公开(公告)号：WO2010047799A1

公开(公告)日：2010-04-29

申请号：PCT/US2009/005739

申请日：2009-10-22

Applicant: SURMODICS, INC. ,  ROLFES MEYERING, Emily R. ,  REED, Pamela J.

Inventor： ROLFES MEYERING, Emily R.

IPC: C08F283/00 ,  C08F283/06 ,  C08F289/00 ,  C08L51/00 ,  C08L53/00 ,  A61K47/00

CPC classification number: C08F283/00 ,  C08F283/06 ,  C08F289/00 ,  C08L51/003 ,  C08L53/00 ,  C08L2666/02

Abstract: The invention provides biodegradable polymeric hydrogel matrices having excellent durability and swellability. The matrices are formed from a combination of poly-α(l— >4)glucopyranose macromer and a biocompatible biostable hydrophilic macromer. The matrices can be used in association with a medical device or alone. In some methods the polymeric matrix is placed or formed at a target site in which the matrix swells and occludes the target area, and is able to be degraded at the target site after period of time.

Abstract translation: 本发明提供具有优异的耐久性和溶胀性的可生物降解的聚合物水凝胶基质。 基质由poly-a（1→4）吡喃葡萄糖大分子单体和生物相容性生物稳定的亲水大分子单体的组合形成。 矩阵可以与医疗装置或单独使用。 在一些方法中，聚合物基质被放置或形成在其中基质膨胀并封闭目标区域的靶位点，并且能够在一段时间后在靶位点降解。

公开(公告)号：WO2009126830A3

公开(公告)日：2009-10-15

申请号：PCT/US2009/040108

申请日：2009-04-09

Applicant: SURMODICS, INC. ,  MCGONIGLE, Joseph, Schmidt ,  ANDERSON, Aron, Brent

Inventor： MCGONIGLE, Joseph, Schmidt ,  ANDERSON, Aron, Brent

IPC: A61L31/10 ,  A61L31/16 ,  A61L27/34 ,  A61L27/54

Abstract: Embodiments of the invention include devices and methods for the controlled elution of nucleic acid delivery complexes. In an embodiment, the invention includes a medical device including a substrate surface, a polymeric coating disposed on the surface, the polymeric coating coupled to the substrate surface through the reaction product of a photoreactive group; the polymeric coating comprising negatively charged species on the surface; and a plurality of nucleic acid delivery complexes disposed on the polymeric coating, the nucleic acid delivery complexes comprising a nucleic acid and a cationic carrier agent complexed to the nucleic acid. Other embodiments are included herein.

公开(公告)号：WO2008002482A3

公开(公告)日：2009-07-09

申请号：PCT/US2007014582

申请日：2007-06-22

Applicant: SURMODICS INC ,  CHUDZIK STEPHEN J

Inventor： CHUDZIK STEPHEN J

IPC: A61L27/16 ,  A61L27/18 ,  A61L27/52

CPC classification number: A61L27/52 ,  A61F2/441 ,  A61F2/4611 ,  A61F2002/30075 ,  A61F2002/3008 ,  A61F2002/30291 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2210/0061 ,  A61F2230/0091 ,  A61F2250/0098 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L2430/38 ,  C08L33/08 ,  C08L71/02 ,  C08L5/08

Abstract: The invention provides a system and method for treating an orthopedic condition using a hydrogel-forming composition, which forms a hydrogel in situ at a target location and at least bio-mechanically treats the condition. The invention also provides a hydrogel forming composition designed to form a hydrogel with desirable biocompatible and biomechanical properties. In some aspects the hydrogel is formed in a water-permeable casing, which is delivered to an orthopedic joint in a minimally invasive manner. In particular, the system and method can be used for intervertebral disc replacement or repair.

Abstract translation: 本发明提供了一种使用水凝胶形成组合物治疗整形外科病症的系统和方法，其在目标位置原位形成水凝胶，并且至少生物机械处理该病症。 本发明还提供了一种设计成形成具有所需生物相容性和生物力学性质的水凝胶的水凝胶形成组合物。 在一些方面，水凝胶形成在透水的外壳中，其以微创方式递送至矫形关节。 具体来说，系统和方法可用于椎间盘置换或修复。

公开(公告)号：WO2008002852A3

公开(公告)日：2009-04-30

申请号：PCT/US2007071978

申请日：2007-06-25

Applicant: SURMODICS INC ,  CHUDZIK STEPHEN J ,  CHINN JOSEPH A

Inventor： CHUDZIK STEPHEN J ,  CHINN JOSEPH A

IPC: A61L27/34 ,  A61L27/16 ,  A61L27/54 ,  A61L29/04 ,  A61L29/08 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/16 ,  C08J3/24

CPC classification number: A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  Y10S623/92 ,  Y10S623/926

Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more multifunctional initiator groups. The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant. In a preferred embodiment, polymers with pendent polymerizable groups, for use in the macromer system, are prepared by reacting a polysaccharide polymer with a reactive moiety in an organic, polar solvent such as formamide.

Abstract translation: 一种可交联的大分子单体系统和相关的制备该系统的方法以及在组织部位和植入物制品例如组织植入物或假体装置的多孔表面之间使用交联基质形式的系统。 大分子单体体系包括两个或多个聚合物侧基可聚合基团和一个或多个多官能引发剂基团。 当聚合物侧链可聚合基团和引发剂基团可以悬挂在相同或不同的聚合物主链上。 大分子单体体系提供优于使用可聚合的大分子单体和分离的低分子量引发剂，包括关于无毒性，效率和溶解性等性质的优点。 本发明的大分子单体系统可以以足以允许组织生长通过交联基质和组织部位和植入物之间的方式用作组织部位和植入物之间的界面。 在优选的实施方案中，用于大分子单体体系中的具有侧链可聚合基团的聚合物通过使多糖聚合物与有机极性溶剂如甲酰胺中的反应性部分反应来制备。

公开(公告)号：WO2008088593A3

公开(公告)日：2009-04-02

申请号：PCT/US2007079704

申请日：2007-09-27

Applicant: SURMODICS INC ,  CHAPPA RALPH A

Inventor： CHAPPA RALPH A

IPC: A61K31/56

CPC classification number: A61K31/56 ,  A61K9/0024 ,  A61K9/0048 ,  A61K47/32 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/602 ,  C08L39/06 ,  C08L33/10 ,  C08L29/04

Abstract: The present invention relates to methods and additives for increasing active agent elution control coatings and 'elution control coatings including the same. In an embodiment the invention includes an elution control coating comprising a polymeric matrix and at least about 0.1 wt. % of an additive dispersed in the polymeric matrix. The additive can include polyvinylpyrrolidone or a copolymer thereof. An active agent can be dispersed within the polymeric matrix, the active agent having limited solubility in water. Embodiments of the invention also include a method of forming an elution control coating comprising estradiol, ployethylene-co-vinyl acetate copolymer (PEVA), poly-n-butylmethacrylate (PBMA) and polyvinylpyrrolidone (PVP).

Abstract translation: 本发明涉及用于增加活性剂洗脱控制涂层和“洗脱控制涂层”的方法和添加剂。 在一个实施方案中，本发明包括洗脱控制涂层，其包含聚合物基质和至少约0.1wt。 分散在聚合物基质中的添加剂的％。 添加剂可以包括聚乙烯吡咯烷酮或其共聚物。 活性剂可以分散在聚合物基质内，活性剂在水中的溶解度有限。 本发明的实施方案还包括形成包含雌二醇，聚乙烯 - 共 - 乙酸乙烯酯共聚物（PEVA），聚甲基丙烯酸正丁酯（PBMA）和聚乙烯吡咯烷酮（PVP））的洗脱控制涂层的方法。

公开(公告)号：WO2009038783A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/010928

申请日：2008-09-19

Applicant: SURMODICS, INC. ,  REED, Pamela, J. ,  ROLFES, Emily R.

Inventor： ROLFES, Emily R.

IPC: C08J9/00 ,  C08L3/02 ,  C08L3/14 ,  C08L5/00 ,  C08L5/14 ,  A61L15/28 ,  C08J9/08 ,  A61K9/12

CPC classification number: C08J9/0004 ,  A61K9/122 ,  A61L15/28 ,  A61L15/425 ,  A61L15/62 ,  A61L26/0023 ,  A61L26/0085 ,  A61L26/009 ,  C08J9/0061 ,  C08J9/08 ,  C08J2201/024 ,  C08J2303/02 ,  C08J2303/14 ,  C08J2305/00 ,  C08J2305/16 ,  C08J2371/02 ,  C08J2403/00 ,  C08J2405/00 ,  C08J2471/00

Abstract: Biocompatible foams having excellent physical and chemical properties are described. The biocompatible foams can be formed in situ or applied as a pre-formed gel for the treatment of tissue. The invention provides biocompatible degradable foams formed with a poly-α(1- 4)glucopyranose macromer. The invention also provides biostable foams formed with a poly(alkylene oxide) macromer.

Abstract translation: 描述了具有优异的物理和化学性质的生物相容性泡沫。 生物相容的泡沫可以原位形成或作为预先形成的凝胶施用，用于治疗组织。 本发明提供了由poly-a（1-4）吡喃葡萄糖大分子单体形成的生物相容的可降解泡沫体。 本发明还提供由聚（环氧烷）大分子单体形成的生物稳定泡沫体。

公开(公告)号：WO2008003043A3

公开(公告)日：2009-02-12

申请号：PCT/US2007072357

申请日：2007-06-28

Applicant: SURMODICS INC ,  CHAPPA RALPH A ,  HERGENROTHER ROBERT W ,  BUSHENDORF PAULA ,  SLAGER JORAM

Inventor： CHAPPA RALPH A ,  HERGENROTHER ROBERT W ,  BUSHENDORF PAULA ,  SLAGER JORAM

IPC: A61L27/26 ,  A61L27/34 ,  A61L27/48 ,  A61L31/04 ,  A61L31/12

CPC classification number: A61L27/58 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/604 ,  C08L23/0853 ,  C08L23/0869 ,  C08L33/08 ,  C08L71/02 ,  C08L2201/06 ,  C08L2666/22

Abstract: The present invention relates to combination degradable and non- degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.

Abstract translation: 本发明涉及可降解和不可降解的组合和相关方法。 在一个实施方案中，本发明包括活性剂递送基质，其包括可降解聚合物网络，不可降解聚合物网络，散布在可降解聚合物网络内的不可降解聚合物网络和活性剂。 在一个实施方案中，本发明包括包含可降解聚合物的活性剂洗脱控制基质; 和散布有可降解聚合物的不可降解聚合物。 在一个实施方案中，本发明包括制备活性剂递送基质的方法，包括将可降解聚合物与第一溶剂混合以形成可降解聚合物溶液; 将不可降解的聚合物与第二溶剂混合以形成不可降解的聚合物溶液; 同时将可降解聚合物溶液和不可降解聚合物溶液沉积在基材上。

公开(公告)号：WO2007127318A3

公开(公告)日：2008-11-20

申请号：PCT/US2007010158

申请日：2007-04-25

Applicant: SURMODICS INC ,  CHUDZIK STEPHEN J ,  JELLE BRUCE M

Inventor： CHUDZIK STEPHEN J ,  JELLE BRUCE M

IPC: A61L31/04 ,  A61L31/14

CPC classification number: A61L31/14 ,  A61L31/04 ,  A61L2400/16

Abstract: Insertable medical articles with a shape memory property having a body member formed of crosslinked hydrophilic polymers are described.

Abstract translation: 描述具有由交联亲水性聚合物形成的主体部件的形状记忆性的可插入医疗用品。

公开(公告)号：WO2008022258A3

公开(公告)日：2008-07-24

申请号：PCT/US2007076096

申请日：2007-08-16

Applicant: SURMODICS INC ,  CHAPPA RALPH A ,  FINLEY MICHAEL J

Inventor： CHAPPA RALPH A ,  FINLEY MICHAEL J

IPC: A61L27/34 ,  A61F2/06 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61L29/085 ,  A61L29/06 ,  A61L29/16 ,  A61L31/06 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/608 ,  A61L2420/08 ,  C08L83/04 ,  C08L65/04

Abstract: The present invention relates to methods and components for increasing adhesion of an elution control matrix to a polymeric substrate, and medical devices including such components. In an embodiment, the invention includes a medical device including a substrate having a surface, the substrate comprising a polysiloxane, a parylene layer contacting the surface of the substrate, and an elution control matrix contacting the parylene layer, the elution control matrix comprising a polymeric matrix and an active agent dispersed within the polymeric matrix. Other embodiments are included herein.

Abstract translation: 本发明涉及用于增加洗脱控制基质与聚合物基质的粘附性的方法和组分以及包含这些组分的医疗装置。 在一个实施方案中，本发明包括医疗装置，所述医疗装置包括具有表面的基材，所述基材包含聚硅氧烷，接触所述基材表面的聚对二甲苯层和接触所述聚对亚苯基二甲基层的洗脱控制基质，所述洗脱控制基质包含聚合物 基质和分散在聚合物基质内的活性剂。 其他实施例在此包括。

公开(公告)号：WO2008039749A2

公开(公告)日：2008-04-03

申请号：PCT/US2007079379

申请日：2007-09-25

Applicant: SURMODICS INC ,  CHAPPA RALPH A

Inventor： CHAPPA RALPH A

IPC: A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L2300/608 ,  A61L2420/08 ,  C08L65/04

Abstract: Embodiments of the invention include multi-layered coatings for controlling the elution rates of active agents and methods. In an embodiment, the invention includes a method of applying an elution control coating to a substrate. The method can include depositing a coating solution onto the substrate to form a base layer. The method can also include selecting a desired concentration of the solvent based on a desired elution rate. The method can further include removing solvent from the base layer to reach a desired concentration of the solvent and depositing a layer of parylene on the base layer. In an embodiment, the invention can include a medical device including a substrate, a base layer, and a porous layer. The base layer can include a polymeric matrix and an active agent dispersed within the polymeric matrix. The porous layer can include parylene. Other embodiments are also included herein.

Abstract translation: 本发明的实施方案包括用于控制活性剂的洗脱速率的多层涂层和方法。 在一个实施方案中，本发明包括将洗脱控制涂层施加到基底上的方法。 该方法可以包括将涂覆溶液沉积到基底上以形成基底层。 该方法还可以包括基于所需的洗脱速率来选择所需浓度的溶剂。 该方法还可以包括从基层去除溶剂以达到所需浓度的溶剂并在基层上沉积聚对二甲苯层。 在一个实施例中，本发明可以包括包括基底，基底层和多孔层的医疗装置。 基层可以包括分散在聚合物基质内的聚合物基质和活性剂。 多孔层可以包括聚对二甲苯。 本文还包括其它实施例。