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公开(公告)号：WO2013154999A3
公开(公告)日：2014-11-20
申请号：PCT/US2013035635
申请日：2013-04-08
Applicant: UNIV COLUMBIA , US GOVERNMENT , JU JINGYUE , KUMAR SHIV , TAO CHUANJUAN , CHIEN MINCHEN , RUSSO JAMES J , KASIANOWICZ JOHN J , ROBERTSON JOSEPH W F
Inventor： JU JINGYUE , KUMAR SHIV , TAO CHUANJUAN , CHIEN MINCHEN , RUSSO JAMES J , KASIANOWICZ JOHN J , ROBERTSON JOSEPH W F
IPC: C12Q1/42
CPC classification number: C12Q1/6883 , B82Y5/00 , C07H19/06 , C07H19/16 , C12Q1/42 , C12Q1/48 , C12Q1/6869 , C12Q2600/158 , G01N33/48721 , G01N2333/9125 , C12Q2565/631 , C12Q2521/525 , C12Q2521/543 , C12Q2535/107
Abstract: This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.
Abstract translation: 本公开提供了使用核苷酸类似物对核酸进行测序的系统和方法，以及通过纳米孔从掺入的核苷酸类似物转移标签。 在一些方面，本公开涉及使用标签分子对核酸测序的组合物，方法和系统，以及通过从分子掺入释放的标记的纳米孔的易位检测。
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公开(公告)号：WO2014144883A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/029477
申请日：2014-03-14
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , KUMAR, Shiv , PALLA, Mirko , RUSSO, James, J.
Inventor： JU, Jingyue , KUMAR, Shiv , PALLA, Mirko , RUSSO, James, J.
CPC classification number: C12Q1/6869 , C12Q1/6874 , G01N21/65 , G01N21/658 , C12Q2535/122 , C12Q2561/113 , C12Q2565/632
Abstract: This invention provides nucleoside polyphosphate analogs each of which comprises a tag comprising a plurality of Raman-scattering moieties; compounds comprising said nucleoside polyphosphate analogs; and methods for determining the sequence of a single- stranded DNA or RNA using said nucleoside polyphosphate analogs. This invention also provides methods for detecting the interaction of a plurality of predetermined compounds, at least one of which having attached thereto a tag comprising a plurality of Raman- scattering moieties.
Abstract translation: 本发明提供核苷多磷酸酯类似物，其各自包含包含多个拉曼散射部分的标签; 包含所述核苷多磷酸酯类似物的化合物; 以及使用所述核苷多磷酸酯类似物测定单链DNA或RNA的序列的方法。 本发明还提供了用于检测多个预定化合物的相互作用的方法，其中至少一个化合物与其附着有包含多个拉曼散射部分的标签。
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公开(公告)号：WO2021155119A2
公开(公告)日：2021-08-05
申请号：PCT/US2021/015672
申请日：2021-01-29
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , JOCKUSCH, Steffen , TAO, Chuanjuan , CHIEN, Minchen , RUSSO, James J. , KUMAR, Shiv , LI, Xiaoxu , WANG, Xuanting
Inventor： JU, Jingyue , JOCKUSCH, Steffen , TAO, Chuanjuan , CHIEN, Minchen , RUSSO, James J. , KUMAR, Shiv , LI, Xiaoxu , WANG, Xuanting
IPC: A61K39/12 , A61K39/215 , A61K45/06 , A61K31/4025 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/439 , A61K31/454 , A61K31/47 , A61K31/513 , A61K31/5365 , A61K31/675 , A61K31/683 , A61K31/7072 , A61P31/12 , A61P31/14 , A61P31/16
Abstract: This invention relates to the use of nucleoside, nucleotide and other compounds which are inhibitors or terminators of viral RNA dependent RNA polymerases or inhibitors of exonucleases as antiviral agents. These antiviral agents can be used alone or in combination with other polymerase or exonuclease inhibitors, helicase inhibitors, HCV NS5A inhibitors, HIV integrase inhibitors and HCV NS3-4A and other protease inhibitors to treat viral infections such as SARS-CoV-2, the causative agent of the COVID-19 infection.
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公开(公告)号：WO2019178393A1
公开(公告)日：2019-09-19
申请号：PCT/US2019/022326
申请日：2019-03-14
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
Inventor： JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
IPC: A61K31/70 , A61K31/7042 , A61K31/7052 , C07H19/04 , C07H21/00 , C07H21/04
Abstract: The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.
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公开(公告)号：WO2016100864A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066771
申请日：2015-12-18
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , BESTOR, Timothy, H. , JU, Jingyue , LI, Xiaoxu , RUSSO, James, J.
Inventor： BESTOR, Timothy, H. , JU, Jingyue , LI, Xiaoxu , RUSSO, James, J.
IPC: C07H19/167
CPC classification number: C07H19/16 , C07H19/167 , C12N9/1007 , C12P19/34 , C12Q1/6806 , C12Q1/6827 , C12Q1/6874 , C12Y201/01 , C12Q2535/101 , C12Q2535/122 , C12Q2563/101 , C12Q2565/631 , C12Q2563/167 , C12Q2563/107
Abstract: The present invention provides a method of determining whether cytosine residues present at a predetermined positions within a singl strand of a double stranded DNA of known sequence are methylated as well as compounds for carrying out this method. The present invention also provides a process of producing a derivative of a double-stranded DNA comprising contacting the double-stranded DNA with a CpG methyltransferase and an S-adenosylmethionine analog.
Abstract translation: 本发明提供了确定存在于已知序列的双链DNA的单链中的预定位置处的胞嘧啶残基是否被甲基化的方法以及用于实施该方法的化合物。 本发明还提供了制备双链DNA衍生物的方法，包括使双链DNA与CpG甲基转移酶和S-腺苷甲硫氨酸类似物接触。
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Patent Agency Ranking
公开(公告)号：WO2013154999A2
公开(公告)日：2013-10-17
申请号：PCT/US2013/035635
申请日：2013-04-08
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF COMMERCE , JU, Jingyue , KUMAR, Shiv , TAO, Chuanjuan , CHIEN, Minchen , RUSSO, James, J. , KASIANOWICZ, John, J. , ROBERTSON, Joseph, W.F.
Inventor： JU, Jingyue , KUMAR, Shiv , TAO, Chuanjuan , CHIEN, Minchen , RUSSO, James, J. , KASIANOWICZ, John, J. , ROBERTSON, Joseph, W.F.
IPC: C12Q1/42
CPC classification number: C12Q1/6883 , B82Y5/00 , C07H19/06 , C07H19/16 , C12Q1/42 , C12Q1/48 , C12Q1/6869 , C12Q2600/158 , G01N33/48721 , G01N2333/9125 , C12Q2521/525 , C12Q2521/543 , C12Q2535/107 , C12Q2565/631
Abstract: This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.
Abstract translation: 本公开提供了使用核苷酸类似物对核酸进行测序的系统和方法，以及通过纳米孔从掺入的核苷酸类似物转移标签。 在一些方面，本公开涉及使用标签分子对核酸进行测序的组合物，方法和系统，以及通过从分子掺入释放的标记的纳米孔的易位检测。
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7.发明申请DNA SEQUENCING BY SYNTHESIS USING MODIFIED NUCLEOTIDES AND NANOPORE DETECTION 审中-公开通过使用修饰的核苷酸和纳米RNA检测合成DNA
公开(公告)号：WO2012083249A2
公开(公告)日：2012-06-21
申请号：PCT/US2011065640
申请日：2011-12-16
Applicant: UNIV COLUMBIA , JU JINGYUE , KUMAR SHIV , LI ZENGMIN , TAO CHUANJUAN , CHIEN MINCHEN , RUSSO JAMES J , KALACHIKOV SERGEY , SHEPARD KEN , ROSENSTEIN JACOB KARL
Inventor： JU JINGYUE , KUMAR SHIV , LI ZENGMIN , TAO CHUANJUAN , CHIEN MINCHEN , RUSSO JAMES J , KALACHIKOV SERGEY , SHEPARD KEN , ROSENSTEIN JACOB KARL
CPC classification number: C12Q1/6869 , C07H19/10 , C07H21/00 , G01N33/48721 , C12Q2525/113 , C12Q2525/117 , C12Q2565/518 , C12Q2565/631
Abstract: This disclosure is related to a method of sequencing a single- stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.
Abstract translation: 本公开涉及使用脱氧核苷酸多磷酸酯类似物测序单链DNA的方法和通过纳米孔从掺入的脱氧核苷酸多磷酸酯类似物转移标签的方法。
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公开(公告)号：WO2022140655A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/065050
申请日：2021-12-23
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , KUMAR, Shiv , RUSSO, James, J. , TAO, Chuanjuan , JOCKUSCH, Steffen , LI, Xiaoxu
Inventor： JU, Jingyue , KUMAR, Shiv , RUSSO, James, J. , TAO, Chuanjuan , JOCKUSCH, Steffen , LI, Xiaoxu
IPC: C07K16/18 , G01N33/487 , G01N33/68 , A61K39/12
Abstract: This invention provides methods for detecting viruses, viral antigens, viral antibodies, and other antigens and antibodies using single molecule electronic nanopores and polymer tags.
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公开(公告)号：WO2019178393A9
公开(公告)日：2019-09-19
申请号：PCT/US2019/022326
申请日：2019-03-14
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
Inventor： JU, Jingyue , LI, Xiaoxu , KUMAR, Shiv , CHEN, Xin , RUSSO, James, J. , CHIEN, Minchen , JOCKUSCH, Steffen , TAO, Chuanjuan , WANG, Xuanting , KALACHIKOV, Sergey , MOROZOVA, Irina , SHI, Shundi
IPC: A61K31/70 , A61K31/7042 , A61K31/7052 , C07H19/04 , C07H21/00 , C07H21/04
Abstract: The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.
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10.发明申请DESIGN AND SYNTHESIS OF NOVEL DISULFIDE LINKER BASED NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS 审中-公开基于合成的DNA顺序连接反应型核苷酸的设计与合成
公开(公告)号：WO2017058953A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/054236
申请日：2016-09-28
Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , JU, Jingyue , LI, Xiaoxu , CHEN, Xin , LI, Zengmin , KUMAR, Shiv , SHI, Shundi , GUO, Cheng , REN, Jianyi , HSIEH, Min-Kang , CHIEN, Minchen , TAO, Chuanjuan , ERTURK, Ece , KALACHIKOV, Sergey , RUSSO, James, J.
Inventor： JU, Jingyue , LI, Xiaoxu , CHEN, Xin , LI, Zengmin , KUMAR, Shiv , SHI, Shundi , GUO, Cheng , REN, Jianyi , HSIEH, Min-Kang , CHIEN, Minchen , TAO, Chuanjuan , ERTURK, Ece , KALACHIKOV, Sergey , RUSSO, James, J.
CPC classification number: C07H19/14 , C07H19/10 , C12Q1/6869 , C12Q2525/117 , C12Q2563/107
Abstract: Disclosed herein, inter alia , are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
Abstract translation: 本文公开了在核酸测序中的化合物，组合物及其使用方法。
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