公开(公告)号：WO2023086454A1

公开(公告)日：2023-05-19

申请号：PCT/US2022/049518

申请日：2022-11-10

Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： SEGEL, Rebecca Nicole ,  WILMER, Christopher Eli ,  MCKONE, James R.

IPC: H01M8/18 ,  H01M10/44 ,  H01M8/0258

Abstract: The invention provides an integrated multi-channel battery analyzer including one or more measurement units and accompanying pluggable battery capsules that physically and electrically connect to the measurement unit(s) to obtain multiple measurements simultaneously of electro-chemical properties for flowable materials, e.g., flowable batteries. The battery capsules are in a stacked configuration and include electrical components, e.g., positive and negative electrodes, and positive and negative flow channels through which the positive and negative electrolyte travels, respectively, as well as a separator positioned between the flow channels, and at least one pump. In addition, the battery capsules have a small size as compared to battery capsules known in the art.

公开(公告)号：WO2019055906A1

公开(公告)日：2019-03-21

申请号：PCT/US2018/051319

申请日：2018-09-17

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： KUMTA, Prashant N. ,  DATTA, Moni K. ,  HANUMANTHA, Prashanth Jampani ,  GATTU, Bharat ,  SHANTHI, Pavithra Murugavel

IPC: G06F3/0338

Abstract: The invention, relates to flexible, thin trim batteries for use in a variety of applications including, but not limited to, flexible electronics, flexible energy storage systems, wearable textile-like energy devices and various other integrated electronic and mobile device-based applications. The flexible, thin, film batteries allow the design and development of weavable, conformable, wearable and flexible components for advanced battery technology. The invention relates to flexible energy storage system that include an electrospun, textile-like, weaved assembly including a flexible cathode, a flexible anode, and an electrolyte. The electrolyte can include a flexible gel-polymer and a nanostractured filler.

公开(公告)号：WO2017066389A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/056751

申请日：2016-10-13

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： CHEN, Yanfei ,  CHUN, Young Jae ,  EMERY, Stephen ,  GU, Xinzhu ,  WAGNER, William ,  GREENE, Stephanie

IPC: A61M27/00 ,  A61L31/12 ,  A61L31/02 ,  A61M25/00 ,  A61B5/055

CPC classification number: A61M27/00 ,  A61B5/031 ,  A61B5/055 ,  A61B5/4362 ,  A61L31/128 ,  A61M25/00 ,  A61M27/006

Abstract: The invention relates to an in-utero ventriculoamniotic shunting device that includes a shunt tube (26) composed of polymer composite and having metallic wire embedded therein, one or more anchors (30) composed of superelastic wire, e.g., thermal shape-set nitinol structures, that are mechanically attached to an exterior surface of the shunt tube (26), and a one-way passive valve (32) composed of a thin polymer membrane. The anchors (30) are effective to prevent migration and dislodgement of the shunting device following its deployment, and the valve (32) is effective to prevent the backflow of amniotic fluid (23).

Abstract translation: 本发明涉及一种宫内脑室羊膜分流装置，其包括由聚合物复合材料构成并且具有嵌入其中的金属丝的分流管（26），由超弹性丝构成的一个或多个锚（30） 例如热机械连接到分流管（26）的外表面的热成型镍钛诺结构，以及由薄聚合物膜组成的单向被动阀（32）。 锚（30）有效地防止分流装置在其展开后移动和移位，并且阀（32）有效地防止羊水（23）的回流。

公开(公告)号：WO2016179581A1

公开(公告)日：2016-11-10

申请号：PCT/US2016/031441

申请日：2016-05-09

Applicant: SCIALDONE, Mark Andrew

Inventor： SCIALDONE, Mark Andrew

IPC: A61K31/352 ,  A61K31/192 ,  A61K31/05 ,  C11C3/12

CPC classification number: A61K36/185 ,  A61K31/05 ,  A61K31/192 ,  A61K31/352 ,  A61K2236/31 ,  A61P35/00 ,  C07D311/80 ,  A61K2300/00

Abstract: The present invention relates to the extraction and hydrogenation of essential oil of a cannabis plant. The invention includes hydrogenated cannabis compounds and compositions, as well as methods of preparation and therapeutic uses for regressing tumors in a cancer patient. The extract can include 9-tetrahydrocannabinoic acid and 9-cannabidiolic acid, and the hydrogenated cannabis oil can include hydrogenated 9-tetrahydrocannabinoic acid, hydrogenated 9-cannabidioc acid and, mixtures and blends thereof.

Abstract translation: 本发明涉及大麻植物精油的提取和氢化。 本发明包括氢化大麻化合物和组合物，以及用于在癌症患者中回归肿瘤的制备方法和治疗用途。 提取物可以包括9-四氢大麻酚酸和9-大麻脂肪酸，氢化大麻脂油可以包括氢化9-四氢大麻酚，氢化9-大麻脂肪酸及其混合物和混合物。

公开(公告)号：WO2016100440A2

公开(公告)日：2016-06-23

申请号：PCT/US2015/065980

申请日：2015-12-16

Applicant: GREER STEEL COMPANY

Inventor： CAMPBELL, Douglas B. ,  DAENZER, Todd

IPC: C21D9/16 ,  C22C38/58

CPC classification number: C21D9/16 ,  C21D6/004 ,  C21D6/005 ,  C21D6/008 ,  C21D8/0205 ,  C21D8/0236 ,  C21D8/0247 ,  C22C38/002 ,  C22C38/02 ,  C22C38/06 ,  C22C38/42 ,  C22C38/44 ,  C22C38/58 ,  C23C2/02 ,  C23C2/06 ,  C23C2/26 ,  F42B5/32 ,  F42B33/001

Abstract: The present invention relates generally to steel compositions, methods of manufacturing the compositions and using the compositions to produce rimfire ammunition cartridges. The steel compositions for use in the rimfire cartridges are processed through cold-rolling and annealing steps to create suitable physical properties.

Abstract translation: 本发明一般涉及钢组合物，制造组合物的方法以及使用该组合物制备膛火弹药筒。 通过冷轧和退火步骤处理用于边缘火药筒中的钢组合物以产生合适的物理性质。

公开(公告)号：WO2015142642A1

公开(公告)日：2015-09-24

申请号：PCT/US2015/020418

申请日：2015-03-13

Applicant: ENERSCIENCES HOLDINGS, LLC

Inventor： TRAHAN, David O. ,  SAPIENZA, Richard ,  AMBATIPATI, Srinivasan

IPC: C07C45/00

CPC classification number: C02F1/683 ,  C02F1/008 ,  C02F1/20 ,  C02F1/686 ,  C02F2101/101 ,  C02F2103/007 ,  C02F2103/10 ,  C02F2201/008 ,  C02F2209/001 ,  C02F2209/40 ,  C02F2303/04 ,  C07C45/52 ,  C07C47/22

Abstract: The invention relates to systems and methods for treating produced water with acrolein and, in particular, with an acrolein composition or water stream that is composed of less than pure or less than substantially pure acrolein. The systems and methods are portable such that the water treatment can be conducted on-site where the water to be treated is located.

Abstract translation: 本发明涉及用丙烯醛处理生产水的系统和方法，特别是丙烯醛组合物或由小于或小于基本上纯的丙烯醛组成的水流。 系统和方法是便携式的，使得水处理可以在待处理的水所在的现场进行。

公开(公告)号：WO2015142631A1

公开(公告)日：2015-09-24

申请号：PCT/US2015/020338

申请日：2015-03-13

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： SFEIR, Charles S. ,  BROWN, Andrew J.

IPC: A61L27/44

CPC classification number: A61L27/446 ,  A61L27/047 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L29/126 ,  A61L29/148 ,  A61L29/16 ,  A61L31/128 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2430/02 ,  A61L2430/34

Abstract: The invention relates to magnesium-polymer composites, methods for their preparation and applications for their use. The composites include a combination of magnesium particles and polymer matrix. The polymer can include, but is not limited to, poly(lactic co-glycolic) acid. In certain embodiments, the composites of the invention are particularly useful for forming medical devices for implantation into a body of a patient. In certain other embodiments, the magnesium-polymer composites are useful for wound healing compositions for administration to an exterior surface of a body of a patient.

Abstract translation: 本发明涉及镁 - 聚合物复合材料，其制备方法和应用。 复合材料包括镁颗粒和聚合物基体的组合。 聚合物可包括但不限于聚（乳酸乙醇酸）酸。 在某些实施方案中，本发明的复合材料特别适用于形成用于植入患者体内的医疗装置。 在某些其它实施方案中，镁 - 聚合物复合物可用于伤口愈合组合物，用于给予患者身体的外表面。

公开(公告)号：WO2014165652A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/032790

申请日：2014-04-03

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： KUMTA, Prashant N. ,  KUNJUKUNJU, Sangeetha ,  OSTROWSKI, Nichole J. ,  ROY, Abhijit ,  LEE, Boeun ,  RAMANATHAN, Madhumati

IPC: A61L27/34 ,  A61L27/04 ,  A61L27/58 ,  A61L27/54 ,  A61M31/00

CPC classification number: C09D177/04 ,  A61F2/02 ,  A61F2210/0076 ,  A61F2310/00976 ,  A61L27/04 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/608 ,  A61L2420/08 ,  B05D7/58 ,  C09D105/04 ,  C09D167/04

Abstract: The invention relates to polyelectrolyte multilayer coatings and, methods for their preparation and application to substrates to enhance the bioactivity and corrosion protection of the substrates' surface. The invention is particularly suitable for coating substrates employed for medical applications, such as but not limited to medical implant devices for drug and/or biologics delivery in a patient. The substrate has a positive or negative charge. The polyelectrolyte multilayer coatings include at least a first polymer layer and a second polymer layer. The first polymer and second polymer have opposite charges. Each of the polymer layers is individually applied using a layer-by-layer such that an alternating charge multilayer coating is formed.

Abstract translation: 本发明涉及聚电解质多层涂层及其制备和应用于底物以增强基底表面的生物活性和腐蚀保护的方法。 本发明特别适合于用于医疗应用的涂层基底，例如但不限于用于在患者中进行药物和/或生物制剂输送的医疗植入装置。 衬底具有正或负电荷。 聚电解质多层涂层至少包括第一聚合物层和第二聚合物层。 第一聚合物和第二聚合物具有相反的电荷。 使用层叠法分别施加每个聚合物层，从而形成交替电荷多层涂层。

公开(公告)号：WO2014159939A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/025489

申请日：2014-03-13

Applicant: CUREMETA LLC

Inventor： SCHOPPERLE, William Michael

IPC: G01N33/574

CPC classification number: G01N33/57492 ,  C12Q1/6886 ,  G01N33/57434 ,  G01N2400/02 ,  G01N2400/40 ,  G01N2800/52

Abstract: The invention relates to systems and methods to detect podocalyxin-expressing and TRA-expressing cancer stem cells or cancer cells with stem cell-like properties in a tissue cell sample obtained from a localized tumor of a patient, and to determine a diagnosis or prognosis of aggressive and metastatic cancer by employing podocalyxin and TRA human stem cell markers as prognostic markers.

Abstract translation: 本发明涉及在从患者的局部肿瘤获得的组织细胞样品中检测表达表皮脂蛋白和表达TRA的癌症干细胞或具有干细胞样特性的癌细胞的系统和方法，并且确定诊断或预后 通过使用足癣和TRA人干细胞标记作为预后标志物，侵袭性和转移性癌症。

公开(公告)号：WO2014004809A2

公开(公告)日：2014-01-03

申请号：PCT/US2013/048152

申请日：2013-06-27

Applicant: HASUMI INTERNATIONAL RESEARCH FOUNDATION

Inventor： HASUMI, Kenichiro

IPC: A61K35/15 ,  A61K35/17

CPC classification number: A61K39/3955 ,  A61K35/15 ,  A61K35/17 ,  C07K16/241 ,  C12N5/0638 ,  C12N5/0645 ,  C12N5/0646 ,  A61K2300/00

Abstract: The invention relates to therapy and methods of applying the therapy to cancer patients. The invention includes introducing intratumorally cytotoxic T lymphocyte and/or NKT cells, and prior to, coincident with, or following introducing intratumorally the cytotoxic T lymphocyte and/or NKT cells, introducing intratumorally anti-TNF and/or anti-IL-10 to the patient. The cytotoxic T lymphocyte and/or NKT cells can be induced by the intratumoral introduction of immature dendritic cells to the patient. This therapy of the invention can be effective to regress, reduce or eliminate tumor cells in tumor tissue of the patients in the absence of radiation therapy.

Abstract translation: 本发明涉及将治疗应用于癌症患者的疗法和方法。 本发明包括引入瘤内细胞毒性T淋巴细胞和/或NKT细胞，并且在肿瘤内引入肿瘤内的细胞毒性T淋巴细胞和/或NKT细胞之前，在肿瘤内引入肿瘤内抗TNF和/或抗IL-10到 患者。 细胞毒性T淋巴细胞和/或NKT细胞可以通过肿瘤内引入未成熟树突细胞给患者来诱导。 本发明的这种治疗可以有效地在没有放射治疗的情况下回归，减少或消除患者的肿瘤组织中的肿瘤细胞。