公开(公告)号：WO2003070320A1

公开(公告)日：2003-08-28

申请号：PCT/US2002/004474

申请日：2002-02-15

Applicant: SECOND SIGHT, LLC ,  GREENBERG, Robert, J. ,  MANN, Alfred, E. ,  LITTLE, James, S. ,  IHRIG, Karl-Heinz ,  MECH, Brian, V. ,  TALBOT, Neil, H. ,  ZHOU, Dao, Min

Inventor： GREENBERG, Robert, J. ,  MANN, Alfred, E. ,  LITTLE, James, S. ,  IHRIG, Karl-Heinz ,  MECH, Brian, V. ,  TALBOT, Neil, H. ,  ZHOU, Dao, Min

IPC: A61N1/08

CPC classification number: A61N1/0543

Abstract: The invention is a retinal electrode array assembly (28) having an array of electrodes on an array body (6) that has a generally oval shape and is curved such that it substantially conforms to the spherical curvature of the retina and methods of using the same that facilitate surgical implant procedures by providing the operating surgeon with visual references and grasping means with innovations that reduce actual and potential damage to the retina and the surrounding tissue.

Abstract translation: 本发明是一种视网膜电极阵列组件（28），其具有阵列体（6）上的电极阵列，该阵列体具有大致卵形的形状并且弯曲，使得其基本上符合视网膜的球形曲率以及使用该视网膜电极阵列组件的方法 通过为操作外科医生提供具有减少对视网膜和周围组织的实际和潜在损伤的创新的手段来提供手术植入程序。

公开(公告)号：WO2006116765A3

公开(公告)日：2006-11-02

申请号：PCT/US2006/016655

申请日：2006-04-28

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  GREENBERG, Robert Jay ,  TALBOT, Neil ,  NEYSMITH, Jordan ,  LITTLE, James S. ,  MECH, Brian, V. ,  HUMAYAN, Mark ,  GUVEN, Dilek ,  RIPLEY, Ann Marie de Merlier

Inventor： GREENBERG, Robert Jay ,  TALBOT, Neil ,  NEYSMITH, Jordan ,  LITTLE, James S. ,  MECH, Brian, V. ,  HUMAYAN, Mark ,  GUVEN, Dilek ,  RIPLEY, Ann Marie de Merlier

IPC: A61N1/05

Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

公开(公告)号：WO2009111570A1

公开(公告)日：2009-09-11

申请号：PCT/US2009/036042

申请日：2009-03-04

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  DOHENY EYE INSTITUTE ,  GREENBERG, Robert, J. ,  HUMAYUN, Mark, S. ,  LITTLE, James, S. ,  NEYSMITH, Jordan, M.

Inventor： GREENBERG, Robert, J. ,  HUMAYUN, Mark, S. ,  LITTLE, James, S. ,  NEYSMITH, Jordan, M.

IPC: A61N1/05

CPC classification number: A61N1/0543 ,  A61N1/0558 ,  H05K1/0281 ,  H05K1/118 ,  H05K1/141 ,  H05K1/189 ,  H05K3/284 ,  H05K3/321 ,  H05K2201/0162 ,  H05K2201/2009 ,  H05K2203/1327

Abstract: An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention multiple and selective attachment points are provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.

Abstract translation: 附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。 更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。 因此，有利的是在阵列场上获得相等的压力。 在本发明中，在电极阵列上提供多个选择性附着点，允许外科医生选择提供最佳电极组织接触的附着点。

公开(公告)号：WO2007149571A3

公开(公告)日：2008-06-26

申请号：PCT/US2007014618

申请日：2007-06-21

Applicant: SECOND SIGHT MEDICAL PROD INC ,  GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

Inventor： GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

IPC: A61N1/05

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/118 ,  H05K3/0014 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

Abstract translation: 本发明提供了一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层，并且所述金属跟踪至少一个开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层以三维形状热成形。 本发明进一步提供一种制造柔性电路电极阵列的方法，该方法包括沉积聚合物基层; 在所述聚合物基底层上沉积金属; 图案化所述金属以形成金属迹线; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个平头开口; 以及在模具中加热所述柔性电路电极阵列以在所述柔性电路电极阵列中形成三维形状。

公开(公告)号：WO2007149571A2

公开(公告)日：2007-12-27

申请号：PCT/US2007/014618

申请日：2007-06-21

Applicant: SECOND SIGHT MEDICAL PRODUCTS, INC. ,  GREENBERG, Robert, J. ,  TALBOT, Neil, Hamilton ,  NEYSMITH, Jordan ,  LITTLE, James, S. ,  MECH, Brian, V.

Inventor： GREENBERG, Robert, J. ,  TALBOT, Neil, Hamilton ,  NEYSMITH, Jordan ,  LITTLE, James, S. ,  MECH, Brian, V.

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/036 ,  H05K1/0393 ,  H05K1/118 ,  H05K3/0014 ,  H05K2201/05 ,  H05K2201/053 ,  H05K2201/09063 ,  H05K2201/09409 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

Abstract translation: 本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。 本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。

公开(公告)号：WO2006116765A2

公开(公告)日：2006-11-02

申请号：PCT/US2006016655

申请日：2006-04-28

Applicant: SECOND SIGHT MEDICAL PROD INC ,  GREENBERG ROBERT JAY ,  TALBOT NEIL ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V ,  HUMAYAN MARK ,  GUVEN DILEK ,  RIPLEY ANN MARIE DE MERLIER

Inventor： GREENBERG ROBERT JAY ,  TALBOT NEIL ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V ,  HUMAYAN MARK ,  GUVEN DILEK ,  RIPLEY ANN MARIE DE MERLIER

IPC: A61N1/05

CPC classification number: H05K3/0011 ,  A61N1/0541 ,  A61N1/0543 ,  A61N1/36036 ,  A61N1/36046 ,  Y10T29/49124

Abstract: Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

Abstract translation: 聚合物材料可用作神经刺激的电极阵列体。 它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。 通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。 由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。 此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。 通过将适量的热应用于完整的阵列，可以引起曲线。 对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。 此外，沿着边缘添加材料是有利的。 在柔性电路阵列中提供折叠或扭曲是更有利的。 可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

公开(公告)号：WO2009132296A1

公开(公告)日：2009-10-29

申请号：PCT/US2009/041701

申请日：2009-04-24

Applicant: SECOND SIGHT MEDICAL PRODUCTS ,  GREENBERG, Robert, J. ,  KHALDI, Mohamed ,  LITTLE, James, S. ,  NEYSMITH, Jordan, M. ,  TALBOT, Neil, Hamilton

Inventor： GREENBERG, Robert, J. ,  KHALDI, Mohamed ,  LITTLE, James, S. ,  NEYSMITH, Jordan, M. ,  TALBOT, Neil, Hamilton

IPC: A61N1/05 ,  A61N1/36

CPC classification number: A61N1/0543 ,  A61N1/36046

Abstract: The present invention is an electrode array for neural stimulation suitable to be attached to neural tissue such that the attachment point acts as a fulcrum like point and contact with an end of the array body presses the other end of the array body into the neural tissue to be stimulated. This invention is particularly useful in a retinal electrode array for a visual prosthesis. By curving an electrode portion of an array body to approximate but not exceed (never more tightly curved) the curvature of the retina and applying force to the array by external means at the fulcrum like point, approximately even pressure across all electrodes is achieved.

Abstract translation: 本发明是一种用于神经刺激的电极阵列，其适用于附着于神经组织，使得附着点作为支点，并且与阵列体的端部接触将阵列体的另一端压入神经组织， 被刺激。 本发明在用于视觉假体的视网膜电极阵列中特别有用。 通过将阵列体的电极部分弯曲成近似但不超过（从不更紧密地弯曲）视网膜的曲率并且通过外部装置在支点点处向阵列施加力，实现了跨所有电极的大致均匀的压力。

公开(公告)号：WO2007149571A9

公开(公告)日：2008-02-14

申请号：PCT/US2007014618

申请日：2007-06-21

Applicant: SECOND SIGHT MEDICAL PROD INC ,  GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

Inventor： GREENBERG ROBERT J ,  TALBOT NEIL HAMILTON ,  NEYSMITH JORDAN ,  LITTLE JAMES S ,  MECH BRIAN V

CPC classification number: A61N1/0543 ,  A61N1/36046 ,  H05K1/118 ,  H05K3/0014 ,  Y10T29/49002 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49156 ,  Y10T29/49158 ,  Y10T29/49174 ,  Y10T29/49176

Abstract: The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.

Abstract translation: 本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。 本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。