公开(公告)号：WO01068575A1

公开(公告)日：2001-09-20

申请号：PCT/JP2001/001060

申请日：2001-02-15

IPC: C07C19/16 ,  C07C25/13 ,  C07C211/64 ,  C07C381/12 ,  C07C391/00 ,  C07C395/00 ,  C07D211/76 ,  C07D295/067 ,  C07D309/30 ,  C07D333/06 ,  C07D333/46 ,  C07D333/50 ,  C07D333/54 ,  C07D333/76 ,  C07D335/06 ,  C07D339/08 ,  C07D345/00 ,  C07F9/54 ,  C07F9/59 ,  C08K5/00 ,  C08L101/00 ,  C09K3/00 ,  G03F7/004 ,  G03F7/038 ,  G03F7/039 ,  H01L21/027 ,  C07C25/02 ,  C07C211/62

CPC classification number: C07D295/067 ,  C07C25/13 ,  C07C211/64 ,  C07C381/12 ,  C07C391/00 ,  C07C395/00 ,  C07C2601/14 ,  C07D211/76 ,  C07D309/30 ,  C07D333/06 ,  C07D333/46 ,  C07D333/50 ,  C07D333/54 ,  C07D333/76 ,  C07D335/06 ,  C07D339/08 ,  C07D345/00 ,  C07F9/5407 ,  C07F9/5449 ,  C07F9/591 ,  G03F7/0045

Abstract: A cation or acid generator which, upon irradiation with energy rays, can generate cations or an acid with high sensitivity and which is suitable for use in chemical amplification type resist materials. It comprises an energy-ray-sensitive fluoroalkylonium salt represented by the formula (1) in which R to R (each is alkyl, aryl, etc.) and Rf (fluoroalkyl) are bonded to the central element A (iodine, sulfur, selenium, tellurium, nitrogen, or phosphorus). Also provided is a chemical amplification type resist material which contains the acid generator.

Abstract translation: 阳离子或酸发生剂，其在能量射线照射时，可以以高灵敏度产生阳离子或酸，并且适用于化学放大型抗蚀剂材料。 它包括由式（1）表示的能量射线敏感性氟代烷基盐，其中R 1至R 3（各自为烷基，芳基等）和Rf（氟烷基）键合至中心元素A （碘，硫，硒，碲，氮或磷）。 还提供含有酸发生剂的化学放大型抗蚀剂材料。

公开(公告)号：WO98037117A1

公开(公告)日：1998-08-27

申请号：PCT/JP1998/000714

申请日：1998-02-23

IPC: C07C391/00 ,  C07D331/02 ,  C07D345/00 ,  C07D421/14 ,  C08F30/00 ,  C08G18/38 ,  C08G18/76 ,  C08G18/77 ,  C08G75/02 ,  C08G75/04 ,  G02B1/04 ,  C08G18/78 ,  C08G18/40 ,  C08G79/00

CPC classification number: C07D421/14 ,  C07C391/00 ,  C07D331/02 ,  C07D345/00 ,  C08F30/00 ,  C08G18/3876 ,  C08G18/3897 ,  C08G18/7642 ,  C08G18/77 ,  C08G75/02 ,  C08G75/045 ,  G02B1/041 ,  C08L81/00 ,  C08L85/00

Abstract: A transparent optical material containing at least one selenium atom; a plastic lens made of the optical material; processes for producing these; and novel selenium compounds useful for producing the transparent optical material and plastic lens and represented by general formula (1), formula (2): (Z ) q - (SH) r, or formula (4): (Z ) - (X ) s, wherein Y and Z each represents C, S, etc.; X represents a polymerizable functional group such as SH, NCO, or acryloyl; Z2 represents alkylene containing at least one Se atom; q is an integer of 1 to 20; r is an integer of 3 to 6; Z represents Se or alkylene containing at least one Se atom; X represents a functional group such as (meth)acrylol; and s is an integer of 2 to 6.

Abstract translation: 含有至少一个硒原子的透明光学材料; 由光学材料制成的塑料透镜; 制作过程; 由通式（1），式（2）：（Z 2）q - （SH）r或式（4）表示的用于制造透明光学材料和塑料透镜的新颖硒化合物：（Z < 3）） - （X 2）s，其中Y 1和Z 1各自表示C，S等; X 1表示可聚合官能团，例如SH，NCO或丙烯酰基; Z2表示含有至少一个Se原子的亚烷基; q为1〜20的整数， r为3〜6的整数; Z 3表示Se或含有至少一个Se原子的亚烷基; X 2表示官能团，例如（甲基）丙烯酰; s为2〜6的整数。

公开(公告)号：WO2023279426A1

公开(公告)日：2023-01-12

申请号：PCT/CN2021/106687

申请日：2021-07-16

Applicant: 苏州大学

Inventor： 纪顺俊 ,  蔡忠建 ,  王典亮

IPC: C07C391/02 ,  C07C391/00 ,  C07D213/55 ,  C07D333/24

Abstract: 一种多取代含硒环戊(己)烯骨架衍生物及其合成方法，以芳基乙炔类化合物、不饱和硒醚试剂作为反应原料，在自由基引发剂的作用下，一锅法制备了多取代含硒环戊(己)烯骨架衍生物。上述合成过程简单高效、无需金属催化剂、反应条件温和，具有良好的官能团耐受性和底物普适性。此外，不同取代基团的环戊(己)烯化合物广泛存在于药物活性分子中，且含硒化合物在抗肿瘤、抗氧化、抗炎、抗菌、抗病毒等方面也具有良好的生物活性，因此利用上述合成方法通过简便、高效和可持续的策略来构建C-Se键以实现由简单底物出发获得复杂的含硒环戊(己)烯骨架衍生物，具有广泛的应用前景。

公开(公告)号：WO2022245627A1

公开(公告)日：2022-11-24

申请号：PCT/US2022/028942

申请日：2022-05-12

Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

Inventor： IYER, Malliga R.

IPC: C07D231/06 ,  C07D295/215 ,  C07D401/12 ,  C07C335/42 ,  C07C391/00 ,  C07C395/00

Abstract: In one aspect, the application relates to sulfonyl chalcogenide urea derivatives of Formula II, including sulfonyl thioureas and sulfonyl selenoureas, and methods of making the same, wherein the methods can be carried out under mild conditions and do not require the use of malodorous reagents. In one aspect, the methods are one- pot, two-step reactions wherein an intermediate imidoyl chloride is treated with a compound having formula M2X2O3 or M2XJO3 (where X and J can independently be Se, S, and/or Te) or a hydrate thereof, forming a Bunte salt which quickly decomposes to form the sulfonyl chalcogenide urea derivatives. The application also relates to substituted sulfonyl chalcogenide urea derivatives of Formula V and a method for their preparation from sulfonyl chalcogenide urea derivatives of Formula II, to a method for synthesizing a substituted guanidine from a sulfonyl chalcogenide urea of Formula II as well as to substituted guanidine derivatives thus prepared.

公开(公告)号：WO2020065086A1

公开(公告)日：2020-04-02

申请号：PCT/EP2019/076366

申请日：2019-09-30

Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS ,  UNIVERSIDAD DE NAVARRA ,  UNIVERSITY OF SZEGED ,  UNIVERSITÄT DES SAARLANDES

Inventor： DOMÍNGUEZ ÁLVAREZ, Enrique ,  SPENGLER, Gabriella ,  JACOB, Claus ,  SANMARTÍN GRIJALBA, María del Carmen

IPC: C07C391/00 ,  A61K31/095 ,  A61K31/12 ,  A61K31/277 ,  A61P31/04 ,  A61P35/00

Abstract: The invention relates to a compound of formula (I) for use in the treatment of microbial infections or colorectal cancer, wherein R 1 to R 4 , X, n, p, q, r and s are defined in the description.

公开(公告)号：WO2019093699A1

公开(公告)日：2019-05-16

申请号：PCT/KR2018/012826

申请日：2018-10-26

Applicant: 서울대학교 산학협력단

Inventor： 박형근 ,  이상국 ,  한혜주 ,  변웅섭

IPC: C07C391/00 ,  A61K31/4035

Abstract: 본 발명은 항암 활성을 갖는 신규 셀레노사마필린 A와 그 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 약학적 조성물에 관한 것으로, 보다 구체적으로는 암세포의 성장억제 효과가 알려진 사마필린 A와 관련하여 구조 활성 연구에 따라 디설파이드 부분이 디셀레나이드로 치환되어 더 우수한 항암활성을 나타내는 새로운 화합물 셀레노사마필린 A 및 그 유도체와, 이의 제조방법 및 이를 유효성분으로 포함하는 암 예방 또는 치료용 조성물에 대한 것이다. 본 발명에 따른 신규 셀레노사마필린 A와 그 유도체는 다양한 인간 암 세포주에 대해 우수한 항암 활성을 나타낸바, 암 예방 및 치료를 위한 약학 조성물로 유용하게 사용될 수 있을 것으로 기대된다.

公开(公告)号：WO2017182885A3

公开(公告)日：2017-10-26

申请号：PCT/IB2017/000638

申请日：2017-04-18

Applicant: M.G. THERAPEUTICS LTD.

Inventor： ALSTER, Yair ,  RAFAELI, Omer ,  AMSELEM, Shimon ,  FRIEDMAN, Doron ,  NUDELMAN, Zakhar

IPC: A61K31/198 ,  C07C391/00

Abstract: Described herein are compositions and methods for treating hyperkeratosis disorders such as dandruff, psoriasis, acne vulgaris, warts, corns, calluses, palmoplantar keratodermas, ichthyosis, seborrheic dermatitis, meibomian gland dysfunction, HPV infection, lichen planus, aclinic keratosis, seborrheic keratosis, etc. Said compositions comprise a selenium-containing amino acid as keratolytic agent, and are topically administered to the skin or eyelid margin of the patient. In some embodiments, the composition comprises a selenium-containing amino acid such as selenium methionine or selenium cysteine formulated in a ophthalmic, dermatological, or cosmetic dosage form.

公开(公告)号：WO2015131421A1

公开(公告)日：2015-09-11

申请号：PCT/CN2014/074095

申请日：2014-03-26

Applicant: 上海爱启生态科技有限公司

Inventor： 陈躬 ,  宋昆元

IPC: C07C391/00 ,  C07D493/00

CPC classification number: C07D311/62 ,  A23L33/105 ,  A23L33/16 ,  C01B19/00

Abstract: 一种高硒含量硒化茶多酚，其包含碱金属离子硒配合物。制备所述的高硒含量硒化茶多酚的方法，包括：A.将茶多酚至少与一种金属无机碱反应，获得茶多酚羟酸基盐；B.将获得的所述茶多酚羟酸基盐与SeO 2 反应，获得所述的高硒含量硒化茶多酚。

公开(公告)号：WO2011160060A3

公开(公告)日：2012-04-12

申请号：PCT/US2011040949

申请日：2011-06-17

Applicant: SELENIUM LTD

Inventor： EUGENE HANES ROBERT

IPC: C07C391/00 ,  A01N55/00 ,  A61L29/16 ,  B05D3/10 ,  C07D517/02

CPC classification number: C09D5/14 ,  A01N55/00 ,  A61L27/06 ,  A61L27/54 ,  A61L29/02 ,  A61L29/16 ,  A61L2300/10 ,  A61L2300/216 ,  A61L2300/404 ,  C07C391/00 ,  A01N25/34

Abstract: The present invention comprises compositions and methods for a selenium attachment agent and uses thereof, wherein the selenium attachment agent facilitates the attachment of desired molecules to a surface. In particular, surfaces are enhanced to include antimicrobial or biocidal characteristics, including an organoselenium compound for biocidal properties.

Abstract translation: 本发明包括硒附着剂的组合物和方法及其用途，其中硒附着剂有助于将所需分子附着到表面。 特别地，表面被增强以包括抗微生物或杀生物特性，包括用于杀生物性的有机硒化合物。

公开(公告)号：WO2010131962A2

公开(公告)日：2010-11-18

申请号：PCT/NL2010/050277

申请日：2010-05-12

Applicant: STICHTING HET NEDERLANDS KANKER INSTITUUT ,  OVAA, Huib ,  EL OUALID, Farid

Inventor： OVAA, Huib ,  EL OUALID, Farid

IPC: C07C271/22 ,  A61K31/198 ,  C07K1/13 ,  C07C323/59 ,  C07C391/00

CPC classification number: A61K38/02 ,  C07C271/22 ,  C07C323/59 ,  C07C391/00 ,  C07C2603/18 ,  C07K1/02

Abstract: The present invention concerns new thiolysine and selenolysine compounds that can be used as building blocks for peptides and proteins, providing ligation handles for site-and chemoselective modification of said peptides and proteins. In particular, the invention provides. In particular, the invention provides (the use of) the compounds 5-thiolysine (also referred to as δ-thiolysine); 4-thiolysine (also referred to as γ-thiolysine); 5-selenolysine (also referred to as δ-selenolysine) and 4- selenolysine (also referred to as γ-selenolysine). The positioning of the thiol or selenol group at the respective carbon atom allows for a very efficient intramolecular transfer reaction to take place after conjugation with a selected ligand, and the thiol or selenol group may subsequently be removed using reported procedures, thereby restoring the native lysine structure, or be used as an additional conjugation handle. The methodology is fast and gives well-defined material.

Abstract translation: 本发明涉及可用作肽和蛋白质的结构单元的新的硫代赖氨酸和硒代赖氨酸化合物，提供用于所述肽和蛋白质的位点和化学选择性修饰的连接手柄。 具体地，本发明提供。 特别地，本发明提供化合物5-硫代赖氨酸（也称为d-硫代赖氨酸）的用途（用途）。 4-硫代赖氨酸（也称为β-硫代赖氨酸）; 5-硒代赖氨酸（也称为d-硒代赖氨酸）和4-硒代赖氨酸（也称为α-硒代赖氨酸）。 硫醇或硒醇基团在相应碳原子上的定位允许在与所选择的配体缀合之后进行非常有效的分子内转移反应，并且随后可以使用报道的方法除去硫醇或硒酚基团，由此恢复天然赖氨酸 结构，或用作附加共轭手柄。 该方法很快，并提供了明确的材料。