公开(公告)号：WO2012021792A2

公开(公告)日：2012-02-16

申请号：PCT/US2011/047565

申请日：2011-08-12

Applicant: SEVENTH SENSE BIOSYSTEMS, INC. ,  CHICKERING, Donald, E. III. ,  LEVINSON, Douglas, A. ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  BERNSTEIN, Howard ,  WALT, David, R.

Inventor： CHICKERING, Donald, E. III. ,  LEVINSON, Douglas, A. ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  BERNSTEIN, Howard ,  WALT, David, R.

IPC: A61M5/142

CPC classification number: A61M37/0015 ,  A61B5/117 ,  A61B5/14514 ,  A61B5/150984 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B90/96 ,  A61B90/98 ,  A61B2560/0412 ,  A61M5/14248 ,  A61M37/00 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2205/3576 ,  A61M2205/6009 ,  A61M2205/6072 ,  A61N1/30 ,  A61N1/325

Abstract: The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.

Abstract translation: 本发明一般涉及用于递送和/或接受来自受试者，例如来自皮肤和/或来自身体的其它组织的物质或物质例如血液的系统和方法。 在一些情况下，该装置可以包含诸如针或微针的物质转移组件，其可以插入到皮肤或另一个器官中以从受试者输送和/或接收流体或其他物质。 在一些实施方案中，该装置可以包括构造和布置成将一种或多种物质转移组分插入皮肤或其它器官中的活化剂。 在某些情况下，该装置还可以包括用于接收从受试者接收的流体的储存室。

公开(公告)号：WO2011088214A9

公开(公告)日：2012-02-02

申请号：PCT/US2011021134

申请日：2011-01-13

Applicant: SEVENTH SENSE BIOSYSTEMS INC ,  CHICKERING DONALD E III ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN ,  BERNSTEIN HOWARD ,  LEVINSON DOUGLAS A ,  MICHELMAN MARK

Inventor： CHICKERING DONALD E III ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN ,  BERNSTEIN HOWARD ,  LEVINSON DOUGLAS A ,  MICHELMAN MARK

IPC: A61M5/178 ,  A61B5/145 ,  A61B5/151

CPC classification number: A61B5/6849 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

Abstract translation: 本发明一般涉及用于递送和/或从皮肤和/或皮肤下方的受试者递送和/或从物质或诸如血液或间质液体中取出物质的方法。 一方面，本发明一般涉及使用包含流体转运器（例如，一个或多个微针）的装置从例如皮肤和/或从皮肤下面抽出或提取血液的装置和方法 ）和在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，可将该装置应用于皮肤并被激活以从受试者中抽出血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。 例如，血液可以从装置中取出，和/或该装置可以包含能够确定血液和/或怀疑含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于抽出血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

公开(公告)号：WO2011163347A2

公开(公告)日：2011-12-29

申请号：PCT/US2011/041430

申请日：2011-06-22

Applicant: SEVENTH SENSE BIOSYSTEMS, INC. ,  CHICKERING, Donald, E., III ,  BERNSTEIN, Howard ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  LEVINSON, Douglas, A. ,  MICHELMAN, Mark ,  GONG, Ping

Inventor： CHICKERING, Donald, E., III ,  BERNSTEIN, Howard ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin ,  LEVINSON, Douglas, A. ,  MICHELMAN, Mark ,  GONG, Ping

IPC: A61M37/00

CPC classification number: A61B5/150984 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1468 ,  A61B5/150022 ,  A61B5/150091 ,  A61B5/150099 ,  A61B5/150106 ,  A61B5/150129 ,  A61B5/150145 ,  A61B5/15016 ,  A61B5/150229 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150969 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15119 ,  A61B5/15125 ,  A61B5/15134 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/154 ,  A61B5/157 ,  A61B17/00234 ,  A61B2010/0225 ,  A61B2562/0238 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046

Abstract: The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., to the skin and/or from the skin. In one aspect, the present invention is generally directed to devices and methods for receiving blood from a subject, e.g., from the skin, using devices including a substance transfer component (which may contain, for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In certain embodiments, substances may be received from and/or delivered to the subject with relatively little pain. The pain may be assessed, for example, using pain scales such as the Wong-Baker FACES Pain Scale. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

Abstract translation: 本发明一般涉及用于递送和/或接受诸如血液的物质或物质从受试者例如皮肤和/或从皮肤接收的系统和方法。 一方面，本发明一般涉及使用包括物质转移组件（其可以包含例如一个或多个微针）的装置从例如皮肤接收血液的装置和方法，以及 存储室在接收血液之前具有小于大气压的内部压力。 在某些实施方案中，可以相对较少的疼痛从受试者接受和/或递送物质。 可以评估疼痛，​​例如使用诸如Wong-Baker FACES Pain Scale的疼痛量表。 在一些情况下，该装置可以是独立的，并且在某些情况下，可以将该装置应用于皮肤并被激活以从受试者接收血液。 然后可以处理装置或其一部分，以单独或与外部装置一起确定血液和/或血液内的分析物。 例如，可以从装置接收血液，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。 本发明的其它方面涉及用于接收血液（或其他体液，例如间质液）的其他装置，涉及这种装置的试剂盒，制造这种装置的方法，使用这种装置的方法等。

公开(公告)号：WO2011088214A3

公开(公告)日：2011-09-29

申请号：PCT/US2011021134

申请日：2011-01-13

Applicant: SEVENTH SENSE BIOSYSTEMS INC ,  CHICKERING DONALD E III ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN ,  BERNSTEIN HOWARD ,  LEVINSON DOUGLAS A ,  MICHELMAN MARK

Inventor： CHICKERING DONALD E III ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN ,  BERNSTEIN HOWARD ,  LEVINSON DOUGLAS A ,  MICHELMAN MARK

IPC: A61M5/178 ,  A61B5/145 ,  A61B5/151

CPC classification number: A61B5/6849 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685

Abstract: The present invention generally relates to systems and methods for delivering and/or withdrawing a substance or substances such as blood or interstitial fluid, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for withdrawing or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to withdraw blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be withdrawn from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. Other aspects of the present invention are directed at other devices for withdrawing blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

Abstract translation: 本发明总体上涉及用于从受试者（例如从皮肤和/或从皮肤下方）输送和/或排出一种或多种物质（例如血液或间质液）的系统和方法。 在一个方面，本发明总体上涉及用于使用含有液体转运体的装置（例如，一个或多个微针）从受试者（例如从皮肤和/或皮肤下面）抽取或抽取血液的装置和方法 ）以及在接收血液之前具有小于大气压的内部压力的储存室。 在一些情况下，该装置可以是独立的，并且在某些情况下，该装置可以被施加到皮肤上，并被激活以从受试者中抽取血液。 然后可以处理装置或其一部分，以单独地或利用外部装置来确定血液和/或血液内的分析物。 例如，血液可以从装置中取出，和/或装置可以包含能够确定血液和/或怀疑包含在血液中的分析物的传感器或试剂。 本发明的其它方面针对用于抽取血液（或其他体液，例如间质液）的其他装置，涉及这种装置的套件，制造这种装置的方法，使用这些装置的方法等。

公开(公告)号：WO2011053787A3

公开(公告)日：2011-09-01

申请号：PCT/US2010054723

申请日：2010-10-29

Applicant: SEVENTH SENSE BIOSYSTEMS INC ,  CHICKERING DONALD E ,  LEVINSON DOUGLAS A ,  DAVIS SHAWN ,  HAGHOOIE RAMIN ,  BERNSTEIN HOWARD ,  WALT DAVID R

Inventor： CHICKERING DONALD E ,  LEVINSON DOUGLAS A ,  DAVIS SHAWN ,  HAGHOOIE RAMIN ,  BERNSTEIN HOWARD ,  WALT DAVID R

IPC: A61M5/32 ,  A61B5/151 ,  A61B5/155 ,  A61M35/00

CPC classification number: A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150106 ,  A61B5/150122 ,  A61B5/150129 ,  A61B5/150137 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150809 ,  A61B5/150824 ,  A61B5/150893 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61M5/425 ,  A61M35/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/588

Abstract: The present invention generally relates, in certain aspects, to systems and methods for application to the skin, and control of actuation, delivery, and/or perception thereof. For example, certain aspects of the invention are generally directed to devices for delivering to and/or withdrawing fluid or from subjects, e.g., to or from the skin and/or beneath the skin. In one aspect, the delivery and/or withdrawal of fluid is at least partially obscured. For example, the obscuration may be by time, and/or by sensory obscuration (e.g., by providing tactile, olfactory, auditory, and/or visual sensations). Certain aspects of the invention are generally directed to devices able to automatically deliver to and/or withdraw fluid from the skin and/or beneath the skin after activation, e.g., where the fluid is delivered and/or withdrawn without the need for any additional intervention. The devices may be activated by any suitable technique. In other aspects, a device may be contained in a package, and when removed from the package, the device may be constructed and arranged to be able to deliver and/or withdraw fluid when the device is applied to the skin, and in some cases, automatically and/or without any further intervention by the subject or another person.

Abstract translation: 在某些方面，本发明一般涉及用于施用于皮肤的系统和方法，以及对其致动，递送和/或感知的控制。 例如，本发明的某些方面通常涉及用于递送和/或抽出流体或从受试者例如去往或来自皮肤和/或皮肤下方的流体的装置。 在一个方面，流体的输送和/或排出至少部分被遮蔽。 例如，遮蔽可以是按时间和/或通过感觉遮蔽（例如通过提供触觉，嗅觉，听觉和/或视觉感觉）。 本发明的某些方面通常涉及能够在激活之后自动地向皮肤和/或皮肤下方输送流体和/或从皮肤下面抽取流体的装置，例如，在输送和/或抽出流体而不需要任何额外干预的情况下 。 这些设备可以通过任何合适的技术来激活。 在其他方面，装置可以被包含在包装中，并且当从包装中取出时，装置可以被构造和布置成当装置被施加到皮肤时能够输送和/或抽出流体，并且在一些情况下 ，自动和/或不需要主体或另一个人的任何进一步介入。

公开(公告)号：WO2011053788A2

公开(公告)日：2011-05-05

申请号：PCT/US2010/054725

申请日：2010-10-29

Applicant: SEVENTH SENSE BIOSYSTEMS, INC. ,  BERNSTEIN, Howard ,  CHICKERING, Donald, E. ,  LEVINSON, Douglas, A. ,  WALT, David, R. ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin

Inventor： BERNSTEIN, Howard ,  CHICKERING, Donald, E. ,  LEVINSON, Douglas, A. ,  WALT, David, R. ,  DAVIS, Shawn ,  HAGHGOOIE, Ramin

IPC: A61M5/32 ,  A61B5/151 ,  A61B5/157

CPC classification number: A61B5/14514 ,  A61B5/150022 ,  A61B5/150099 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150297 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/150977 ,  A61B5/150984 ,  A61B5/15105 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15125 ,  A61B5/15144 ,  A61B5/15186 ,  A61B5/157 ,  A61B5/685 ,  A61B2560/0412 ,  A61B2560/0443 ,  A61M5/425 ,  A61M35/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/588

Abstract: The present invention generally relates, in certain aspects, to relatively small devices applied to the skin, modular systems, and methods of use thereof. In some aspects, the device is constructed and arranged to have more than one module. For instance, the device may have a module for delivering to and/or withdrawing fluid from the skin and/or beneath the skin of a subject and a module for transmitting a signal indicative of the fluid delivered to and/or withdrawn from the skin and/or beneath the skin of the subject, a module for analyzing a fluid withdrawn from the skin and/or beneath the skin of the subject, or the like. In some embodiments, the modules are connectable and/or detachable from each other, and in some cases, the connections and/or detachments may be performed while the device is in contact with the subject, e.g., while affixed to the subject. In some embodiments, the device may be repeatedly applicable to the skin of the subject to deliver to and/or withdraw fluid from the skin and/or beneath the skin of a subject, e.g., at the same location, or at different locations on the skin of the subject. In some aspects, the devices may be self-contained and/or have a relatively small size, and in some cases, the device may be sized such that it is wearable and/or able to be carried by a subject. For example, the device may have a mass and/or dimensions that allow the device to be carried or worn by a subject for various periods of time, e.g., at least about an hour, at least about a day, at least about a week, etc., or no more than about an hour, no more than about 10 min, etc.

Abstract translation: 在某些方面，本发明一般涉及应用于皮肤的相对较小的装置，模块化系统及其使用方法。 在一些方面，该装置被构造并布置成具有多于一个模块。 例如，该装置可以具有用于向皮肤和/或皮肤下方递送和/或抽出流体的模块和用于传输指示输送到皮肤和/或从皮肤抽出的流体的信号的模块，以及 /或在受试者的皮肤下方，用于分析从皮肤和/或受试者的皮肤下面抽出的流体的模块等。 在一些实施例中，模块可彼此连接和/或可拆卸，并且在一些情况下，连接和/或分离可在装置与对象接触时执行，例如在固定到对象时。 在一些实施例中，该装置可以重复地适用于受试者的皮肤，以例如在相同的位置处或者在受试者的皮肤上的不同位置向受试者的皮肤和/或皮肤下方递送流体和/ 受试者的皮肤。 在一些方面中，装置可以是独立的和/或具有相对较小的尺寸，并且在一些情况下，装置的尺寸可以是可穿戴的和/或能够由对象携带。 例如，该装置可以具有允许装置被对象携带或佩戴不同时间段的质量和/或尺寸，例如至少约一小时，至少约一天，至少约一周 等，或不超过约一小时，不超过约十分钟等。

公开(公告)号：WO2010110916A3

公开(公告)日：2010-12-02

申请号：PCT/US2010000919

申请日：2010-03-26

Applicant: SEVENTH SENSE BIOSYSTEMS INC ,  LEVINSON DOUGLAS A

Inventor： LEVINSON DOUGLAS A

IPC: A61K47/48 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36

CPC classification number: A61K49/006 ,  A61K47/549 ,  A61K47/60 ,  A61K47/62 ,  A61K49/0006

Abstract: The present invention generally relates to the use of tracers, for example, to track a substance that has been administered to a subject. A tracer may be separate from the substance to be administered, or in some cases, the tracer and the substance are chemically bonded to each other. When administered to a subject (e.g., ingested), the tracer and the substance to be administered may be absorbed and/or metabolized by the subject, and the pharmacokinetic activity of the tracer within the subject may be related to the pharmacokinetic activity of the substance. Thus, by following the pharmacokinetic activity of the tracer, the pharmacokinetic activity of the substance may be determined. The tracer itself may be determined within a subject using any suitable method, depending on the tracer. As an example, the tracer may be determined by administering an indicator able to interact with the tracer. For instance, the indicator may be applied to the skin of the subject, and the indicator may give a different visual appearance based on the concentration of the tracer, or otherwise exhibit a determinable change in a property of the indicator. Other aspects of the invention are generally directed to methods of making or using tracers, methods of promoting the making or use of such tracers, kits involving such tracers, and the like.

Abstract translation: 本发明一般涉及使用示踪剂，例如追踪已被施用于受试者的物质。 示踪剂可以与要施用的物质分离，或者在一些情况下，示踪剂和物质彼此化学键合。 当被施用于受试者（例如摄入）时，示踪剂和待施用的物质可被受试者吸收和/或代谢，并且受试者内示踪剂的药代动力学活性可能与物质的药代动力学活性有关 。 因此，通过跟踪示踪剂的药代动力学活性，可以确定该物质的药代动力学活性。 取决于示踪剂，可以使用任何合适的方法在对象内确定示踪剂本身。 作为示例，可以通过施用能够与示踪剂相互作用的指示剂来确定示踪剂。 例如，指示剂可以施用于受试者的皮肤，并且指示剂可以基于示踪剂的浓度给出不同的视觉外观，或以其他方式表现指示剂的性质的可确定的变化。 本发明的其它方面一般涉及制造或使用示踪剂的方法，促进制造或使用这种示踪剂的方法，涉及这种示踪剂的试剂盒等。

公开(公告)号：WO2010101620A3

公开(公告)日：2010-11-04

申请号：PCT/US2010000623

申请日：2010-03-02

Applicant: SEVENTH SENSE BIOSYSTEMS INC ,  LEVINSON DOUGLAS A ,  ANDERSON RICHARD ROX ,  BERNSTEIN HOWARD

Inventor： LEVINSON DOUGLAS A ,  ANDERSON RICHARD ROX ,  BERNSTEIN HOWARD

IPC: A61B5/15

CPC classification number: A61B5/150099 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0077 ,  A61B5/1438 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/14865 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150389 ,  A61B5/150412 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/151 ,  A61B5/15125 ,  A61B5/157 ,  A61B5/411 ,  A61B5/4839 ,  A61B5/4845 ,  A61B5/486 ,  A61B5/685 ,  A61B5/6898 ,  A61B5/743

Abstract: The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.

Abstract translation: 本发明一般涉及与诊断，治疗和其它应用相关联的装置和技术，包括皮肤相关应用，例如用于递送和/或从主体（例如通过皮肤）排出流体的装置。 在一些实施方案中，该装置包括用于在进入位置处从受试者皮肤和/或通过皮肤接触可提取介质的系统，以及由支撑结构支撑的压力调节器，其能够在 访问站点的最少一部分。 在一些情况下，该装置还可以包括由支撑结构支持的传感器，用于确定来自受试者的可提取介质的至少一个状况，以及可选地由支撑结构支撑的信号发生器，用于产生与 介质由传感器确定。

公开(公告)号：WO2010110919A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/000922

申请日：2010-03-26

Applicant: SEVENTH SENSE BIOSYSTEMS, INC. ,  LEVINSON, Douglas, A. ,  LANGER, Robert, S.

Inventor： LEVINSON, Douglas, A. ,  LANGER, Robert, S.

IPC: A61L27/50

CPC classification number: A61L27/50 ,  A61B1/042 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1473 ,  A61B5/411 ,  A61B5/4504 ,  A61B5/6846 ,  A61F2002/488 ,  A61L27/54 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/442

Abstract: The present invention generally relates to implants and, in particular, to systems and methods for monitoring the condition of an implant within a subject. In some embodiments, an implant may be prepared that contains a tracer. After implantation, the tracer from the implant may be determined within a subject using any suitable method, depending on the tracer. As an example, the tracer may be determined by administering an indicator able to interact with the tracer to the subject. For instance, the indicator may be applied to the skin of the subject, and the indicator may give a different visual appearance based on the tracer, or otherwise exhibits a determinable change in a property of the indicator. Other aspects of the invention are generally directed to methods of making or using implants, methods of promoting the making or use of such implants, kits involving such implants, or the like.

Abstract translation: 本发明一般涉及植入物，特别是涉及用于监测受试者内的植入物的状态的系统和方法。 在一些实施例中，可以制备包含示踪剂的植入物。 植入后，取决于示踪剂，可以使用任何合适的方法在对象内确定来自植入物的示踪剂。 作为示例，可以通过施用能够与对象相关的示踪剂来确定示踪剂。 例如，指示剂可以施加到受试者的皮肤，并且指示器可以基于示踪剂给出不同的视觉外观，或者以其他方式表现出指示符的性质的可确定的变化。 本发明的其他方面通常涉及制造或使用植入物的方法，促进这种植入物的制造或使用的方法，涉及这种植入物的试剂盒等。

公开(公告)号：WO2012021792A8

公开(公告)日：2013-05-23

申请号：PCT/US2011047565

申请日：2011-08-12

Applicant: SEVENTH SENSE BIOSYSTEMS INC ,  CHICKERING DONALD E III ,  LEVINSON DOUGLAS A ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN ,  BERNSTEIN HOWARD ,  WALT DAVID R

Inventor： CHICKERING DONALD E III ,  LEVINSON DOUGLAS A ,  DAVIS SHAWN ,  HAGHGOOIE RAMIN ,  BERNSTEIN HOWARD ,  WALT DAVID R

IPC: A61M5/142

CPC classification number: A61M37/0015 ,  A61B5/117 ,  A61B5/14514 ,  A61B5/150984 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B90/96 ,  A61B90/98 ,  A61B2560/0412 ,  A61M5/14248 ,  A61M37/00 ,  A61M2037/0023 ,  A61M2037/0061 ,  A61M2205/3576 ,  A61M2205/6009 ,  A61M2205/6072 ,  A61N1/30 ,  A61N1/325

Abstract: The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.

Abstract translation: 本发明一般涉及用于递送和/或接受来自受试者，例如来自皮肤和/或来自身体的其它组织的物质或物质例如血液的系统和方法。 在一些情况下，该装置可以包含诸如针或微针的物质转移组件，其可以插入到皮肤或另一个器官中以从受试者输送和/或接收流体或其他物质。 在一些实施方案中，该装置可以包括构造和布置成将一种或多种物质转移组分插入皮肤或其它器官中的活化剂。 在某些情况下，该装置还可以包括用于接收从受试者接收的流体的储存室。