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公开(公告)号：WO2016196690A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035356
申请日：2016-06-01
Applicant: MILLER, Benjamin, Aaron , JUSTMAN, Jason, D. , BOUCHARD, Lora, Clark , BOUCHARD, Michael, Ellery , COTLOVE, Kevin, James , GITCHELL, Mathew, Keith , HAISCH, Stacia, Lynn , KERSTEN, Jonathan, David , MARCHIO, Matthew, Karl , PULLIAM, Peter, Arthur , SMITH, George, Allen , TIBBETTS, Todd, Christopher
Inventor： MILLER, Benjamin, Aaron , JUSTMAN, Jason, D. , BOUCHARD, Lora, Clark , BOUCHARD, Michael, Ellery , COTLOVE, Kevin, James , GITCHELL, Mathew, Keith , HAISCH, Stacia, Lynn , KERSTEN, Jonathan, David , MARCHIO, Matthew, Karl , PULLIAM, Peter, Arthur , SMITH, George, Allen , TIBBETTS, Todd, Christopher
CPC classification number: H04N21/8352 , H04N21/2407 , H04N21/2541 , H04N21/26258 , H04N21/2668 , H04N21/44204
Abstract: Systems, devices, and methods are described herein for distributing syndicated content or content with one or more distribution restrictions. In one aspect, a method may include assigning a unique ID to a plurality of content items, where the unique ID of at least one of the content items is associated with one or more property distribution restrictions. The method may further include streaming in a video stream the content items to at least two properties and monitoring the unique IDs of the plurality of content items streamed in the video stream to detect least one content item associated with the one or more property distribution restrictions. The distribution of the least one content item associated with the one or more property distribution restrictions may be blocked from the one or more properties concurrently with streaming the video stream, based on the one or more property distribution restrictions.
Abstract translation: 本文描述了用于分发具有一个或多个分发限制的联合内容或内容的系统，设备和方法。 一方面，方法可以包括向多个内容项目分配唯一ID，其中至少一个内容项目的唯一ID与一个或多个属性分配限制相关联。 该方法还可以包括将视频流中的内容项流传输到至少两个属性，并监视流在视频流中的多个内容项的唯一ID，以检测与一个或多个属性分布限制相关联的最少一个内容项。 基于一个或多个属性分布限制，与一个或多个属性分发限制相关联的最少一个内容项目的分发可以与流式传输视频流同时从该一个或多个属性中被阻止。
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公开(公告)号：WO2011156590A4
公开(公告)日：2012-07-05
申请号：PCT/US2011039792
申请日：2011-06-09
Applicant: SEMPRUS BIOSCIENCES CORP , ZHANG ZHENG , LI JUN , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
Inventor： ZHANG ZHENG , LI JUN , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
CPC classification number: A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/252 , A61L2300/404 , A61L2300/42 , A61L2300/606 , A61L2420/02 , B32B5/022 , B32B5/024 , B32B5/16 , B32B5/26 , B32B5/30 , B32B9/00 , B32B9/005 , B32B9/04 , B32B9/041 , B32B9/043 , B32B9/047 , B32B9/048 , B32B15/04 , B32B15/043 , B32B15/08 , B32B15/14 , B32B15/16 , B32B27/08 , B32B27/12 , B32B27/14 , B32B27/28 , B32B27/281 , B32B27/283 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/34 , B32B27/36 , B32B27/365 , B32B27/38 , B32B27/40 , B32B2255/10 , B32B2255/26 , B32B2307/538 , B32B2307/7145 , B32B2307/732 , B32B2535/00 , Y10T428/24364 , Y10T428/26 , Y10T428/265 , Y10T428/2962 , Y10T428/31504 , Y10T428/31551 , Y10T428/31598 , Y10T428/31612 , Y10T428/31663 , Y10T428/31678 , Y10T428/31855 , Y10T442/30 , Y10T442/60
Abstract: The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.
Abstract translation: 本发明一般涉及具有包含接枝聚合物材料的非结垢表面的制品，例如医疗装置。 表面抗生物材料的粘附。
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13.发明申请
公开(公告)号：WO2011156589A4
公开(公告)日：2012-06-28
申请号：PCT/US2011039790
申请日：2011-06-09
Applicant: SEMPRUS BIOSCIENCES CORP , LI JUN , ZHANG ZHENG , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
Inventor： LI JUN , ZHANG ZHENG , HUVAL CHAD , BOUCHARD MICHAEL , COURY ARTHUR J , LOOSE CHRISTOPHER R
CPC classification number: C08F255/02 , A61L29/06 , A61L29/085 , A61L33/0088 , C08F291/00 , C08G18/836 , C08G64/42 , C08G77/38 , C08J7/16 , C08J7/18 , C08J2323/12 , C08J2369/00 , C08J2383/04 , C08J2433/14 , Y10T428/24355 , Y10T428/265 , Y10T442/30 , Y10T442/60 , C08F220/00
Abstract: A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37 C in 70 µg/mL fibrinogen derived from human plasma containing 1.4 µg/mL I-125 radiolabeled fibrinogen.
Abstract translation: 用于制备和生成的制品的方法包括具有表面，表面下的块体和基体表面上的接枝聚合物层的基材，基材表面和接枝聚合物层组合构成改性表面，所述改性表面具有 在纤维蛋白原结合试验中纤维蛋白原吸附小于约125ng / cm 2，其中修饰的表面在37℃下在70μg/ mL源自含有1.4μg/ mL I-125放射性标记的纤维蛋白原的人血浆的纤维蛋白原中温育60分钟。
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14.发明申请
公开(公告)号：WO2010065960A3
公开(公告)日：2010-07-29
申请号：PCT/US2009067013
申请日：2009-12-07
Applicant: SEMPRUS BIOSCIENCES CORP , LI JUN , SQUIER TREVOR , ZHANG ZHENG , O'SHAUGHNESSEY WILLIAM SHANNAN , HENCKE MICHAEL , BOUCHARD MICHAEL , LOOSE CHRISTOPHER R , HUVAL CHAD
Inventor： LI JUN , SQUIER TREVOR , ZHANG ZHENG , O'SHAUGHNESSEY WILLIAM SHANNAN , HENCKE MICHAEL , BOUCHARD MICHAEL , LOOSE CHRISTOPHER R , HUVAL CHAD
IPC: C09D5/16 , A61L27/14 , C08F4/40 , C09D151/00
CPC classification number: C09D5/1693 , A61L27/14 , A61L27/50 , A61L33/06 , C08F4/40 , C08F265/04 , C08F283/00 , C08F283/006 , C08F291/18 , C09D5/1637 , C08F220/38 , C08F220/56
Abstract: Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
Abstract translation: 本文描述了任选地涂覆有底涂层的底物，其从一种或多种非结垢材料接枝在那里。 不污染的聚合物材料可以从各种基材，特别是聚合物基材和/或聚合物底涂层移植。 本文所述的接枝技术可以导致非污染材料相对于接枝与制剂的更高的表面密度。 可以使用接枝方法制备共价连接的聚合物。 本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。 本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。 非污染材料可以从衬底或任选地从衬底上的底涂层移植，优选不显着影响衬底材料的机械和/或物理性能。
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15.发明申请
公开(公告)号：WO2010065960A2
公开(公告)日：2010-06-10
申请号：PCT/US2009/067013
申请日：2009-12-07
Applicant: SEMPRUS BIOSCIENCES CORP. , LI, Jun , SQUIER, Trevor , ZHANG, Zheng , O'SHAUGHNESSEY, William Shannan , HENCKE, Michael , BOUCHARD, Michael , LOOSE, Christopher R. , HUVAL, Chad
Inventor： LI, Jun , SQUIER, Trevor , ZHANG, Zheng , O'SHAUGHNESSEY, William Shannan , HENCKE, Michael , BOUCHARD, Michael , LOOSE, Christopher R. , HUVAL, Chad
IPC: C09D5/16 , A61L27/14 , C08F4/40 , C09D151/00
CPC classification number: A61L33/06 , A61L27/14 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F4/40 , C08F265/04 , C08F283/00 , C08F283/006 , C08F291/18 , C08L25/08 , C08L75/04 , C09D5/1637 , C09D5/1693 , C09D151/003 , C09D151/06 , C09D151/08 , C09D151/085 , C08F220/38 , C08F220/56 , C08L2666/02
Abstract: Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted from the substrate, or optionally from an undercoating layer on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
Abstract translation: 本文描述了任选地用底涂层涂覆的已从一种或多种防污材料接枝在其上的底材。 该防污聚合物材料可以从各种基材材料，特别是聚合物基材和/或聚合物底涂层接枝。 本文所述的接枝 - 来自技术可以导致相对于接枝 - 配方的非污染物质的更高的表面密度。 可使用嫁接法来生产共价连接的聚合物。 本文所述的组合物具有高度抗性的蛋白质吸收，特别是在复合介质中并且长时间保持高度的防污活性。 本文所述的组合物还可以表现出抗微生物和/或抗血栓形成活性。 优选地，在不显着影响基底材料的机械和/或物理性质的情况下，可以从基底或任选地从基底上的底涂层接枝非污染材料。
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Patent Agency Ranking
公开(公告)号：WO2010065958A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/067007
申请日：2009-12-07
Applicant: SEMPRUS BIOSCIENCES CORP. , ZHANG, Zheng , HUVAL, Chad , O'SHAUGHNESSEY, William, Shannan , HENCKE, Michael , SQUIER, Trevor , LI, Jun , BOUCHARD, Michael , LOOSE, Christopher, R.
Inventor： ZHANG, Zheng , HUVAL, Chad , O'SHAUGHNESSEY, William, Shannan , HENCKE, Michael , SQUIER, Trevor , LI, Jun , BOUCHARD, Michael , LOOSE, Christopher, R.
CPC classification number: A61L31/14 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/404 , A61L2420/08 , C09D5/1637 , C09D5/1693 , Y10T428/31507 , Y10T428/31511 , Y10T428/31544 , Y10T428/31576 , Y10T428/31663 , Y10T428/31667 , Y10T428/31699 , Y10T428/31725 , Y10T428/31743 , Y10T428/3175 , Y10T428/31786 , Y10T428/31797 , Y10T428/31913 , Y10T428/31928 , Y10T442/2525 , C08L33/10
Abstract: Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non- fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.
Abstract translation: 本文描述了可选地涂覆有底涂层的底物，其具有接枝到其上的一种或多种非结垢材料。 非结垢的聚合物材料可以接枝到各种官能化的基底材料，特别是固定在基底上的聚合物基底和/或聚合底涂层。 本文描述的组合物是高度抗性的蛋白质吸收，特别是在复合介质中并且在长时间内保持高度的非结垢活性。 本文所述的组合物还可以显示抗微生物和/或抗血栓形成活性。 可以将非结垢材料接枝到官能化基材上，或任选地从基底上的底涂层上接枝，优选不显着影响基材的机械和/或物理性能。
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公开(公告)号：WO2016196692A1
公开(公告)日：2016-12-08
申请号：PCT/US2016/035358
申请日：2016-06-01
Applicant: MILLER, Benjamin, Aaron , JUSTMAN, Jason, D. , BOUCHARD, Lora, Clark , BOUCHARD, Michael, Ellery , COTLOVE, Kevin, James , GITCHELL, Mathew, Keith , HAISCH, Stacia, Lynn , KERSTEN, Jonathan, David , MARCHIO, Matthew, Karl , PULLIAM, Peter, Arthur , SMITH, George, Allen , TIBBETTS, Todd, Christopher
Inventor： MILLER, Benjamin, Aaron , JUSTMAN, Jason, D. , BOUCHARD, Lora, Clark , BOUCHARD, Michael, Ellery , COTLOVE, Kevin, James , GITCHELL, Mathew, Keith , HAISCH, Stacia, Lynn , KERSTEN, Jonathan, David , MARCHIO, Matthew, Karl , PULLIAM, Peter, Arthur , SMITH, George, Allen , TIBBETTS, Todd, Christopher
IPC: G06F15/16
CPC classification number: H04N21/458 , G11B27/036 , H04N21/44016 , H04N21/6332
Abstract: Techniques are described herein for placing secondary content into a break of unknown duration in a primary content stream. In one aspect, the described techniques may include receiving information indicative of a break in streaming of the primary content. A duration of the stream of the primary content may be obtained, and secondary content may be played. Upon detecting that the duration of the stream of the primary content has increased to a second duration, the primary content may be streamed. In another aspect, the described techniques may include streaming a segment of primary content, for example, by a device. The device may receive information indicative of a break in the streaming of the primary content and may play secondary content based on receiving the information. The device may begin streaming the next segment of the primary content upon detecting that the second segment of the primary content is available.
Abstract translation: 这里描述了将主要内容流中的次要内容置于未知持续时间的中断的技术。 在一个方面，所描述的技术可以包括接收指示主要内容的流媒体中断的信息。 可以获得主要内容的流的持续时间，并且可以播放次要内容。 在检测到主内容的流的持续时间已经增加到第二持续时间时，主要内容可以被流传输。 在另一方面，所描述的技术可以包括例如通过设备流传送主要内容的段。 设备可以接收指示主内容的流传输中断的信息，并且可以基于接收到该信息来播放辅助内容。 在检测到主要内容的第二段可用时，设备可以开始流式传送主要内容的下一个段。
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18.发明申请ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME INCLUDING PRETREATMENT OF SUBSTRATES 审中-公开具有非浮选表面的制品及其制备方法，包括基材预处理
公开(公告)号：WO2011156596A4
公开(公告)日：2012-06-21
申请号：PCT/US2011039799
申请日：2011-06-09
Applicant: SEMPRUS BIOSCIENCES CORP , ROTH LAURENCE A , ZHANG ZHENG , HUVAL CHAD C , BOUCHARD MICHAEL A , LOOSE CHRISTOPHER R
Inventor： ROTH LAURENCE A , ZHANG ZHENG , HUVAL CHAD C , BOUCHARD MICHAEL A , LOOSE CHRISTOPHER R
CPC classification number: A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
Abstract translation: 本文描述了用于制备在包含聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。 聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。 该方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理性能，然后在经处理的基材表面上形成接枝聚合物层。
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19.发明申请ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME INCLUDING APPLYING A PRIMER COAT 审中-公开具有非浮选表面的制品及其制备方法，包括适用于底漆
公开(公告)号：WO2011156612A3
公开(公告)日：2012-05-18
申请号：PCT/US2011039815
申请日：2011-06-09
Applicant: SEMPRUS BIOSCIENCES CORP , SCHULTZ KAREN ANN , ZHANG ZHENG , HUVAL CHAD C , BOUCHARD MICHAEL A , LOOSE CHRISTOPHER R
Inventor： SCHULTZ KAREN ANN , ZHANG ZHENG , HUVAL CHAD C , BOUCHARD MICHAEL A , LOOSE CHRISTOPHER R
CPC classification number: A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve coating the substrate to conceal or reduce flaws on or in the surface of the medical device or other article substrate, and thereafter forming a grafted polymer layer on the treated substrate surface
Abstract translation: 本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。 聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。 该方法包括涂覆基底以隐藏或减少医疗装置或其它制品基底表面上或其表面上的缺陷，然后在经处理的基底表面上形成接枝聚合物层
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20.发明申请
公开(公告)号：WO2011156603A4
公开(公告)日：2011-12-15
申请号：PCT/US2011/039806
申请日：2011-06-09
Applicant: SEMPRUS BIOSCIENCES CORP. , WEAVER, Douglas J.K. , LI, Jun , ZHANG, Zheng , DELEAULT, Abby N. , MARCHESE, Eric W. , NGUYEN, Phu C. , HUVAL, Chad C. , BOUCHARD, Michael A. , COURY, Arthur J. , LOOSE, Christopher R.
Inventor： WEAVER, Douglas J.K. , LI, Jun , ZHANG, Zheng , DELEAULT, Abby N. , MARCHESE, Eric W. , NGUYEN, Phu C. , HUVAL, Chad C. , BOUCHARD, Michael A. , COURY, Arthur J. , LOOSE, Christopher R.
Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
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