公开(公告)号：WO2012102551A2

公开(公告)日：2012-08-02

申请号：PCT/KR2012000606

申请日：2012-01-25

Applicant: UNIV KEIMYUNG IACF ,  LEE SAM PIN ,  SON SE JIN ,  JIN IK HUN

Inventor： LEE SAM PIN ,  SON SE JIN ,  JIN IK HUN

IPC: A23L11/00 ,  A23L7/10

CPC classification number: A23L11/07 ,  A23L7/107 ,  A23L29/284

Abstract: The present invention relates to a soybean product with increased rice content and a preparation method thereof, and more specifically, the invention: can be prepared in a non-compressed manner in which a rice solution processed into a starch-hydrololytic enzyme is mixed with a micronized full-fat soybean powder solution processed into gelatin; increases rice content by using enzymes; improves texture, and simplifies the manufacturing process; and enhances nutritional value and at the same time, improves material properties.

Abstract translation: 本发明涉及水稻含量增加的大豆产品及其制备方法，更具体地说，本发明可以非压缩方式制备，其中将加工成淀粉 - 水解酶的米溶液与 微粉化全脂大豆粉末溶液加工成明胶; 通过酶增加水稻含量; 改善纹理，简化制造工艺; 并提高营养价值，同时提高材料性能。

公开(公告)号：WO2012083105A1

公开(公告)日：2012-06-21

申请号：PCT/US2011/065334

申请日：2011-12-16

Applicant: COCRYSTAL DISCOVERY, INC. ,  LEE, Sam, Sk ,  SHEN, Wang ,  ZHENG, Xiaoliang ,  JACOBSON, Irina, C.

Inventor： LEE, Sam, Sk ,  SHEN, Wang ,  ZHENG, Xiaoliang ,  JACOBSON, Irina, C.

IPC: C07D277/00 ,  A01N43/78 ,  A61K31/425 ,  A01N43/40 ,  A61K31/44

CPC classification number: C07D401/04 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/519 ,  A61K31/7056 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides, among other things, compounds represented by the general Formula (I) and pharmaceutically acceptable salts thereof, wherein X, Y, R 1A , R 1B , R 2 , and R 3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.

Abstract translation: 本发明尤其提供由通式（I）表示的化合物及其药学上可接受的盐，其中X，Y，R 1A，R 1B，R 2和R 3如本文中的类别和亚类所定义，并且组合物（例如， 药物组合物），该化合物可用作丙型肝炎病毒聚合酶的抑制剂，因此可用作例如用于治疗HCV感染的药物。

公开(公告)号：WO2011028860A3

公开(公告)日：2011-07-21

申请号：PCT/US2010047615

申请日：2010-09-02

Applicant: CANTHERA THERAPEUTICS INC ,  FOLEY MICHAEL ANDREW ,  GOULD ROBERT ,  ELLIOT PETER ,  MANDINOVA ANNA ,  LEE SAM

Inventor： FOLEY MICHAEL ANDREW ,  GOULD ROBERT ,  ELLIOT PETER ,  MANDINOVA ANNA ,  LEE SAM

IPC: C07D413/12 ,  A61K31/5377 ,  A61P35/00 ,  C07D211/76

CPC classification number: C07D211/86 ,  A61K31/4412 ,  A61K31/5377

Abstract: The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.

Abstract translation: 本发明涉及用于治疗和预防癌症的化合物和组合物。 本发明还涵盖可以通过选择性调节患病细胞中的活性氧水平与正常细胞来治疗的所有疾病。 还公开了制备和施用这些组合物的方法。

公开(公告)号：WO2008156270A3

公开(公告)日：2008-12-24

申请号：PCT/KR2008/003385

申请日：2008-06-16

Applicant: BIONEER CORPORATION ,  PARK, Han-Oh ,  LEE, Jae-Don ,  LEE, Sam-Yong ,  JUNG, Eun-Jung

Inventor： PARK, Han-Oh ,  LEE, Jae-Don ,  LEE, Sam-Yong ,  JUNG, Eun-Jung

IPC: A61L27/28

Abstract: The present invention relates to a gold-plated stent and its preparation method. More specifically, it relates to a gold- plated stent that is coated with various chemical materials such as 2-aminoalkanethiol, epihalogenhydrin, and diamine compounds in a sequence and also oligonucleotide gold-plated stent, which is prepared by binding oligonucleotide, a biomaterial, to the gold- plated stent coated with said chemicals. The oligonucleotide gold-plated stent of the present invention has an advantages of raising the local concentration in injured parts and minimizing the toxicity overall the body, so it can be used for prevention of restenosis after angioplasty.

公开(公告)号：WO2005044873A1

公开(公告)日：2005-05-19

申请号：PCT/EP2004/012388

申请日：2004-11-03

Applicant: DEGUSSA AG ,  GRÜN, Michael ,  HEYNE, Klaus ,  MOLLENKOPF, Claudine ,  LEE, Sam ,  UHRHAMMER, Roger

Inventor： GRÜN, Michael ,  HEYNE, Klaus ,  MOLLENKOPF, Claudine ,  LEE, Sam ,  UHRHAMMER, Roger

IPC: C08F10/06

CPC classification number: C08F10/00 ,  C07C31/28 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F4/6548 ,  C08F4/6541 ,  C08F4/02 ,  C08F4/651 ,  C08F2500/12 ,  C08F2500/18 ,  C08F2500/24 ,  C08F210/16

Abstract: Spherical particles comprising magnesium alcoholate and having a poured cone height of less than 17 mm are prepared by reacting magnesium, an alcohol or a mixture of various alcohols and a halogen and/or an optionally organic halogen compound with one another at below the boiling point of the alcohols. The spherical particles are employed as a precursor for olefin polymerization catalysts.

Abstract translation: 通过镁，醇或各种醇和卤素和/或任选的有机卤素化合物的混合物使镁，醇或其混合物与低于沸点的沸点反应制备包含醇镁的球形颗粒， 醇。 球形颗粒用作烯烃聚合催化剂的前体。

公开(公告)号：WO2012030408A1

公开(公告)日：2012-03-08

申请号：PCT/US2011/025022

申请日：2011-02-16

Applicant: CANTHERA THERAPEUTICS, INC. ,  MASSACHUSETTS GENERAL HOSPITAL CORPORATION ,  FOLEY, Michael, Andrew ,  GOULD, Robert ,  ELLIOTT, Peter ,  MANDINOVA, Anna ,  LEE, Sam

Inventor： FOLEY, Michael, Andrew ,  GOULD, Robert ,  ELLIOTT, Peter ,  MANDINOVA, Anna ,  LEE, Sam

IPC: A01N43/40 ,  A01N43/42 ,  A61K31/44

CPC classification number: A61K31/4412 ,  A61K31/5377 ,  C07D211/86

Abstract: The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.

Abstract translation: 本发明涉及用于治疗和预防癌症的化合物和组合物。 本发明还涵盖可以通过选择性调节患病细胞中的活性氧水平与正常细胞来治疗的所有疾病。 还公开了制备和施用这些组合物的方法。

公开(公告)号：WO2010131916A3

公开(公告)日：2011-04-07

申请号：PCT/KR2010003039

申请日：2010-05-13

Applicant: BIONEER CORP ,  HAN BO RAM ,  PARK HAN OH ,  SHIN MI SIK ,  LEE SAM YOUNG

Inventor： HAN BO RAM ,  PARK HAN OH ,  SHIN MI SIK ,  LEE SAM YOUNG

IPC: C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C12N15/87

CPC classification number: A61K47/48215 ,  A61K9/1075 ,  A61K47/34 ,  A61K47/60 ,  B82Y5/00 ,  C07F7/0836 ,  C07H21/02 ,  C08G65/3356 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/30 ,  C12N2320/51 ,  Y10S977/773 ,  Y10S977/906

Abstract: The present invention relates to an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalentely bonding siRNA and a polymeric compound for improving the biostability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the biostability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relatively low concentration. Therefore, the conjugate can advantageously be used not only as an siRNA treatment tool for cancers and other infectious diseases, but also as a novel type siRNA delivery system.

Abstract translation: 本发明涉及siRNA-聚合物缀合物及其制备方法，更具体地说，涉及通过共价键合siRNA和用于提高siRNA生物稳定性的高分子化合物形成的杂合共轭体的制备方法， 杂交缀合物。 本发明的缀合物可以改善siRNA的生物稳定性，从而实现将治疗性siRNA有效地递送到细胞中，并且即使以较低浓度的小剂量也显示出siRNA的活性。 因此，缀合物不仅可以有效地用作癌症和其他感染性疾病的siRNA治疗工具，而且可以用作新型的siRNA递送系统。

公开(公告)号：WO2011028860A2

公开(公告)日：2011-03-10

申请号：PCT/US2010/047615

申请日：2010-09-02

Applicant: CANTHERA THERAPEUTICS, INC. ,  FOLEY, Michael, Andrew ,  GOULD, Robert ,  ELLIOT, Peter ,  MANDINOVA, Anna ,  LEE, Sam

Inventor： FOLEY, Michael, Andrew ,  GOULD, Robert ,  ELLIOT, Peter ,  MANDINOVA, Anna ,  LEE, Sam

IPC: C07D413/12 ,  C07D211/76 ,  A61K31/5377 ,  A61P35/00

CPC classification number: C07D211/86 ,  A61K31/4412 ,  A61K31/5377

Abstract: The invention relates to compounds and composition for the treatment and prevention of cancer. The invention also covers all diseases that may be treated by selective modulation of levels of reactive oxygen species in diseased cells versus normal cells. Methods for the preparation and administration of such compositions are also disclosed.

Abstract translation: 本发明涉及用于治疗和预防癌症的化合物和组合物。 本发明还包括可以通过选择性调节患病细胞与正常细胞中活性氧水平的水平来治疗的所有疾病。 还公开了用于制备和施用这种组合物的方法。

公开(公告)号：WO2009114126A1

公开(公告)日：2009-09-17

申请号：PCT/US2009/001521

申请日：2009-03-10

Applicant: THE GENERAL HOSPITAL CORPORATION ,  LEE, Sam, W. ,  MANDINOVA, Anna

Inventor： LEE, Sam, W. ,  MANDINOVA, Anna

IPC: A61K31/45 ,  C07D211/94 ,  A61P35/00

CPC classification number: A61K31/45 ,  A61K45/06 ,  C07D211/86 ,  A61K2300/00

Abstract: The invention provides methods for the treatment of cancer in a subject using piperlongumine and/or piperlongumine analogs.

Abstract translation: 本发明提供了使用哌龙肝素和/或哌龙子类似物治疗受试者的癌症的方法。

公开(公告)号：WO2008156270A2

公开(公告)日：2008-12-24

申请号：PCT/KR2008003385

申请日：2008-06-16

Applicant: BIONEER CORP ,  PARK HAN-OH ,  LEE JAE-DON ,  LEE SAM-YONG ,  JUNG EUN-JUNG

Inventor： PARK HAN-OH ,  LEE JAE-DON ,  LEE SAM-YONG ,  JUNG EUN-JUNG

IPC: A61L27/28

CPC classification number: A61L31/088 ,  A61L31/10 ,  A61L2400/18

Abstract: The present invention relates to a gold-plated stent and its preparation method. More specifically, it relates to a gold- plated stent that is coated with various chemical materials such as 2-aminoalkanethiol, epihalogenhydrin, and diamine compounds in a sequence and also oligonucleotide gold-plated stent, which is prepared by binding oligonucleotide, a biomaterial, to the gold- plated stent coated with said chemicals. The oligonucleotide gold-plated stent of the present invention has an advantages of raising the local concentration in injured parts and minimizing the toxicity overall the body, so it can be used for prevention of restenosis after angioplasty.

Abstract translation: 本发明涉及镀金支架及其制备方法。 更具体地说，涉及一种金相支架，其以序列方式涂覆有各种化学物质如2-氨基烷硫醇，表卤代醇和二胺化合物，还涉及寡核苷酸金镀支架，其通过结合寡核苷酸，生物材料， 到涂有所述化学品的镀金支架上。 本发明的寡核苷酸镀金支架具有提高受伤部位局部浓度，使体内毒性最小化的优点，因此可用于预防血管成形术后的再狭窄。