公开(公告)号：WO2011082318A2

公开(公告)日：2011-07-07

申请号：PCT/US2010/062531

申请日：2010-12-30

Applicant: PIONEER HI-BRED INTERNATIONAL, INC. ,  GORDON-KAMM, William, J. ,  KLEIN, Theodore, M. ,  LOWE, Keith, S. ,  MCBRIDE, Kevin, E. ,  SCELONGE, Christopher, J. ,  WANG, Bing-Bing ,  WANG, Ning ,  WU, Xinli, E.

Inventor： GORDON-KAMM, William, J. ,  KLEIN, Theodore, M. ,  LOWE, Keith, S. ,  MCBRIDE, Kevin, E. ,  SCELONGE, Christopher, J. ,  WANG, Bing-Bing ,  WANG, Ning ,  WU, Xinli, E.

IPC: C12N15/82

CPC classification number: C12N15/8241 ,  C12N15/8213 ,  C12N15/8216 ,  C12N15/8262

Abstract: Compositions and methods are provided for the introduction and the regulated expression of genes in plants. Compositions include promoter constructs that provide a level of activity useful for the regulated expression of site-specific recombinases, while avoiding premature excision. Further provided are isolated polynucleotides encoding novel babyboom polypeptides, expression cassettes, and plants comprising the same. Methods for the introduction of genes into plants are provided, including methods for plastid transformation and methods for the transformation of tissues from mature seeds and leaves.

Abstract translation: 提供了用于在植物中引入和调控基因表达的组合物和方法。 组合物包括启动子构建体，其提供可用于位点特异性重组酶的调控表达的一定水平的活性，同时避免过早切除。 进一步提供了编码新型babyboom多肽的分离的多核苷酸，表达盒和包含其的植物。 提供了将基因导入植物的方法，包括质体转化方法和从成熟种子和叶片转化组织的方法。

公开(公告)号：WO2011082310A2

公开(公告)日：2011-07-07

申请号：PCT/US2010/062518

申请日：2010-12-30

Applicant: PIONEER HI-BRED INTERNATIONAL, INC. ,  GORDON-KAMM, William, J. ,  LOWE, Keith, S. ,  PETERSON, David, J. ,  SCELONGE, Christopher, J. ,  ST. CLAIR, Grace, M. ,  WANG, Bing-Bing

Inventor： GORDON-KAMM, William, J. ,  LOWE, Keith, S. ,  PETERSON, David, J. ,  SCELONGE, Christopher, J. ,  ST. CLAIR, Grace, M. ,  WANG, Bing-Bing

IPC: C12N15/82

CPC classification number: C12N15/8216 ,  C07K14/415 ,  C12N15/8213

Abstract: A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism, methods for integrating polynucleotides of interest, methods to assess promoter activity, directly select transformed organisms, minimize or eliminate expression resulting from random integration into the genome of an organism, such as a plant, remove polynucleotides of interest, combine multiple transfer cassettes, invert or excise a polynucleotide, silence a gene, and identify and/or characterize transcriptional regulating regions. The methods involve the introduction of a cell proliferation factor and a double-strand break-inducing enzyme into an organism.

Abstract translation: 提供了各种方法和组合物，包括用于靶向修饰细胞或生物体中特定靶位点的方法和组合物，用于整合感兴趣的多核苷酸的方法，评估启动子活性的方法，直接选择转化的生物体，最小化或消除产生的表达 从随机整合到诸如植物的生物体的基因组中，去除感兴趣的多核苷酸，组合多个转移盒，反转或切割多核苷酸，使基因沉默，并鉴定和/或表征转录调节区。 该方法涉及将细胞增殖因子和双链断裂诱导酶引入生物体。

公开(公告)号：WO2010048340A3

公开(公告)日：2010-07-29

申请号：PCT/US2009061555

申请日：2009-10-21

Applicant: LEAD THERAPEUTICS INC ,  CHU DANIEL ,  YE TAO ,  WANG BING

Inventor： CHU DANIEL ,  YE TAO ,  WANG BING

IPC: A01N37/18 ,  A01N43/16 ,  A01P1/00 ,  A61K38/00 ,  A61K38/14

CPC classification number: C07K9/006

Abstract: Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of the a glycopeptide (Compound A, Compound B, Compound H or Compound C) or the monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; conversion of the amide group in amino acid-3 on these scaffolds to various acylamide, acylsulfonamide, acylsulfonylurea derivatives; aminomethylation with substituent containing sulfonamide or acylsulfonamide group on amino acid -7 through Mannich reaction; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

Abstract translation: 描述了具有抗菌活性的半合成糖肽，具体而言，通过化学修饰糖肽（化合物A，化合物B，化合物H或化合物C）或通过水解二糖制备的单糖来制备本文所述的半合成糖肽 亲本糖肽的氨基酸-4的部分在酸性介质中反应以产生氨基酸-4单糖; 将单糖转化为氨基糖衍生物; 用某些酰基将这些支架上的氨基酸-4氨基取代的糖部分上的氨基取代基酰化; 在这些支架上的氨基酸-3中的酰胺基团转化为各种酰基酰胺，酰基磺酰胺，酰基磺酰脲衍生物; 通过曼尼希反应在氨基酸-7上用含有磺酰胺或酰基磺酰胺基团的取代基氨基甲基化; 并将这些支架的大环上的酸部分转化成某些取代的酰胺。 还提供了用于合成所述化合物的方法，含有所述化合物的药物组合物，以及所述化合物用于治疗和/或预防疾病，特别是细菌感染的方法。

公开(公告)号：WO2008124703A3

公开(公告)日：2009-02-05

申请号：PCT/US2008059599

申请日：2008-04-07

Applicant: SIEMENS MEDICAL SOLUTIONS ,  KOLB HARTMUTH C ,  WALSH JOSEPH C ,  KASI DHANALAKSHMI ,  MOCHARLA VANI ,  WANG BING ,  GANGADHARMATH UMESH B ,  DUCLOS BRIAN A ,  CHEN KAI ,  ZHANG WEI ,  CHEN GANG ,  PADGETT HENRY CLIFTON ,  KARIMI FARHAD ,  SCOTT PETER J H ,  GAO ZHIYONG ,  LIANG QIANWA ,  COLLIER THOMAS LEE ,  ZHAO TIEMING ,  XIA CHUNFANG

Inventor： KOLB HARTMUTH C ,  WALSH JOSEPH C ,  KASI DHANALAKSHMI ,  MOCHARLA VANI ,  WANG BING ,  GANGADHARMATH UMESH B ,  DUCLOS BRIAN A ,  CHEN KAI ,  ZHANG WEI ,  CHEN GANG ,  PADGETT HENRY CLIFTON ,  KARIMI FARHAD ,  SCOTT PETER J H ,  GAO ZHIYONG ,  LIANG QIANWA ,  COLLIER THOMAS LEE ,  ZHAO TIEMING ,  XIA CHUNFANG

IPC: C07D249/04 ,  A61K31/4192 ,  A61P35/00 ,  C07D249/06 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  G01N33/532

CPC classification number: C07D417/04 ,  C07D249/04 ,  C07D249/06 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C12Q1/485 ,  G01N2500/04 ,  G01N2500/10

Abstract: The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

Abstract translation: 本申请公开了使用点击化学法鉴定对碳酸酐酶IX（CA-IX）酶具有高结合亲和力的抑制剂的方法，并将其候选用作正电子发射断层摄影（PET）成像剂。

公开(公告)号：WO2008033557A3

公开(公告)日：2008-03-20

申请号：PCT/US2007/020130

申请日：2007-09-17

Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC. ,  KOLB, Hartmuth ,  CHEN, Kai ,  WALSH, Joseph, C. ,  GANGADHARMATH, Umesh ,  KASI, Dhanalakshmi ,  WANG, Bing ,  DUCLOS, Brian ,  LIANG, Qianwa ,  PADGETT, Henry, Clifton ,  KARIMI, Farhad

Inventor： KOLB, Hartmuth ,  CHEN, Kai ,  WALSH, Joseph, C. ,  GANGADHARMATH, Umesh ,  KASI, Dhanalakshmi ,  WANG, Bing ,  DUCLOS, Brian ,  LIANG, Qianwa ,  PADGETT, Henry, Clifton ,  KARIMI, Farhad

IPC: C07K5/12 ,  A61K38/12 ,  A61P35/00

Abstract: The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).

公开(公告)号：WO2007020077A1

公开(公告)日：2007-02-22

申请号：PCT/EP2006/008093

申请日：2006-08-11

Applicant: SAUDI BASIC INDUSTRIES CORPORATION ,  XU, Wei ,  PALACKAL, Syriac, J. ,  ABU-RAQABAH, Atieh ,  MUKTIBODH, Maneet ,  WANG, Bing ,  FRIEDERICHS, Nicolaas, Hendrika

Inventor： XU, Wei ,  PALACKAL, Syriac, J. ,  ABU-RAQABAH, Atieh ,  MUKTIBODH, Maneet ,  WANG, Bing ,  FRIEDERICHS, Nicolaas, Hendrika

IPC: C08F10/00 ,  C08F4/654 ,  C08F4/6592

CPC classification number: C08F10/00 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/65927 ,  C08F210/16 ,  C08F2410/02 ,  C08F4/65904 ,  C08F210/08 ,  C08F2500/04 ,  C08F2500/12 ,  C08F2500/18

Abstract: The present invention relates to a supported catalyst composition for polymerization of olefins comprising at least two catalytic components; and a polymerization process using that catalyst composition; and a method for its preparation.

Abstract translation: 本发明涉及包含至少两种催化组分的烯烃聚合负载型催化剂组合物; 和使用该催化剂组合物的聚合方法; 及其制备方法。

公开(公告)号：WO2006065686A3

公开(公告)日：2006-08-24

申请号：PCT/US2005044768

申请日：2005-12-09

Applicant: GALILEO PHARMACEUTICALS INC ,  CHU DANIEL T W ,  CHEN JIAN ,  CONG QIANG ,  JAMES DONALD R ,  LI XIANFENG ,  SONG JIANGAO ,  WANG BING ,  ZHANG WEI

Inventor： CHU DANIEL T W ,  CHEN JIAN ,  CONG QIANG ,  JAMES DONALD R ,  LI XIANFENG ,  SONG JIANGAO ,  WANG BING ,  ZHANG WEI

IPC: C07D311/96 ,  A61K31/352 ,  A61K31/382 ,  A61K31/4747 ,  A61P35/00 ,  C07D221/20 ,  C07D335/04 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D405/06 ,  C07D407/04 ,  C07D413/04 ,  C07D417/04

CPC classification number: C07D221/20 ,  C07D311/96 ,  C07D335/04 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D405/06 ,  C07D407/04 ,  C07D413/04 ,  C07D417/04

Abstract: The present invention is concerned with certain novel spiro substituted heterocyclic ring derivatives. These compounds may be useful in the manufacture of pharmaceutical compositions for treating disorders mediated by lipoxygenase. They may also be useful in the manufacture of pharmaceutical formulations for the treatment of lipoxygenase-mediated disorders.

Abstract translation: 本发明涉及一些新的螺取代杂环衍生物。 这些化合物可用于制备用于治疗由脂氧合酶介导的病症的药物组合物。 它们也可用于制备用于治疗脂氧合酶介导的病症的药物制剂。

公开(公告)号：WO2005123342A1

公开(公告)日：2005-12-29

申请号：PCT/SG2004/000183

申请日：2004-06-17

Applicant: SYSTEMS ON SILICON MANUFACTURING CO. PTE. LTD. ,  KOH, Meng, Fei ,  POH, Choon, Siong ,  GOH, Inn, Swee ,  LEONG, Theng, Wei ,  NEO, Teck, Leong ,  WANG, Bing

Inventor： KOH, Meng, Fei ,  POH, Choon, Siong ,  GOH, Inn, Swee ,  LEONG, Theng, Wei ,  NEO, Teck, Leong ,  WANG, Bing

IPC: B24D3/22

CPC classification number: B24B37/30

Abstract: The present invention relates generally to the field of chemical/mechanical polishing of substrates. In particular the invention relates to methods of producing improved membranes for use in chemical/mechanical polishing systems. The present invention provides a method of improving the properties of a flexible membrane for use in chemical/mechanical polishing, the method including subjecting the membrane to elevated temperatures.

Abstract translation: 本发明一般涉及衬底的化学/机械抛光领域。 特别地，本发明涉及生产用于化学/机械抛光系统的改进膜的方法。 本发明提供了一种改善用于化学/机械抛光的柔性膜的性质的方法，该方法包括使膜升高温度。

公开(公告)号：WO2005060250A1

公开(公告)日：2005-06-30

申请号：PCT/IB2004/052669

申请日：2004-12-06

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  LAM, Weng, K. ,  WANG, Bing, B. ,  NG, Teck, K.

Inventor： LAM, Weng, K. ,  WANG, Bing, B. ,  NG, Teck, K.

IPC: H04N5/45

CPC classification number: H04N5/45 ,  H04N21/4316

Abstract: A video display device comprising a display to display a primary image, originating from a first input signal, and a picture-in-picture (PIP) overlaying the primary image and originating from a second input signal. The display characteristics of the PIP are changed in response to information, preferably a file extension, relating to the type of the first input signal in order to obscure as little as possible of the important parts of the primary image. In case the primary image contains much visual information the PIP is chosen small, positioned in the periphery of the display and/or transparent. In case the primary image contains little visual information the PIP is chosen large, centered and/or non-transparent. Useful for Integrated Digital TV cum Broadband TV (IDTV-BBTV) devices, where the primary image is a broadband image and the PIP is a TV image.

Abstract translation: 一种视频显示装置，包括显示器，用于显示源自第一输入信号的主图像和覆盖主图像并源自第二输入信号的画中画（PIP）。 PIP的显示特性响应于与第一输入信号的类型相关的信息，优选地是文件扩展名来改变，以便尽可能少地遮蔽主图像的重要部分。 在主图像包含大量视觉信息的情况下，PIP被选择为小的，定位在显示器的外围和/或透明的位置。 如果主图像包含很少的视觉信息，则PIP被选择为大的，居中的和/或不透明的。 适用于集成数字电视暨宽带电视（IDTV-BBTV）设备，其主要图像是宽带图像，PIP是电视图像。

公开(公告)号：WO2004081329A3

公开(公告)日：2005-06-16

申请号：PCT/US2004007534

申请日：2004-03-11

Applicant: FULLER H B LICENSING FINANC ,  WANG BING ,  GREENZWEIG JOHN E ,  HACKBARTH MARK E

Inventor： WANG BING ,  GREENZWEIG JOHN E ,  HACKBARTH MARK E

IPC: B32B17/10 ,  C03C27/10 ,  E06B3/24 ,  E06B3/56 ,  E06B3/663

CPC classification number: C03C27/10 ,  Y02A30/25 ,  Y02B80/24

Abstract: A process for making an insulating glass assembly is disclosed, the process including applying a sealant composition to a surface of a spacer; contacting the sealant composition with a glass pane, and applying pressure on the glass pane to bond the glass pane to the spacer through the sealant composition, the pressure being applied at an ambient temperature of from about 15 °C to about 60 °C.

Abstract translation: 公开了制造绝缘玻璃组件的方法，该方法包括将密封剂组合物施加到间隔物的表面; 使密封剂组合物与玻璃板接触，并且在玻璃板上施加压力以通过密封剂组合物将玻璃板粘合到间隔件上，该压力在约15℃至约60℃的环境温度下施加。