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公开(公告)号：WO2003088755A1
公开(公告)日：2003-10-30
申请号：PCT/CA2003/000411
申请日：2003-03-25
Applicant: VITALSTATE CANADA LTD. , FARBER, Michael , FARBER, Jonathan
Inventor： FARBER, Michael , FARBER, Jonathan
IPC: A23G3/00
CPC classification number: A23G3/36 , A23G3/0021 , A23G3/0051 , A23G3/0068 , A23G3/0242 , A23G3/362 , A23G3/366 , A23G3/368 , A23G3/40 , A23G3/42 , A23G3/44 , A23G3/48 , A23L33/10 , A23L33/17 , A23L33/175 , A23P10/30 , A23V2002/00 , A23V2250/5072 , A23V2250/5432 , A23V2250/1866 , A23V2250/5062 , A23V2250/2108 , A23V2250/264 , A23V2250/606 , A23V2200/224 , A23V2250/6406 , A23V2250/1872 , A23V2250/6416 , A23V2250/61 , A23V2250/306 , A23V2250/1842 , A23V2250/1586 , A23V2250/5118 , A23V2250/5054 , A23V2250/0606 , A23V2250/21
Abstract: The present invention provides oral delivery systems for functional ingredients, such as drugs, nutritional supplements, botanicals, and vitamins. The delivery systems comprise an ingestible matrix within which the functional ingredient(s) are substantially uniformly and completely dispersed and in which degradation of the functional ingredient(s) is minimised. The matrix comprises 1) one or more carbohydrate; 2) one or more sugar, sugar syrup and/or sugar alcohol; 3) one or more hydrocolloid; 4) one or more polyhydric alcohol; 5) one or more source of mono- or divalent cations, and 5) water. The combination of carbohydrate and hydrocolloid in the matrix ensures that the delivery system readily retains the solvent component and thereby prevents separation of the solvent from other components of the matrix. The invention also provides methods of preparing and using the delivery systems.
Abstract translation: 本发明提供功能成分的口服递送系统，例如药物，营养补充剂，植物药和维生素。 递送系统包括可摄取的基质，其中功能成分基本均匀且完全分散，功能成分的降解最小化。 基质包括1）一种或多种碳水化合物; 2）一种或多种糖，糖浆和/或糖醇; 3）一种或多种水胶体; 4）一种或多种多元醇; 5）一种或多种单价或二价阳离子源，以及5）水。 基质中碳水化合物和水胶体的组合确保了输送系统容易地保留溶剂组分，从而防止溶剂与基质的其它组分分离。 本发明还提供了制备和使用递送系统的方法。
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公开(公告)号：WO2004009053A3
公开(公告)日：2004-01-29
申请号：PCT/CA2003/001034
申请日：2003-07-18
Applicant: VITALSTATE CANADA LTD. , FARBER, Michael , FARBER, Jonathan
Inventor： FARBER, Michael , FARBER, Jonathan
IPC: A61K9/127
Abstract: A transmucosal delivery system for oral delivery of one or more biologically active agent associated with an artificial membrane vesicle (AMV), such as a liposome, is provided. The system is especially suited for the delivery of biologically active agents with poor solubility, that are easily degraded in the gastrointestinal tract or that tend to have an unpleasant taste and mouth feel. The delivery system comprises a two-phase system whereby one or more AMV-associated biologically active agents are substantially uniformly dispersed in a semi-solid matrix that allows for maintenance of bioactivity. The dual phase system may further comprise one or more non-AMV associated biologically active agents incorporated within the matrix. Methods of preparing the delivery system and methods of use for delivering biologically active agents to animals, including humans, are also provided.
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公开(公告)号：WO2004009053A2
公开(公告)日：2004-01-29
申请号：PCT/CA0301034
申请日：2003-07-18
Applicant: VITALSTATE CANADA LTD , FARBER MICHAEL , FARBER JONATHAN
Inventor： FARBER MICHAEL , FARBER JONATHAN
CPC classification number: A61K31/00 , A23L33/175 , A23P10/30 , A23V2002/00 , A61K9/0056 , A61K9/127 , A61K9/1277 , A23V2250/606 , A23V2250/264 , A23V2250/5432 , A23V2250/5054 , A23V2250/306 , A23V2250/5118 , A23V2250/628 , A23V2250/026 , A23V2250/0644 , A23V2250/712 , A23V2250/061 , A23V2250/6406
Abstract: A transmucosal delivery system for oral delivery of one or more biologically active agent associated with an artificial membrane vesicle (AMV), such as a liposome, is provided. The system is especially suited for the delivery of biologically active agents with poor solubility, that are easily degraded in the gastrointestinal tract or that tend to have an unpleasant taste and mouth feel. The delivery system comprises a two-phase system whereby one or more AMV-associated biologically active agents are substantially uniformly dispersed in a semi-solid matrix that allows for maintenance of bioactivity. The dual phase system may further comprise one or more non-AMV associated biologically active agents incorporated within the matrix. Methods of preparing the delivery system and methods of use for delivering biologically active agents to animals, including humans, are also provided.
Abstract translation: 提供了用于口服递送与人造膜囊泡（AMV）如脂质体相关的一种或多种生物活性剂的经粘膜递送系统。 该系统特别适合于递送具有较差溶解性的生物活性剂，其易于在胃肠道中降解或倾向于具有不愉快的口感和口感。 递送系统包括两相系统，其中一个或多个与AMV相关的生物活性剂基本均匀地分散在允许维持生物活性的半固体基质中。 双相系统可以进一步包含并入基质内的一种或多种非AMV相关的生物活性剂。 还提供了制备递送系统的方法和用于将生物活性剂递送到包括人类的动物的方法。
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公开(公告)号：WO2004014152A1
公开(公告)日：2004-02-19
申请号：PCT/CA2003/001206
申请日：2003-08-13
Applicant: VITALSTATE CANADA LTD. , FARBER, Jonathan , FARBER, Michael
Inventor： FARBER, Jonathan , FARBER, Michael
IPC: A23L1/29
CPC classification number: A23G3/36 , A23G3/54 , A23K50/40 , A23L33/10 , A23L33/40 , A23P10/30 , A23P30/25 , A23V2002/00 , A61K9/0056 , A23V2250/5118 , A23V2250/5432 , A23V2250/5072 , A23V2250/6406 , A23V2200/224 , A23V2250/5054 , A23V2250/306 , A23V2250/026 , A23V2250/0644
Abstract: A multi-phase delivery system that provides for the oral delivery of one or more biologically active agents, methods for the production of the delivery system and uses thereof for the delivery of biologically active agents to animals, as food supplements and as meal replacements are provided. The delivery system comprises at least two phases, one of which is a semi-solid matrix phase having at least one bioactive agents substantially uniformly dispersed therein.
Abstract translation: 提供了一种多阶段递送系统，其提供一种或多种生物活性剂的口服递送，用于生产递送系统的方法及其用于将生物活性剂递送至动物，作为食物补充剂和作为膳食替代物的用途 。 递送系统包括至少两个相，其中之一是具有基本均匀分散在其中的至少一种生物活性剂的半固体基质相。
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