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公开(公告)号：WO2005107762A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/015666
申请日：2005-05-06
申请人： CYTOKINETICS, INC. , SMITHKLINE BEECHAM CORPORATION , QIAN, Xiangping , MCDONALD, Andrew, I. , ZHOU, Han-Jie , ASHCRAFT, Luke, W. , YAO, Bing , JIANG, Hong , HUANG, Jennifer, Kuo, Chen , WANG, Jianchao , MORGANS, David, J., Jr. , MORGAN, Bradley, P. , BERGNES, Gustave , DHANAK, Dashyant , KNIGHT, Steven, D. , ADAMS, Nicholas, D. , PARRISH, Cynthia, A.
发明人： QIAN, Xiangping , MCDONALD, Andrew, I. , ZHOU, Han-Jie , ASHCRAFT, Luke, W. , YAO, Bing , JIANG, Hong , HUANG, Jennifer, Kuo, Chen , WANG, Jianchao , MORGANS, David, J., Jr. , MORGAN, Bradley, P. , BERGNES, Gustave , DHANAK, Dashyant , KNIGHT, Steven, D. , ADAMS, Nicholas, D. , PARRISH, Cynthia, A.
IPC分类号： A61K31/55
CPC分类号： C07D403/12 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/28 , C07C275/40 , C07C281/06 , C07C311/37 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D213/30 , C07D231/12 , C07D233/62 , C07D235/18 , C07D235/26 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/56 , C07D285/02 , C07D295/155 , C07D333/38 , C07D403/10 , C07D471/04 , C07F9/65062 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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公开(公告)号：WO2005107762A3
公开(公告)日：2006-08-17
申请号：PCT/US2005015666
申请日：2005-05-06
申请人： CYTOKINETICS INC , SMITHKLINE BEECHAM CORP , QIAN XIANGPING , MCDONALD ANDREW I , ZHOU HAN-JIE , ASHCRAFT LUKE W , YAO BING , JIANG HONG , HUANG JENNIFER KUO CHEN , WANG JIANCHAO , MORGANS DAVID J JR , MORGAN BRADLEY P , BERGNES GUSTAVE , DHANAK DASHYANT , KNIGHT STEVEN D , ADAMS NICHOLAS D , PARRISH CYNTHIA A , DUFFY KEVIN , FITCH DUKE , TEDESCO ROSANNA
发明人： QIAN XIANGPING , MCDONALD ANDREW I , ZHOU HAN-JIE , ASHCRAFT LUKE W , YAO BING , JIANG HONG , HUANG JENNIFER KUO CHEN , WANG JIANCHAO , MORGANS DAVID J JR , MORGAN BRADLEY P , BERGNES GUSTAVE , DHANAK DASHYANT , KNIGHT STEVEN D , ADAMS NICHOLAS D , PARRISH CYNTHIA A , DUFFY KEVIN , FITCH DUKE , TEDESCO ROSANNA
IPC分类号： C07C233/65 , A61K31/165 , A61K31/4184 , A61K31/4196 , A61K31/421 , A61K31/424 , A61K31/4745 , A61K31/55 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/28 , C07C275/40 , C07C281/06 , C07C311/37 , C07D207/26 , C07D207/273 , C07D211/76 , C07D213/30 , C07D231/12 , C07D235/18 , C07D235/26 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/56 , C07D285/02 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D471/04 , C07D487/02 , C07D491/02 , C07F9/6506 , C07F9/6561
CPC分类号： C07D403/12 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/28 , C07C275/40 , C07C281/06 , C07C311/37 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D213/30 , C07D231/12 , C07D233/62 , C07D235/18 , C07D235/26 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/56 , C07D285/02 , C07D295/155 , C07D333/38 , C07D403/10 , C07D471/04 , C07F9/65062 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译： 公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。
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3.发明申请METHOD FOR PREPARING CRAMBESCIDIN CORE ACID INTERMEDIATES AND THEIR USE FOR PREPARING CRAMBESCIDIN ALKALOID ANALOGS AS THERAPEUTIC AGENTS 审中-公开制备克必定酸核酸中间体的方法及其在制备作为治疗剂的克伦贝类生物碱类似物中的用途
公开(公告)号：WO2004028452A3
公开(公告)日：2004-05-21
申请号：PCT/US0329888
申请日：2003-09-23
IPC分类号： A01N43/54 , A61K20060101 , C07D239/00 , C07D491/22
CPC分类号： C07D491/22
摘要： The invention provides methods to synthesize zwitterionic pentacyclic crambescidin core intermediates having the carboxylate side chain in the natural axial orientation, and a range of crambescidin alkaloid analogs.
摘要翻译： 本发明提供合成具有天然轴向取向的羧酸侧链的两性离子五环松金合欢核心中间体和一系列crambescidin生物碱类似物的方法。
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4.发明申请METHOD FOR PREPARING CRAMBESCIDIN CORE ACID INTERMEDIATES AND THEIR USE FOR PREPARING CRAMBESCIDIN ALKALOID ANALOGS AS THERAPEUTIC AGENTS 审中-公开CRAMBESCIDIN CORE ACID中间体的制备方法及其制备CRAMBESCIDIN ALKALOID ANALOG作为治疗剂的用途
公开(公告)号：WO2004028452A2
公开(公告)日：2004-04-08
申请号：PCT/US2003/029888
申请日：2003-09-23
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , OVERMAN, Larry, E. , STAPPENBECK, Frank , MCDONALD, Andrew, I. , ARON, Zachary, D.
IPC分类号： A61K
CPC分类号： C07D491/22
摘要： The invention provides methods to synthesize zwitterionic pentacyclic crambescidin core intermediates having the carboxylate side chain in the natural axial orientation, and a range of crambescidin alkaloid analogs.
摘要翻译： 本发明提供了合成具有天然轴向取向的羧酸侧链的两性离子五环crambescidin核心中间体和一系列crambescidin生物碱类似物的方法。
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