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    WATER DISSOLVABLE MACROCYCLIC LACTONE CYCLODEXTRIN COMPLEXES
    1.
    发明申请
    WATER DISSOLVABLE MACROCYCLIC LACTONE CYCLODEXTRIN COMPLEXES 审中-公开

    公开(公告)号：WO2022103450A1

    公开(公告)日：2022-05-19

    申请号：PCT/US2021/041072

    申请日：2021-07-09

    Applicant: MOUNTAIN VALLEY MD INC ,  FARBER, Michael

    Inventor： FARBER, Michael

    IPC: A61K31/724 ,  A61K47/26 ,  A61K9/00

    Abstract: Injectable Ivermectin solution is safely administrable to humans and animals used the disclosed technology. A macrocyclic lactone cyclodextrin complex which is completely dissolvable or dissolved in water in a ratio of at least 5 or 10 mg of macrocyclic lactone to 1 mL of water. The macrocyclic lactone cyclodextrin complex is non-toxic, without using organic solvents, and in embodiments, formed by adding a surfactant to the macrocyclic lactone complex to water. The macrocyclic lactone cyclodextrin complex is Ivermectin or an Ivermectin derivative in some embodiments. The cyclodextrin complex is 2-hydroxypropyl-beta-cyclodextrin in some embodiments of the disclosed technology. The surfactant can be polysorbate 80 and is in a ratio of 0.01% to 25%, by weight, to said water. The water soluble complexes can be added to the water. The water-soluble complexes can have at least one of an anti parasitic, anti viral and anti-cancer complex.

    JOB BOARD/HRIS INTEGRATION AND SELECTIVE SHARING OF INTERVIEW RESPONSES
    3.
    发明申请
    JOB BOARD/HRIS INTEGRATION AND SELECTIVE SHARING OF INTERVIEW RESPONSES 审中-公开
    工作委员会/人力资源综合与采购回答的选择性共享

    公开(公告)号：WO2008100958A2

    公开(公告)日：2008-08-21

    申请号：PCT/US2008/053754

    申请日：2008-02-12

    Applicant: TREND INTEGRATION LLC ,  FARBER, Michael, Allen ,  COHEN, Hal, Marc

    Inventor： FARBER, Michael, Allen ,  COHEN, Hal, Marc

    IPC: G06Q10/00

    CPC classification number: G06Q30/02

    Abstract: A system and method to collect, transmit and access user information from an information collection system. User information is received with is submitted by a user in response to a posting of an opportunity made at a host web site. In response to receiving the user information, the user is transmitted a confirmation page comprising one or more tags. The one or more of the one or more tags are used in connection with enrolling the user with an information collection system by transmitting user identifier and user contact information to the information collection system. The enrolling step is accomplished without activity by the user. The one or more of the one or more tags are invisible or visible to the user. Data is collected from the user in response to one or more questions posed to the user. Access is provided to the user information and the user data to the sponsor through an access page. The access page includes a tag that visually indicates to the sponsor a status of data collection from the user. The sponsor activates the tag to thereby access the user data by the sponsor.

    Abstract translation: 一种从信息收集系统收集，传输和访问用户信息的系统和方法。 接收用户信息，由用户提交以响应在主机网站上发布的机会。 响应于接收到用户信息，向用户发送包括一个或多个标签的确认页面。 通过将用户标识符和用户联系信息发送到信息收集系统，一个或多个标签中的一个或多个标签用于通过向用户注册信息收集系统。 注册步骤在用户没有活动的情况下完成。 一个或多个标签中的一个或多个不可见或对用户可见。 响应于对用户提出的一个或多个问题，从用户收集数据。 通过访问页面向赞助商提供对用户信息和用户数据的访问。 访问页面包括标签，该标签向赞助商向用户显示数据收集的状态。 赞助者激活标签，从而由赞助商访问用户数据。

    COMPOSITION AND PROPHYLACTIC DEVICE FOR ENHANCING SEXUAL PERFORMANCE OR PLEASURE
    6.
    发明申请
    COMPOSITION AND PROPHYLACTIC DEVICE FOR ENHANCING SEXUAL PERFORMANCE OR PLEASURE 审中-公开
    用于增强性能或性能的组合物和预防装置

    公开(公告)号：WO2011057386A1

    公开(公告)日：2011-05-19

    申请号：PCT/CA2010/001725

    申请日：2010-10-28

    Applicant: ORAL DELIVERY TECHNOLOGY LTD. ,  FARBER, Michael

    Inventor： FARBER, Michael

    IPC: A61K31/223 ,  A61F5/41 ,  A61K38/05 ,  A61P15/00 ,  A61P15/10

    CPC classification number: A61K31/223 ,  A61F5/41 ,  A61K9/0034 ,  A61K38/05

    Abstract: There is provided a novel topical composition, a novel prophylactic device, and a method of using them for stimulating and maintaining an erection of a sexual organ in a subject in need thereof. The topical composition, prophylactic device and method comprise an amino acid ester compound with at least one nitric oxide releasing group, or a pharmaceutical salt thereof.

    Abstract translation: 提供了一种新型的局部组合物，一种新的预防装置，以及一种使用它们来刺激并维持有需要的受试者中性器官勃起的方法。 局部组合物，预防装置和方法包括具有至少一种一氧化氮释放基团的氨基酸酯化合物或其药学盐。

    NON-STEROIDAL ANTI-INFLAMMATORY DRUGS COADMINISTERED WITH NITRIC OXIDE AMINO ACID ESTER COMPOUNDS AS PROPHYLAXIS IN HYPERTENSIVE PATIENTS
    7.
    发明申请
    NON-STEROIDAL ANTI-INFLAMMATORY DRUGS COADMINISTERED WITH NITRIC OXIDE AMINO ACID ESTER COMPOUNDS AS PROPHYLAXIS IN HYPERTENSIVE PATIENTS 审中-公开
    用硝酸氧化氨基酸酯化合物作为高血压患者预防的非甾体抗炎药物

    公开(公告)号：WO2011041870A1

    公开(公告)日：2011-04-14

    申请号：PCT/CA2009/001427

    申请日：2009-10-07

    Applicant: NITROGENIX INC. ,  FARBER, Michael

    Inventor： FARBER, Michael

    IPC: A61K38/05 ,  A61K31/223 ,  A61P29/00

    CPC classification number: A61K31/223 ,  A61K45/06 ,  A61K2300/00

    Abstract: There is provided a novel pharmaceutical composition containing amino acid ester compounds comprising at least one nitric oxide releasing group and pharmaceutical salts thereof, for the boosting nitric oxide levels. There is also provided a novel pharmaceutical composition containing amino acid ester compounds comprising at least one nitric oxide releasing group and pharmaceutical salts thereof, in combination with non-stereoidal anti-inflammatory drug (NSAID) and/or a cyclooxygenase-2 (COX-2) selective inhibitor, for the relief of pain.

    Abstract translation: 提供一种包含至少一种一氧化氮释放基团的氨基酸酯化合物及其药用盐的新型药物组合物，用于增强一氧化氮水平。 还提供了含有包含至少一种一氧化氮释放基团的氨基酸酯化合物和其药用盐与非立体抗炎药（NSAID）和/或环氧合酶-2（COX-2）的组合的新型药物组合物 ）选择性抑制剂，用于缓解疼痛。

    ORAL DELIVERY SYSTEM CONTAINING A GEL MATRIX AND LIPOSOMES
    9.
    发明申请
    ORAL DELIVERY SYSTEM CONTAINING A GEL MATRIX AND LIPOSOMES 审中-公开

    公开(公告)号：WO2004009053A3

    公开(公告)日：2004-01-29

    申请号：PCT/CA2003/001034

    申请日：2003-07-18

    Applicant: VITALSTATE CANADA LTD. ,  FARBER, Michael ,  FARBER, Jonathan

    Inventor： FARBER, Michael ,  FARBER, Jonathan

    IPC: A61K9/127

    Abstract: A transmucosal delivery system for oral delivery of one or more biologically active agent associated with an artificial membrane vesicle (AMV), such as a liposome, is provided. The system is especially suited for the delivery of biologically active agents with poor solubility, that are easily degraded in the gastrointestinal tract or that tend to have an unpleasant taste and mouth feel. The delivery system comprises a two-phase system whereby one or more AMV-associated biologically active agents are substantially uniformly dispersed in a semi-solid matrix that allows for maintenance of bioactivity. The dual phase system may further comprise one or more non-AMV associated biologically active agents incorporated within the matrix. Methods of preparing the delivery system and methods of use for delivering biologically active agents to animals, including humans, are also provided.

    TRANSMUCOSAL DELIVERY SYSTEM
    10.
    发明申请
    TRANSMUCOSAL DELIVERY SYSTEM 审中-公开
    转运系统

    公开(公告)号：WO2004009053A2

    公开(公告)日：2004-01-29

    申请号：PCT/CA0301034

    申请日：2003-07-18

    Applicant: VITALSTATE CANADA LTD ,  FARBER MICHAEL ,  FARBER JONATHAN

    Inventor： FARBER MICHAEL ,  FARBER JONATHAN

    IPC: A23L1/00 ,  A23L1/305 ,  A61K9/00 ,  A61K9/127 ,  A61K31/00

    CPC classification number: A61K31/00 ,  A23L33/175 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/127 ,  A61K9/1277 ,  A23V2250/606 ,  A23V2250/264 ,  A23V2250/5432 ,  A23V2250/5054 ,  A23V2250/306 ,  A23V2250/5118 ,  A23V2250/628 ,  A23V2250/026 ,  A23V2250/0644 ,  A23V2250/712 ,  A23V2250/061 ,  A23V2250/6406

    Abstract: A transmucosal delivery system for oral delivery of one or more biologically active agent associated with an artificial membrane vesicle (AMV), such as a liposome, is provided. The system is especially suited for the delivery of biologically active agents with poor solubility, that are easily degraded in the gastrointestinal tract or that tend to have an unpleasant taste and mouth feel. The delivery system comprises a two-phase system whereby one or more AMV-associated biologically active agents are substantially uniformly dispersed in a semi-solid matrix that allows for maintenance of bioactivity. The dual phase system may further comprise one or more non-AMV associated biologically active agents incorporated within the matrix. Methods of preparing the delivery system and methods of use for delivering biologically active agents to animals, including humans, are also provided.

    Abstract translation: 提供了用于口服递送与人造膜囊泡（AMV）如脂质体相关的一种或多种生物活性剂的经粘膜递送系统。 该系统特别适合于递送具有较差溶解性的生物活性剂，其易于在胃肠道中降解或倾向于具有不愉快的口感和口感。 递送系统包括两相系统，其中一个或多个与AMV相关的生物活性剂基本均匀地分散在允许维持生物活性的半固体基质中。 双相系统可以进一步包含并入基质内的一种或多种非AMV相关的生物活性剂。 还提供了制备递送系统的方法和用于将生物活性剂递送到包括人类的动物的方法。

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