Abstract:
The present invention provides Danshensu derivatives containing a moiety of Chuanxiongqin (tetramethylpyrazine), and pharmaceutical compositions containing the Danshensu derivatives or their salts and pharmaceutically acceptable carriers. The invention also provides methods for preparing the Danshensu derivatives or their salts, and uses of the compositions in manufacture of medicaments for prevention and treatment of diseases or disorders including cardiovascular and cerebrovascular diseases and their complications.
Abstract:
Embodiments of the present disclosure provide for contrast agents, methods of making contrast agents, and methods of using contrast agents, and the like.
Abstract:
The present invention provides novel nitrones, their preparation and use. The novel compounds have the following formula: I The compounds of the present invention have strong antioxidative activity, and are thrombolytic. These compounds can be used to treat and/or prevent diseases caused by overproduction of free radicals and/or formation of thrombus.
Abstract:
Methods and apparatuses are provided for inhibiting articular cartilage mineralization in a subject comprising administering to articular cartilage of the subject an amount of a functional domain of parathyroid hormone- related peptide (PTHrP). In addition, methods and apparatuses for preventing or treating osteoarthritis in a subject comprising administering to articular cartilage of the subject a prophylactically or therapeutically effective amount of a functional domain of parathyroid hormone- related peptide (PTHrP), respectively, are provided. Also, methods and apparatuses for promoting articular cartilage repair in a subject comprising comprising administering to articular cartilage of the subject an effective amount functional domain of parathyroid hormone-related peptide (PTHrP) are provided. Further, methods for diminishing damaging effects of physical activity on a joint in a subject comprising administering to articular cartilage of the subject an amount of a functional domain of parathyroid hormone-related peptide (PTHrP) are provided.
Abstract:
One embodiment in accordance with the invention is a method that includes detecting a failure in a ring network and transmitting a multicast message across the ring network that includes information regarding the failure. Additionally, a new ring master of the ring network is designated. Furthermore, a ring port coupled to the failure is blocked.
Abstract:
This invention pertains to materials and methods relating to the biological fixation of one tissue type to another different tissue type, i.e., the fixation of cartilage to bone. A scaffold apparatus for osteochondral tissue engineering is described. The apparatus comprises regions of varying matrices which provide a functional interface between multiple tissue types. Further, a method for preparing the scaffold apparatus is provided. Methods for treating osteochondral tissue injury and cartilage degeneration using the scaffold apparatus are also described. In addition, a method for evaluating cellmediated and scaffold-related parameters of development and maintenance of multiple tissue zones in vitro is described.
Abstract:
Embodiments of the present disclosure provide for contrast agents, methods of making contrast agents, and methods of using contrast agents, and the like.
Abstract:
A fiber optic sensor is provided. The fiber optic sensor includes a fiber core having a plurality of Bragg grating elements wherein, the grating elements comprise a periodic or a quasiperiodic modulated microcrystalline and rigid silicon dioxide tetrahedral structure and a cladding disposed about the fiber core.
Abstract:
A point of sale (POS) device (400) includes a primary display (102) to illustrate content in a first direction, and a secondary display (104) to reflect a first content illustrated from a first section of the primary display (102), wherein the first content is reflected in a second direction opposite to the first direction.
Abstract:
A method of making a pump housing that is net-molded and immediately assumes its final shape and design specification without requiring more than de minimis secondary machining processes. The method utilizes molds and cores configured such that none of the fluid ports of the housing produced using the molds and cores have any intersecting geometry.