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公开(公告)号：WO2007103754A2
公开(公告)日：2007-09-13
申请号：PCT/US2007063112
申请日：2007-03-02
IPC分类号： A61K31/496
CPC分类号： A61K31/496
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using substituted thiazolones. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of substituted thiazolones.
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公开(公告)号：WO2005107762A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/015666
申请日：2005-05-06
申请人： CYTOKINETICS, INC. , SMITHKLINE BEECHAM CORPORATION , QIAN, Xiangping , MCDONALD, Andrew, I. , ZHOU, Han-Jie , ASHCRAFT, Luke, W. , YAO, Bing , JIANG, Hong , HUANG, Jennifer, Kuo, Chen , WANG, Jianchao , MORGANS, David, J., Jr. , MORGAN, Bradley, P. , BERGNES, Gustave , DHANAK, Dashyant , KNIGHT, Steven, D. , ADAMS, Nicholas, D. , PARRISH, Cynthia, A.
发明人： QIAN, Xiangping , MCDONALD, Andrew, I. , ZHOU, Han-Jie , ASHCRAFT, Luke, W. , YAO, Bing , JIANG, Hong , HUANG, Jennifer, Kuo, Chen , WANG, Jianchao , MORGANS, David, J., Jr. , MORGAN, Bradley, P. , BERGNES, Gustave , DHANAK, Dashyant , KNIGHT, Steven, D. , ADAMS, Nicholas, D. , PARRISH, Cynthia, A.
IPC分类号： A61K31/55
CPC分类号： C07D403/12 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/28 , C07C275/40 , C07C281/06 , C07C311/37 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D213/30 , C07D231/12 , C07D233/62 , C07D235/18 , C07D235/26 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/56 , C07D285/02 , C07D295/155 , C07D333/38 , C07D403/10 , C07D471/04 , C07F9/65062 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：WO2005042697A2
公开(公告)日：2005-05-12
申请号：PCT/US2004032569
申请日：2004-10-05
发明人： BERGNES GUSTAVE , DHANAK DASHYANT
IPC分类号： A61K31/35 , A61K31/353 , A61K31/44 , A61K31/55 , C07D223/10 , C07D311/04 , C07D471/02 , C12N20060101 , C12N
CPC分类号： C07D491/052 , C07D405/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：WO2004032840A2
公开(公告)日：2004-04-22
申请号：PCT/US0331413
申请日：2003-10-02
申请人： CYTOKINETICS INC , SMITHKLINE BEECHAM CORP , BERGNES GUSTAVE , QIAN XIANPING , MORGANS DAVID J JR , KNIGHT STEVEN DAVID , DHANAK DASHYANT
IPC分类号： A61K20060101 , A61K31/4196 , A61P9/00 , A61P29/00 , A61P35/00 , C07D249/12 , A61K
CPC分类号： C07D249/12 , C07D403/04
摘要： 1, 2, 4-Triazole-5-ones useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译： 公开了用于通过调节KSP活性来治疗细胞增殖性疾病和病症的1,2,4-三唑-5-酮。
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公开(公告)号：WO2003094839A2
公开(公告)日：2003-11-20
申请号：PCT/US2003/013627
申请日：2003-05-02
申请人： CYTOKINETICS, INC. , SMITHKLINE BEECHAM CORPORATION , ZHOU, Han-Jie , MORGANS, David, J., C., Jr. , KNIGHT, Steven, David , NEWLANDER, Kenneth, A. , DHANAK, Dashyant , ADAMS, Nicholas, D. , BERGNES, Gustave
发明人： ZHOU, Han-Jie , MORGANS, David, J., C., Jr. , KNIGHT, Steven, David , NEWLANDER, Kenneth, A. , DHANAK, Dashyant , ADAMS, Nicholas, D. , BERGNES, Gustave
IPC分类号： A61K
CPC分类号： C07D239/36 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/91 , C07D249/08 , C07D403/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译： 公开了通过调节KSP活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：WO2003088903A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/011432
申请日：2003-04-11
申请人： CYTOKINETICS, INC. , SMITHKLINE BEECHAM CORPORATION , MCDONALD, Andrew , BERGNES, Gustave , FENG, Bainian , MORGANS, David, J., C., Jr. , KNIGHT, Steven, David , NEWLANDER, Kenneth, A. , DHANAK, Dashyant , BROOK, Christopher, S.
发明人： MCDONALD, Andrew , BERGNES, Gustave , FENG, Bainian , MORGANS, David, J., C., Jr. , KNIGHT, Steven, David , NEWLANDER, Kenneth, A. , DHANAK, Dashyant , BROOK, Christopher, S.
IPC分类号： C07D233/02
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
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公开(公告)号：WO0247456A3
公开(公告)日：2003-01-23
申请号：PCT/US0146370
申请日：2001-12-05
发明人： DHANAK DASHYANT , KNIGHT STEVEN D
IPC分类号： A61K31/4709 , A61P3/10 , A61P9/04 , A61P9/06 , A61P9/10 , A61P11/06 , A61P25/22 , A61P25/24 , A61P39/02 , C07D215/38 , C07D401/12 , A61K31/47 , C07D215/16
CPC分类号： C07D215/38 , C07D401/12
摘要： The present invention relates to novel quinolones and their use as urotensin antagonists.
摘要翻译： 本发明涉及新型喹诺酮及其作为尿素调节素拮抗剂的用途。
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公开(公告)号：WO2002090353A1
公开(公告)日：2002-11-14
申请号：PCT/US2002/014408
申请日：2002-05-07
申请人： SMITHKLINE BEECHAM CORPORATION , DHANAK, Dashyant , GALLAGHER, Timothy, F. , KNIGHT, Steven, D.
IPC分类号： C07D403/10
CPC分类号： C07D405/12 , C07D207/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
摘要翻译： 本发明涉及磺酰胺，含有它们的药物组合物以及它们作为尾加压素II的拮抗剂的用途。
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公开(公告)号：WO2002090348A1
公开(公告)日：2002-11-14
申请号：PCT/US2002/014406
申请日：2002-05-07
申请人： SMITHKLINE BEECHAM CORPORATION , DHANAK, Dashyant , GALLAGHER, Timothy, F. , KNIGHT, Steven, D.
IPC分类号： C07D401/10
CPC分类号： C07D207/12 , C07D333/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
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公开(公告)号：WO2002089793A1
公开(公告)日：2002-11-14
申请号：PCT/US2002/014409
申请日：2002-05-07
申请人： SMITHKLINE BEECHAM CORPORATION , DHANAK, Dashyant , GALLAGHER, Timothy, F. , KNIGHT, Steven, D.
IPC分类号： A61K31/41
CPC分类号： C07D401/12 , C07D207/12 , C07D207/36 , C07D401/14 , C07D405/12 , C07D409/12 , C07D471/04
摘要： The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II.
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