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1.发明申请
公开(公告)号：WO2020181129A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/021253
申请日：2020-03-05
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , FULLER, Carl, W. , KUMAR, Shiv , KALACHIKOV, Sergey , LI, Xiaoxu , MOROZOVA, Irina , RUSSO, James , JOCKUSCH, Steffen
Inventor： JU, Jingyue , FULLER, Carl, W. , KUMAR, Shiv , KALACHIKOV, Sergey , LI, Xiaoxu , MOROZOVA, Irina , RUSSO, James , JOCKUSCH, Steffen
IPC: G01N33/487 , C12Q1/6869 , C12Q1/6874 , C12N9/12 , C12M1/34 , C12P19/34 , C07H21/04
Abstract: Disclosed herein are highly accurate approaches for single molecule electronic nanopore-based SBS.
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公开(公告)号：WO2019178393A1
公开(公告)日：2019-09-19
申请号：PCT/US2019/022326
申请日：2019-03-14
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
Inventor： JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
IPC: A61K31/70 , A61K31/7042 , A61K31/7052 , C07H19/04 , C07H21/00 , C07H21/04
Abstract: The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.
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3.发明申请DNA SEQUENCING BY SYNTHESIS USING MODIFIED NUCLEOTIDES AND NANOPORE DETECTION 审中-公开通过使用修饰的核苷酸和纳米RNA检测合成DNA
公开(公告)号：WO2012083249A2
公开(公告)日：2012-06-21
申请号：PCT/US2011065640
申请日：2011-12-16
Applicant: UNIV COLUMBIA , JU JINGYUE , KUMAR SHIV , LI ZENGMIN , TAO CHUANJUAN , CHIEN MINCHEN , RUSSO JAMES J , KALACHIKOV SERGEY , SHEPARD KEN , ROSENSTEIN JACOB KARL
Inventor： JU JINGYUE , KUMAR SHIV , LI ZENGMIN , TAO CHUANJUAN , CHIEN MINCHEN , RUSSO JAMES J , KALACHIKOV SERGEY , SHEPARD KEN , ROSENSTEIN JACOB KARL
CPC classification number: C12Q1/6869 , C07H19/10 , C07H21/00 , G01N33/48721 , C12Q2525/113 , C12Q2525/117 , C12Q2565/518 , C12Q2565/631
Abstract: This disclosure is related to a method of sequencing a single- stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.
Abstract translation: 本公开涉及使用脱氧核苷酸多磷酸酯类似物测序单链DNA的方法和通过纳米孔从掺入的脱氧核苷酸多磷酸酯类似物转移标签的方法。
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公开(公告)号：WO2020023405A1
公开(公告)日：2020-01-30
申请号：PCT/US2019/042864
申请日：2019-07-22
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , RUSSO, James, J. , KALACHIKOV, Sergey , TAO, Chuanjuan , KUMAR, Shiv , MOROZOVA, Irina , LI, Xiaoxu
Inventor： JU, Jingyue , RUSSO, James, J. , KALACHIKOV, Sergey , TAO, Chuanjuan , KUMAR, Shiv , MOROZOVA, Irina , LI, Xiaoxu
IPC: B82B3/00 , B82Y5/00 , C12Q1/68 , C12Q1/6869 , G01N27/00 , G01N27/26 , C12Q1/6804 , G01N33/48721 , G01N33/6872
Abstract: The present application discloses novel and inventive methods, apparatuses, and the required molecules to detect compounds (analytes) utilizing antibodies or other protein-binding molecules and nanopore- detectable tags using specially designed nanopores, coupled with ionic current readout, to provide a single molecule electronic detection solution, offering unique opportunities for multiplexing and quantitation.
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5.发明申请
公开(公告)号：WO2016154215A1
公开(公告)日：2016-09-29
申请号：PCT/US2016/023607
申请日：2016-03-22
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , CHO, Youngjin , KUMAR, Shiv , KALACHIKOV, Sergey , TAO, Chuanjuan , CHIEN, Minchen , RUSSO, James, J.
Inventor： JU, Jingyue , CHO, Youngjin , KUMAR, Shiv , KALACHIKOV, Sergey , TAO, Chuanjuan , CHIEN, Minchen , RUSSO, James, J.
IPC: C12Q1/68 , G01N15/00 , G01N33/487
CPC classification number: C12Q1/6827 , C12Q1/6869 , C12Q2565/301 , C12Q2565/401 , C12Q2565/631 , G01N33/48721 , C12Q2563/113 , C12Q2565/607 , C12Q2527/127 , C12Q2563/137
Abstract: This invention provides methods of using labeled nucleotide polyphosphate analogues to detect the identity or presence of a nucleotide at certain positions in nucleic acid sequences with single molecule sensitivity using nanopore detection, nucleotides and primer- conjugated nanopore proteins for use in such methods, and processes for producing such nucleotides and primer-conjugated nanopore proteins.
Abstract translation: 本发明提供了使用标记的核苷酸多磷酸酯类似物来检测使用纳米孔检测的单分子敏感性的核酸序列的某些位置的核苷酸的同一性或存在，用于此类方法的核苷酸和引物结合的纳米孔蛋白的方法， 产生这样的核苷酸和引物缀合的纳米孔蛋白。
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Patent Agency Ranking
公开(公告)号：WO2016144973A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/021396
申请日：2016-03-08
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , LI, Zengmin , KALACHIKOV, Sergey , JU, Jingyue , FULLER, Carl, W.
Inventor： LI, Zengmin , KALACHIKOV, Sergey , JU, Jingyue , FULLER, Carl, W.
IPC: A61K47/48 , C07D237/26 , C07D403/04
CPC classification number: C12Q1/6874 , A61K47/545 , A61K47/62 , A61K47/6889 , A61K47/69 , C07K14/31 , C12N9/1252 , C12N9/96 , C12Y207/07007
Abstract: The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore- forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods.
Abstract translation: 本公开涉及基于用于将成孔蛋白（例如α-溶血素）与生物分子（例如抗体，受体和酶如DNA聚合酶）共轭的快速有效的化学反应的组合物和方法，以及 在纳米孔装置和方法中使用这种造孔蛋白缀合物。
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公开(公告)号：WO2014144898A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/029495
申请日：2014-03-14
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , KUMAR, Shiv , TAO, Chuanjuan , KALACHIKOV, Sergey , RUSSO, James, J.
Inventor： JU, Jingyue , KUMAR, Shiv , TAO, Chuanjuan , KALACHIKOV, Sergey , RUSSO, James, J.
IPC: C12Q1/00
CPC classification number: G01N33/6818 , C08G65/48 , G01N33/48721
Abstract: This invention provides methods for detecting the presence of a plurality of predetermined compounds in a sample using a plurality of tag moieties and at least one nanopore. This invention also provides methods for determining the quantity of each of a plurality of predetermined compounds in a sample using a plurality of tag moieties and at least one nanopore. This invention further provides methods for detecting interaction of at least two predetermined compounds using at least one tag moiety and at least one nanopore.
Abstract translation: 本发明提供了使用多个标签部分和至少一个纳米孔检测样品中多个预定化合物的存在的方法。 本发明还提供了使用多个标签部分和至少一个纳米孔来确定样品中多个预定化合物中的每一个的量的方法。 本发明还提供了使用至少一个标签部分和至少一个纳米孔检测至少两种预定化合物的相互作用的方法。
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公开(公告)号：WO2021007458A1
公开(公告)日：2021-01-14
申请号：PCT/US2020/041455
申请日：2020-07-09
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , KUMAR, Shiv , RUSSO, James , LI, Xiaoxu , CHEN, Xin , CHIEN, Minchen , JOCKUSCH, Steffen , WANG, Xuanting , MOROZOVA, Irina , TAO, Chuanjuan , KALACHIKOV, Sergey , SHI, Shundi
Inventor： JU, Jingyue , KUMAR, Shiv , RUSSO, James , LI, Xiaoxu , CHEN, Xin , CHIEN, Minchen , JOCKUSCH, Steffen , WANG, Xuanting , MOROZOVA, Irina , TAO, Chuanjuan , KALACHIKOV, Sergey , SHI, Shundi
IPC: C07H21/00 , C12Q1/6823 , C12Q1/6869
Abstract: The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.
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公开(公告)号：WO2019178393A9
公开(公告)日：2019-09-19
申请号：PCT/US2019/022326
申请日：2019-03-14
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
Inventor： JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
IPC: A61K31/70 , A61K31/7042 , A61K31/7052 , C07H19/04 , C07H21/00 , C07H21/04
Abstract: The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.
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10.发明申请DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开基于合成的DNA顺序连接反应型核苷酸的设计与合成
公开(公告)号：WO2017058953A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/054236
申请日：2016-09-28
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , LI, Xiaoxu , CHEN, Xin , LI, Zengmin , KUMAR, Shiv , SHI, Shundi , GUO, Cheng , REN, Jianyi , HSIEH, Min-Kang , CHIEN, Minchen , TAO, Chuanjuan , ERTURK, Ece , KALACHIKOV, Sergey , RUSSO, James, J.
Inventor： JU, Jingyue , LI, Xiaoxu , CHEN, Xin , LI, Zengmin , KUMAR, Shiv , SHI, Shundi , GUO, Cheng , REN, Jianyi , HSIEH, Min-Kang , CHIEN, Minchen , TAO, Chuanjuan , ERTURK, Ece , KALACHIKOV, Sergey , RUSSO, James, J.
CPC classification number: C07H19/14 , C07H19/10 , C12Q1/6869 , C12Q2525/117 , C12Q2563/107
Abstract: Disclosed herein, inter alia , are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
Abstract translation: 本文公开了在核酸测序中的化合物，组合物及其使用方法。
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