公开(公告)号：WO2003056296A3

公开(公告)日：2003-07-10

申请号：PCT/US2002/028163

申请日：2002-08-30

Applicant: KLAKAMP Scott, L. ,  MYSZKA, David, G.

Inventor： KLAKAMP Scott, L. ,  MYSZKA, David, G.

IPC: G01N557

Abstract: The present invention relates generally to methods for screening a plurality of ligands using a biosensor device. More particularly, the present invention relates to methods for screening a plurality of antibodies from complex solutions using a surface plasmon resonance device. The methods of this invention provide kinetic and equilibrium information for such screening assays. The present invention also relates to systems for determining kinetic rate constants for such screening assays.

公开(公告)号：WO2003056296A2

公开(公告)日：2003-07-10

申请号：PCT/US2002/028163

申请日：2002-08-30

Applicant: KLAKAMP Scott, L. ,  MYSZKA, David, G.

Inventor： MYSZKA, David, G.

IPC: G01N

CPC classification number: G01N33/54373 ,  G01N33/557

Abstract: The present invention relates generally to methods for screening a plurality of ligands using a biosensor device. More particularly, the present invention relates to methods for screening a plurality of antibodies from complex solutions using a surface plasmon resonance device. The methods of this invention provide kinetic and equilibrium information for such screening assays. The present invention also relates to systems for determining kinetic rate constants for such screening assays.

Abstract translation: 本发明一般涉及使用生物传感器装置筛选多个配体的方法。 更具体地说，本发明涉及使用表面等离子体共振装置从复合溶液中筛选多种抗体的方法。 本发明的方法为这种筛选测定提供了动力学和平衡信息。 本发明还涉及用于确定这种筛选测定的动力学速率常数的系统。

公开(公告)号：WO1995024221A1

公开(公告)日：1995-09-14

申请号：PCT/US1995003045

申请日：1995-03-07

Applicant: THE DOW CHEMICAL COMPANY ,  DENDRITECH INCORPORATED ,  REGENTS OF THE UNIVERSITY OF MICHIGAN ,  TOMALIA, Donald, A. ,  BAKER, James, R. ,  BIELINSKA, Anna, U. ,  BROTHERS, Herbert, M., II ,  CHENG, Roberta, C. ,  FAZIO, Michael, J. ,  HEDSTRAND, David, M. ,  JOHNSON, Jennifer, A. ,  KAPLAN, Donald, A. ,  KLAKAMP, Scott, L. ,  KRUPER, William, J., Jr ,  KUKOWSKA-LATALLO, Jolanta ,  MAXON, Bartley, D. ,  PIEHLER, Lars, T. ,  TOMLINSON, Ian, A. ,  WILSON, Larry, R. ,  YIN, Rui

Inventor： THE DOW CHEMICAL COMPANY ,  DENDRITECH INCORPORATED ,  REGENTS OF THE UNIVERSITY OF MICHIGAN

IPC: A61K47/48

CPC classification number: A01N25/10 ,  A61K47/59 ,  A61K47/595 ,  A61K47/61 ,  A61K47/6949 ,  A61K49/085 ,  A61K49/124 ,  B82Y5/00 ,  C07C211/29 ,  C07C233/11 ,  C07C237/20 ,  C08G83/003 ,  C08L101/005 ,  C12N15/87 ,  Y10S424/16

Abstract: Dendritic polymer conjugates which are composed of at least one dendrimer in association with at least one unit of a carried material, where the carrier material can be a biological response modifier, have been prepared. The conjugate can also have a target director present, and when it is present, then the carried material may be a bioactive agent. Preferred dendritic polymers are dense starr polymers, which have been complexed with biological response modifiers. These conjugates and complexes have particularly advantageous properties due to their unique characteristics.

Abstract translation: 已经制备了由载体材料可以是生物反应调节剂的至少一种携带材料的至少一个单元组成的树枝状聚合物共轭物。 缀合物还可以具有存在的靶向导体，并且当存在时，载体材料可以是生物活性剂。 优选的树枝状聚合物是与生物反应调节剂复合的致密星形聚合物。 这些共轭物和复合物由于其独特的特性而具有特别有利的性质。

公开(公告)号：WO2006081139A3

公开(公告)日：2007-02-15

申请号：PCT/US2006002011

申请日：2006-01-19

Applicant: ABGENIX INC ,  GREEN LARRY ,  FAGGIONI RAFFAELLA ,  FOORD ORIT ,  KLAKAMP SCOTT L ,  SENALDI GIORGIO ,  SCHNEIDER AMY K

Inventor： GREEN LARRY ,  FAGGIONI RAFFAELLA ,  FOORD ORIT ,  KLAKAMP SCOTT L ,  SENALDI GIORGIO ,  SCHNEIDER AMY K

IPC: C07K16/00 ,  A61K39/00 ,  A61K39/395

CPC classification number: C07K16/245 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S424/801 ,  Y10S530/867

Abstract: Antibodies directed to the antigen IL-1ß and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen IL-1ß are discussed. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are described.

Abstract translation: 描述了针对抗原IL-1β的抗体和这种抗体的用途。 特别地，讨论了针对抗原IL-1β的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 描述了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：WO2005012479A3

公开(公告)日：2006-10-12

申请号：PCT/US2004020564

申请日：2004-06-25

Applicant: ABGENIX INC ,  WEBER RICHARD ,  FENG XIAO ,  FOORD ORIT ,  GREEN LARRY ,  GUDAS JEAN ,  KEYT BRUCE ,  LIU YING ,  RATHANASWAMI PALANI ,  RAYA ROBERT ,  YANG XIAO DONG ,  CORVALAN JOSE ,  FOLTZ IAN ,  JIA XIAO-CHI ,  KANG JASPAL ,  KING CHADWICK T ,  KLAKAMP SCOTT L ,  SU QIAOJUAN JANE

Inventor： WEBER RICHARD ,  FENG XIAO ,  FOORD ORIT ,  GREEN LARRY ,  GUDAS JEAN ,  KEYT BRUCE ,  LIU YING ,  RATHANASWAMI PALANI ,  RAYA ROBERT ,  YANG XIAO DONG ,  CORVALAN JOSE ,  FOLTZ IAN ,  JIA XIAO-CHI ,  KANG JASPAL ,  KING CHADWICK T ,  KLAKAMP SCOTT L ,  SU QIAOJUAN JANE

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/44 ,  A61K47/48 ,  C07H21/04 ,  C07K14/71 ,  C07K16/22 ,  C07K16/42 ,  C07K17/00 ,  C12N20060101 ,  C12N5/06 ,  C12N5/12 ,  C12P21/08 ,  G01N33/53 ,  G01N33/552 ,  G01N33/577

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract translation: 本发明涉及新型抗体，特别是针对表皮生长因子受体的缺失突变体的抗体，特别涉及III型缺失突变体EGFRvIII的抗体。 本发明还涉及针对表皮生长因子受体，特别是EGFRvIII的缺失突变体的人单克隆抗体。 还提供了这种抗体的诊断和治疗制剂及其免疫偶联物。

公开(公告)号：WO2005010151A3

公开(公告)日：2005-02-03

申请号：PCT/US2004/020295

申请日：2004-06-25

Applicant: ABGENIX, INC ,  WEBER, Richard ,  FENG, Xiao ,  FOORD, Orit ,  GREEN, Larry ,  GUDAS, Jean ,  KEYT, Bruce ,  LIU, Ying ,  RATHANASWAMI, Palani ,  RAYA, Robert ,  YANG, Xiao, Dong ,  CORVALAN, Jose ,  FOLTZ, Ian ,  JIA, Xiao-Chi ,  KANG, Jaspal ,  KING, Chadwick, T. ,  KLAKAMP, Scott, L. ,  SU, Qiaojuan, Jane

Inventor： WEBER, Richard ,  FENG, Xiao ,  FOORD, Orit ,  GREEN, Larry ,  GUDAS, Jean ,  KEYT, Bruce ,  LIU, Ying ,  RATHANASWAMI, Palani ,  RAYA, Robert ,  YANG, Xiao, Dong ,  CORVALAN, Jose ,  FOLTZ, Ian ,  JIA, Xiao-Chi ,  KANG, Jaspal ,  KING, Chadwick, T. ,  KLAKAMP, Scott, L. ,  SU, Qiaojuan, Jane

IPC: A61K39/395

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

公开(公告)号：WO2006081139A2

公开(公告)日：2006-08-03

申请号：PCT/US2006/002011

申请日：2006-01-19

Applicant: ABGENIX, INC. ,  GREEN, Larry ,  FAGGIONI, Raffaella ,  FOORD, Orit ,  KLAKAMP, Scott, L. ,  SENALDI, Giorgio ,  SCHNEIDER, Amy, K.

Inventor： GREEN, Larry ,  FAGGIONI, Raffaella ,  FOORD, Orit ,  KLAKAMP, Scott, L. ,  SENALDI, Giorgio ,  SCHNEIDER, Amy, K.

IPC: A61K39/395

CPC classification number: C07K16/245 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S424/801 ,  Y10S530/867

Abstract: Antibodies directed to the antigen IL-1β and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen IL-1β are discussed. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are described.

Abstract translation: 描述针对抗原IL-1β的抗体和这种抗体的用途。 特别地，讨论了针对抗原IL-1β的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 描述了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：WO2005012479A2

公开(公告)日：2005-02-10

申请号：PCT/US2004/020564

申请日：2004-06-25

Applicant: ABGENIX, INC ,  WEBER, Richard ,  FENG, Xiao ,  FOORD, Orit ,  GREEN, Larry ,  GUDAS, Jean ,  KEYT, Bruce ,  LIU, Ying ,  RATHANASWAMI, Palani ,  RAYA, Robert ,  YANG, Xiao, Dong ,  CORVALAN, Jose ,  FOLTZ, Ian ,  JIA, Xiao-Chi ,  KANG, Jaspal ,  KING, Chadwick, T. ,  KLAKAMP, Scott, L. ,  SU, Qiaojuan, Jane

Inventor： WEBER, Richard ,  FENG, Xiao ,  FOORD, Orit ,  GREEN, Larry ,  GUDAS, Jean ,  KEYT, Bruce ,  LIU, Ying ,  RATHANASWAMI, Palani ,  RAYA, Robert ,  YANG, Xiao, Dong ,  CORVALAN, Jose ,  FOLTZ, Ian ,  JIA, Xiao-Chi ,  KANG, Jaspal ,  KING, Chadwick, T. ,  KLAKAMP, Scott, L. ,  SU, Qiaojuan, Jane

IPC: C12N

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract translation: 本发明涉及新型抗体，特别是针对表皮生长因子受体缺失突变体的抗体，特别是涉及III型缺失突变体EGFRvIII的抗体。 本发明还涉及针对表皮生长因子受体缺失突变体特别是EGFRvIII的人单克隆抗体。 还提供了此类抗体的诊断和治疗制剂及其免疫偶联物。

公开(公告)号：WO2005010151A2

公开(公告)日：2005-02-03

申请号：PCT/US2004020295

申请日：2004-06-25

Applicant: ABGENIX INC ,  WEBER RICHARD ,  FENG XIAO ,  FOORD ORIT ,  GREEN LARRY ,  GUDAS JEAN ,  KEYT BRUCE ,  LIU YING ,  RATHANASWAMI PALANI ,  RAYA ROBERT ,  YANG XIAO DONG ,  CORVALAN JOSE ,  FOLTZ IAN ,  JIA XIAO-CHI ,  KANG JASPAL ,  KING CHADWICK T ,  KLAKAMP SCOTT L ,  SU QIAOJUAN JANE

Inventor： WEBER RICHARD ,  FENG XIAO ,  FOORD ORIT ,  GREEN LARRY ,  GUDAS JEAN ,  KEYT BRUCE ,  LIU YING ,  RATHANASWAMI PALANI ,  RAYA ROBERT ,  YANG XIAO DONG ,  CORVALAN JOSE ,  FOLTZ IAN ,  JIA XIAO-CHI ,  KANG JASPAL ,  KING CHADWICK T ,  KLAKAMP SCOTT L ,  SU QIAOJUAN JANE

IPC: A61K39/395 ,  A61K47/48 ,  C07K16/22 ,  C07K16/28 ,  C07K17/00 ,  C12N20060101 ,  C12N5/06 ,  G01N33/53 ,  C12N

CPC classification number: C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract translation: 本发明涉及新型抗体，特别是针对表皮生长因子受体缺失突变体的抗体，特别是涉及III型缺失突变体EGFRvIII的抗体。 本发明还涉及针对表皮生长因子受体缺失突变体特别是EGFRvIII的人单克隆抗体。 还提供了此类抗体的诊断和治疗制剂及其免疫缀合物。

公开(公告)号：WO03056296A8

公开(公告)日：2003-08-21

申请号：PCT/US0228163

申请日：2002-08-30

Applicant: KLAKAMP SCOTT L ,  MYSZKA DAVID G

Inventor： KLAKAMP SCOTT L ,  MYSZKA DAVID G

IPC: G01N21/64 ,  C12Q1/68 ,  G01N21/27 ,  G01N33/15 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/557 ,  G01N33/566 ,  G06F19/00 ,  G01N

CPC classification number: G01N33/54373 ,  G01N33/557

Abstract: The present invention relates generally to methods for screening a plurality of ligands using a biosensor device. More particularly, the present invention relates to methods for screening a plurality of antibodies from complex solutions using a surface plasmon resonance device. The methods of this invention provide kinetic and equilibrium information for such screening assays. The present invention also relates to systems for determining kinetic rate constants for such screening assays.

Abstract translation: 本发明一般涉及使用生物传感器装置筛选多个配体的方法。 更具体地，本发明涉及使用表面等离子体共振装置从复合溶液中筛选多种抗体的方法。 本发明的方法提供了用于这种筛选测定的动力学和平衡信息。 本发明还涉及用于确定这种筛选测定的动力学速率常数的系统。