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公开(公告)号：WO2015138514A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/019796
申请日：2015-03-10
Applicant: 3-D MATRIX, LTD.
Inventor： GIL, Eun Seok , GILBERT, Karl , MEHTA, Manav
CPC classification number: C07K7/08 , A61K38/00 , A61L24/108 , A61L27/227
Abstract: The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide concentration, pH, ionic strength [including salt identity and/or concentration), etc that show particularly useful material properties. The present disclosure also provides technologies for selecting and/or formulating particular peptide compositions useful in specific contexts. In some embodiments, provided peptide compositions have an elevated pH within the range of about 2.5 to about 3.5 and/or an ionic strength that is above that of a corresponding composition of the same peptide, at the same concentration, in water, but is below a critical salt point for the peptide (e.g., so that the composition is not cloudy).
Abstract translation: 本公开提供具有特别有用的材料性质的特定属性（例如肽同一性，肽浓度，pH，离子强度（包括盐同一性和/或浓度）等）的肽组合物（例如自组装肽）。 本公开还提供了用于选择和/或配制在特定上下文中有用的特定肽组合物的技术。 在一些实施方案中，所提供的肽组合物具有在约2.5至约3.5范围内的升高的pH值和/或高于相同肽在相同浓度的水中的相应组合物的离子强度，但低于 肽的临界盐点（例如，使得组合物不浑浊）。
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公开(公告)号：WO2015138473A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/019738
申请日：2015-03-10
Applicant: 3-D MATRIX, LTD. , MEHTA, Manav , TSUKADA, Hisashi
Inventor： MEHTA, Manav , TSUKADA, Hisashi , GIL, Eun, Seok , GILBERT, Karl, Patrick , KOBAYASHI, Satoru
CPC classification number: A61K38/07 , A61K2121/00 , A61L26/0047 , A61L26/008 , A61L2400/06
Abstract: Materials and methods for treatment of pulmonary leakage are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary leakage.
Abstract translation: 提供了治疗肺部渗漏的材料和方法。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 为了治疗肺部渗漏，可以在目标部位设置水凝胶屏障。
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公开(公告)号：WO2021202577A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/024954
申请日：2021-03-30
Applicant: 3-D MATRIX, LTD.
Inventor： RIOULT, Marika, G. , GIL, Eun Seok , ALEKSI, Elton , YAMAMOTO, Naoki
IPC: A61K38/16 , A61K38/00 , A61L27/52 , A61L27/50 , A61L2/0035 , A61L2/081 , A61L2/26 , A61L27/227 , C07K7/08 , C12N5/0068
Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self- assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.
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公开(公告)号：WO2020008377A3
公开(公告)日：2020-01-09
申请号：PCT/IB2019/055661
申请日：2019-07-03
Applicant: 3-D MATRIX, LTD.
Inventor： GIL, Eun Seok , ALEKSI, Elton , YAMAMOTO, Naoki
Abstract: Provided herein are ionic self-assembling peptides, pharmaceutical compositions comprising the peptides, and methods of using and making the same.
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公开(公告)号：WO2020008377A2
公开(公告)日：2020-01-09
申请号：PCT/IB2019/055661
申请日：2019-07-03
Applicant: 3-D MATRIX, LTD.
Inventor： GIL, Eun Seok , ALEKSI, Elton , YAMAMOTO, Naoki
Abstract: Provided herein are ionic self-assembling peptides, pharmaceutical compositions comprising the peptides, and methods of using and making the same.
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Patent Agency Ranking
公开(公告)号：WO2019116092A1
公开(公告)日：2019-06-20
申请号：PCT/IB2018/001511
申请日：2018-11-30
Applicant: 3-D MATRIX, LTD.
Inventor： ALESKI, Elton , GIL, Eun, Seok , MATSUDA, Noriaki
IPC: A61K9/00
Abstract: Disclosed herein are surfactant peptide nanostmctures wherein the peptides have repeating hydrophobic amino acids in an integer equal to or less than four. The peptide nanostmctures are useful for therapeutic applications, including for delivery of drugs and siRNA.
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17.发明申请SELF-ASSEMBLING PEPTIDE MATRIX FOR THE PREVENTION OF ESOPHAGEAL STRICTURE AFTER ENDOSCOPIC DISSECTION 审中-公开自组装多肽基质预防内窥镜剥离术后食管狭窄
公开(公告)号：WO2018005427A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039407
申请日：2017-06-27
Inventor： GIL, Eun, Seok , REVEILLER-BUFFIER, Marie , PRAT, Frederic , BARRET, Maximilien, Louis, François, Benjamin
Abstract: Methods for preventing esophageal stricture following an endoscopic resection procedure in a subject are provided. A solution having a pH level of about 3.5 and including a self-assembling peptide comprising between about 7 amino acids and about 32 amino acids in an effective amount and in an effective concentration to form a hydrogel under esophageal conditions to provide prevention of esophageal stricture may be introduced to a target site.
Abstract translation: 提供了在受试者的内窥镜切除手术之后预防食管狭窄的方法。 具有约3.5的pH水平并且包含有效量且包含约7个氨基酸和约32个氨基酸的自组装肽以及有效浓度以在食管条件下形成水凝胶以提供预防食管狭窄的溶液可以 被引入目标网站。
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公开(公告)号：WO2017210416A1
公开(公告)日：2017-12-07
申请号：PCT/US2017/035424
申请日：2017-06-01
Applicant: 3-D MATRIX, LTD. , GIL, Eun, Seok , ALEKSI, Elton
Inventor： GIL, Eun, Seok , ALEKSI, Elton , RIOULT, Marc
CPC classification number: A61L15/26 , A61L15/28 , A61L15/32 , A61L15/425 , A61L15/44 , A61L15/64 , C08L67/04
Abstract: Hemostatic dressings are synergistically used in conjunction with self-assembling peptide hydrogels to promote hemostasis at a target site. Related methods, kits, and devices for hemostasis are disclosed.
Abstract translation: 止血敷料与自组装肽水凝胶协同使用以促进目标部位的止血。 披露了相关的方法，试剂盒和用于止血的装置。
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公开(公告)号：WO2017158435A1
公开(公告)日：2017-09-21
申请号：PCT/IB2017/000387
申请日：2017-03-17
Applicant: 3-D MATRIX, LTD.
Inventor： KOBAYASHI, Satoru
Abstract: Methods and materials for treating a cerebrospinal fluid leakage are described herein. One method for treating cerebrospinal fluid leakage includes occluding cerebrospinal fluid leakage by administering an effective amount of a self-assembling peptide solution to a target area of a cerebrospinal fluid leakage, where the self-assembling peptide is between 7 amino acids and 32 amino acids in length and the self-assembling peptide solution forms a hydrogel under physiological conditions.
Abstract translation: 本文描述了用于治疗脑脊液漏出的方法和材料。 一种用于治疗脑脊液漏的方法包括通过将有效量的自组装肽溶液施用于脑脊液漏的目标区域来封闭脑脊髓液泄漏，其中自组装肽在7个氨基酸与32个氨基酸之间 并且自组装肽溶液在生理条件下形成水凝胶。
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公开(公告)号：WO2015196020A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036590
申请日：2015-06-19
Applicant: 3-D MATRIX, LTD. , FORSYTH DENTAL INFIRMARY FOR CHILDREN , HASTURK, Hatice , VAN DYKE, Thomas, E.
Inventor： HASTURK, Hatice , VAN DYKE, Thomas, E. , SPIRO, Lisa
IPC: A61B17/88
CPC classification number: A61C8/0092 , A61C8/0006 , A61C19/063 , A61L27/10 , A61L27/227 , A61L27/3865 , A61L27/52 , A61L27/54 , A61L2300/406 , A61L2300/41 , A61L2300/412 , A61L2400/06 , A61L2400/12 , A61L2430/02 , A61L2430/12
Abstract: Materials and methods for dental bone void filling such as during a sinus lift procedure are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. The peptide may undergo self-organization under physiological conditions and/or in the presence of a cation.
Abstract translation: 提供牙龈空隙填充的材料和方法，例如在窦升高过程中。 在溶液中含有约7个氨基酸和约32个氨基酸之间的肽可被引入到靶位点。 肽可以在生理条件下和/或在阳离子存在下进行自组织。
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