公开(公告)号：WO2006014270A2

公开(公告)日：2006-02-09

申请号：PCT/US2005/022968

申请日：2005-06-28

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  STEWART, Gordon ,  ZHANG, Gina ,  KIRSTEN, Nancy ,  CONSIGNY, Paul ,  DUGAN, Stephen ,  PARK, Gene ,  FEEZOR, Christopher ,  ROORDA, Wouter ,  HOSSAINY, Syed, F.A.

Inventor： STEWART, Gordon ,  ZHANG, Gina ,  KIRSTEN, Nancy ,  CONSIGNY, Paul ,  DUGAN, Stephen ,  PARK, Gene ,  FEEZOR, Christopher ,  ROORDA, Wouter ,  HOSSAINY, Syed, F.A.

IPC: A61K45/06

CPC classification number: A61K31/4745 ,  A61F2250/0067 ,  A61K31/573 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/606 ,  A61K2300/00

Abstract: Drug-delivery systems such as drug-delivery stents having an anti-proliferative agent such as everolimus and an anti-flammatory agent such as clobetasol are provided. Also, disclosed are methods of treating a vascular impairment such as restenosis or vulnerable plaque.

Abstract translation: 提供药物输送系统，例如具有抗增殖剂（例如依维莫司）和抗炎剂（例如氯倍他索）的药物输送支架。 还公开了治疗血管损伤如再狭窄或易损斑块的方法。

公开(公告)号：WO2005115493A2

公开(公告)日：2005-12-08

申请号：PCT/US2005/018579

申请日：2005-05-26

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  HOSSAINY, Syed, F.A. ,  TANG, Yiwen ,  GADA, Manish

Inventor： HOSSAINY, Syed, F.A. ,  TANG, Yiwen ,  GADA, Manish

IPC: A61L27/34

CPC classification number: A61F2/82 ,  A61F2/91 ,  A61F2210/0004 ,  A61F2240/001 ,  A61F2250/0067 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2420/02 ,  B29C71/02 ,  C08L67/04

Abstract: A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.

Abstract translation: 公开了一种制造可植入医疗装置的方法，例如药物洗脱支架。 该方法包括使包含聚合物的可植入医疗装置经受热条件。 加热条件可导致活性剂从植入装置之后的装置释放速率降低，和/或改善装置上的聚合物涂层的机械性能。

公开(公告)号：WO2005051453A1

公开(公告)日：2005-06-09

申请号：PCT/US2004/038135

申请日：2004-11-15

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  HOSSAINY, Syed, F.A. ,  TANG, Yiwen

Inventor： HOSSAINY, Syed, F.A. ,  TANG, Yiwen

IPC: A61L31/10

CPC classification number: A61L31/10 ,  C08L71/02 ,  C08L101/04 ,  C08L67/02

Abstract: Coatings for an implantable medical device and a method of fabricating the coatings are disclosed. The coatings comprise a fluorinated polymer and a biologically beneficial polymer, an example of which includes poly(ethylene-glycol)-block poly (butylene terephthalate)-block-poly(ethylene-glycol). A biologically active agent can be additionally conjugated to the biologically beneficial polymer.

Abstract translation: 公开了用于可植入医疗装置的涂层和制造涂层的方法。 涂层包括氟化聚合物和生物有益的聚合物，其实例包括聚（乙二醇） - 嵌段聚（对苯二甲酸丁二醇酯） - 嵌段 - 聚（乙二醇）。 生物活性剂可另外缀合到生物有益的聚合物上。

公开(公告)号：WO2009126590A3

公开(公告)日：2009-10-15

申请号：PCT/US2009/039691

申请日：2009-04-06

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  TROLLSAS, Mikael, O. ,  LIM, Florencia ,  HOSSAINY, Syed, F.a.

Inventor： TROLLSAS, Mikael, O. ,  LIM, Florencia ,  HOSSAINY, Syed, F.a.

IPC: A61L31/10

Abstract: Methods for fabricating coatings for implantable medical devices are disclosed. The method comprises forming a coating on an implantable device comprising an interpenetrating network or semi-interpenetrating network. The interpenetrating network or semi-interpenetrating network comprises poly(ethylene glycol) and an aliphatic polyester copolymer. It is also provided an implantable device and a method of using the implantable device.

公开(公告)号：WO2007021558A2

公开(公告)日：2007-02-22

申请号：PCT/US2006/030169

申请日：2006-08-01

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  CALLOL, Joe ,  HUANG, Bin ,  GALE, David C. ,  SRIDHARAN, Srinivasan ,  KLEINE, Klaus ,  HOSSAINY, Syed F.a. ,  LEE, Jeong ,  LIMON, Timothy ,  ABBATE, Anthony J.

Inventor： HUANG, Bin ,  GALE, David C. ,  SRIDHARAN, Srinivasan ,  KLEINE, Klaus ,  HOSSAINY, Syed F.a. ,  LEE, Jeong ,  LIMON, Timothy ,  ABBATE, Anthony J.

IPC: A61L31/12

CPC classification number: A61F2/915 ,  A61F2/04 ,  A61F2/06 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/072 ,  A61F2002/91508 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2210/0009 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2230/0013 ,  A61F2250/0098 ,  A61L31/129 ,  B23K26/402 ,  B23K26/50 ,  B23K2203/42 ,  B23K2203/50 ,  B29C43/02 ,  B29C45/0001 ,  B29C45/0005 ,  B29C45/0055 ,  B29C47/0004 ,  B29C47/0023 ,  B29C47/0026 ,  B29C47/0066 ,  B29C47/06 ,  B29C47/1045 ,  B29C53/566 ,  B29C53/583 ,  B29C59/02 ,  B29C59/021 ,  B29C2043/028 ,  B29K2101/00 ,  B29K2105/12 ,  B29K2267/043 ,  B29K2995/0056 ,  B29K2995/006 ,  B29L2023/003 ,  B29L2031/7546 ,  D03D3/02

Abstract: Polymeric composite stents reinforced with fibers for implantation into a bodily lumen are disclosed.

Abstract translation: 公开了用纤维增强的用于植入体腔的聚合复合支架。

公开(公告)号：WO2005110505A2

公开(公告)日：2005-11-24

申请号：PCT/US2005/014614

申请日：2005-04-27

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  HOSSAINY, Syed F.A. ,  MICHAL, Eugene ,  GLAUSER, Thierry ,  KWOK, Connie ,  PACETTI, Stephen, D.

Inventor： HOSSAINY, Syed F.A. ,  MICHAL, Eugene ,  GLAUSER, Thierry ,  KWOK, Connie ,  PACETTI, Stephen, D.

IPC: A61L27/00

CPC classification number: A61L31/10 ,  A61K31/727 ,  A61K31/728 ,  A61K31/785 ,  A61L31/16 ,  A61K2300/00 ,  C08L5/08 ,  C08L5/10

Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

Abstract translation: 提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。 可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管 梗阻，输尿管阻塞，肿瘤阻塞及其组合。

公开(公告)号：WO2009129503A3

公开(公告)日：2009-10-22

申请号：PCT/US2009/041031

申请日：2009-04-17

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  TROLLSAS, Mikael, O. ,  NGO, Michael, Huy ,  HOSSAINY, Syed, F.A. ,  SHERMAN, David, J.

Inventor： TROLLSAS, Mikael, O. ,  NGO, Michael, Huy ,  HOSSAINY, Syed, F.A. ,  SHERMAN, David, J.

IPC: A61L31/10 ,  A61L31/14 ,  A61L31/16

Abstract: The present invention provides a block copolymer for a coating on an implantable device for controlling release of drug and methods of making and using the same.

公开(公告)号：WO2009070211A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/012794

申请日：2008-11-14

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  HOSSAINY, Syed, F.A. ,  WAN, Jinping ,  DAVALIAN, Dariush ,  LUDWIG, Florian ,  MURASE, Katsuyuki

Inventor： HOSSAINY, Syed, F.A. ,  WAN, Jinping ,  DAVALIAN, Dariush ,  LUDWIG, Florian ,  MURASE, Katsuyuki

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/17 ,  A61K9/50

CPC classification number: A61K31/661 ,  A61K9/1647 ,  A61K9/5084 ,  A61K38/00

Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

Abstract translation: 一种方法，包括使递送装置通过血管腔推进到血管中的特定区域; 并且将包含缓释载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入血管的特定区域或血管周围部位的壁中，其中所述肽具有使肽有效反转的性质 胆固醇运输。 以适合递送到血管中的形式包含载脂蛋白AI（apo AI）合成肽或者apo AI合成模拟肽和酰基CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合物，所述肽包括氨基酸 序列的顺序与各种apo AI模拟肽或内源性apo AI类似物或内源性apo AI的螺旋1和螺旋9的嵌合体的顺序相反。

公开(公告)号：WO2009070209A2

公开(公告)日：2009-06-04

申请号：PCT/US2008/012767

申请日：2008-11-14

Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC. ,  MURASE, Katsuyuki ,  HOSSAINY, Syed, F.A. ,  ASTAFIEVA, Irina ,  ZHAO, Li ,  MA, Hong

Inventor： MURASE, Katsuyuki ,  HOSSAINY, Syed, F.A. ,  ASTAFIEVA, Irina ,  ZHAO, Li ,  MA, Hong

IPC: A61K9/14 ,  A61K9/16 ,  A61K38/17

CPC classification number: C07K7/08 ,  A61F2/95 ,  A61K9/1075 ,  A61K9/127 ,  A61K38/00 ,  A61L29/16 ,  A61L2300/25 ,  A61L2300/802 ,  A61M25/1011 ,  A61M2025/0086 ,  A61M2025/105 ,  A61M2025/1075 ,  C07K7/06 ,  C07K14/775

Abstract: A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region or a perivascular site, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (apo A-I) synthetic peptide, or combination of an apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various apo A-I mimetic peptides, or endogenous apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous apo A-I.

Abstract translation: 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白AI（apo AI）合成模拟肽的组合物引入所述特定区域或血管周围部位的血管壁中，其中所述肽具有使所述肽有效反转的性质 胆固醇运输。 包含载体载脂蛋白AI（apo AI）合成肽或apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与各种apo AI模拟肽或内源性载脂蛋白AI类似物的顺序相反的顺序，或内源性apo AI的螺旋1和螺旋9的嵌合体。

公开(公告)号：WO2005092406A1

公开(公告)日：2005-10-06

申请号：PCT/US2005/008844

申请日：2005-03-17

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC. ,  GLAUSER, Thierry ,  PACETTI, Stephen, D. ,  HOSSAINY, Syed, F.A. ,  DING, Ni

Inventor： GLAUSER, Thierry ,  PACETTI, Stephen, D. ,  HOSSAINY, Syed, F.A. ,  DING, Ni

IPC: A61L31/10

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L31/148 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/08 ,  A61L2300/40 ,  A61L2300/42 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/18 ,  C08L33/14

Abstract: ABSTRACT A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

Abstract translation: 摘要一种包含磷脂部分和生物相容性聚合物骨架的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置，例如包含聚合物和任选的生物活性剂的涂层，其包含该涂层，以及使用该装置的方法 用于治疗人类疾病。