METHOD FOR PRODUCING A CRYSTALLINE TABLETING ADDITIVE, ADDITIVE THUS OBTAINED AND USE THEREOF
    31.
    发明申请
    METHOD FOR PRODUCING A CRYSTALLINE TABLETING ADDITIVE, ADDITIVE THUS OBTAINED AND USE THEREOF 审中-公开
    生产结晶添加剂的方法,获得的添加剂及其用途

    公开(公告)号:WO02008470A1

    公开(公告)日:2002-01-31

    申请号:PCT/EP2001/008394

    申请日:2001-07-19

    CPC classification number: C13B30/028 A61K9/2018 A61K47/26 C13K5/00

    Abstract: The present invention relates to a method for producing a tableting additive, which method comprises providing a spray dried tableting additive in particulate form which particles at least partially consist of amorphous additive material and at least partially of crystalline additive material; and crystallising the amorphous additive material by subjecting the particles for a short time and under agitation to a temperature between 30 and 100 DEG C at a relative humidity between 60 and 25 %. More in particular, the relationship between relative humidity and temperature is defined by the formula: % relative humidity = 218-47*Ln(T( DEG C)), wherein T( DEG C) is the temperature to which the particles are subjected.

    Abstract translation: 本发明涉及一种压片添加剂的制造方法,该方法包括提供颗粒形式的喷雾干燥的压片添加剂,该颗粒至少部分地由无定形添加剂材料组成并且至少部分地由结晶添加剂材料组成; 并通过在短时间和搅拌下将颗粒在相对湿度为60至25%之间的温度下在30至100℃之间进行结晶而使无定形添加剂材料结晶。 更特别地,相对湿度和温度之间的关系由下式定义:%相对湿度= 218-47 * Ln(T(℃)),其中T(℃)是颗粒经受的温度。

    HIGH PURITY LACTOSE
    34.
    发明申请
    HIGH PURITY LACTOSE 审中-公开
    高纯度的乳糖

    公开(公告)号:WO2018071665A1

    公开(公告)日:2018-04-19

    申请号:PCT/US2017/056334

    申请日:2017-10-12

    Abstract: An example system for purifying a supply stream including lactose includes a clarification system configured to separate insoluble impurities from the stream to produce a clarified stream. The system includes an adsorption system fluidically coupled to the clarification system. The adsorption system includes an adsorbent resin configured to purify the clarified stream. An example technique for purifying a supply stream including lactose includes separating insoluble impurities from the supply stream to produce a clarified stream and passing the clarified stream over an adsorbent resin to produce a decolorized stream.

    Abstract translation: 用于纯化包括乳糖的供应物流的示例系统包括澄清系统,其被配置为从流中分离不溶性杂质以产生澄清的物流。 该系统包括与澄清系统流体耦合的吸附系统。 吸附系统包括构造成净化澄清流的吸附树脂。 用于纯化包括乳糖的供应物流的示例性技术包括从供应物流中分离不溶性杂质以产生澄清的物流,并使澄清的物流通过吸附树脂以产生脱色物流。

    REFINER FOR LACTOSE AND HIGH LACTOSE PRODUCTS
    35.
    发明申请
    REFINER FOR LACTOSE AND HIGH LACTOSE PRODUCTS 审中-公开
    用于乳糖和高乳糖产品的精制剂

    公开(公告)号:WO2017210162A1

    公开(公告)日:2017-12-07

    申请号:PCT/US2017/034949

    申请日:2017-05-30

    Inventor: KELLER, A. Kent

    Abstract: An example method for refining lactose may include washing lactose crystals in a lactose stream in an upstream wash stream including an upstream recirculating wash medium. Washed lactose crystals may be sieved from the upstream recirculating wash medium. The upstream recirculating wash medium may be recirculated back to the upstream wash stream. The washed lactose crystals may be discharged to a downstream wash stream comprising a downstream recirculating wash medium. An example system may include a plurality of refining stages. At least one refining stage may include a washing tank including a lactose crystal inlet and a crystal slurry outlet. The refining stage may include a pump to recirculate a wash stream from the crystal slurry outlet back to the washing tank at a predetermined flow rate. The refining stage includes a screen to separate washed lactose crystals from the wash stream.

    Abstract translation: 一种用于精制乳糖的示例性方法可以包括在包括上游再循环洗涤介质的上游洗涤流中乳糖流中洗涤乳糖晶体。 洗涤的乳糖晶体可以从上游循环洗涤介质中筛分。 上游再循环洗涤介质可以再循环回到上游洗涤流。 洗过的乳糖晶体可以排放到包含下游循环洗涤介质的下游洗涤流中。 示例系统可以包括多个精炼阶段。 至少一个精制阶段可以包括包含乳糖晶体入口和晶体浆料出口的洗涤罐。 精制阶段可以包括泵以预定流率将来自晶体浆料出口的洗涤流再循环回洗涤罐。 精炼阶段包括将洗过的乳糖晶体与洗涤流分离的筛网。

    DRYER FOR LACTOSE AND HIGH LACTOSE PRODUCTS
    36.
    发明申请
    DRYER FOR LACTOSE AND HIGH LACTOSE PRODUCTS 审中-公开
    干燥器用于乳糖和高乳糖产品

    公开(公告)号:WO2017106008A1

    公开(公告)日:2017-06-22

    申请号:PCT/US2016/065628

    申请日:2016-12-08

    Inventor: KELLER, A. Kent

    CPC classification number: C13K5/00 A23C1/00 A23C1/04 A23C21/00 F26B1/005 F26B3/08

    Abstract: A system for drying a wet lactose product stream includes a disperser configured to disperse agglomerated lactose particulates in a wet lactose stream into a dispersed wet lactose stream. A back-mixed partial drying zone is configured to at least partially dry the dispersed wet lactose stream by recirculating a partially dried lactose stream with the dispersed wet lactose stream. A plug-flow secondary drying zone is configured to dry the partially dried lactose stream to generate a substantially dried lactose stream.

    Abstract translation: 用于干燥湿乳糖产品流的系统包括分散器,其被配置成将凝聚的乳糖微粒分散在湿乳糖流中分散到分散的湿乳糖流中。 将回混的部分干燥区构造成通过用分散的湿乳糖物流再循环部分干燥的乳糖物流来至少部分地干燥分散的湿乳糖物流。 活塞流二次干燥区构造成干燥部分干燥的乳糖物流以产生基本上干燥的乳糖物流。

    INFANT FORMULAE AND THEIR PREPARATIONS
    38.
    发明申请
    INFANT FORMULAE AND THEIR PREPARATIONS 审中-公开
    婴儿配方及其制剂

    公开(公告)号:WO2013169097A1

    公开(公告)日:2013-11-14

    申请号:PCT/NL2012/050330

    申请日:2012-05-11

    CPC classification number: A23L1/296 A23L33/10 A23L33/40 A23V2002/00 C13K5/00

    Abstract: The invention pertains to an infant formula powder composition comprising micronized lactose or lactose microcrystals (i) smaller than 30 micrometer, and/or (ii) of which at least 80 % has a size less than 20 micrometer, and/or (iii) at least 80 % has a size less than 10 micrometer, and/or (iv) having a median particle size D50 below 10 micrometer. The invention also pertains to the use of micronized lactose or lactose microcrystals for improving flow of an infant formula powder composition.

    Abstract translation: 本发明涉及一种婴儿配方粉末组合物,其包含微粉化的乳糖或乳糖微晶(i)小于30微米,和/或(ii)其中至少80%具有小于20微米的尺寸,和/或(iii)在 至少80%的尺寸小于10微米,和/或(iv)中值粒度D50低于10微米。 本发明还涉及使用微粉化乳糖或乳糖微晶来改善婴儿配方粉末组合物的流动性。

    MUTAROTASE IN CRYSTALLIZATION
    40.
    发明申请
    MUTAROTASE IN CRYSTALLIZATION 审中-公开
    木糖醇在结晶中

    公开(公告)号:WO2012007445A1

    公开(公告)日:2012-01-19

    申请号:PCT/EP2011/061813

    申请日:2011-07-12

    Abstract: This invention describes the use of mutarotase (also known as aldose-1-epimerase) in a process for carbohydrate crystallization. Preferably the carbohydrate is a reducing sugar, more preferably the carbohydrate is lactose. The mutarotase can be obtained from an organism, preferably a micro-organism, more preferably from a fungus, even more preferably from a fungus of the genus Aspergillus, most preferably from Aspergillus niger. Carbohydrate crystallization can be performed from a pure, partly purified or a crude solution of carbohydrate. In general, carbohydrates are first concentrated into a supersaturated solution, after which temperature decreases and optional seeding with carbohydrate crystals initiate crystallization. Mutarotase is preferably added before or during the crystallization process.

    Abstract translation: 本发明描述了在碳水化合物结晶的过程中使用灭活酶(也称为醛糖-1-差向异构酶)。 优选地,碳水化合物是还原糖,更优选碳水化合物是乳糖。 变性酶可以从生物体,优选微生物,更优选来自真菌,甚至更优选来自曲霉属的真菌,最优选来自黑曲霉获得。 碳水化合物结晶可以从纯的,部分纯化的或粗制的碳水化合物溶液中进行。 通常,碳水化合物首先被浓缩成过饱和溶液,之后温度降低,并且用碳水化合物晶体任选的接种引发结晶。 Mutarotase优选在结晶过程之前或期间加入。

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