中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

51 records (took 0.037 seconds)

    BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS
    9.
    发明申请
    BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
    苯并噻唑和亚苄基唑类化合物作为激酶抑制剂有用

    公开(公告)号：WO2007016392A3

    公开(公告)日：2007-05-24

    申请号：PCT/US2006029520

    申请日：2006-07-28

    Applicant: SQUIBB BRISTOL MYERS CO ,  LIU CHUNJIAN ,  LEFTHERIS KATERINA ,  LIN JAMES

    Inventor： LIU CHUNJIAN ,  LEFTHERIS KATERINA ,  LIN JAMES

    IPC: C07D417/04 ,  A61K31/428 ,  C07D513/04

    CPC classification number: C07D513/04 ,  C07D417/04

    Abstract: A compound of Formula (I), or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is independently selected from: (a); (b); (c); or (d), further wherein R1, R2, R3, R4, R5, R6, R7, and W are as described herein. Also disclosed is a compound of Formula (II), or an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein each of G, X and Y are independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH; and B is independently selected from: (a); (b); (c); (d); or (e), further wherein R1, R2, R3, R4, R5, R8, R9 and Z are as described herein. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and Formula (II), and methods of treating conditions associated with the activity of p38 kinase.

    Abstract translation: 式（I）的化合物或其对映异构体，非对映异构体或其药学上可接受的盐，其中A独立地选自：（a）; （B）; （C）; 或（d），其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和W如本文所述。 还公开了式（II）的化合物或其对映异构体，非对映异构体或其药学上可接受的盐，其中G，X和Y各自独立地为CH或N，其中在每次出现时，G，X 或Y为N，G，X或Y中的两个为CH; 和B独立地选自：（a）; （B）; （C）; （D）; 或（e），其中R1，R2，R3，R4，R5，R8，R9和Z如本文所述。 还公开了含有式（I）和式（II）化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

    BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS
    10.
    发明申请
    BENZOTHIAZOLE AND AZABENZOTHIAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
    苯并噻唑和氰基苯并噻唑化合物可用作激酶抑制剂

    公开(公告)号：WO2007016392A2

    公开(公告)日：2007-02-08

    申请号：PCT/US2006/029520

    申请日：2006-07-28

    Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  LIU, Chunjian ,  LEFTHERIS, Katerina ,  LIN, James

    Inventor： LIU, Chunjian ,  LEFTHERIS, Katerina ,  LIN, James

    IPC: C07D417/04 ,  C07D513/04 ,  A61K31/428

    CPC classification number: C07D513/04 ,  C07D417/04

    Abstract: A compound of Formula (I), or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein A is independently selected from: (a); (b); (c); or (d), further wherein R1, R2, R3, R4, R5, R6, R7, and W are as described herein. Also disclosed is a compound of Formula (II), or an enantiomer, diastereomer, or a pharmaceutically-acceptable salt thereof, wherein each of G, X and Y are independently CH or N, wherein at each occurrence at least one of G, X or Y is N and the other two of G, X or Y are CH; and B is independently selected from: (a); (b); (c); (d); or (e), further wherein R1, R2, R3, R4, R5, R8, R9 and Z are as described herein. Also disclosed are pharmaceutical compositions containing compounds of Formula (I) and Formula (II), and methods of treating conditions associated with the activity of p38 kinase.

    Abstract translation: 式（I）的化合物或其对映异构体，非对映异构体或药学上可接受的盐，其中A独立地选自：（a）; （B）; （C）; 或（d）中，进一步地，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和W如本文所述。 还公开了式（II）的化合物或其对映异构体，非对映异构体或药学上可接受的盐，其中G，X和Y各自独立地为CH或N，其中在每次出现时，G，X 或者Y是N而G，X或Y中的另外两个是CH; 和B独立地选自：（a）; （B）; （C）; （d）; 或（e）中，进一步其中R 1，R 2，R 3，R 4，R 5，R 8，R 9和Z如本文所述。 还公开了含有式（I）和式（II）化合物的药物组合物，以及治疗与p38激酶活性相关的病症的方法。

Patent Agency Ranking