-
公开(公告)号：WO2022094244A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/057300
申请日：2021-10-29
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , DART, Michael, J. , MURAUSKI, Kathleen, J. , RANDOLPH, John, T. , SHI, Lei , SMITH, Russell, C. , TONG, Yunsong , XU, Xiangdong , BENELKEBIR, Hanae , CHOHAN, Kamaldeep, K. , EDESON, Steven, J. , SCHWENK, Sebastian , STARBUCK, Kathryn, A.
IPC分类号： C07D231/12 , C07D231/18 , C07D231/20 , C07D231/56 , C07D311/24 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D471/04 , C07D213/64 , C07D249/04 , C07D401/04 , C07D401/06 , C07D403/04
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (I SR) and for treating related diseases, disorders, and conditions.
-
公开(公告)号：WO2021127586A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/066243
申请日：2020-12-18
申请人： CALICO LIFE SCIENCES LLC , ABBVIE INC. , VEITS, Gesine Kerstin , FITZGERALD, Mark E. , HIRD, Alexander W. , HENDERSON, James A. , VORA, Harit U. , SWEIS, Ramzi F. , KORT, Michael E. , NASVESCHUK, Christopher G. , DUPLESSIS, Martin
发明人： VEITS, Gesine Kerstin , FITZGERALD, Mark E. , HIRD, Alexander W. , HENDERSON, James A. , VORA, Harit U. , SWEIS, Ramzi F. , NASVESCHUK, Christopher G. , DUPLESSIS, Martin
IPC分类号： C07D417/12 , C07D417/14 , C07D471/10 , A61P3/00 , A61P35/00 , A61K47/00 , A61K31/4523 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K9/0019
摘要： Provided herein are compounds, compositions, and methods useful for degrading protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases favorably responsive to PTPN1 or PTPN2 inhibitor treatment, e.g., a cancer 5 or a metabolic disease.
-
公开(公告)号：WO2020186199A1
公开(公告)日：2020-09-17
申请号：PCT/US2020/022717
申请日：2020-03-13
发明人： BOGDAN, Andrew , HALVORSEN, Geoff T. , FARNEY, Elliot P. , FROST, Jennifer M. , KYM, Philip R. , MATULENKO, Mark A. , O'CONNOR, Matthew , SHIROODI, Reza , VOIGHT, Eric , XIONG, Zhaoming , ZHANG, Qingwei I. , BAUMGARTNER, Christina , ABBOTT, Jason , ECONOMOU, Christos , FOSU, Stacy
IPC分类号： A61P3/10 , A61K31/433 , A61P35/00 , C07D285/02 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Provided herein are compounds, compositions, and methods useful for inhibiting protein tyrosine phosphatase, e.g., protein tyrosine phosphatase non-receptor type 2 (PTPN2) and/or protein tyrosine phosphatase non-receptor type 1 (PTPN1), and for treating related diseases, disorders and conditions favorably responsive to PTPN 1 or PTPN2 inhibitor treatment, e.g., a cancer or a metabolic disease.
-
公开(公告)号：WO2020176591A1
公开(公告)日：2020-09-03
申请号：PCT/US2020/019847
申请日：2020-02-26
摘要： Systems and methods for oblique plane microscopy are disclosed.
-
公开(公告)号：WO2019090082A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058965
申请日：2018-11-02
发明人： MARTIN, Kathleen Ann , SIDRAUSKI, Carmela , FROST, Jennifer M. , TONG, Yunsong , XU, Xiangdong , XIONG, Zhaoming , DART, Michael J.
IPC分类号： C07D231/12 , C07D233/64 , C07D413/04 , C07D413/12 , C07D271/06 , A61K31/4245 , A61P35/00
CPC分类号： C07D271/10 , C07D207/33 , C07D231/12 , C07D233/64 , C07D271/06 , C07D413/04 , C07D413/12
摘要： Provided herein are compounds, compositions, and methods useful for the modulation of elF2B and the integrated stress response (ISR) signaling pathway and for treating related diseases, disorders and conditions.
-
公开(公告)号：WO2019090076A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058957
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , PLIUSHCHEV, Marina, A. , TONG, Yunsong , BLACK, Lawrence, A. , XU, Xiangdong , SHI, Lei , ZHANG, Qingwei, I. , CHUNG, Seungwon , SWEIS, Ramzi, Farah , DART, Michael, J. , RANDOLPH, John, T. , MURAUSKI, Kathleen
IPC分类号： C07D213/74 , C07C255/57 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07C235/14 , C07D277/32 , C07D213/57 , C07D307/56 , C07D307/82 , C07D317/62 , C07D401/04 , C07D413/04 , C07D487/04 , C07D275/03 , C07D495/04 , C07D513/04 , C07D213/54 , A61P35/00 , A61K31/165
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
-
公开(公告)号：WO2019090069A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058949
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , PLIUSHCHEV, Marina, A. , FROST, Jennifer, M. , TONG, Yunsong , BLACK, Lawrence, A. , XU, Xiangdong , SHI, Lei , ZHANG, Qingwei, I. , CHUNG, Seungwon , XIONG, Zhaoming , SWEIS, Ramzi, Farah , DART, Michael, J. , BROWN, Brian, S. , MURAUSKI, Kathleen
IPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07C311/13 , C07D401/04 , C07D237/14 , C07D237/16 , C07D405/08 , C07D241/18 , C07D471/04 , C07D261/08 , C07D261/20 , C07C235/22 , C07D271/113 , C07D213/30 , C07D213/66 , A61K31/44 , A61P35/00
摘要： Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
-
-
-
-
-
-
搜索结果
27 条记录 (耗时 0.015 秒)
