Abstract:
Internal microchannels within microchannel apparatus are uniformly coated. Remarkably, these uniform coatings are formed from materials that are applied to the interior microchannels after an apparatus has been assembled or manufactured. Coatings can be made uniform along the length of a microchannel, in the corner of a microchannel, and/or throughout numerous microchannels in an array of microchannels. Techniques for tailoring the application of washcoats onto microchannels is also described.
Abstract:
Beschrieben wird ein Verfahren zur Aufarbeitung von flüssigen Stoffen, bei dem die Aufarbeitung in einem oder mehreren Mikroreaktoren und/oder Mikromischern durchgeführt wird, wobei der aufzuarbeitende flüssige Stoff in den Mikroreaktoren und/oder Mikromischern kontinuierlich mit einer Waschflüssigkeit gemischt wird.
Abstract:
Bei dem Verfahren zum Überführen eines in einer ersten Strömung befindlichen Moleküls, Molekülkomplexes oder Mikropartikels in eine benachbart zur ersten Strömung fliessenden und diese zumindest bereichsweise entlang einer Grenzschicht kontaktierende zweite Strömung, wobei die mindestens zwei laminaren Strömun-gen unterschiedliche chemische Zusammensetzungen aufweisen und insbesondere zueinander inkompatible Reaktionen(z.B. Katalysatoren, Pufferlösungen) an dem zu überführenden Molekül, Molekülkomplex oder Mikropartikel hervorrufen, bleiben die chemischen Zusammen-setzung in den beiden Strömungen trotz der Kontaktflächen durch die laminare Strömung aufrechterhalten. Zumindest im Kontaktbereich der Grenzschicht der mindestens zwei Strömungen wird zur Überführung des Moleküls, Molekülkomplexes oder Mikropartikels ein elektrisches Feld angelegt, das im wesentlichen quer zur Flussrichtung bzw. zu den Flussrichtungen der mindestens zwei Strömungen gerichtet ist.
Abstract:
A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.
Abstract:
A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.
Abstract:
A micro-component useful as a heat exchanger, vaporizer, or chemical reaction chamber comprising a separator forming on opposite sides thereof adjacent and longitudinally extending micro-channels for laminar fluid flow, the separator being a middle element in a sealed enclosure having inlet and outlet opening transverse to the channels allowing the flow of fluid through the channels.
Abstract:
A sample-processing device (150) comprises a unitary body (152), preferably a molded polymeric part, having formed therein a reaction chamber (154) for chemically reacting a sample, a separation region (158) for separating components of the sample, and a transition region (156) connecting the reaction chamber (154) to the separation region (158). The reaction chamber (154), transition region (156), and separation region (158) are formed in and enclosed by the unitary body (152). Additionally, the transition region (156) includes at least one flow restrictor (180) for controlling the flow of fluid between the reaction chamber (154) and the separation region (158). Further, the portion of the unitary body (152) defining the transition region (156) has lower thermal conduction than the portion of the body defining the reaction chamber (154) so that the transition region (156) thermally isolates the reaction chamber (154) from the separation region (156). In a preferred embodiment, the reaction chamber (154) is an amplification chamber for amplifying nucleic acid in the sample, and the separation region (158) comprises an electrophoresis column or capillary containing a suitable matrix material, such as electrophoresis gel or buffer, for separating nucleic acid fragments in the sample. Electrodes (167, 168, 169) are embedded in the body (152) for forcing the sample to flow from the reaction chamber (154) to the separation region (158). The unitary body (152) may also be surrounded by external, functional components such as an optical detector (186) for detecting separated components of the sample.
Abstract:
A method and apparatus for combining chemical reactants wherein the method comprises the steps of: 1) dispensing the reactants into a conduit system in the form of discrete volumes or droplets (5, 15, 21, 22, 36) separated from each other by an inert immiscible liquid (1); and 2) changing the flow of the inert immiscible liquid within the conduit system in a precise sequence in such a manner that predetermined discrete volumes coalesce with each other, thereby combining the reactants; and wherein the apparatus is formed by holding two plates (42, 44) together in face to face contact, where one or both plates possesses a set of indentations (43) on the surface to be mated, thereby forming the conduits for reactant combinations.
Abstract:
Die Erfindung stellt ein Verfahren zur Synthese von Carbonsäureamiden zur Verfügung, umfassend die Schritte: a) Bereitstellen eines Carbonsäureesters der Formel RCOOR' und Ammoniak (NH 3 ), b) Mischen des Carbonsäureesters der Formel RCOOR' und des Ammoniaks (NE 3 ), und c) Reagieren des Carbonsäureesters der Formel RCOOR' und des Ammoniaks (NH 3 ) zu einem Carbonsäureamid der Formel RCONH 2 und R'OH, dadurch gekennzeichnet, dass der Ammoniak in Schritt a) in flüssiger Form oder in überkritischer Form zugeführt wird. Die Erfindung stellt weiterhin eine Anlage zur Durchführung des erfindungsgemäßen Verfahrens zur Verfügung.