公开(公告)号：WO1998001547A1

公开(公告)日：1998-01-15

申请号：PCT/US1997010101

申请日：1997-07-08

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  LOPEZ-BERESTEIN, Gabriel ,  TARI, Ana, M. ,  ARLINGHAUS, Ralph, B.

IPC: C12N15/11

CPC classification number: C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/111 ,  C12N2310/311 ,  C12N2799/021

Abstract: The present invention provides novel compositions and methods for use in the treatment of cancer, specifically, in the treatment of chronic myelogenous leukemia (CML). The compositions contain antisense oligonucleotides that hybridize to Grb2 and Crk1 nucleic acids, the gene products of which are known to interact with the tumorigenic protein bcr-abl. Used alone, in conjunction with each other, and even in conjunction with antisense oligonucleotides directed to bcr-abl nucleic acids, these compositions inhibit the proliferation of CML cancer cells.

Abstract translation: 本发明提供了用于治疗癌症的新型组合物和方法，特别是治疗慢性骨髓性白血病（CML）。 该组合物含有与Grb2和Crk1核酸杂交的反义寡核苷酸，其基因产物已知与致瘤性蛋白bcr-abl相互作用。 这些组合物单独使用，彼此结合，甚至与针对bcr-abl核酸的反义寡核苷酸结合使用，可抑制CML癌细胞的增殖。

公开(公告)号：WO2017035309A1

公开(公告)日：2017-03-02

申请号：PCT/US2016/048564

申请日：2016-08-25

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： CHEN, Wei ,  MA, Lun

IPC: A61K31/30 ,  A61N5/06 ,  A61N5/10

CPC classification number: A61N5/062 ,  A61K9/0009 ,  A61K9/5115 ,  A61K33/34 ,  A61N5/022 ,  A61K2300/00

Abstract: Disclosed is the use of copper cysteamine nanoparticles for use in photodynamic cancer therapy. The disclosed methods of treatment utilize microwave radiation as a means for activating the copper cysteamine photosensitizer.

Abstract translation: 公开了使用铜半胱胺纳米颗粒用于光动力学癌症治疗。 所公开的治疗方法利用微波辐射作为激活铜半胱胺光敏剂的手段。

公开(公告)号：WO2015184397A1

公开(公告)日：2015-12-03

申请号：PCT/US2015/033393

申请日：2015-05-29

Applicant: TEXAS TECH UNIVERSITY SYSTEM ,  THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： ABDELGAWAD, Amr ,  VARGAS-HENANDEZ, Noe ,  EMARA, Khaled ,  RODRIGUEZ, Mario, E.

IPC: A61B17/80

CPC classification number: A61B17/8004 ,  A61B17/8057 ,  A61B2017/00075 ,  A61B2017/00199 ,  A61B2017/00212 ,  A61B2017/00398 ,  A61B2017/00734 ,  A61B2017/00991

Abstract: An extramedullary bone lengthener and use thereof that is an internal device that does not require nailing. The invention includes a telescoping plate that attaches to the upper and lower portions of the bone via screws; a small motor affixed on or within the plate. This motor, controlled remotely, will controllably lengthen the plate, thus lengthening the bone. The bone will be cut (osteotomy) then the plate will be applied to both ends and fixed to each end with screws. The motor will be controlled from outside by a remote control which will allow the plate to expand causing lengthening of the attached bone.

Abstract translation: 髓外骨加长器及其使用，是不需要钉扎的内部装置。 本发明包括一个伸缩板，其通过螺钉附接到骨的上部和下部; 固定在板上或板内的小马达。 该电机远程控制，可以可控地延长板，从而延长骨骼。 将骨切割（截骨），然后将板施加到两端并用螺钉固定到每一端。 电动机将通过遥控器从外部控制，这将允许板膨胀导致附着的骨骼的延长。

公开(公告)号：WO2015106071A1

公开(公告)日：2015-07-16

申请号：PCT/US2015/010774

申请日：2015-01-09

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： DASGUPTA, Purnendu, K.

IPC: G01N31/00

CPC classification number: G01N21/783 ,  G01N33/0036 ,  G01N33/0042 ,  G01N33/0044 ,  G01N33/0052 ,  G01N33/0054 ,  G01N2021/773 ,  Y02A50/246

Abstract: A sensor platform for analyzing an analyte with a predetermined reagent is presented. The sensor platform has a housing defining an interior chamber configured to hold the analyte. A tube defining an inner lumen extends through the chamber. At least a portion of the tube is porous and configured to absorb the analyte at a predetermined rate. A sensor is coupled to an end of the tube and is configured to sense changes in the material positioned in the inner lumen of the tube as the reagent reacts with the absorbed analyte.

Abstract translation: 提出了一种用于用预定试剂分析分析物的传感器平台。 传感器平台具有限定被配置为保持分析物的内部室的壳体。 限定内腔的管道延伸穿过腔室。 管的至少一部分是多孔的并且被配置为以预定速率吸收分析物。 传感器耦合到管的端部并且被配置为当试剂与吸收的分析物反应时，感测定位在管的内腔中的材料的变化。

公开(公告)号：WO2012006038A3

公开(公告)日：2012-01-12

申请号：PCT/US2011/042061

申请日：2011-06-27

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  SHERRY, Dean A. ,  WU, Yunkou ,  KIEFER, Garry, E.

Inventor： SHERRY, Dean A. ,  WU, Yunkou ,  KIEFER, Garry, E.

IPC: A61K49/06 ,  A61K49/04 ,  A61K51/04 ,  A61K51/00

Abstract: According to an illustrative embodiment, provided herein are paramagnetic chemical exchange saturation transfer MRI contrast agents having a tetraazacyclododecane ligand and a paramagnetic ion that provides a ratiometric imaging measurement that can be used to measure biological parameters including pH, temperature, reactive oxygen species, and specific enzymes, among others. The agents and compounds may also be usable in other applications. Methods of use and synthesis of the agents and compounds herein are also provided.

公开(公告)号：WO2011156729A3

公开(公告)日：2011-12-15

申请号：PCT/US2011/040006

申请日：2011-06-10

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  DARRELL, Carney

Inventor： DARRELL, Carney

IPC: A61K38/03 ,  A61K38/04 ,  A61K38/16 ,  A61P39/00 ,  A61P17/02

Abstract: The present invention is directed to methods of reducing mortality in a subject exposed to a lethal dose of radiation comprising administering to the subject an effective amount of a thrombin peptide derivative described herein. Also included are methods of reducing the risk of developing bacterial, fungal or viral systemic infection a subject who is exposed or not exposed to radiation, methods of treating a subject with traumatic injury, dermal injury and/or bum injury who is also exposed to radiation, methods of reducing radiation related injury in a subject undergoing radiation therapy, methods of reducing the risk of developing a radiation induced illness, and methods of promoting the healing of a wound that is caused by radiation exposure and/or has been exposed to radiation. These methods comprising administering to the subject an effective amount of a thrombin peptide derivative described herein.

公开(公告)号：WO2009110935A1

公开(公告)日：2009-09-11

申请号：PCT/US2008/084972

申请日：2008-11-26

Applicant: MICRO TRANSPONDER INC. ,  THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CAULLER, Lawrence ,  WEINER, Richard

Inventor： CAULLER, Lawrence ,  WEINER, Richard

IPC: A61N1/06

CPC classification number: A61N1/3605 ,  A61B5/0478 ,  A61B5/0492 ,  A61B5/6846 ,  A61B2560/0219 ,  A61B2562/028 ,  A61N1/37205 ,  A61N1/3756 ,  A61N1/3787

Abstract: A wireless microtransponder array constructed as a single structure of joined microtransponders. The microtransponders can be configured as a linear array strip with connective material in between. The microtransponders can also be entirely embedded within a strip of material, or joined by a single, common substrate structure.

Abstract translation: 无线微应答器阵列构造为连接的微转发器的单一结构。 微转发器可以被配置为在其间具有连接材料的线性阵列条。 微型应答器也可以完全嵌入在材料条中，或者通过单个公共基板结构连接。

公开(公告)号：WO2009058331A2

公开(公告)日：2009-05-07

申请号：PCT/US2008/012323

申请日：2008-10-29

Applicant: VERMILLLION, INC. ,  THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  FUNG, Eric, Thomas ,  CLARKE, Charlotte ,  BAST, Robert ,  COOMBES, Kevin

Inventor： FUNG, Eric, Thomas ,  CLARKE, Charlotte ,  BAST, Robert ,  COOMBES, Kevin

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/53 ,  G01N33/48 ,  G01N33/50

CPC classification number: G01N33/57449 ,  G01N33/6848 ,  G01N2800/56

Abstract: The present invention provides methods and compositions for detecting early stage ovarian cancer in a patient. Also, methods for evaluating the ovarian cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biomarkers in biological samples.

Abstract translation: 本发明提供了用于检测患者的早期卵巢癌的方法和组合物。 此外，本文描述了用于评估患者的卵巢癌状态的方法。 这些方法涉及生物样本中生物标志物的检测，分析和分类。

公开(公告)号：WO2009036047A2

公开(公告)日：2009-03-19

申请号：PCT/US2008/075832

申请日：2008-09-10

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  STEVENSON, Keith, J. ,  LYON, Jennifer, L.

Inventor： STEVENSON, Keith, J. ,  LYON, Jennifer, L.

IPC: G01N27/327 ,  G01N27/26

CPC classification number: C12Q1/005 ,  C12Q1/26 ,  C12Q1/54

Abstract: Embodiments of the present invention provide a method for detecting a composition comprising (a) providing a first composition which reacts with an oxidase to generate a second composition; (b) providing nitrogen-doped nanocarbons; and (c) detecting the first composition with the nanocarbons. Devices and systems containing such nitrogen-doped nanocarbons are also provided.

Abstract translation: 本发明的实施方案提供了用于检测组合物的方法，所述方法包括（a）提供与氧化酶反应以产生第二组合物的第一组合物; （b）提供氮掺杂的纳米碳; 和（c）用纳米碳检测第一组合物。 还提供含有这种氮掺杂纳米碳的装置和系统。

公开(公告)号：WO2004005317A2

公开(公告)日：2004-01-15

申请号：PCT/US2003/020626

申请日：2003-07-01

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  CARNEY, Darrell, H.

Inventor： CARNEY, Darrell, H.

IPC: C07K

CPC classification number: C12N9/6429 ,  A61K38/00 ,  C12Y304/21005

Abstract: Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence SEQ ID NO. 2: Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val, or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO. 2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

Abstract translation: 公开了包含两种具有氨基酸序列SEQ ID NO：1的多肽的凝血酶肽衍生物二聚体。 2：Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val或具有至少6个氨基酸的多肽的C末端截短的片段。 多肽或多肽片段中的一个，一个，两个或三个氨基酸不同于SEQ ID NO。 还公开了用凝血酶受体激动剂治疗需要治疗的受试者的方法。 所述方法包括施用有效量的上述凝血酶肽衍生物的步骤。