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    METHOD OF TREATMENT OF THYROID CANCER
    71.
    发明申请
    METHOD OF TREATMENT OF THYROID CANCER 审中-公开
    治疗甲状腺癌的方法

    公开(公告)号：WO2003030908A2

    公开(公告)日：2003-04-17

    申请号：PCT/US2002/032195

    申请日：2002-10-08

    Applicant: THE UNIVERSITY OF CINCINNATI ,  FAGIN, James, Alexander

    Inventor： FAGIN, James, Alexander

    IPC: A61K31/505

    CPC classification number: A61K31/00 ,  A61K31/505 ,  A61K31/517

    Abstract: The present invention relates to a method of treating a warm-blooded animal, especially a human, having a disease which is mediated or characterized by mutations in the RET gene, or thyroid cancer, especially thyroid cancer harboring RET mutations, comprising administering to said animal a therapeutically effective amount of a compound which decreases the activity of the epidermal growth factor (EGF), especially a compound as defined herein.

    Abstract translation: 本发明涉及一种治疗具有RET基因或甲状腺癌，特别是具有RET突变的甲状腺癌的突变介导或表征的疾病的温血动物，特别是人的方法，包括对所述动物施用 治疗有效量的降低表皮生长因子（EGF）的活性的化合物，特别是本文定义的化合物。

    FIBRINOGEN-COATED LIPOSOMES
    72.
    发明申请
    FIBRINOGEN-COATED LIPOSOMES 审中-公开
    纤维蛋白涂层脂质体

    公开(公告)号：WO1996029990A1

    公开(公告)日：1996-10-03

    申请号：PCT/US1996004323

    申请日：1996-03-29

    Applicant: UNIVERSITY OF CINCINNATI

    Inventor： UNIVERSITY OF CINCINNATI ,  RETZINGER, Gregory, Scott ,  DEANGLIS, Ashley, P.

    IPC: A61K09/127

    CPC classification number: A61K9/1271

    Abstract: A method for preparing fibrinogen-coated liposomes is disclosed. In this process, fibrinogen and an acylating agent are reacted in the presence of a dispersion of liposomes under specifically defined reaction conditions. The liposomes formed using this process, pharmaceutical compositions containing those liposomes, and the methods of clotting blood and delivering pharmaceutically-active agents and/or other chemicals utilizing those pharmaceutical compositions are also disclosed.

    Abstract translation: 公开了一种制备纤维蛋白原包被的脂质体的方法。 在此过程中，纤维蛋白原和酰化剂在脂质体分散体存在下在特定的反应条件下反应。 还公开了使用该方法形成的脂质体，含有这些脂质体的药物组合物，以及使用这些药物组合物凝结血液和递送药物活性剂和/或其它化学物质的方法。

    1,4-DIHYDRODIOXINS AND RELATED COMPOUNDS AS DNA CLEAVING REAGENTS
    73.
    发明申请
    1,4-DIHYDRODIOXINS AND RELATED COMPOUNDS AS DNA CLEAVING REAGENTS 审中-公开
    1,4-二氢吲哚和相关化合物作为DNA清除试剂

    公开(公告)号：WO1996020205A1

    公开(公告)日：1996-07-04

    申请号：PCT/US1995016434

    申请日：1995-12-21

    Applicant: UNIVERSITY OF CINCINNATI ,  WILSON, Robert, Marshall ,  SCHNAPP, Karlyn, A. ,  HARSCH, Andreas ,  KELLER, Stephen, J. ,  SCHLEMM, Donna, J.

    Inventor： UNIVERSITY OF CINCINNATI

    IPC: C07H21/00

    CPC classification number: C07D319/14

    Abstract: The present invention relates to a class of 1,4-dihydrodioxin masked quinone compounds which are useful as DNA or RNA cleaving reagents. These compounds may additionally include moieties which target the compounds to specific base sequences on the DNA or RNA molecule to permit site-specific cleavage. The process for using these compounds in a UV or short wavelength visible light-activated reaction for cleaving DNA, as well as pharmaceutical compositions containing these compounds, are also disclosed.

    Abstract translation: 本发明涉及可用作DNA或RNA切割试剂的一类1,4-二氢二恶英掩蔽的醌化合物。 这些化合物还可以包括将化合物靶向DNA或RNA分子上的特定碱基序列以允许位点特异性切割的部分。 还公开了在UV或短波长可见光激活反应中使用这些化合物以切割DNA的方法，以及含有这些化合物的药物组合物。

    OPTICAL SYNCHRONOUS CLOCK DISTRIBUTION NETWORK AND HIGH-SPEED SIGNAL DISTRIBUTION NETWORK
    75.
    发明申请
    OPTICAL SYNCHRONOUS CLOCK DISTRIBUTION NETWORK AND HIGH-SPEED SIGNAL DISTRIBUTION NETWORK 审中-公开
    光同步时钟分配网络和高速信号分配网络

    公开(公告)号：WO1995030164A1

    公开(公告)日：1995-11-09

    申请号：PCT/US1995005365

    申请日：1995-04-25

    Applicant: UNIVERSITY OF CINCINNATI

    Inventor： UNIVERSITY OF CINCINNATI ,  KOH, Seungug ,  CARTER, Harold, W. ,  BOYD, Joseph, T.

    IPC: G02B06/43

    CPC classification number: G02B6/12007 ,  G02B6/29323 ,  G02B6/2938 ,  G02B6/4215 ,  G02B6/43 ,  G06F1/105

    Abstract: An optical waveguide H-tree design is provided for global clock distribution of multichip modules (MCM) which has nearly zero clock skew and is useful for a distributed computer system environment. The optical waveguide H-tree design utilizes channel waveguides (24), curved sections and directional couplers (34) formed using silica glass and silicon oxynitride (SiON) channel waveguide technologies. A hybrid combination of both SiON and silica glass is disclosed which has the advantages of each. The achievable clock speed is limited by the laser diode source and photodiode receiver at each chip module, and not by the optical waveguide distribution network. The high-speed optical waveguide can be configured to transmit clock signals, or for use a multi-wavelength communication network that communicates signals to various integrated circuits (ICs) mounted on the multichip module. This is achieved using multiple laser diodes (121) having different output wavelengths and directing their outputs into an optical multiplexer. At the receiving points on the ICs, optical demultiplexers filter the optical signals into individual output signals. In addition, multiple "stacked" optical waveguides can be constructed on the MCM to transmit multiple optical signals, and such optical signals can be either of single wavelength or multiple wavelength type.

    Abstract translation: 提供了一种光波导H树设计，用于具有几乎零时钟偏移的多芯片模块（MCM）的全局时钟分配，并且对于分布式计算机系统环境是有用的。 光波导H树设计利用了使用石英玻璃和氮氧化硅（SiON）通道波导技术形成的通道波导（24），弯曲部分和定向耦合器（34）。 公开了SiON和石英玻璃的混合组合，其具有各自的优点。 可实现的时钟速度受到每个芯片模块处的激光二极管源和光电二极管接收器的限制，而不受光波导分配网络的限制。 高速光波导可以被配置为传输时钟信号，或者用于使用将信号传送到安装在多芯片模块上的各种集成电路（IC）的多波长通信网络。 这是使用具有不同输出波长的多个激光二极管（121）并将其输出引导到光复用器中来实现的。 在IC上的接收点，光解复用器将光信号滤波为各个输出信号。 此外，可以在MCM上构造多个“堆叠”光波导以传输多个光信号，并且这样的光信号可以是单波长或多波长类型。

    METHOD TO IMPROVE SURVIVAL OF PATIENTS DURING SEPSIS BY DIET COMPOSITION
    78.
    发明申请
    METHOD TO IMPROVE SURVIVAL OF PATIENTS DURING SEPSIS BY DIET COMPOSITION 审中-公开
    通过饮食组合物改善食欲的方法

    公开(公告)号：WO1990004392A1

    公开(公告)日：1990-05-03

    申请号：PCT/US1989004739

    申请日：1989-10-20

    Applicant: UNIVERSITY OF CINCINNATI

    Inventor： UNIVERSITY OF CINCINNATI ,  ALEXANDER, J., Wesley ,  PECK, Michael, D.

    IPC: A61K31/23

    CPC classification number: A23L33/17 ,  A23L33/12

    Abstract: Septic patients are treated with an enteral or parenteral diet that improves mortality rate of the septic patients. The diet which is designed to provide the total caloric intake for the septic patient includes a low concentration of calories provided by protein. Generally from about 4 to about 10 % of the calories in the diet are provided by protein. More preferably no more than 5 % of the calories are provided by protein. The remainder of the diet is formed from lipids, and carbohydrates. The lipids should be in the form of a combination of omega 6 and omega 3 fatty acids. The diet will also include a vitamin and mineral supplement.

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