract: Embodiments of the present invention are directed to kits and methods for the detection of toxins produced by cyanobacteria. The methods and kits feature sample preparation steps with weak cationic and anionic exchange resins and small particle analytical columns operating at 4.000 to 15,000 psi.

Abstract translation: 本发明的实施方案涉及用于检测由蓝细菌产生的毒素的试剂盒和方法。 该方法和试剂盒采用弱阳离子和阴离子交换树脂的样品制备步骤和以4.000至15,000psi操作的小颗粒分析柱。

公开(公告)号：WO2009142743A1

公开(公告)日：2009-11-26

申请号：PCT/US2009/003147

申请日：2009-05-20

Applicant: CANTIMER, INC. ,  STEWART, Ray, F. ,  MORTON, Kathryn, M. ,  DICKERMAN-STEWART, Aaron ,  MAK, Nathan

Inventor： STEWART, Ray, F. ,  MORTON, Kathryn, M. ,  DICKERMAN-STEWART, Aaron ,  MAK, Nathan

IPC: G01N33/545 ,  G01N1/00

CPC classification number: G01N33/545 ,  Y10T436/144444 ,  Y10T436/147777 ,  Y10T436/17 ,  Y10T436/171538 ,  Y10T436/201666 ,  Y10T436/204998

Abstract: Devices, methods and systems effective to evaluate a physical or chemical property of a surfactant-treated biological fluid sample are provided.

Abstract translation: 提供了有效评估表面活性剂处理的生物流体样品的物理或化学性质的装置，方法和系统。

公开(公告)号：WO2009018112A3

公开(公告)日：2009-07-09

申请号：PCT/US2008071085

申请日：2008-07-24

Applicant: INVITROGEN CORP ,  GEE KYLE ,  JANES MICHEAL ,  JOHNSON IAIN ,  KANG HEE CHOL

Inventor： GEE KYLE ,  JANES MICHEAL ,  JOHNSON IAIN ,  KANG HEE CHOL

IPC: C07D491/16

CPC classification number: G01N33/52 ,  C07D491/06 ,  C07D491/16 ,  C07F9/5442 ,  C07K5/0215 ,  G01N33/582 ,  G01N2333/4701 ,  Y10T436/17 ,  Y10T436/182

Abstract: Fluorescent quinolizinocoumarin compounds substituted with electrophilic reactive groups that bind thiol compounds are described. The compounds are useful in detecting oxidative stress and processes associated therewith in live cells.

Abstract translation: 描述了与结合硫醇化合物的亲电子反应性基团取代的荧光喹诺酮香豆素化合物。 这些化合物可用于检测活细胞中的氧化应激和相关过程。

公开(公告)号：WO2009032205A3

公开(公告)日：2009-05-14

申请号：PCT/US2008010265

申请日：2008-08-29

Applicant: GE ANALYTICAL INSTR INC ,  CONWAY GREGORY B ,  SCAER MICHAEL R ,  MELANSON PAUL ,  FRANCIS GORDON K ,  HUANG PEI

Inventor： CONWAY GREGORY B ,  SCAER MICHAEL R ,  MELANSON PAUL ,  FRANCIS GORDON K ,  HUANG PEI

IPC: G01N21/35 ,  G01N33/18

CPC classification number: G01N33/1846 ,  G01N21/3504 ,  G01N31/12 ,  Y02A20/206 ,  Y10T137/8593 ,  Y10T137/87161 ,  Y10T137/87249 ,  Y10T137/87652 ,  Y10T436/11 ,  Y10T436/17 ,  Y10T436/18 ,  Y10T436/204998 ,  Y10T436/23 ,  Y10T436/235 ,  Y10T436/2575

Abstract: Apparatus and methods for measuring the concentrations of organic and inorganic carbon, or of other materials, in aqueous samples are described, together with related, specially adapted components and sub-assemblies and related control, operational and monitoring systems.

Abstract translation: 描述了用于测量含水样品中有机和无机碳或其他材料的浓度的设备和方法，以及相关的特别适应的组件和子组件以及相关的控制，操作和监控系统。

公开(公告)号：WO2009032205A2

公开(公告)日：2009-03-12

申请号：PCT/US2008/010265

申请日：2008-08-29

Applicant: GE ANALYTICAL INSTRUMENTS, INC. ,  CONWAY, Gregory, B. ,  SCAER, Michael, R. ,  MELANSON, Paul ,  FRANCIS, Gordon, K. ,  HUANG, Pei

Inventor： CONWAY, Gregory, B. ,  SCAER, Michael, R. ,  MELANSON, Paul ,  FRANCIS, Gordon, K. ,  HUANG, Pei

IPC: G01N21/35 ,  G01N33/18

CPC classification number: G01N33/1846 ,  G01N21/3504 ,  G01N31/12 ,  Y02A20/206 ,  Y10T137/8593 ,  Y10T137/87161 ,  Y10T137/87249 ,  Y10T137/87652 ,  Y10T436/11 ,  Y10T436/17 ,  Y10T436/18 ,  Y10T436/204998 ,  Y10T436/23 ,  Y10T436/235 ,  Y10T436/2575

Abstract: Apparatus and methods for measuring the concentrations of organic and inorganic carbon, or of other materials, in aqueous samples are described, together with related, specially adapted components and sub-assemblies and related control, operational and monitoring systems.

Abstract translation: 描述了用于测量水性样品中有机和无机碳或其他材料的浓度的装置和方法，连同相关的特别适合的部件和子组件以及相关的控制，操作和监测 系统

公开(公告)号：WO2009009776A2

公开(公告)日：2009-01-15

申请号：PCT/US2008/069892

申请日：2008-07-11

Applicant: TRAGARA PHARMACEUTICALS, INC. ,  LAWHON, Tracy ,  ZAKNOEN, Sara ,  ESTOK, Thomas ,  GREEN, Mark

Inventor： LAWHON, Tracy ,  ZAKNOEN, Sara ,  ESTOK, Thomas ,  GREEN, Mark

IPC: A61K49/00

CPC classification number: G01N33/88 ,  A61K31/40 ,  G01N2333/90216 ,  G01N2500/00 ,  G01N2800/52 ,  Y10T436/17

Abstract: Disclosed herein are methods related generally to a patient selection process for identifying individuals for treatment of cancer, inflammation, pain, and/or related conditions.

Abstract translation: 本文公开的方法通常涉及用于鉴定用于治疗癌症，炎症，疼痛和/或相关病症的个体的患者选择方法。

公开(公告)号：WO2008130376A3

公开(公告)日：2008-12-18

申请号：PCT/US2007021701

申请日：2007-10-11

Applicant: MASSACHUSETTS INST TECHNOLOGY ,  SWAGER TIMOTHY M ,  ANDREW TRISHA L ,  THOMAS SAMUEL W III ,  BOUFFARD JEAN

Inventor： SWAGER TIMOTHY M ,  ANDREW TRISHA L ,  THOMAS SAMUEL W III ,  BOUFFARD JEAN

IPC: G01N21/64

CPC classification number: G01N21/643 ,  G01N33/22 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2021/7786 ,  Y10T436/145555 ,  Y10T436/17 ,  Y10T436/200833

Abstract: The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical reaction, or other chemical, biochemical or biological interaction (e.g., recognition), to form a new emissive species. In some cases, the present invention may be used for the detection of analytes such as explosives (e.g., RDX, PETN). Methods of the present invention may be advantageous in that the high sensitivity of luminescence (e.g., fluorescence) spectroscopy can allow for the reliable detection of small changes in luminescence intensity.

Abstract translation: 本发明提供了用于确定分析物的传感器和方法。 可以通过监测例如暴露于分析物时发射材料的光学信号的变化来确定分析物。 在一些实施例中，分析物和发射材料可以经由化学反应或其他化学，生物化学或生物学相互作用（例如识别）相互作用以形成新的发射物种。 在一些情况下，本发明可以用于检测分析物，例如炸药（例如RDX，PETN）。 本发明的方法可以是有利的，因为发光（例如，荧光）光谱的高灵敏度可以允许可靠地检测发光强度的小变化。

公开(公告)号：WO2008088867A1

公开(公告)日：2008-07-24

申请号：PCT/US2008/000672

申请日：2008-01-18

Applicant: CANTIMER INCORPORATED ,  ARIZONA BOARD OF REGENTS FOR AND ON BEHALF OF NORTHERN ARIZONA UNIVERSITY ,  THE UNIVERSITY OF TEXAS-PAN AMERICAN ,  PORTER, Timothy, L. ,  STEWART, Ray ,  VAIL, Timothy, L. ,  EAST, Michael, P.

Inventor： PORTER, Timothy, L. ,  STEWART, Ray ,  VAIL, Timothy, L. ,  EAST, Michael, P.

IPC: G01N27/12 ,  G01N27/16

CPC classification number: G01N29/036 ,  G01N2291/0257 ,  Y10T436/15 ,  Y10T436/153333 ,  Y10T436/16 ,  Y10T436/17 ,  Y10T436/172307 ,  Y10T436/19 ,  Y10T436/196666 ,  Y10T436/204998 ,  Y10T436/205831

Abstract: The compositions and methods relate to an organic polymer-inorganic particle sensor material for detecting analytes. Interactions between the polymer and the particles are affected by the presence of analyte, which displaces the polymer and increases its free volume. This change in free volume can be detected, e.g., using an embedded piezoresistive microcantilever (EPM) sensor. Analytes that can be detected include noxious substances, such as hydrogen cyanide gas and carbon monoxide.

Abstract translation: 组合物和方法涉及用于检测分析物的有机聚合物 - 无机颗粒传感器材料。 聚合物和颗粒之间的相互作用受到分析物的存在的影响，分析物取代聚合物并增加其自由体积。 可以检测自由体积的这种变化，例如使用嵌入式压阻微型悬臂梁（EPM）传感器。 可检测的分析物包括有毒物质，如氰化氢气体和一氧化碳。

公开(公告)号：WO2008078053A2

公开(公告)日：2008-07-03

申请号：PCT/FR2007/052573

申请日：2007-12-20

Applicant: SOCIETE POUR LA CONCEPTION DES APPLICATIONS DES TECHNIQUES ELECTRONIQUES ,  RICARD, André ,  DIERAS, Françis ,  SIXOU, Michel ,  VILLEGER, Sandrine ,  CANAL, Cristina ,  ERRA, Pilar

Inventor： RICARD, André ,  DIERAS, Françis ,  SIXOU, Michel ,  VILLEGER, Sandrine ,  CANAL, Cristina ,  ERRA, Pilar

CPC classification number: G01N31/226 ,  A61L2/14 ,  A61L2/28 ,  C12Q1/22 ,  Y10T436/17 ,  Y10T436/20

Abstract: L'invention a pour objet un indicateur de stérilisation (17), caractérisé en ce qu'il comprend : un composé (21) du type chauffant lorsqu'il est mis en contact avec des atomes d'oxygène 0 et/ou d'azote N; et un colorant thermochromique (19), en contact thermique avec le composé (21).

Abstract translation: 本发明涉及灭菌指示剂（17），其特征在于它包括：与氧（O）和/或氮（N）原子接触时加热的化合物（21）和位于 与化合物（21）热接触。

公开(公告)号：WO2008019086A3

公开(公告)日：2008-05-29

申请号：PCT/US2007017380

申请日：2007-08-02

Applicant: MASSACHUSETTS INST TECHNOLOGY ,  SWAGER TIMOTHY M ,  THOMAS SAMUEL W

Inventor： SWAGER TIMOTHY M ,  THOMAS SAMUEL W

IPC: G01N21/64 ,  G01N21/77

CPC classification number: G01N33/0057 ,  G01N2021/6432 ,  Y10T436/17 ,  Y10T436/173076 ,  Y10T436/173845 ,  Y10T436/174614 ,  Y10T436/175383

Abstract: The present invention generally relates to methods for modulating the optical properties of a luminescent polymer via interaction with a species (e.g., an analyte). In some cases, the present invention provides methods for determination of an analyte by monitoring a change in an optical signal of a luminescent polymer upon exposure to an analyte. Methods of the present invention may be useful for the vapor phase detection of analytes such as explosives and toxins. The present invention also provides methods for increasing the luminescence intensity of a polymer, such as a polymer that has been photobleached, by exposing the luminescent polymer to a species such as a reducing agent.

Abstract translation: 本发明一般涉及通过与物质（例如分析物）的相互作用来调节发光聚合物的光学性质的方法。 在一些情况下，本发明提供了通过在暴露于分析物时监测发光聚合物的光学信号的变化来测定分析物的方法。 本发明的方法可用于分析物如爆炸物和毒素的气相检测。 本发明还提供了通过将发光聚合物暴露于诸如还原剂的物质来提高聚合物（例如已经漂白的聚合物）的发光强度的方法。