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1.发明申请AN EFFICIENT MICROBIAL PREPARATION OF CAPRAVIRINE METABOLITES M4 AND M5 审中-公开CAPRAVIRINE代谢物M4和M5的有效微生物制备
公开(公告)号：WO2005016912A1
公开(公告)日：2005-02-24
申请号：PCT/IB2004/002589
申请日：2004-08-09
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： The present invention provides a method for producing metabolites of capravirine (2-carbamoyloxymethyl-5-(3,5-dichlorophenyl)thio-4-isopropyl-1-(4-pyridyl)methyl-1H-imidazole) via whole cell biotransformation using fungi and bacterial cells as oxygenation catalysts.
摘要翻译： 本发明提供了通过使用真菌的全细胞生物转化来生产卡拉维林（2-氨基甲酰氧基甲基-5-（3,5-二氯苯基）硫代-4-异丙基-1-（4-吡啶基）甲基-1H-咪唑）的代谢物的方法 和细菌细胞作为氧合催化剂。
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公开(公告)号：WO2009019561A2
公开(公告)日：2009-02-12
申请号：PCT/IB2008/002016
申请日：2008-07-23
申请人： PFIZER PRODUCTS INC. , BAUER, David, William , HU, Shanghui , O'NEILL, Padraig, Mary , WATSON, Timothy, James, Norman
IPC分类号： C12P17/10 , C12P7/62 , C12P13/00 , C07D405/06 , C07D209/48 , C07D319/08
CPC分类号： C07D405/06 , C07D209/48 , C07D319/08 , C12P7/62 , C12P13/001 , C12P13/02 , C12P17/10
摘要： The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.
摘要翻译： 本发明涉及用于制备手性化合物的2-脱氧核糖-5-磷酸醛缩酶（DERA）化学酶法。
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公开(公告)号：WO2006000904A2
公开(公告)日：2006-01-05
申请号：PCT/IB2005/001924
申请日：2005-06-09
申请人： WARNER-LAMBERT COMPANY LLC , HU, Shanghui , MARTINEZ, Carlos, Alberto , TAO, Junhua , TULLY, William, Eugene , KELLEHER, Patrick, Gerard, Thomas , DUMOND, Yves, Rene
发明人： HU, Shanghui , MARTINEZ, Carlos, Alberto , TAO, Junhua , TULLY, William, Eugene , KELLEHER, Patrick, Gerard, Thomas , DUMOND, Yves, Rene
IPC分类号： C07C277/00
CPC分类号： C12P13/02 , C07C227/06 , C07C227/20 , C07C227/22 , C07C229/24 , C07C255/19 , C07D207/277 , C12P7/42 , C12P13/001 , C12P13/002 , C07C229/08
摘要： Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
摘要翻译： 公开了通过酶促动力学拆分制备（S） - （+） - 3-氨基甲基-5-甲基 - 己酸和结构相关化合物的材料和方法。
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公开(公告)号：WO2005054186A2
公开(公告)日：2005-06-16
申请号：PCT/IB2004003812
申请日：2004-11-22
IPC分类号： C07C269/06 , C07C269/08 , C07C271/22 , C07D207/16 , C07D207/24 , C07D277/18 , C07D417/02 , C12P13/04 , C12P13/24 , C12P17/10 , C12P17/14 , C12P41/00 , C07D207/00
CPC分类号： C07C269/06 , C07C269/08 , C07D207/16 , C12P13/04 , C12P13/24 , C12P17/10 , C12P17/14 , C12P41/005 , C07C271/22
摘要： The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R is hydrogen, comprising treating a compound of formula (I), wherein R is chosen from C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkenyl,-(CR R )t(C6-C14 aryl), and -(CR R )t(4-10 membered heterocyclic), and wherein said C6-C14 aryl and 4-10 membered heterocyclic are optionally substituted with at least one substituent chosen from halo, C1-C10 alkyl, -OR , and -N(R R ), with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein at least one stereoisomer is selectively hydrolyzed.
摘要翻译： 本发明涉及制备立体异构体富集的式（I）化合物的方法，其中R 6是氢，包括处理式（I）化合物，其中R 6选自C 1 -C 10烷基，C 2 -C 10烯基，C 2 -C 10烯基， - （CR 7 R 8）t（C 6 -C 14芳基）和 - （CR 7 R 8）t（4-10元杂环），和 其中所述C 6 -C 14芳基和4-10元杂环任选被至少一个选自卤素，C 1 -C 10烷基，-OR 7和-N（R 7 R 8）的取代基取代，与 在水溶液中的生物催化剂，有机溶剂或有机和水性溶剂的混合物，其中至少一种立体异构体被选择性水解。
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公开(公告)号：WO2009019561A3
公开(公告)日：2009-05-14
申请号：PCT/IB2008002016
申请日：2008-07-23
申请人： PFIZER PROD INC , BAUER DAVID WILLIAM , HU SHANGHUI , O'NEILL PADRAIG MARY , WATSON TIMOTHY JAMES NORMAN
IPC分类号： C12P17/10 , C07D209/48 , C07D319/08 , C07D405/06 , C12P7/62 , C12P13/00
CPC分类号： C07D405/06 , C07D209/48 , C07D319/08 , C12P7/62 , C12P13/001 , C12P13/02 , C12P17/10
摘要： The present invention is directed to a 2-deoxyribose-5-phosphate aldolase (DERA) chemoenzymatic process for making chiral compounds.
摘要翻译： 本发明涉及制备手性化合物的2-脱氧核糖-5-磷酸醛缩酶（DERA）化学酶法。
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6.发明申请PROCESS FOR PRODUCING ATORVASTATIN, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND INTERMEDIATES THEREOF 审中-公开生产ATORVASTATIN的方法，其药学上可接受的盐及其中间体
公开(公告)号：WO2006134482A8
公开(公告)日：2008-03-06
申请号：PCT/IB2006001613
申请日：2006-06-06
申请人： PFIZER , HU SHANGHUI , TAO JUNHUA , XIE ZHIYI
发明人： HU SHANGHUI , TAO JUNHUA , XIE ZHIYI
IPC分类号： C12P17/10
CPC分类号： C12P17/10
摘要： A novel process for producing atrovastatin, pharmaceutically acceptable salts thereof, and intermediates thereof using an aldolase is described. Compounds so prepared are useful as inhibitors of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agents.
摘要翻译： 描述了使用醛缩酶制备阿伐他汀，其药学上可接受的盐及其中间体的新方法。 如此制备的化合物可用作HMG-CoA还原酶的抑制剂，因此可用作降血脂药和降血胆固醇药。
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7.发明申请PROCESS FOR PRODUCING ATORVASTATIN, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AND INTERMEDIATES THEREOF 审中-公开生产ATORVASTATIN的方法，其药学上可接受的盐及其中间体
公开(公告)号：WO2006134482A1
公开(公告)日：2006-12-21
申请号：PCT/IB2006/001613
申请日：2006-06-06
申请人： PFIZER INC. , HU, Shanghui , TAO, Junhua , XIE, Zhiyi
发明人： HU, Shanghui , TAO, Junhua , XIE, Zhiyi
IPC分类号： C12P17/10
CPC分类号： C12P17/10
摘要： A novel process for producing atrovastatin, pharmaceutically acceptable salts thereof, and intermediates thereof using an aldolase is described. Compounds so prepared are useful as inhibitors of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agents.
摘要翻译： 描述了使用醛缩酶制备阿托伐他汀，其药学上可接受的盐及其中间体的新方法。 如此制备的化合物可用作HMG-CoA还原酶的抑制剂，因此可用作降血脂药和低胆固醇血症药。
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公开(公告)号：WO2006000904A3
公开(公告)日：2006-04-27
申请号：PCT/IB2005001924
申请日：2005-06-09
申请人： WARNER LAMBERT CO , HU SHANGHUI , MARTINEZ CARLOS ALBERTO , TAO JUNHUA , TULLY WILLIAM EUGENE , KELLEHER PATRICK GERARD THOMAS , DUMOND YVES RENE
发明人： HU SHANGHUI , MARTINEZ CARLOS ALBERTO , TAO JUNHUA , TULLY WILLIAM EUGENE , KELLEHER PATRICK GERARD THOMAS , DUMOND YVES RENE
IPC分类号： C07C253/30 , C07C227/18 , C07C227/22 , C07C229/08 , C07C255/03 , C07D207/04
CPC分类号： C12P13/02 , C07C227/06 , C07C227/20 , C07C227/22 , C07C229/24 , C07C255/19 , C07D207/277 , C12P7/42 , C12P13/001 , C12P13/002 , C07C229/08
摘要： Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.
摘要翻译： 公开了通过酶动力学拆分制备（S） - （+） - 3-氨基甲基-5-甲基 - 己酸和结构相关化合物的材料和方法。
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公开(公告)号：WO2005054186A3
公开(公告)日：2005-06-16
申请号：PCT/IB2004/003812
申请日：2004-11-22
IPC分类号： C07D207/16 , C07D207/24 , C07C271/22 , C12P13/24
摘要： The present invention relates to methods of preparing a stereoisomerically enriched compound of formula (I), wherein R 6 is hydrogen, comprising treating a compound of formula (I), wherein R 6 is chosen from C 1 -C 10 alkyl, C 2 -C 10 alkenyl, C 2 -C 10 alkenyl,-(CR 7 R 8 ) t (C 6 -C 14 aryl), and -(CR 7 R 8 ) t (4-10 membered heterocyclic), and wherein said C 6 -C 14 aryl and 4-10 membered heterocyclic are optionally substituted with at least one substituent chosen from halo, C 1 -C 10 alkyl, -OR 7 , and -N(R 7 R 8 ), with a biocatalyst in an aqueous solution, an organic solvent, or a mixture of organic and aqueous solvents wherein at least one stereoisomer is selectively hydrolyzed.
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