公开(公告)号：WO2006002243A3

公开(公告)日：2006-01-05

申请号：PCT/US2005/022079

申请日：2005-06-21

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  LEBRILLA, Carlito, B. ,  AN, Hyun Joo ,  LAM, Kit S. ,  MIYAMOTO, Suzanne

Inventor： LEBRILLA, Carlito, B. ,  AN, Hyun Joo ,  LAM, Kit S. ,  MIYAMOTO, Suzanne

IPC: C12Q1/34

Abstract: The present invention provides methods for identifying oligosaccharides specific to cancer and methods for determining a strain of cancer in an individual. The present invention also provides methods for diagnosing cancer or a stage of cancer in an individual by detecting the presence or absence of specific cancer markers and methods for treating cancer by administering antibodies directed to such markers. In addition, the present invention provides cancer markers comprising O-linked oligosaccharides and kits for diagnosing or treating cancer.

公开(公告)号：WO2004087933A2

公开(公告)日：2004-10-14

申请号：PCT/US2004009530

申请日：2004-03-25

Applicant: UNIV CALIFORNIA ,  LAM KIT S ,  SONG AIMIN ,  LEBRILLA CARLITO B ,  ZHANG JINHUA

Inventor： LAM KIT S ,  SONG AIMIN ,  LEBRILLA CARLITO B ,  ZHANG JINHUA

IPC: B01J19/00 ,  C12P20060101 ,  C12Q1/68 ,  C40B20/04 ,  C40B30/10 ,  C40B50/16 ,  C40B50/18 ,  G01N33/53 ,  G01N33/543 ,  G01N33/573 ,  C12P

CPC classification number: G01N33/573 ,  B01J19/0046 ,  B01J2219/00454 ,  B01J2219/005 ,  B01J2219/00581 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/0072 ,  C07B2200/11 ,  C40B20/04 ,  C40B30/10 ,  C40B40/04 ,  C40B50/16 ,  C40B50/18 ,  G01N2333/9121

Abstract: The present invention provides a library of compounds, wherein each compound is encoded by several coding building blocks that are each separately attached to a solid support via a cleavable linker. Following screening of the compounds, the coding tags can be cleaved, and then characterized by mass spectrometry.

Abstract translation: 本发明提供了一种化合物文库，其中每种化合物由几个编码构建单元编码，每个编码结构单元通过可切割连接体分别连接到固体支持物上。 在筛选化合物之后，编码标签可以被切割，然后通过质谱法进行表征。

公开(公告)号：WO2007120154A2

公开(公告)日：2007-10-25

申请号：PCT/US2006/016838

申请日：2006-05-03

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  LEBRILLA, Carlito B. ,  AN, Hyunjoo ,  ALVARENGA, Lenio S. ,  MANNIS, Mark D.

Inventor： LEBRILLA, Carlito B. ,  AN, Hyunjoo ,  ALVARENGA, Lenio S. ,  MANNIS, Mark D.

IPC: G01N33/53

CPC classification number: G01N33/5308 ,  G01N2400/40 ,  G01N2800/14

Abstract: The present invention provides methods for identifying oligosaccharides specific to an inflammatory or infectious disease, methods for diagnosing an inflammatory or infectious disease by detecting the presence or absence of such oligosaccharides, and methods for treating an inflammatory or infectious disease by administering antibodies directed to such oligosaccharides. The present invention also provides methods for diagnosing ocular rosacea by determining the presence or absence of specific oligosaccharide markers. In addition, the present invention provides markers for ocular rosacea comprising 0-linked oligosaccharides as well as kits for diagnosing or treating ocular rosacea.

Abstract translation: 本发明提供用于鉴定炎性或感染性疾病特异性的寡糖的方法，通过检测这种寡糖的存在或不存在来诊断炎性或感染性疾病的方法，以及通过施用针对这种寡糖的抗体来治疗炎性或感染性疾病的方法 。 本发明还提供通过确定特异性寡糖标记物的存在或不存在来诊断眼酒渣疽的方法。 此外，本发明提供了包含O-连接的寡糖的眼酒渣鼻标记物，以及用于诊断或治疗眼酒渣酒的试剂盒。

公开(公告)号：WO2004087933A3

公开(公告)日：2004-10-14

申请号：PCT/US2004/009530

申请日：2004-03-25

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  LAM, Kit, S. ,  SONG, Aimin ,  LEBRILLA, Carlito, B. ,  ZHANG, Jinhua

Inventor： LAM, Kit, S. ,  SONG, Aimin ,  LEBRILLA, Carlito, B. ,  ZHANG, Jinhua

IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/543

Abstract: The present invention provides a library of compounds, wherein each compound is encoded by several coding building blocks that are each separately attached to a solid support via a cleavable linker. Following screening of the compounds, the coding tags can be cleaved, and then characterized by mass spectrometry.

公开(公告)号：WO2012009315A3

公开(公告)日：2012-01-19

申请号：PCT/US2011/043644

申请日：2011-07-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  GERMAN, J. Bruce ,  MILLS, David ,  LEBRILLA, Carlito B. ,  BARILE, Daniela ,  LOCASCIO, Riccardo

Inventor： GERMAN, J. Bruce ,  MILLS, David ,  LEBRILLA, Carlito B. ,  BARILE, Daniela ,  LOCASCIO, Riccardo

IPC: C07H1/08 ,  C13K5/00 ,  C08B37/00 ,  A61K31/715 ,  A23C7/00

Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.

公开(公告)号：WO2010105207A1

公开(公告)日：2010-09-16

申请号：PCT/US2010/027206

申请日：2010-03-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  DSM FOOD SPECIALTIES USA INC. ,  BARBOZA, Mariana ,  GERMAN, J. Bruce ,  LEBRILLA, Carlito B. ,  MILLS, David A. ,  FREEMAN, Samara ,  KING, William Robert

Inventor： BARBOZA, Mariana ,  GERMAN, J. Bruce ,  LEBRILLA, Carlito B. ,  MILLS, David A. ,  FREEMAN, Samara ,  KING, William Robert

IPC: A61K31/702 ,  A61P1/06 ,  A61P1/14

CPC classification number: A61K31/702 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L33/125 ,  A23L33/135 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K35/745 ,  A61K38/47 ,  A61K2035/115 ,  C12Y302/01108 ,  A23V2250/28 ,  A23V2200/3204 ,  A23V2200/3202 ,  A23V2200/32

Abstract: The present invention provides galacto-oligosaccharide compositions that preferentially stimulate growth of specific Bifidobacterium species and subspecies.

Abstract translation: 本发明提供优选刺激特异性双歧杆菌物种和亚种的生长的半乳寡聚糖组合物。

公开(公告)号：WO2008033520A3

公开(公告)日：2008-03-20

申请号：PCT/US2007/020032

申请日：2007-09-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  MILLS, David ,  LEBRILLA, Carlito, B. ,  GERMAN, John, Bruce ,  SELA, David

Inventor： MILLS, David ,  LEBRILLA, Carlito, B. ,  GERMAN, John, Bruce ,  SELA, David

IPC: C12P21/00 ,  A23C9/00

Abstract: This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria . The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use.

公开(公告)号：WO2012009315A2

公开(公告)日：2012-01-19

申请号：PCT/US2011043644

申请日：2011-07-12

Applicant: UNIV CALIFORNIA ,  GERMAN J BRUCE ,  MILLS DAVID ,  LEBRILLA CARLITO B ,  BARILE DANIELA ,  LOCASCIO RICCARDO

Inventor： GERMAN J BRUCE ,  MILLS DAVID ,  LEBRILLA CARLITO B ,  BARILE DANIELA ,  LOCASCIO RICCARDO

IPC: C07H1/08 ,  A23C7/00 ,  A61K31/715 ,  C08B37/00 ,  C13K5/00

CPC classification number: A61K31/702 ,  A23L33/135 ,  A23L33/28 ,  A23L33/40 ,  A23V2002/00 ,  A61K31/715 ,  A61K31/726 ,  A61K35/741 ,  A61K35/745 ,  A61K36/062 ,  C08B37/0003 ,  C08B37/006 ,  C08B37/0063 ,  C08L5/00 ,  C08L2205/02 ,  C12P19/14 ,  C12P19/18 ,  A23V2200/3202 ,  A23V2200/3204 ,  A23V2250/28 ,  C08L89/00

Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.

Abstract translation: 提供了来自牛奶，乳清和乳制品的寡糖，以及生产牛乳寡糖的方法。

公开(公告)号：WO2007120154A3

公开(公告)日：2008-10-16

申请号：PCT/US2006016838

申请日：2006-05-03

Applicant: UNIV CALIFORNIA ,  LEBRILLA CARLITO B ,  AN HYUNJOO ,  ALVARENGA LENIO S ,  MANNIS MARK D

Inventor： LEBRILLA CARLITO B ,  AN HYUNJOO ,  ALVARENGA LENIO S ,  MANNIS MARK D

IPC: C12Q1/34

CPC classification number: G01N33/5308 ,  G01N2400/40 ,  G01N2800/14

Abstract: The present invention provides methods for identifying oligosaccharides specific to an inflammatory or infectious disease, methods for diagnosing an inflammatory or infectious disease by detecting the presence or absence of such oligosaccharides, and methods for treating an inflammatory or infectious disease by administering antibodies directed to such oligosaccharides. The present invention also provides methods for diagnosing ocular rosacea by determining the presence or absence of specific oligosaccharide markers. In addition, the present invention provides markers for ocular rosacea comprising 0-linked oligosaccharides as well as kits for diagnosing or treating ocular rosacea.

Abstract translation: 本发明提供用于鉴定炎性或感染性疾病特异性的寡糖的方法，通过检测这种寡糖的存在或不存在来诊断炎性或感染性疾病的方法，以及通过施用针对这种寡糖的抗体来治疗炎性或感染性疾病的方法 。 本发明还提供了通过确定特异性寡糖标记物的存在或不存在来诊断眼酒渣滓的方法。 此外，本发明提供了包含O-连接的寡糖的眼酒渣鼻标记物，以及用于诊断或治疗眼酒渣疽的试剂盒。

公开(公告)号：WO2008033520A2

公开(公告)日：2008-03-20

申请号：PCT/US2007020032

申请日：2007-09-14

Applicant: UNIV CALIFORNIA ,  MILLS DAVID ,  LEBRILLA CARLITO B ,  GERMAN JOHN BRUCE ,  SELA DAVID

Inventor： MILLS DAVID ,  LEBRILLA CARLITO B ,  GERMAN JOHN BRUCE ,  SELA DAVID

IPC: G02F1/13357 ,  A23L33/00

CPC classification number: C12N9/24 ,  A23C9/206 ,  A23L33/40 ,  A23V2002/00 ,  C12N9/18 ,  C12N9/2402 ,  C12N9/2471 ,  C12N9/88 ,  C12N9/90 ,  C12P19/00 ,  C12P19/04 ,  C12Y301/01053 ,  C12Y302/01018 ,  C12Y302/01023 ,  C12Y302/01051 ,  C12Y302/01052 ,  C12Y403/03007 ,  C12Y501/03009 ,  A23V2250/28 ,  A23V2200/3202

Abstract: This invention provides nucleic acids and proteins involved in oligosaccharide modification in the species Bifidobacteria. The invention provides methods for utilizing the proteins of the invention to generate human milk oligosaccharides or oligosaccharide mimics. The invention also provides compositions containing the human milk oligosaccharides or oligosaccharide mimics and methods for use.

Abstract translation: 本发明提供了在双歧杆菌物种中参与寡糖修饰的核酸和蛋白质。 本发明提供了利用本发明的蛋白质产生人乳低聚糖或寡糖模拟物的方法。 本发明还提供含有人乳低聚糖或寡糖模拟物的组合物和使用方法。