公开(公告)号：WO2003081391A2

公开(公告)日：2003-10-02

申请号：PCT/US2003/008628

申请日：2003-03-19

Applicant: MAPINFO CORPORATION ,  MOON, George, C. ,  MATTHEW, Tweedie ,  DOVE, John ,  DEWALD, Edward ,  LI, Xiang ,  PETRONIS, Scott ,  BERRILL, Arthur, R. ,  LEA, Tony

Inventor： MOON, George, C. ,  MATTHEW, Tweedie ,  DOVE, John ,  DEWALD, Edward ,  LI, Xiang ,  PETRONIS, Scott ,  BERRILL, Arthur, R. ,  LEA, Tony

IPC: G06F

CPC classification number: G06F17/3087 ,  H04L29/06 ,  H04L63/083 ,  H04L67/02 ,  H04L67/04 ,  H04L67/16 ,  H04L67/18 ,  H04L67/306 ,  H04L69/329 ,  H04W4/02 ,  H04W8/26 ,  H04W40/00 ,  H04W64/00

Abstract: The disclosed method and system provide extensible or stand-alone location enabled services at granularity down to a stand-alone service. The various interfaces are preferably specified via DTD or schemas for communication based on XML. This collection of services enables management of mobile device locations information, and real-time services. Mobile device location is integrated with other location sensitive data, such as maps or demographics of a particular region or even the location of businesses and consumers to enable a richer service offering for customers of wireless carriers and service providers. Examples of such services include obtaining routes to a destination; providing a geocode corresponding to an address; providing an address corresponding to a geocode; providing maps as image files encompassing specified geocodes, locations, or addresses and the like. Additional services may be added to the disclosed system and method seamlessly due to the use of extensible interfaces.

Abstract translation: 所公开的方法和系统提供可扩展或独立的位置使能的服务，其粒度直到独立服务。 各种接口优选地通过用于基于XML的通信的DTD或模式来指定。 这种服务集合可以管理移动设备位置信息和实时服务。 移动设备位置与其他位置敏感数据集成，例如特定区域的地图或人口统计，甚至企业和消费者的位置，以为无线运营商和服务提供商的客户提供更丰富的服务。 这种服务的示例包括获得到目的地的路线; 提供对应于地址的地理编码; 提供与地理编码相对应的地址; 提供地图作为包含指定的地理编码，位置或地址等的图像文件。 由于使用可扩展接口，附加服务可以无缝地添加到所公开的系统和方法中。

公开(公告)号：WO2021158949A1

公开(公告)日：2021-08-12

申请号：PCT/US2021/016863

申请日：2021-02-05

Applicant: LI, Xiang ,  CHEN, Yiyou

Inventor： LI, Xiang ,  CHEN, Yiyou

IPC: A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C12N15/11 ,  C12N15/113 ,  C12Q1/68

Abstract: Provided are combination therapies and secondary biomarkers for treating MYCC-associated diffuse large B-cell lymphoma (DLBCL) with YM155-based therapies, and related kits, compositions, and methods of use thereof.

公开(公告)号：WO2021119209A1

公开(公告)日：2021-06-17

申请号：PCT/US2020/064129

申请日：2020-12-09

Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION ,  ZHANG, Su-Chun ,  LI, Xiang

Inventor： ZHANG, Su-Chun ,  LI, Xiang

IPC: C12N5/074 ,  C12N5/079 ,  C12N5/0793 ,  C12N5/0797

Abstract: Methods and compositions for expanding dopaminergic neuron progenitor cells are described herein that include use of compositions and culture media that have at least the following components: an FGF, an agonist of SHH signaling, an agonist of canonical Wnt signaling, and Wnt-C59. The methods include contacting dopaminergic neuron progenitor cells with a culture medium comprising an FGF, an agonist of SHH signaling, an agonist of canonical Wnt signaling, and Wnt-C59, to generate an expanded dopaminergic neuron progenitor cell population.

公开(公告)号：WO2014032238A1

公开(公告)日：2014-03-06

申请号：PCT/CN2012/080718

申请日：2012-08-29

Applicant: SICPA HOLDING SA ,  CHINA BANKNOTE PRINTING AND MINTING CORPORATION ,  ZHONGCHAO SPECIAL SECURITY TECHNOLOGY CO., LTD. ,  CHINA BANKNOTE SICPA SECURITY INK CO., LTD. ,  RITTER, Gebhard ,  DEGOTT, Pierre ,  YE, Zhongdong ,  SUN, Fangyi ,  WANG, Weiru ,  HU, Chunhua ,  LI, Xiang

Inventor： RITTER, Gebhard ,  DEGOTT, Pierre ,  YE, Zhongdong ,  SUN, Fangyi ,  WANG, Weiru ,  HU, Chunhua ,  LI, Xiang

IPC: D21H21/42 ,  D21H21/44

CPC classification number: B42D25/355 ,  B42D25/00 ,  B42D25/351 ,  B42D25/40 ,  D21H21/42 ,  D21H21/44 ,  D21H21/48

Abstract: A more sophisticated optically variable security thread or stripe was provided. It could be used in the field of anti-counterfeiting, and comprised: a substrate and i ) a first optically variable layer (1) imparting a first different color impression at different viewing angles, ii )a second optically variable layer (2) imparting a second different color impression at different viewing angles, iii)a first color constant layer (4) having a color matching the color impression of the first or second optically variable layer at a first viewing angle, iv) a second color constant layer (5) having a color matching the color impression of the first or second optically variable layer at a second viewing angle, and v ) one or more material-free regions (0), wherein the first optically variable layer (l), the second optically variable layer (2), the first color constant layer (4), the second color constant layer (5) and the one or more material-free regions (0) are jointly visible from one side of the security thread or stripe. A process for making said security thread or stripe was also disclosed.

Abstract translation: 提供了更复杂的光学可变安全线程或条带。 它可以用于防伪领域，并且包括：基底和i）在不同视角赋予第一不同颜色印象的第一光学可变层（1），ii）赋予第二光学可变层（2）的第二光学可变层 在不同视角下的第二不同颜色印象，iii）具有与第一或第二光学可变层的第一视角的颜色匹配的颜色的第一颜色恒定层（4），iv）第二颜色常数层（5） ）具有与第一或第二光学可变层的颜色印象匹配的颜色，以及v）一个或多个无材料区域（0），其中第一光学可变层（1），第二光学变量 层（2），第一颜色常数层（4），第二颜色常数层（5）和一个或多个无材料区域（0）从安全线或条的一侧共同可见。 还公开了用于制作所述安全线程或条带的过程。

公开(公告)号：WO2013100929A1

公开(公告)日：2013-07-04

申请号：PCT/US2011/067474

申请日：2011-12-28

Applicant: INTEL CORPORATION ,  LI, Xiang ,  ZHAO, Chong J. ,  KRIEGER, Jefferey L. ,  WILLIS, Dan ,  LYNCH, John M. ,  LING, Yun

Inventor： LI, Xiang ,  ZHAO, Chong J. ,  KRIEGER, Jefferey L. ,  WILLIS, Dan ,  LYNCH, John M. ,  LING, Yun

IPC: H01R12/77 ,  H05K7/14

CPC classification number: H01R12/732 ,  H01R12/721 ,  H01R12/83 ,  H05K1/181 ,  H05K2201/10159

Abstract: According to some embodiments, a SODIMM memory connector comprises a first socket to electrically couple a first SODIMM, and a second socket to electrically couple a second SODIMM, where the first socket is disposed vertically adjacent to the second socket.

Abstract translation: 根据一些实施例，SODIMM存储器连接器包括用于电耦合第一SODIMM的第一插座和用于电耦合第二SODIMM的第二插座，其中第一插座垂直地邻近第二插座设置。

公开(公告)号：WO2009089680A1

公开(公告)日：2009-07-23

申请号：PCT/CN2008/002027

申请日：2008-12-18

Applicant: YANG, Dan ,  LI, Xiang ,  SHEN, Bing ,  YAO, Xiao-Qiang

Inventor： YANG, Dan ,  LI, Xiang ,  SHEN, Bing ,  YAO, Xiao-Qiang

IPC: A61K31/16 ,  A61K31/215 ,  A61K31/4412 ,  C07C239/14 ,  C07C239/20 ,  C07C217/48 ,  C07C217/46 ,  C07C237/42 ,  C07C225/08 ,  C07C225/14 ,  C07C225/16 ,  C07D213/63 ,  C07D213/79 ,  C07D213/81 ,  A61P9/12 ,  A61P27/00 ,  A61P13/12 ,  A61P25/14 ,  A61P25/08 ,  A61P25/00 ,  A61P19/08

CPC classification number: A61K31/166

Abstract: Provided herein are methods of modulating membrane potential of a cell membrane using self-assembling compounds. Also provided herein are methods of regulating a natural voltage-dependent ion channel in a cell membrane using the self-assembling compounds disclosed herein. Further provided herein are methods of treating, preventing and /or managing a disease that is related to the abnormal membrane potential responses by using the self-assembling compounds disclosed herein.

Abstract translation: 本文提供了使用自组装化合物调节细胞膜的膜电位的方法。 本文还提供了使用本文公开的自组装化合物来调节细胞膜中天然的依赖于电压的离子通道的方法。 本文还提供了通过使用本文公开的自组装化合物治疗，预防和/或控制与异常膜电位反应相关的疾病的方法。

公开(公告)号：WO2008086047A1

公开(公告)日：2008-07-17

申请号：PCT/US2008/050014

申请日：2008-01-02

Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH ,  BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG ,  DAHMANN, George ,  HICKEY, Eugene Richard ,  LI, Xiang ,  MAO, Wang ,  MARSHALL, Daniel Richard ,  MORWICK, Tina Marie ,  SIBLEY, Robert ,  SNOW, Roger John ,  SORCEK, Ronald John ,  WU, Frank ,  YOUNG, Erick Richard Roush

Inventor： DAHMANN, George ,  HICKEY, Eugene Richard ,  LI, Xiang ,  MAO, Wang ,  MARSHALL, Daniel Richard ,  MORWICK, Tina Marie ,  SIBLEY, Robert ,  SNOW, Roger John ,  SORCEK, Ronald John ,  WU, Frank ,  YOUNG, Erick Richard Roush

IPC: C07C237/42 ,  C07C275/42 ,  C07D217/22 ,  A61K31/167 ,  A61K31/277 ,  A61K31/472 ,  A61P9/10

CPC classification number: C07C275/28 ,  C07C275/30 ,  C07C275/34 ,  C07C275/38 ,  C07C275/42 ,  C07C323/62 ,  C07C2602/08 ,  C07D209/44 ,  C07D211/26 ,  C07D211/34 ,  C07D217/02 ,  C07D217/04 ,  C07D223/16 ,  C07D231/12 ,  C07D249/08 ,  C07D277/46 ,  C07D277/60 ,  C07D285/135 ,  C07D295/088 ,  C07D295/135 ,  C07D307/68 ,  C07D417/04 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

Abstract: Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile dysfunction and glaucoma.

Abstract translation: 描述了用作Rho激酶抑制剂的取代的酰胺和脲衍生物，该抑制剂可用于治疗各种疾病如心血管疾病，癌症，神经疾病，肾脏疾病，支气管哮喘，勃起功能障碍和青光眼。

公开(公告)号：WO2007046882A2

公开(公告)日：2007-04-26

申请号：PCT/US2006/021832

申请日：2006-06-06

Applicant: UNIVERSITY OF MARYLAND, BALTIMORE COUNTY ,  BIEBERICH, Charles ,  LI, Xiang

Inventor： BIEBERICH, Charles ,  LI, Xiang

IPC: G01N33/53

CPC classification number: C12Q1/00 ,  C12Q1/485 ,  G01N2500/02

Abstract: The present invention relates to apparatus and methods for separating and detecting enzyme substrates using separation gels. For example, the apparatus and methods can be used to separate and detect kinase substrates for further analysis. The apparatus and methods can also be used to detect enzyme inhibitors, such as kinase inhibitors.

Abstract translation: 本发明涉及使用分离凝胶分离和检测酶底物的装置和方法。 例如，该装置和方法可用于分离和检测激酶底物用于进一步分析。 该装置和方法也可用于检测酶抑制剂，例如激酶抑制剂。

公开(公告)号：WO2005087806A2

公开(公告)日：2005-09-22

申请号：PCT/US2005/004357

申请日：2005-02-09

Applicant: BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. ,  LI, Jun ,  LI, Xiang ,  LOSACCO, Baerbel ,  QI, Zhenhao

Inventor： LI, Jun ,  LI, Xiang ,  LOSACCO, Baerbel ,  QI, Zhenhao

IPC: C07K14/705

CPC classification number: C07K14/70596 ,  A61K38/00

Abstract: The invention provides for a substantially purified polypeptide referred to herein as CD38JL that is a CD38 splice variant comprised of the polypeptide of SEQ ID NO: 1 or a fragment thereof. The invention also provides methods for treating preventing and diagnosing disorders associated with expression of CD38JL.

Abstract translation: 本发明提供了本文中称为CD38JL的基本上纯化的多肽，其是由SEQ ID NO：1的多肽或其片段组成的CD38剪接变体。 本发明还提供了治疗预防和诊断与CD38JL表达相关的疾病的方法。

公开(公告)号：WO2005079791A1

公开(公告)日：2005-09-01

申请号：PCT/US2005/004183

申请日：2005-02-09

Applicant: BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. ,  BENTZIEN, Joerg, Martin ,  COOK, Brian, Nicholas ,  LI, Xiang ,  LO, Ho Yin ,  MAN, Chuk, Chui ,  MUGGE, Ingo, Andreas ,  PULLEN, Steven, S. ,  ROTH, Gregory, Paul ,  SOLEYMANZADEH, Fariba ,  TAKAHASHI, Hidenori ,  WANG, Ji ,  WHITE, Andre ,  ZINDELL, Renee, M. ,  RIETHER, Doris, Edith ,  NEMOTO, Peter, Allen ,  YAO, Xin ,  MANGETTE, John Edward

Inventor： BENTZIEN, Joerg, Martin ,  COOK, Brian, Nicholas ,  LI, Xiang ,  LO, Ho Yin ,  MAN, Chuk, Chui ,  MUGGE, Ingo, Andreas ,  PULLEN, Steven, S. ,  ROTH, Gregory, Paul ,  SOLEYMANZADEH, Fariba ,  TAKAHASHI, Hidenori ,  WANG, Ji ,  WHITE, Andre ,  ZINDELL, Renee, M. ,  RIETHER, Doris, Edith ,  NEMOTO, Peter, Allen ,  YAO, Xin ,  MANGETTE, John Edward

IPC: A61K31/4184

CPC classification number: C07D235/30 ,  C07D401/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D491/10

Abstract: Disclosed are compounds of formula (I): wherein Ar 1 , Ar 2 , R 1 , R 2 , R 3 , R 4 and X a are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

Abstract translation: 公开了式（I）的化合物：其中Ar1，Ar2，R1，R2，R3，R4和Xa在本文中定义。 本发明的化合物抑制Itk激酶，因此可用于治疗涉及炎症，免疫学障碍和过敏性疾病的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。