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    METHOD FOR DIAGNOSING AND PREDICTING CEREBELLAR ATAXIA
    3.
    发明申请
    METHOD FOR DIAGNOSING AND PREDICTING CEREBELLAR ATAXIA 审中-公开
    用于诊断和预测小麦蛔虫的方法

    公开(公告)号：WO2010001263A3

    公开(公告)日：2010-04-22

    申请号：PCT/IB2009006844

    申请日：2009-07-02

    申请人： AGRONOMIQUE INST NAT RECH ,  ECOLE VETERINAIRE DE MAISONS A ,  ABITBOL MARIE ,  BLOT STEPHANE

    发明人： ABITBOL MARIE ,  BLOT STEPHANE

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

    摘要： The present invention relates to an in vitro method for diagnosing and/or predicting hereditary cerebellar ataxia in a dog, and/or identifying a dog which is healthy carrier of hereditary cerebellar ataxia, comprising determining the presence or absence of an homozygous or heterozygous genetic variation in the arylsulfatase G gene sequence in a biological sample from said dog, as compared with the arylsulfatase G gene sequence of a healthy non-carrier dog, wherein the presence of said homozygous genetic variation indicates that said dog is or will be affected by hereditary cerebellar ataxia, and the presence of said heterozygous genetic variation indicates that said dog is healthy carrier of hereditary cerebellar ataxia, said dog being of a breed selected in the group consisting of American Staffordshire Terrier, American Pit Bull Terrier and Pit Bull type.

    摘要翻译： 本发明涉及用于诊断和/或预测狗中的遗传性小脑共济失调的体外方法，和/或鉴定作为遗传性小脑共济失调的健康载体的狗，包括确定是否存在纯合或杂合遗传变异 与来自所述狗的生物样品中的芳基硫酸酯酶G基因序列相比，与健康非载体狗的芳基硫酸酯酶G基因序列相比，其中所述纯合遗传变异的存在表明所述狗是或将受到遗传小脑的影响 共济失调，并且所述杂合遗传变异的存在表明所述狗是遗传性小脑共济失调的健康载体，所述狗属于由美国斯塔福德郡梗，美国猎犬和Pit Bull型组成的组中选择的品种。

    N PROTEIN FUSION PROTEINS OF A VIRUS IN THE PARAMYXOVIRIDAE-PROTEIN OF INTEREST FAMILY
    5.
    发明申请
    N PROTEIN FUSION PROTEINS OF A VIRUS IN THE PARAMYXOVIRIDAE-PROTEIN OF INTEREST FAMILY 审中-公开
    N蛋白融合蛋白在感兴趣的家族中的病原体蛋白

    公开(公告)号：WO2007119011A3

    公开(公告)日：2008-03-06

    申请号：PCT/FR2007000651

    申请日：2007-04-18

    申请人： AGRONOMIQUE INST NAT RECH ,  ELEOUET JEAN-FRANCOIS ,  RIFFAULT SABINE

    发明人： ELEOUET JEAN-FRANCOIS ,  RIFFAULT SABINE

    IPC分类号： C12N15/62 ,  A61K39/155 ,  A61K47/48 ,  C07K14/115 ,  C07K14/135 ,  C12N15/45

    CPC分类号： C07K14/005 ,  A61K47/646 ,  A61K2039/525 ,  C12N2760/18022 ,  C12N2760/18522

    摘要： The invention relates to N protein fusion proteins of interest, possibly in the form of N protein protein of interest/P protein soluble complexes, the N and P proteins being proteins of a virus in the Paramyxoviridae family. When the protein of interest is an antigen, the invention also relates to vaccine compositions and reagents of the diagnostic comprising these N protein-antigen fusion proteins or these N protein-antigen/P protein complexes. The N protein-protein of interest fusion may also be used as a 'vector' to transport therapeutic molecules of interest in the cells, such as antiviral or anticancer molecules.

    摘要翻译： 本发明涉及感兴趣的N蛋白融合蛋白，可能以N蛋白质蛋白质/ P蛋白可溶性复合物的形式存在，N和P蛋白是副粘病毒科中病毒的蛋白质。 当感兴趣的蛋白质是抗原时，本发明还涉及包含这些N蛋白 - 抗原融合蛋白或这些N蛋白 - 抗原/ P蛋白复合物的诊断的疫苗组合物和试剂。 感兴趣的N蛋白质融合蛋白也可以用作“载体”，以运送细胞中感兴趣的治疗分子，例如抗病毒或抗癌分子。

    PRODUCTION OF DICARBOXYLIC ACIDS BY IMPROVED MUTANT STRAINS OFYARROWIA LIPOLYTICA
    7.
    发明申请
    PRODUCTION OF DICARBOXYLIC ACIDS BY IMPROVED MUTANT STRAINS OFYARROWIA LIPOLYTICA 审中-公开
    通过改良紫杉醇的改良菌株生产二羧酸

    公开(公告)号：WO2006064131A8

    公开(公告)日：2007-08-02

    申请号：PCT/FR2005003140

    申请日：2005-12-13

    申请人： INST FRANCAIS DU PETROLE ,  CENTRE NAT RECH SCIENT ,  AGRONOMIQUE INST NAT RECH ,  NICAUD JEAN-MARC ,  THEVENIEAU FRANCE ,  LE DALL MARIE-THERESE ,  MARCHAL REMY

    发明人： NICAUD JEAN-MARC ,  THEVENIEAU FRANCE ,  LE DALL MARIE-THERESE ,  MARCHAL REMY

    IPC分类号： C12P7/40

    CPC分类号： C12N9/0042 ,  C12N9/0077 ,  C12P7/44

    摘要： The invention concerns a method for producing dicarboxylic acids (DCA) with long hydrocarbon chains, also called diacids, which consists in culturing a mutant strain of Yarrowia lipolytica obtained by mutagenesis directed and more particularly disrupted at least for the POX2, POX3, POX4 and POX5 genes encoding acyl-CoA oxydase, in a medium consisting essentially of an energetic substrate including at least one carbon source and one nitrogen source and in subjecting said strain to a bioconversion substrate selected among n-alkanes of at least 10 carbon atoms, fatty acids of at least 10 carbon atoms, their alkyl esters and natural oils.

    摘要翻译： 本发明涉及一种生产具有长烃链（也称为二酸）的二羧酸（DCA）的方法，其中包括通过诱变获得的解脂耶氏酵母突变株，至少对于POX2，POX3，POX4和POX5， 在基本上由包含至少一个碳源和一个氮源的能量底物组成的培养基中，并且将所述菌株置于选自至少10个碳原子的正烷烃的生物转化底物的基础上的编码酰基-CoA氧化酶的基因， 至少10个碳原子，它们的烷基酯和天然油。

    METHOD FOR PURIFYING EFFLUENT IN AN ANAEROBIC REACTOR
    8.
    发明申请
    METHOD FOR PURIFYING EFFLUENT IN AN ANAEROBIC REACTOR 审中-公开
    在厌氧反应器中净化液体的方法

    公开(公告)号：WO2006114552A3

    公开(公告)日：2007-04-12

    申请号：PCT/FR2006050392

    申请日：2006-04-27

    申请人： AGRONOMIQUE INST NAT RECH ,  TORRIJOS MICHEL ,  MOLETTA RENE ,  THANIKAL JOSEPH V ,  BERNET NICOLAS

    发明人： TORRIJOS MICHEL ,  MOLETTA RENE ,  THANIKAL JOSEPH V ,  BERNET NICOLAS

    IPC分类号： C02F3/28

    CPC分类号： C02F3/2806 ,  Y02E50/343

    摘要： The invention relates to a method for purifying effluents in an anaerobic reactor (1) in which the micro-organisms are held by supports, said supports forming a bed which is fixed in a part (4, 5) of the reactor. The inventive method is characterised in that it comprises a step wherein the reactor is backwashed once it has been at least partially clogged, by temporarily suspending the supports. Advantageously, the method comprises an initial step for starting the reactor, during which the load of the reactor is increased with a short and constant hydraulic residence time.

    摘要翻译： 本发明涉及一种在厌氧反应器（1）中净化污水的方法，其中微生物被支撑物保持，所述载体形成固定在反应器的一部分（4,5）中的床。 本发明的方法的特征在于，其包括一个步骤，其中一旦其被至少部分堵塞，通过暂时悬浮载体反应器被反洗。 有利地，该方法包括用于启动反应器的初始步骤，在此期间反应器的负载以短暂且恒定的液压停留时间增加。