公开(公告)号：WO2017044789A1

公开(公告)日：2017-03-16

申请号：PCT/US2016/051010

申请日：2016-09-09

Applicant: MICELL TECHNOLOGIES, INC.

Inventor： CARLYLE, Wenda, C.

IPC: A61K9/16 ,  A61K31/00

CPC classification number: A61K9/1647 ,  A61K9/1676 ,  A61K31/00

Abstract: Drug delivery systems are disclosed which include a drug in dry powder form and a biodegradable or metabolizable carrier having an average particle size of less than about 1 mm for delivery of the drug to a particular location in the body and for providing for the timed elution of the drug at that location, preferably by exhibiting a linear drug elution profile for a sustained drug release period of at least 30 days. Methods for manufacturing these drug delivery systems are also disclosed.

Abstract translation: 公开了药物递送系统，其包括干粉形式的药物和平均粒度小于约1mm的可生物降解或代谢的载体，用于将药物递送至身体中的特定位置，并提供定时洗脱 该药物在该位置，优选通过显示持续药物释放期至少30天的线性药物洗脱曲线。 还公开了制备这些药物递送系统的方法。

公开(公告)号：WO2014165264A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/025017

申请日：2014-03-12

Applicant: MICELL TECHNOLOGIES, INC.

Inventor： MCCLAIN, James, B. ,  TAYLOR, Charles, Douglas ,  BURGERMEISTER, Robert, Steven

IPC: A61F2/00

CPC classification number: A61F2/86 ,  A61F2210/0004 ,  A61F2250/0035 ,  A61F2250/0067 ,  A61L31/06 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  C08L67/04

Abstract: A bioabsorbable biomedical implant is disclosed. The implant includes a tubular scaffold comprising a plurality of interconnected polymer struts. The interconnected polymer struts defines a plurality of deformable cells. The polymer struts have an average strut thickness of no more than about 120 μιη. Methods for making the bioabsorbable biomedical implant, including the methods for making the polymer materials for the tubular scaffold, are also disclosed.

Abstract translation: 公开了一种生物可吸收的生物医学植入物。 植入物包括包括多个互连的聚合物支柱的管状支架。 互连的聚合物支柱限定多个可变形单元。 聚合物支柱的平均支撑厚度不超过约120微米。 还公开了制备生物可吸收生物医学植入物的方法，包括制备用于管状支架的聚合物材料的方法。

公开(公告)号：WO2013059509A1

公开(公告)日：2013-04-25

申请号：PCT/US2012/060896

申请日：2012-10-18

Applicant: MICELL TECHNOLOGIES, INC.

Inventor： MCCLAIN, James, B. ,  TAYLOR, Charles, Douglas

IPC: A61M31/00

CPC classification number: A61L29/08 ,  A61B17/12136 ,  A61K31/436 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/62 ,  A61L2300/63 ,  A61M25/1002 ,  A61M2025/105 ,  A61M2025/1065 ,  A61M2025/1081 ,  A61M2210/12 ,  C08L67/04

Abstract: A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer layer. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer layer; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.

Abstract translation: 公开了将药剂释放到目标部位的医疗装置。 该医疗装置包括气囊和至少一部分气囊上的涂层。 药剂颗粒的每个颗粒至少部分地包封在聚合物层中。 该方法包括以下步骤：在球囊的至少一部分上提供包括球囊和涂层的装置，所述涂层包括药剂的颗粒，药剂的每个颗粒至少部分地包封在聚合物层 ; 定位设备以允许气球到达目标位置; 并使装置的气球膨胀。

公开(公告)号：WO2012092504A3

公开(公告)日：2012-07-05

申请号：PCT/US2011/067921

申请日：2011-12-29

Applicant: MICELL TECHNOLOGIES, INC. ,  MCCLAIN, James, B. ,  TAYLOR, Charles, Douglas ,  ZANI, Brett, G. ,  KIORPES, Timothy, Charles

Inventor： MCCLAIN, James, B. ,  TAYLOR, Charles, Douglas ,  ZANI, Brett, G. ,  KIORPES, Timothy, Charles

IPC: A61K9/14

Abstract: Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.

公开(公告)号：WO2011133655A1

公开(公告)日：2011-10-27

申请号：PCT/US2011/033225

申请日：2011-04-20

Applicant: MICELL TECHNOLOGIES, INC. ,  MCCLAIN, James, B. ,  BENVENUTO, Arthur, J.

Inventor： MCCLAIN, James, B. ,  BENVENUTO, Arthur, J.

IPC: A61F2/02

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L31/148 ,  A61L2300/30 ,  A61L2300/62 ,  A61L2420/02 ,  A61L2420/08 ,  C09D167/04

Abstract: Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.

Abstract translation: 本文提供了包括支架的装置; 以及所述支架上的包含聚合物和活性剂的涂层，其中所述活性剂包括细胞外基质和细胞外基质组分中的至少一种。 本文提供了制备包括支架和在所述支架上的涂层的装置的方法; 所述方法包括：提供支架; 并在所述支架上形成多个层; 其中所述涂层包含聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中所述活性剂的至少一部分包含细胞外基质和细胞外基质组分中的至少一种。

公开(公告)号：WO2010120552A3

公开(公告)日：2011-03-31

申请号：PCT/US2010029494

申请日：2010-03-31

Applicant: MICELL TECHNOLOGIES INC ,  TAYLOR DOUGLAS ,  MCCLAIN JAMES B

Inventor： TAYLOR DOUGLAS ,  MCCLAIN JAMES B

IPC: A61F2/82 ,  A61L27/04 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58

CPC classification number: A61L31/10 ,  A61F2/82 ,  A61F2210/0004 ,  A61F2250/0067 ,  A61L31/16 ,  C08L67/04

Abstract: Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

Abstract translation: 本文提供了一种涂覆的冠状动脉支架，包括：a。 支架; 湾 沉积在所述支架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

公开(公告)号：WO2008052000A3

公开(公告)日：2008-06-26

申请号：PCT/US2007082275

申请日：2007-10-23

Applicant: MICELL TECHNOLOGIES INC ,  MCCLAIN JAMES B ,  TAYLOR DOUG ,  DICKINSON ED ,  WORM STEVE

Inventor： MCCLAIN JAMES B ,  TAYLOR DOUG ,  DICKINSON ED ,  WORM STEVE

IPC: B05D1/04

CPC classification number: B05B5/0533 ,  A61L31/10 ,  B05B5/082 ,  B05B13/0207 ,  B05C13/025

Abstract: A stent holder for mounting and electrically charging a stent during coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. An assembly for supporting and electrically charging a stent during the coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A chamber for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A method for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles comprising inert polymers, pharmaceutical or biological agents is provided.

Abstract translation: 提供了一种支架保持器，用于在使用干颗粒涂覆支架期间安装和充电支架，所述颗粒包含惰性聚合物，药物或生物制剂。 提供了在使用干颗粒涂覆支架期间支撑和给支架充电的组件，所述颗粒包含惰性聚合物，药物或生物制剂。 提供了用于在支架周围产生电场并用于支撑，充电和暴露支架以干燥颗粒的腔室，所述颗粒包含惰性聚合物，药物或生物制剂。 提供了用于在支架周围产生电场并用于支撑，充电和暴露支架以干燥包含惰性聚合物，药物或生物制剂的颗粒的方法。

公开(公告)号：WO2007011708A3

公开(公告)日：2007-06-28

申请号：PCT/US2006027322

申请日：2006-07-14

Applicant: MICELL TECHNOLOGIES INC ,  TAYLOR DOUG ,  DAYOUNG JAMES ,  MCCLAIN JIM

Inventor： TAYLOR DOUG ,  DAYOUNG JAMES ,  MCCLAIN JIM

IPC: A61F2/06 ,  A61L27/00 ,  B05D7/22

CPC classification number: A61F2/86 ,  A61F2/07 ,  A61F2002/821 ,  A61F2240/002 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/216 ,  A61L2300/606 ,  A61L2420/08

Abstract: A coated coronary stent, comprising: a stainless steel sent framework coated with a primer layer of Parylene C; and a rapamycin-polyrner coating having substantially uniform thickness disposed on the stent framework, wherein the rapamycin-polymer coating comprises polybutyl methacrylate (PBMA), polyethylene-co-vinyl acetate (PEVA) and rapamycin, wherein substantially all of the rapamycin in the coating is in amorphous form and substantially uniformly dispersed within the rapamycin-polymer coating.

公开(公告)号：WO2005072095A2

公开(公告)日：2005-08-11

申请号：PCT/US2004/042001

申请日：2004-12-15

Applicant: MICELL TECHNOLOGIES, INC. ,  DEYOUNG, James, P. ,  MCCLAIN, James, B. ,  GROSS, Stephen, M. ,  TAYLOR, Doug ,  WAGNER, Mark, I. ,  BRAINARD, David

Inventor： DEYOUNG, James, P. ,  MCCLAIN, James, B. ,  GROSS, Stephen, M. ,  TAYLOR, Doug ,  WAGNER, Mark, I. ,  BRAINARD, David

IPC: H01L21/288 ,  H01L21/3205 ,  H01L21/4763 ,  H01L21/768 ,  H01L23/48 ,  H01L23/52 ,  H01L29/40

CPC classification number: H01L21/32051 ,  H01L21/283 ,  H01L21/288 ,  H01L21/76814 ,  H01L21/76843 ,  H01L21/76871

Abstract: A method of treating a dielectric surface portion of a semiconductor substrate, comprising the steps of: (a) providing a semiconductor substrate having a dielectric surface portion; and then (b) treating said dielectric surface portion with a coating reagent, the coating reagent comprising a reactive group coupled to a coordinating group, with the coordinating group having a metal bound thereto, so that the metal is deposited on the dielectric surface portion to produce a surface portion treated with a metal.

Abstract translation: 一种处理半导体衬底的电介质表面部分的方法，包括以下步骤：（a）提供具有电介质表面部分的半导体衬底; 然后（b）用涂层试剂处理所述电介质表面部分，所述涂覆试剂包含与配位基团偶联的反应基团，所述配位基团与其结合金属，使得金属沉积在电介质表面部分上 产生用金属处理的表面部分。

公开(公告)号：WO2004070776A2

公开(公告)日：2004-08-19

申请号：PCT/US2003/040155

申请日：2003-12-08

Applicant: MICELL TECHNOLOGIES, INC. ,  MCCLAIN, James, B. ,  DEYOUNG, James, P. ,  GROSS, Stephen, M. ,  WAGNER, Mark, I.

Inventor： MCCLAIN, James, B. ,  DEYOUNG, James, P. ,  GROSS, Stephen, M. ,  WAGNER, Mark, I.

IPC: H01L

CPC classification number: B08B7/0021 ,  B05D1/18 ,  B05D2401/90 ,  H01L21/02063 ,  H01L21/02101 ,  H01L21/67017 ,  H01L21/67028 ,  Y10T137/0324

Abstract: A method of displacing a supercritical fluid from a pressure vessel (e.g., in a microelectronic manufacturing process), comprises the steps of: providing an enclosed pressure vessel containing a first supercritical fluid (said supercritical fluid preferably comprising carbon dioxide); adding a second fluid (typically also a supercritical fluid) to said vessel, with said second fluid being added at a pressure greater than the pressure of the first supercritical fluid, and with said second fluid having a density less than that of the first supercritical fluid; forming an interface between the first supercritical fluid and the second fluid; and displacing at least a portion of the first supercritical fluid from the vessel with the pressure of the second, preferably fluid while maintaining the interface therebetween.

Abstract translation: 从压力容器（例如，微电子制造工艺）中移出超临界流体的方法包括以下步骤：提供包含第一超临界流体（所述超临界流体优选包含二氧化碳）的封闭压力容器; 向所述容器中加入第二流体（通常也是超临界流体），其中所述第二流体以大于第一超临界流体的压力的压力加入，并且所述第二流体的密度小于第一超临界流体的密度 ; 在所述第一超临界流体和所述第二流体之间形成界面; 并且使第二超临界流体的至少一部分与第二流体（优选流体）的压力从容器移位，同时保持其间的界面。