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公开(公告)号：WO2019090085A8
公开(公告)日：2019-05-09
申请号：PCT/US2018/058969
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , CHUNG, Seungwon , ZHANG, Qingwei, I. , SHI, Lei , MURAUSKI, Kathleen , DART, Michael, J. , RANDOLPH, John, T.
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , A61P19/00 , A61P25/00 , A61P3/00 , A61P21/00 , A61P29/00 , A61P35/00 , A61K31/16 , A61K31/165 , A61K31/538 , A61K31/352 , A61K31/36 , A61K31/498 , C07D311/66 , C07D319/20 , C07D405/12 , C07D413/06 , C07D265/36 , C07D493/04 , C07D207/22 , C07D209/42 , C07D307/84
摘要： Provided herein are compounds of formula (I), compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions. (Formula I).
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公开(公告)号：WO2019090081A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058963
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , TONG, Yunsong , XU, Xiangdong , SHI, Lei , CHUNG, Seungwon , XIONG, Zhaoming , MURAUSKI, Kathleen , ZHANG, Qingwei, I. , BROWN, Brian, S. , DART, Michael, J.
IPC分类号： C07D207/26 , C07D209/46 , C07D207/273 , C07D233/32 , C07D239/88 , C07D239/96 , C07D263/20 , C07D265/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D413/12 , A61P3/00 , A61P19/00
CPC分类号： C07D207/273 , A61P3/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , C07D207/26 , C07D209/46 , C07D233/32 , C07D239/88 , C07D239/96 , C07D263/20 , C07D265/10 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D413/12
摘要： Provided herein are compounds of Formula (I) or Formula (II), compositions, and methods there of useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
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公开(公告)号：WO2019090076A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058957
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , FROST, Jennifer, M. , PLIUSHCHEV, Marina, A. , TONG, Yunsong , BLACK, Lawrence, A. , XU, Xiangdong , SHI, Lei , ZHANG, Qingwei, I. , CHUNG, Seungwon , SWEIS, Ramzi, Farah , DART, Michael, J. , RANDOLPH, John, T. , MURAUSKI, Kathleen
IPC分类号： C07D213/74 , C07C255/57 , C07D231/14 , C07D237/10 , C07D241/12 , C07D241/44 , C07D261/08 , C07C235/14 , C07D277/32 , C07D213/57 , C07D307/56 , C07D307/82 , C07D317/62 , C07D401/04 , C07D413/04 , C07D487/04 , C07D275/03 , C07D495/04 , C07D513/04 , C07D213/54 , A61P35/00 , A61K31/165
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：WO2019090069A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058949
申请日：2018-11-02
发明人： MARTIN, Kathleen, Ann , SIDRAUSKI, Carmela , PLIUSHCHEV, Marina, A. , FROST, Jennifer, M. , TONG, Yunsong , BLACK, Lawrence, A. , XU, Xiangdong , SHI, Lei , ZHANG, Qingwei, I. , CHUNG, Seungwon , XIONG, Zhaoming , SWEIS, Ramzi, Farah , DART, Michael, J. , BROWN, Brian, S. , MURAUSKI, Kathleen
IPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07C311/13 , C07D401/04 , C07D237/14 , C07D237/16 , C07D405/08 , C07D241/18 , C07D471/04 , C07D261/08 , C07D261/20 , C07C235/22 , C07D271/113 , C07D213/30 , C07D213/66 , A61K31/44 , A61P35/00
摘要： Provided herein are compounds, compositions, and methods useful for the modulation of elF2B, for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：WO2017193041A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031367
申请日：2017-05-05
申请人： CALICO LIFE SCIENCES , ABBVIE, INC.
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farah , SHI, Lei , ZHANG, Qinwei, I , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： C07D231/12 , C07D237/08 , C07D239/34 , C07D241/12 , C07D471/04 , C07D261/08 , C07D263/32 , C07D271/07 , C07D277/28 , C07D209/14 , C07D213/40 , C07D213/64 , C07D307/52 , A61K31/4402 , A61P35/00
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：WO2017193030A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031352
申请日：2017-05-05
申请人： CALICO LIFE SCIENCES , ABBVIE INC.
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farah , SHI, Lei , ZHANG, Qinwei, I. , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： C07D233/64 , C07D401/12 , C07D413/12 , C07D471/04 , C07D271/06 , C07D271/10 , A61K31/4245 , A61P35/00
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：WO2017193034A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031360
申请日：2017-05-05
申请人： CALICO LIFE SCIENCES , ABBVIE, INC.
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farath , SHI, Lei , ZHANG, Qinwei, I. , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07D401/04 , C07D237/14 , C07D237/16 , C07D405/08 , C07D241/18 , C07D471/04 , C07D261/08 , C07D261/20 , C07C235/00 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , A61K31/44 , A61P35/00
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
摘要翻译： 本文提供了用于调节整合应激反应（ISR）和用于治疗相关疾病的化合物，组合物和方法; 障碍和条件。
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公开(公告)号：WO2017193063A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/031393
申请日：2017-05-05
申请人： CALICO LIFE SCIENCES , ABBVIE, INC.
发明人： SIDRAUSKI, Carmela , PLIUSCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farah , SHI, Lei , ZHANG, Qinwei, I. , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： C07D241/12 , C07D261/08 , C07D213/57 , C07C233/74 , C07D213/74 , C07D231/14 , C07D237/10 , C07D241/44 , C07D277/32 , C07D213/54 , C07D307/56 , C07D307/82
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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