利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.015 秒)

    AMINOPYRIDINE DERIVATIVES AS SELECTIVE DOPAMINE D3 AGONISTS
    2.
    发明申请
    AMINOPYRIDINE DERIVATIVES AS SELECTIVE DOPAMINE D3 AGONISTS 审中-公开
    氨基吡啶衍生物作为选择性多巴胺D3激动剂

    公开(公告)号：WO2005115985A1

    公开(公告)日：2005-12-08

    申请号：PCT/IB2005/001554

    申请日：2005-05-17

    申请人： PFIZER LIMITED ,  PFIZER INC. ,  ALLERTON, Charlotte, Moira, Norfor ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  MILLER, Duncan, Charles

    发明人： ALLERTON, Charlotte, Moira, Norfor ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  MILLER, Duncan, Charles

    IPC分类号： C07D213/73

    CPC分类号： C07D213/73 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04

    摘要： The present invention provides for compounds of formula (I) which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

    摘要翻译： 本发明提供了作为一类多巴胺激动剂的式（I）化合物，更具体地，一类在D3上对D2有选择性的一类激动剂。 这些化合物可用于治疗和/或预防性功能障碍，例如女性性功能障碍（FSD），特别是女性性唤醒障碍（FSAD），性欲低下症（HSDD;对性不感兴趣），女性高潮 无效（FOD;无法达到性高潮）; 男性性功能障碍，特别是男性勃起功能障碍（MED）。 本文所提及的男性性功能障碍意在包括射精性疾病，例如早泄，无汗（无法达到性高潮）或期望障碍，如性欲低下症（HSDD;对性不感兴趣）。 这些化合物也可用于治疗神经精神障碍和神经变性疾病。

    MORPHOLINE DERIVATIVES FOR USE AS DOPAMINE AGONISTS IN THE TREATMENT OF I.A. SEXUAL DYSFUNCTION
    4.
    发明申请
    MORPHOLINE DERIVATIVES FOR USE AS DOPAMINE AGONISTS IN THE TREATMENT OF I.A. SEXUAL DYSFUNCTION 审中-公开
    用于多巴胺激动剂的多巴酚丁胺衍生物在治疗I.A. 性功能障碍

    公开(公告)号：WO2004052372A1

    公开(公告)日：2004-06-24

    申请号：PCT/IB2003/005683

    申请日：2003-12-02

    申请人： PFIZER LIMITED ,  PFIZER INC. ,  ALLERTON, Charlotte, Moria, Norfor ,  BAXTER, Andrew, Douglas ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  WONG, Stephen, Kwok-Fung

    发明人： ALLERTON, Charlotte, Moria, Norfor ,  BAXTER, Andrew, Douglas ,  COOK, Andrew, Simon ,  HEPWORTH, David ,  WONG, Stephen, Kwok-Fung

    IPC分类号： A61K31/5375

    CPC分类号： C07D265/30 ,  C07D413/04

    摘要： The present invention provides for compounds of formula (I), (la) and (lb) Wherein: A is selected from C-X and N, B is selected from C-Y and N, R 1 is selected from H and (C 1 -C 6 )alkyl R 2 is selected from H and (C 1 -C 6 )alkyl, X is selected from H, HO, C(O)NH 2 , NH 2 Y is selected from H HO,, NH 2 , Br, Cl and F Z is selected from H, HO, F, CONH2 and CN; And pharmaceutically acceptable salts, solvates and prodrugs thereof; With the provisos that: for a compound of formula (I), (la) or (lb), when A is C-X, B is C-Y, at least one of X, Y and Z must be OH; for a compound of formula (I), when A is C-X and B is C-Y, Y is H, Z is H, R 1 is H and R 2 is H, then X cannot be OH; these compounds are useful as dopamine agonists for the treatment of i.a. secual dysfunction.

    摘要翻译： 本发明提供式（I），（Ia）和（Ib）的化合物，其中A选自CX和N，B选自CY和N，R 1选自H和（C 1 -C 6 ）烷基R 2选自H和（C 1 -C 6）烷基，X选自H，HO，C（O）NH 2，NH 2 Y选自H，HO，NH 2，Br，Cl和FZ 来自H，HO，F，CONH 2和CN; 其药学上可接受的盐，溶剂合物和前药; 条件是：对于式（I），（Ia）或（Ib）的化合物，当A是C-X时，B是C-Y，X，Y和Z中的至少一个必须是OH; 对于式（I）化合物，当A为C-X且B为C-Y时，Y为H，Z为H，R 1为H且R 2为H，则X不能为OH; 这些化合物可用作治疗i.a的多巴胺激动剂。 二次功能障碍

    CHROMAN COMPOUNDS
    7.
    发明申请
    CHROMAN COMPOUNDS 审中-公开
    色素化合物

    公开(公告)号：WO2006056850A2

    公开(公告)日：2006-06-01

    申请号：PCT/IB2005/003485

    申请日：2005-11-15

    申请人： PFIZER LIMITED ,  PFIZER INC. ,  COOK, Andrew, Simon ,  MILLER, Duncan, Charles

    发明人： COOK, Andrew, Simon ,  MILLER, Duncan, Charles

    IPC分类号： C07D311/58 ,  C07D405/04 ,  C07D413/04 ,  C07D491/04 ,  C07D493/04

    CPC分类号： C07D491/04 ,  C07D311/58 ,  C07D405/04 ,  C07D413/04 ,  C07D493/04

    摘要： PC26133A The present invention provides for compounds of formula (I) wherein A, R 1 , R 2 , R 3 , R 4 and R 5 are defined herein. The compounds of formula (I) are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of neuropsychiatric disorders, neurodegenerative disorders, pain and sexual dysfunction.

    摘要翻译： PC26133A本发明提供式（I）的化合物，其中A，R 1，R 2，R 3，R 4， 和R 5 5在本文中定义。 式（I）的化合物是一类多巴胺激动剂，更特别的是一类在D2上对D3具有选择性的激动剂。 这些化合物可用于治疗和/或预防神经精神障碍，神经变性疾病，疼痛和性功能障碍。