公开(公告)号：WO2013019642A3

公开(公告)日：2013-05-02

申请号：PCT/US2012048609

申请日：2012-07-27

Applicant: CALERA CORP ,  CONSTANTZ BRENT R ,  MONTEIRO PAULO J ,  SELF KYLE ,  CHEN IRVIN

Inventor： CONSTANTZ BRENT R ,  MONTEIRO PAULO J ,  SELF KYLE ,  CHEN IRVIN

IPC: C04B14/28 ,  C04B14/38 ,  C04B16/04 ,  C04B18/24 ,  C04B22/12

CPC classification number: C01F11/18 ,  C01P2004/61 ,  C01P2006/80 ,  C01P2006/82 ,  C04B2/06 ,  C04B28/02 ,  C04B28/10 ,  C04B2111/00112 ,  C04B2111/00379 ,  Y02P40/18 ,  Y02W30/97 ,  C04B7/02 ,  C04B14/386 ,  C04B14/42 ,  C04B14/46 ,  C04B16/06 ,  C04B18/24 ,  C04B18/26 ,  C04B32/02 ,  C04B14/28 ,  C04B22/10 ,  C04B16/0641

Abstract: Provided are compositions, methods and systems including cementitious compositions and reinforcing materials wherein the cementitious composition comprises a metastable component.

Abstract translation: 提供了包括水泥组合物和增强材料的组合物，方法和系统，其中水泥组合物包含亚稳组分。

公开(公告)号：WO2012149173A2

公开(公告)日：2012-11-01

申请号：PCT/US2012/035232

申请日：2012-04-26

Applicant: CALERA CORPORATION ,  FERNANDEZ, Miguel ,  CHEN, Irvin ,  LEE, Patricia Tung ,  GINDER-VOGEL, Matthew

Inventor： FERNANDEZ, Miguel ,  CHEN, Irvin ,  LEE, Patricia Tung ,  GINDER-VOGEL, Matthew

IPC: C01F11/18 ,  C04B14/28 ,  C09K3/00

CPC classification number: C04B7/345 ,  C01F11/182 ,  C01F11/183 ,  C01F11/184 ,  C01P2006/37 ,  C04B14/28 ,  C04B28/02 ,  C04B28/28 ,  C04B22/141 ,  C04B22/142 ,  C04B22/147 ,  C04B22/16 ,  C04B22/165 ,  C04B24/02 ,  C04B24/04 ,  C04B24/045 ,  C04B24/18 ,  C04B24/32

Abstract: Provided herein are compositions, methods, and systems for a material containing metastable carbonate and stabilizer. Methods for making the compositions and using the compositions are also provided.

Abstract translation: 本文提供了含有亚稳碳酸盐和稳定剂的材料的组合物，方法和系统。 还提供了制备组合物和使用组合物的方法。

公开(公告)号：WO2011008348A3

公开(公告)日：2011-03-10

申请号：PCT/US2010036247

申请日：2010-05-26

Applicant: CALIMMUNE INC ,  CHEN IRVIN ,  AN DONG SUNG ,  MILLINGTON MICHELLE ,  BOYD MAUREEN ,  SYMONDS GEOFFREY P ,  BRETON LOUIS RANDALL

Inventor： CHEN IRVIN ,  AN DONG SUNG ,  MILLINGTON MICHELLE ,  BOYD MAUREEN ,  SYMONDS GEOFFREY P ,  BRETON LOUIS RANDALL

IPC: A01K67/027 ,  A61K35/28 ,  A61K48/00 ,  C07K14/00 ,  C07K14/16 ,  C07K14/47 ,  C12N9/90 ,  C12N15/113 ,  C12N15/85 ,  C12N15/867

CPC classification number: A61K35/28 ,  A01K67/0271 ,  A01K2207/12 ,  A01K2227/105 ,  A01K2267/0337 ,  A61K31/713 ,  A61K38/162 ,  A61K48/00 ,  A61K48/0058 ,  A61K2035/124 ,  C07K14/00 ,  C07K14/4702 ,  C07K2319/03 ,  C12N5/0647 ,  C12N7/00 ,  C12N9/90 ,  C12N15/1138 ,  C12N15/86 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2510/00 ,  C12N2740/16021 ,  C12N2740/16033 ,  C12N2740/16043 ,  C12N2740/16071 ,  C12N2740/16171 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2830/008 ,  C12N2830/85

Abstract: The present invention provides an expression vector for preventing or inhibiting HlV entry, fusion or replication in mammalian cells. In particular, the invention provides a recombinant retroviral vector that encodes an inhibitor of a HlV co-receptor, such as CCR5 or CXCR4, and a protein that inhibits HIV fusion to target cells and/or HIV replication. Pharmaceutical compositions comprising such constructs and methods of use thereof to prevent or treat HIV infection in a patient are also disclosed.

Abstract translation: 本发明提供了用于在哺乳动物细胞中预防或抑制HlV进入，融合或复制的表达载体。 特别地，本发明提供编码H1V共受体抑制剂如CCR5或CXCR4的重组逆转录病毒载体和抑制HIV融合靶向细胞和/或HIV复制的蛋白质。 还公开了包含这种构建体的药物组合物及其用于预防或治疗患者HIV感染的方法。

公开(公告)号：WO2004003153A8

公开(公告)日：2004-04-01

申请号：PCT/US0320325

申请日：2003-06-27

Applicant: US GOV HEALTH & HUMAN SERV ,  FOLKS THOMAS M ,  CHEN IRVIN S Y

Inventor： FOLKS THOMAS M ,  CHEN IRVIN S Y

IPC: A61K39/12 ,  C07K14/16 ,  C12N7/00 ,  C12N15/86 ,  C12N15/867 ,  C12N

CPC classification number: C07K14/005 ,  A61K2039/5256 ,  C12N15/86 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/17043

Abstract: The present invention provides a vector or vector containing composition comprising a spumavirus backbone and a antigen-encoding nucleic acid. The present invention also provides methods of treating or preventing a condition resulting from a viral, bacterial, or parasitic infection in a subject comprising administering to the subject an effective amount of the vector or vector containing composition comprising a spumavirus backbone and an antigen-encoding nucleic acid. Also provided in the present invention are methods of treating a condition resulting from a cancer in a subject comprising administering to the subject an effective amount of the vector or vector containing composition comprising a spumavirus backbone and an antigen-encoding nucleic acid.

Abstract translation: 本发明提供了含有发泡病毒骨架和抗原编码核酸的载体或载体。 本发明还提供了治疗或预防受试者中由病毒，细菌或寄生虫感染引起的病症的方法，所述方法包括向所述受试者施用有效量的含有载体或载体的组合物，所述组合物包含泡沫病毒骨架和抗原编码核酸 酸。 本发明还提供了治疗受试者中由癌症引起的病症的方法，其包括向受试者施用有效量的含有发怒病毒骨架和抗原编码核酸的含有载体或载体的组合物。

公开(公告)号：WO2011081681A1

公开(公告)日：2011-07-07

申请号：PCT/US2010/045620

申请日：2010-08-16

Applicant: CALERA CORPORATION ,  CONSTANTZ, Brent, R. ,  FARSAD, Kasra ,  CAMIRE, Chris ,  PATTERSON, Joshua ,  FERNANDEZ, Miguel ,  GINDER-VOGEL, Matthew ,  YACCATO, Karin ,  THATCHER, Ryan ,  STAGNARO, John ,  CHEN, Irvin ,  OMELON, Sidney ,  HODSON, Keith ,  CLODIC, Laurence ,  DEVENNEY, Martin ,  GERAMITA, Katharine ,  HOLLAND, Terence, C.

Inventor： CONSTANTZ, Brent, R. ,  FARSAD, Kasra ,  CAMIRE, Chris ,  PATTERSON, Joshua ,  FERNANDEZ, Miguel ,  GINDER-VOGEL, Matthew ,  YACCATO, Karin ,  THATCHER, Ryan ,  STAGNARO, John ,  CHEN, Irvin ,  OMELON, Sidney ,  HODSON, Keith ,  CLODIC, Laurence ,  DEVENNEY, Martin ,  GERAMITA, Katharine ,  HOLLAND, Terence, C.

IPC: C04B40/00

CPC classification number: C04B28/04 ,  B01D53/62 ,  B01D2251/404 ,  B01D2257/504 ,  B01D2258/0233 ,  C04B14/28 ,  C04B28/02 ,  Y02C10/00 ,  Y02C10/04 ,  Y10S264/43

Abstract: Provided herein are compositions and methods including hydraulic cement, supplementary cementitious material, and/or self-cementing material. Methods for making the compositions and using the compositions are provided.

Abstract translation: 本文提供了包括水硬性水泥，补充水泥材料和/或自固化材料的组合物和方法。 提供了制备组合物和使用组合物的方法。

公开(公告)号：WO2008109837A3

公开(公告)日：2008-11-13

申请号：PCT/US2008056245

申请日：2008-03-07

Applicant: CALIFORNIA INST OF TECHN ,  UNIV CALIFORNIA ,  LOIS-CABALLE CARLOS ,  BALTIMORE DAVID ,  QIN XIAO-FENG ,  CHEN IRVIN S Y ,  AN DONG SUNG

Inventor： LOIS-CABALLE CARLOS ,  BALTIMORE DAVID ,  QIN XIAO-FENG ,  CHEN IRVIN S Y ,  AN DONG SUNG

IPC: C12N15/09 ,  C12Q1/68 ,  A01N43/04 ,  A61K31/7088 ,  A61K48/00 ,  A61P31/18 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12N15/63 ,  C12N15/867 ,  C12N15/88 ,  C12P19/34

CPC classification number: C12N15/1132 ,  A61K48/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1138 ,  C12N15/63 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2330/30 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2760/20122 ,  C12N2799/027 ,  C12N2810/609 ,  C12N2830/003 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2840/203

Abstract: In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (Fig. IA). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.

Abstract translation: 一方面，本发明提供了使用逆转录病毒载体在细胞内表达小RNA分子的方法和组合物（图1A）。 小干扰RNA（siRNA）可以使用本发明的方法在细胞内表达。 另一方面，本发明提供了产生编码慢病毒的siRNA的方法，其中siRNA活性可干扰慢病毒生命周期。 在又一方面，本发明提供了用于在细胞内表达小RNA分子的方法，所述方法例如能够下调CCR5的siRNA，其中小RNA分子的表达对细胞相对无细胞毒性。 本发明还包括小RNA分子，如能够下调CCR5的siRNA，其对细胞相对无细胞毒性。

公开(公告)号：WO2008109837A2

公开(公告)日：2008-09-12

申请号：PCT/US2008/056245

申请日：2008-03-07

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  LOIS-CABALLE, Carlos ,  BALTIMORE, David ,  QIN, Xiao-feng ,  CHEN, Irvin, S.Y. ,  AN, Dong, Sung

Inventor： LOIS-CABALLE, Carlos ,  BALTIMORE, David ,  QIN, Xiao-feng ,  CHEN, Irvin, S.Y. ,  AN, Dong, Sung

IPC: C07H21/04 ,  C12N15/86

CPC classification number: C12N15/1132 ,  A61K48/00 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1138 ,  C12N15/63 ,  C12N15/86 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2330/30 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2760/20122 ,  C12N2799/027 ,  C12N2810/609 ,  C12N2830/003 ,  C12N2830/008 ,  C12N2830/48 ,  C12N2840/203

Abstract: In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (Fig. IA). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.

Abstract translation: 一方面，本发明提供了使用逆转录病毒载体在细胞内表达小RNA分子的方法和组合物（图1A）。 可以使用本发明的方法在细胞内表达小干扰RNA（siRNA）。 另一方面，本发明提供了用于产生编码慢病毒的siRNA的方法，其中siRNA活性可能干扰慢病毒生命周期。 在另一方面，本发明提供了在细胞内表达小RNA分子的方法，例如能够下调CCR5的siRNA，其中小RNA分子的表达对细胞是相对非细胞毒性的。 本发明还包括对细胞相对非细胞毒性的小RNA分子，例如能够下调CCR5的siRNA。

公开(公告)号：WO2004003153A9

公开(公告)日：2004-05-21

申请号：PCT/US0320325

申请日：2003-06-27

Applicant: US GOV HEALTH & HUMAN SERV ,  FOLKS THOMAS M ,  CHEN IRVIN S Y

Inventor： FOLKS THOMAS M ,  CHEN IRVIN S Y

IPC: A61K39/12 ,  C07K14/16 ,  C12N7/00 ,  C12N15/86 ,  C12N15/867 ,  C12N

CPC classification number: C07K14/005 ,  A61K2039/5256 ,  C12N15/86 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/17043

Abstract: The present invention provides a vector or vector containing composition comprising a spumavirus backbone and a antigen-encoding nucleic acid. The present invention also provides methods of treating or preventing a condition resulting from a viral, bacterial, or parasitic infection in a subject comprising administering to the subject an effective amount of the vector or vector containing composition comprising a spumavirus backbone and an antigen-encoding nucleic acid. Also provided in the present invention are methods of treating a condition resulting from a cancer in a subject comprising administering to the subject an effective amount of the vector or vector containing composition comprising a spumavirus backbone and an antigen-encoding nucleic acid.

公开(公告)号：WO2022051555A2

公开(公告)日：2022-03-10

申请号：PCT/US2021/048943

申请日：2021-09-02

Applicant: CHEN, Irvin S.Y. ,  RAMPART BIOSCIENCE, INC. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： BARTLETT, Jeffrey S. ,  BRETON, Louis Randall ,  YAN, Ming ,  ZHEN, Anjie

IPC: A61K38/16 ,  A61P19/00 ,  C12N9/16 ,  A61K38/00

Abstract: The present disclosure is directed to polypeptides, such as polypeptides comprising an alkaline phosphatase and a bone-targeting moiety. Also disclosed are expression vectors, such as lentiviral expression vectors, including a nucleotide sequence encoding a polypeptide. Also disclosed are methods of treating hypophosphatasia or treating, mitigating, or preventing one or more symptoms of hypophosphatasia by administering to a subject in need of treatment thereof the disclosed polypeptides or host cells transduced to express any of the disclosed polypeptides.

公开(公告)号：WO2014093966A1

公开(公告)日：2014-06-19

申请号：PCT/US2013/075362

申请日：2013-12-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  LU, Yunfeng ,  YAN, Ming ,  CHEN, Irvin S.Y. ,  LIANG, Min

Inventor： LU, Yunfeng ,  YAN, Ming ,  CHEN, Irvin S.Y. ,  LIANG, Min

IPC: C12N15/86 ,  A61K9/51

CPC classification number: A61K9/513 ,  A61K9/5184 ,  A61K9/5192 ,  A61K31/7088 ,  A61K47/62 ,  A61K47/6925 ,  C12N15/86 ,  C12N2740/15045 ,  C12N2760/20245 ,  C12N2810/80 ,  C12N2810/859

Abstract: The invention provides novel methods, materials and systems that can be used to generate viral vectors having altered tissue and cell targeting abilities. In illustrative embodiments of the invention, the specificity of lentiviral vectors was modulated by a thin polymer shell that synthesized and coupled to the viral envelope in situ. The polymer shell can confers such vectors with new targeting ability via agents such as cyclic RGD (cRGD) peptides that are coupled to the polymer shell. These polymer encapsulated viral vectors exhibit a number of highly desirable characteristics including a higher thermal stability, resistance to serum inactivation in vivo , and an ability to infect dividing and non-dividing cells with high efficiencies.

Abstract translation: 本发明提供可用于产生具有改变的组织和细胞靶向能力的病毒载体的新颖方法，材料和系统。 在本发明的说明性实施方案中，慢病毒载体的特异性由通过原位合成并与病毒包膜偶联的薄聚合物壳调制。 聚合物壳可以通过诸如与聚合物壳耦合的环状RGD（cRGD）肽的试剂赋予新的靶向能力。 这些聚合物包封的病毒载体表现出许多高度期望的特征，包括较高的热稳定性，体内血清失活的抗性，以及以高效率感染分裂和非分裂细胞的能力。