公开(公告)号：WO2012082731A2

公开(公告)日：2012-06-21

申请号：PCT/US2011/064627

申请日：2011-12-13

Applicant: J. CRAIG VENTER INSTITUTE ,  ALLEN, Andrew ,  DUPONT, Christopher, L.

Inventor： ALLEN, Andrew ,  DUPONT, Christopher, L.

IPC: C12N1/13 ,  C12N15/63 ,  C12P7/64 ,  C12N15/52

CPC classification number: C12N15/8247 ,  C12N15/52 ,  C12N15/74 ,  C12P7/6463

Abstract: Described herein are engineered microalgae that exhibit enhanced lipid production during exponential growth. Such engineered microalgae are useful, for example, for the production of biofuels.

Abstract translation: 本文描述的是在指数生长期间表现出增强的脂质产生的工程化微藻。 这种工程化的微藻例如用于生产生物燃料是有用的。

公开(公告)号：WO2011091412A1

公开(公告)日：2011-07-28

申请号：PCT/US2011/022383

申请日：2011-01-25

Applicant: ALERE SCARBOROUGH, INC. ,  MERMER, Brion ,  PALIN, William, J. ,  TURCOTTE, Nancy

Inventor： MERMER, Brion ,  PALIN, William, J. ,  TURCOTTE, Nancy

IPC: C12N9/26 ,  C12Q1/14 ,  G01N33/50

CPC classification number: G01N33/56944 ,  C07K14/005 ,  C12N1/06 ,  C12N2795/00022 ,  G01N2469/10 ,  G01N2800/26

Abstract: The invention relates to the identification, sequencing, and isolation of an A25 bacteriophage lysin gene that expresses a protein involved in the lysis of bacterial cells during the phage life cycle. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in a diagnostic procedure designed to detect these bacteria.

Abstract translation: 本发明涉及在噬菌体生命周期中表达参与细菌细胞裂解的蛋白质的A25噬菌体溶素基因的鉴定，测序和分离。 本发明还涉及使用溶素裂解某些细菌的方法，其可用于例如设计用于检测这些细菌的诊断程序。

公开(公告)号：WO2008022319A2

公开(公告)日：2008-02-21

申请号：PCT/US2007/076219

申请日：2007-08-17

Applicant: THE GENERAL HOSPITAL CORPORATION ,  ELMALEH, David, R. ,  FISCHMAN, Alan, J. ,  SHOUP, Timothy, M.

Inventor： ELMALEH, David, R. ,  FISCHMAN, Alan, J. ,  SHOUP, Timothy, M.

IPC: C07C209/74 ,  C07C211/64 ,  C07C381/12 ,  A61K51/04 ,  G21G4/08

CPC classification number: A61K51/04 ,  A61B6/507 ,  A61K9/0021 ,  A61K49/0433 ,  A61K51/00 ,  A61K51/0459 ,  A61K51/0489 ,  C07B2200/05 ,  C07C209/74 ,  C07C211/64 ,  C07C381/12 ,  C07D241/04 ,  C07D295/073 ,  C07F9/5442

Abstract: One aspect of the present invention relates to a method of preparing radio fluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to arylammonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the ammonium compound is a tetraaryl ammonium salt. Another aspect of the invention relates to arylsulfonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the sulfonium compound is a triaryl sulfonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.

Abstract translation: 本发明的一个方面涉及制备无线氟化取代的烷基，环烷基，芳基和链烯基化合物的方法。 在优选的实施方案中，使用氟化钾-18。 本发明的另一方面涉及可用作成像剂的含氟-18的芳基铵化合物。 在某些实施方案中，铵化合物是四芳基铵盐。 本发明的另一方面涉及可用作成像剂的含有氟-18的芳基锍化合物。 在某些实施方案中，锍化合物是三芳基锍盐。 本发明的另一方面涉及一种获得哺乳动物正电子发射图像的方法，包括以下步骤：向哺乳动物施用本发明的化合物，并获得哺乳动物的正电子发射光谱。

公开(公告)号：WO2006133460A2

公开(公告)日：2006-12-14

申请号：PCT/US2006/022819

申请日：2006-06-09

Applicant: YALE UNIVERSITY ,  RIMM, David, L. ,  PEREIRA, Gino ,  HARIGOPAL, Malini ,  GITNANE, Jennifer

Inventor： RIMM, David, L. ,  PEREIRA, Gino ,  HARIGOPAL, Malini ,  GITNANE, Jennifer

IPC: G01N33/574

CPC classification number: G01N33/57415 ,  G01N2333/71 ,  G01N2800/52

Abstract: Provided are improved, quantitative methods for determining whether a subject is likely to respond to a breast cancer therapy, methods for selecting breast cancer therapies and methods for diagnosis and prognosis of breast cancer in subjects.

Abstract translation: 提供了用于确定受试者是否可能对乳腺癌治疗做出反应的改进的定量方法，用于选择乳腺癌疗法的方法以及受试者中乳腺癌的诊断和预后的方法。

公开(公告)号：WO2005042566A2

公开(公告)日：2005-05-12

申请号：PCT/US2004/028476

申请日：2004-08-30

Applicant: CHILDREN'S MEDICAL CENTER CORPORATION ,  FOLKMAN, Judah ,  JAVAHERIAN, Kashi ,  BECKER, Christian ,  D'AMATO, Robert

Inventor： FOLKMAN, Judah ,  JAVAHERIAN, Kashi ,  BECKER, Christian ,  D'AMATO, Robert

IPC: C07K7/00

CPC classification number: A61K38/10 ,  A61K38/17 ,  C07K14/78

Abstract: Provided herein are peptides and nucleic acids encoding the peptides, pharmaceutical compositions comprising the nucleic acids and proteins and methods for using the pharmaceuticals to treat or prevent endometriosis in a subject.

Abstract translation: 本文提供了编码肽的肽和核酸，包含核酸和蛋白质的药物组合物以及使用该药物治疗或预防受试者子宫内膜异位症的方法。

公开(公告)号：WO2004080597A2

公开(公告)日：2004-09-23

申请号：PCT/US2004/003541

申请日：2004-02-05

Applicant: IQUUM, INC.

Inventor： CHEN, Shuqi ,  LEMIEUX, Bertrand ,  WANG, Zihua ,  KOPCZYNSKI, Kevin, R. ,  CHEN, Lingjun

IPC: B01L

CPC classification number: C12N15/1003 ,  B01L3/502 ,  B01L3/505 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/042 ,  B01L2300/046 ,  B01L2300/047 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/087 ,  B01L2300/10 ,  B01L2400/0481 ,  B01L2400/0677 ,  G01N1/10 ,  G01N33/543 ,  Y02A50/52 ,  Y02A50/53 ,  Y02A50/55 ,  Y02A50/58 ,  Y02A50/60 ,  Y10S435/81 ,  Y10T436/25

Abstract: A sample processing tubule may include a first segment, a second segment, and a third segment. Each segment may be defined by the tubule, may be fluidly isolated, at least in part by a breakable seal, may be so expandable as to receive a volume of fluid expelled from another segment, and may be so compressible as to contain substantially no fluid when so compressed. Each segment may contain at least one reagent.

Abstract translation: 样本处理小管可以包括第一段，第二段和第三段。 每个段可以由小管限定，至少部分地通过可破坏的密封件被流体隔离，可以是如此可扩张的，以便接收从另一个部分排出的体积的体积，并且可以是如此可压缩的，从而基本上不含流体 当这样压缩。 每个片段可以含有至少一种试剂。

公开(公告)号：WO2004041192A2

公开(公告)日：2004-05-21

申请号：PCT/US2003/034678

申请日：2003-10-31

Applicant: PFIZER PRODUCTS, INC. ,  UNIVERSITY OF CHICAGO ,  NEOTE, Kuldeep, S. ,  ZAGOURAS, Panayiotis ,  GAJEWSKI, Thomas

Inventor： NEOTE, Kuldeep, S. ,  ZAGOURAS, Panayiotis ,  GAJEWSKI, Thomas

IPC: A61K

CPC classification number: C40B30/04 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: The present invention provides novel panels of molecular targets that are differentially expressed during CD8+ T cell priming. The novel panels of the invention may be used, for example, in therapeutic intervention, therapeutic agent screening, and in diagnostic methods for diseases and/or disorders of the immune system.

Abstract translation: 本发明提供了在CD8 + T细胞引发期间差异表达的分子靶标的新颖小组。 本发明的新颖小组可用于例如治疗干预，治疗剂筛选和用于免疫系统疾病和/或病症的诊断方法。

公开(公告)号：WO2003102162A2

公开(公告)日：2003-12-11

申请号：PCT/US2003/017777

申请日：2003-06-04

Applicant: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： QIAN, Shiguang ,  LU, Lina ,  FUNG, John, J.

IPC: C12N

CPC classification number: C12N5/064 ,  A61K2035/122 ,  A61K2035/124 ,  C12N2501/23 ,  C12N2501/52

Abstract: The present invention relates to tolerogenic dendritic cells (DCs) and methods for enriching for these cells in tissue preparations and using the cells for preventing or minimizing transplant rejection or for treating or preventing an autoimmune disease.

Abstract translation: 本发明涉及耐受性树突状细胞（DC）以及用于在组织制备中富集这些细胞并使用该细胞预防或最小化移植排斥或用于治疗或预防自身免疫性疾病的方法。

公开(公告)号：WO2003089619A3

公开(公告)日：2003-10-30

申请号：PCT/US2003/012554

申请日：2003-04-21

Applicant: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  STROM, Stephen, C. ,  MIKI, Toshio

Inventor： STROM, Stephen, C. ,  MIKI, Toshio

IPC: C12N15/85

Abstract: The present invention features novel placental derived stem cells and provides methods and compositions for the therapeutic uses of placental derived stem cells or placental derived stem cells that have been induced to differentiate into a desired tissue type into a recipient host in amounts sufficient to result in production of the desired cell type, i.e. , hepatic, pancreatic, neurinal, or nervous tissue.

公开(公告)号：WO2001023385A3

公开(公告)日：2001-04-05

申请号：PCT/US2000/026566

申请日：2000-09-27

Applicant: GEORGETOWN UNIVERSITY ,  KOZIKOWSKI, Alan, P. ,  HOEPPING, Wolfgang, Alexander

IPC: C07D471/18

Abstract: The present invention provides compounds, specifically novel tropane analogs, capable of acting as inhibitors of reuptake of monoamines. In preferred embodiments, these compositions are selective inhibitors of serotonin and/or norepinephrine reuptake. Also provided herein are pharmaceutical compositions comprising novel tropane analogs and a pharmaceutically acceptable carrier, and methods for treating conditions in which inhibition of reuptake of monoamines is desired. The inventive compositions as described herein are also useful for medical therapy and diagnosis.