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公开(公告)号：WO2009038868A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/070664
申请日：2008-07-21
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , BASU, Shubhayu , MICHAL, Gene , LUDWIG, Florian, N. , WAN, Jinping , STANKUS, John
Inventor： BASU, Shubhayu , MICHAL, Gene , LUDWIG, Florian, N. , WAN, Jinping , STANKUS, John
IPC: A61K9/00
CPC classification number: A61L27/52 , A61L27/20 , A61L27/3604 , A61L27/3641 , A61L27/365 , A61L27/3804 , A61L27/3839 , C08L5/04
Abstract: The present invention relates to a method of making cytocompatible alginate gels and their use in the treatment of cardiomyopathy.
Abstract translation: 本发明涉及一种制备细胞相容性藻酸盐凝胶的方法及其在治疗心肌病中的应用。
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公开(公告)号：WO2008144137A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/060380
申请日：2008-04-15
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , PACETTI, Stephen, D. , HOSSAINY, Syed Faiyaz, Ahmed , LUDWIG, Florian, N.
CPC classification number: A61K9/0019 , A61K9/127 , A61K9/16 , A61K9/1694 , A61K9/51 , A61K47/6915 , A61K47/6925
Abstract: Methods for treating a vascular disease by delivering therapeutic compositions with enhanced endothelium targeting are disclosed. The compositions comprise bioactive agent nanoparticles encapsulated within polymeric microspheres or adhered to micrometer-sized particles.
Abstract translation: 公开了通过递送具有增强的内皮靶向的治疗组合物治疗血管疾病的方法。 该组合物包含包封在聚合物微球体内的生物活性剂纳米颗粒或粘附到微米级颗粒上。
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公开(公告)号：WO2008109230A3
公开(公告)日：2008-10-23
申请号：PCT/US2008053707
申请日：2008-02-12
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS , LUDWIG FLORIAN N , HOSSAINY SYED FAIYAZ AHMED , PACETTI STEPHEN D
Inventor： LUDWIG FLORIAN N , HOSSAINY SYED FAIYAZ AHMED , PACETTI STEPHEN D
CPC classification number: A61K9/0087 , A61K47/6907 , A61K47/6911 , A61K47/6913 , A61K47/6915 , A61K47/6935 , B82Y5/00
Abstract: A composition that includes nanoparticles with binding affinity for platelets, and methods for using this composition to treat vascular disease are disclosed.
Abstract translation: 公开了包含对血小板具有结合亲和力的纳米颗粒的组合物，以及使用该组合物治疗血管疾病的方法。
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公开(公告)号：WO2008036144A3
公开(公告)日：2008-06-19
申请号：PCT/US2007014657
申请日：2007-06-21
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS , LUDWIG FLORIAN NIKLAS , PACETTI STEPHEN D , HOSSAINY SYED F A , DAVALIAN DARIUSH
Inventor： LUDWIG FLORIAN NIKLAS , PACETTI STEPHEN D , HOSSAINY SYED F A , DAVALIAN DARIUSH
CPC classification number: A61K9/5031 , A61K9/0004 , A61K9/0019 , A61K9/5115 , A61K9/5138 , A61K38/446 , A61K41/0052 , A61K47/6923 , A61K47/6925 , A61K47/6929 , A61K47/6931 , A61L31/16 , A61L2300/00 , A61L2400/06 , A61L2400/12 , B01J13/02 , B22F1/025 , B82Y5/00 , Y10S977/773 , Y10S977/906 , Y10T428/2991 , Y10T428/2998
Abstract: Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
Abstract translation: 提供了包含纳米壳的纳米构建体以及使用纳米构建体治疗或改善医学状况的方法。
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公开(公告)号：WO2007143063A3
公开(公告)日：2008-01-24
申请号：PCT/US2007012889
申请日：2007-05-31
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS , KLEINE KLAUS , GALE DAVID C , EL-NOUNOU FOZAN , HOSSAINY SYED FAIYAZ AHMED , LUDWIG FLORIAN N
Inventor： KLEINE KLAUS , GALE DAVID C , EL-NOUNOU FOZAN , HOSSAINY SYED FAIYAZ AHMED , LUDWIG FLORIAN N
CPC classification number: A61M31/002 , A61F2/88 , A61F2/885 , A61F2250/0039 , A61F2250/0067
Abstract: An implantable medical device is disclosed having a helical construct including a set of spiral coils for local in vivo application of a therapeutic substance in a biological lumen. The helical construct is configured to apply less than 0.75 Bar of pressure to the biological lumen wall. The helical construct can have at least two sets of spiral coils having opposing helical directions. The device can be used for the treatment of vascular disorders such as restenosis and vulnerable plaque.
Abstract translation: 公开了一种植入式医疗装置，其具有螺旋构造，其包括用于在生物腔内局部体内施用治疗物质的一组螺旋线圈。 螺旋结构被配置为向生物腔壁施加小于0.75巴的压力。 螺旋结构可以具有至少两组具有相反螺旋方向的螺旋线圈。 该装置可用于治疗血管疾病如再狭窄和易损斑块。
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Patent Agency Ranking
公开(公告)号：WO2007123921A3
公开(公告)日：2008-01-10
申请号：PCT/US2007009418
申请日：2007-04-17
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS , EL-NOUNOU FOZAN O , CONSIGNY PAUL M , LUDWIG FLORIAN N
Inventor： EL-NOUNOU FOZAN O , CONSIGNY PAUL M , LUDWIG FLORIAN N
CPC classification number: A61M25/0082 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/04 , A61M25/10 , A61M2025/0057 , A61M2025/0096 , A61M2025/0681 , A61M2025/105
Abstract: A catheter configured for delivering an agent to a patient's vessel wall, having self-expanding frame, and a method of delivering an agent to a patient's vessel wall. A first catheter has an elongated shaft with an agent delivery lumen and self-expanding frame on a distal shaft section formed of plurality of hollow tubes having joined first ends and free second ends, the free end of each hollow tube having an agent delivery port in fluid communication with the shaft agent delivery lumen and having a hooked tip configured for penetrating the vessel wall in the expanded configuration. Another catheter has a frame around the outer surface of a lining member such as a balloon or a tubular sleeve, such that the frame expanded against the vessel wall and the lining member together define a plurality of pockets between the vessel wall and the outer surface of the lining member.
Abstract translation: 导管，其构造成将药剂递送到患者的血管壁，具有自扩张框架，以及将药剂递送至患者血管壁的方法。 第一导管具有细长轴，其具有代理输送管腔和远端轴部分上的自膨胀框架，该远端轴部分由多个具有接合的第一端和自由的第二端的中空管形成，每个中空管的自由端具有代理输送口 与轴剂输送管腔的流体连通并且具有被构造用于在扩张构型中穿透血管壁的钩状末端。 另一导管具有围绕诸如球囊或管状套筒的衬里构件的外表面的框架，使得框架相对于容器壁膨胀并且衬里构件一起在容器壁和外表面的外表面之间限定多个袋 衬里构件。
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公开(公告)号：WO2007146426A2
公开(公告)日：2007-12-21
申请号：PCT/US2007014079
申请日：2007-06-14
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS , LUDWIG FLORIAN NIKLAS , PACETTI STEPHEN D , HOSSAINY SYED F A , DAVALIAN DARIUSH
Inventor： LUDWIG FLORIAN NIKLAS , PACETTI STEPHEN D , HOSSAINY SYED F A , DAVALIAN DARIUSH
CPC classification number: A61K9/5115 , A61K9/0009 , A61K9/127 , A61K41/0019 , A61K41/0028
Abstract: Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.
Abstract translation: 提供包含纳米壳的纳米构建体和使用纳米构建体治疗或改善医学状况的方法。
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公开(公告)号：WO2007142738A2
公开(公告)日：2007-12-13
申请号：PCT/US2007/009114
申请日：2007-04-13
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , LUDWIG, Florian N. , HOSSAINY, Syed Faiyaz Ahmed , SRIDHARAN, Srinivasan , LEE, Carol
Inventor： LUDWIG, Florian N. , HOSSAINY, Syed Faiyaz Ahmed , SRIDHARAN, Srinivasan , LEE, Carol
CPC classification number: A61L31/10 , A61L27/34 , A61L27/50 , A61L27/54 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61M31/002
Abstract: Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The methods comprise fixing the morphology or phase distribution of the active agent prior to removing solvent from the coating composition. The coating layers can be used for controlled the delivery of an active agent or a combination of active agents.
Abstract translation: 公开了用于控制活性剂从包含聚合物基质和一种或多种活性剂的医疗装置的涂层的形态和释放速率的方法。 所述方法包括在从涂料组合物中除去溶剂之前固定活性剂的形态或相分布。 涂层可用于控制活性剂或活性剂组合的递送。
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69.发明申请METHODS, COMPOSITIONS AND DEVICES FOR TREATING LESIONED SITES USING BIOABSORBABLE CARRIERS 审中-公开方法，组合物和使用生物可降解载体处理裂解位点的装置
公开(公告)号：WO2007133382A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/009526
申请日：2007-04-18
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , KLEINER, Lothar, W. , HOSSAINY, Syed , ASTAFIEVA, Irina , PACETTI, Stephen , GLAUSER, Thierry , DESNOYER, Jessica , LUDWIG, Florian, N.
Inventor： KLEINER, Lothar, W. , HOSSAINY, Syed , ASTAFIEVA, Irina , PACETTI, Stephen , GLAUSER, Thierry , DESNOYER, Jessica , LUDWIG, Florian, N.
CPC classification number: A61K9/0019 , A61K9/143 , A61K9/1611 , A61L31/148 , A61L31/16 , A61L2300/602
Abstract: Methods and compositions for the sustained release of treatment agents to treat an occluded blood vessel and affected tissue and/or organs are disclosed. Porous or non-porous bioabsorbable glass, metal or ceramic bead, rod or fiber particles can be loaded with a treatment agent, and optionally an image-enhancing agent, and coated with a sustained-release coating for delivery to an occluded blood vessel and affected tissue and/or organs by a delivery device.
Abstract translation: 公开了用于持续释放治疗剂以治疗闭塞的血管和受影响的组织和/或器官的方法和组合物。 多孔或无孔生物可吸收玻璃，金属或陶瓷珠，棒或纤维颗粒可以加载处理剂和任选的图像增强剂，并涂覆有持续释放的涂层以递送至闭塞的血管并受影响 组织和/或器官。
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公开(公告)号：WO2007126606A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/006704
申请日：2007-03-16
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. , LUDWIG, Florian N. , ASTAFIEVA, Irina , GALE, David C. , HOSSAINY, Syed Faiyaz Ahmed
Inventor： LUDWIG, Florian N. , ASTAFIEVA, Irina , GALE, David C. , HOSSAINY, Syed Faiyaz Ahmed
IPC: A61F2/06
CPC classification number: A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2250/003 , A61F2250/0068 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/604 , A61L2300/61 , B23K2203/42 , B23K2203/50
Abstract: The invention provides for a stent for implanting in a bodily lumen comprising a degradable structural element including: an abluminal layer comprising an active agent; and a luminal layer, wherein the abluminal layer has a faster degradation rate than the luminal layer.
Abstract translation: 本发明提供一种用于植入体内的支架，其包括可降解结构元件，包括：包含活性剂的外膜层; 以及腔层，其中所述囊膜层具有比内腔层更快的降解速率。
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