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    MEDICAL DEVICES HAVING SELF-FORMING RATE-CONTROLLING BARRIER FOR DRUG RELEASE
    3.
    发明申请
    MEDICAL DEVICES HAVING SELF-FORMING RATE-CONTROLLING BARRIER FOR DRUG RELEASE 审中-公开
    具有用于药物释放的自成型速率控制障碍物的医疗装置

    公开(公告)号：WO2006029012A1

    公开(公告)日：2006-03-16

    申请号：PCT/US2005/031410

    申请日：2005-09-02

    Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  SCHWARZ, Marlene, C.

    Inventor： SCHWARZ, Marlene, C.

    IPC: A61L31/04 ,  A61L31/16 ,  A61L29/04 ,  A61L29/16

    CPC classification number: A61L29/041 ,  A61L29/16 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/604

    Abstract: Therapeutic-agent-releasing medical devices are provided herein, which contain a rate controlling release region that includes a biodisintegrable agent and a biostable low glass transition temperature polymer. Upon contact (e.g., implantation or insertion) of the medical device with a subject, at least the surface of the release region becomes depleted of the biodisintegrable agent, and the low glass transition temperature polymer migrates to occupy at least a portion of the volume that is created by the departure of the biodisintegrable agent, thereby forming a barrier layer for therapeutic agent remaining within the device.

    Abstract translation: 本文提供了治疗剂释放的医疗装置，其包含速率控制释放区域，其包括生物可分解药剂和生物稳定的低玻璃化转变温度聚合物。 在与受试者接触（例如，植入或插入）医疗装置时，至少释放区域的表面变得贫化生物可整合剂，并且低玻璃化转变温度聚合物迁移至占据体积的至少一部分， 是通过生物分解剂的离开产生的，从而形成用于保留在该装置内的治疗剂的阻挡层。

    METHOD AND APPARATUS FOR COATING A MEDICAL DEVICE USING A COATING HEAD
    4.
    发明申请
    METHOD AND APPARATUS FOR COATING A MEDICAL DEVICE USING A COATING HEAD 审中-公开
    使用涂层头涂敷医疗装置的方法和装置

    公开(公告)号：WO2005105321A1

    公开(公告)日：2005-11-10

    申请号：PCT/US2005/012231

    申请日：2005-04-12

    Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  SCHWARZ, Marlene, C.

    Inventor： SCHWARZ, Marlene, C.

    IPC: B05C5/00

    CPC classification number: B05C5/008 ,  B05C5/007 ,  B05C5/0245 ,  B05D1/26 ,  B05D7/56

    Abstract: Methods and apparatuses for coating surface of medical devices using coating heads are disclosed. In one embodiment, the invention includes a coating method using a coating head, wherein the coating head comprises at least one outlet orifice from which flows a coating material, to deposit at least one layer of coating material dispelled through the outlet orifice onto the surface of the medical device. In another embodiment, a slide coating head is used to deposit multiple layers of superposed coating materials. These methods are used to apply one or more coating materials, simultaneously or in sequence. In certain embodiments of the invention, the coating materials include therapeutic agents, polymers, sugars, waxes, or fats.

    Abstract translation: 公开了使用涂覆头涂覆医疗装置表面的方法和装置。 在一个实施方案中，本发明包括使用涂覆头的涂覆方法，其中涂覆头包括至少一个出口孔，涂覆头将涂覆材料流过，以将至少一层涂料通过出口孔排出到 医疗器械。 在另一个实施例中，使用滑动涂覆头来沉积多层叠加的涂层材料。 这些方法用于同时或按顺序施用一种或多种涂料。 在本发明的某些实施方案中，涂层材料包括治疗剂，聚合物，糖，蜡或脂肪。

    MEDICAL DEVICES HAVING POROUS POLYMERIC REGIONS FOR CONTROLLED DRUG DELIVERY AND REGULATED BIOCOMPATIBILITY
    8.
    发明申请
    MEDICAL DEVICES HAVING POROUS POLYMERIC REGIONS FOR CONTROLLED DRUG DELIVERY AND REGULATED BIOCOMPATIBILITY 审中-公开
    具有多个聚合物区域用于控制药物递送和调节生物活性的医疗装置

    公开(公告)号：WO2006083904A2

    公开(公告)日：2006-08-10

    申请号：PCT/US2006/003455

    申请日：2006-02-01

    Applicant: BOSTON SCIENTIFIC SCIMED, INC. ,  RICHARD, Robert, E. ,  STRICKLER, Frederick, H. ,  SCHWARZ, Marlene, C. ,  FAUST, Rodolf ,  SHRIRANG, Ranade, V. ,  HELMUS, Michael, N.

    Inventor： RICHARD, Robert, E. ,  STRICKLER, Frederick, H. ,  SCHWARZ, Marlene, C. ,  FAUST, Rodolf ,  SHRIRANG, Ranade, V. ,  HELMUS, Michael, N.

    CPC classification number: A61L31/129 ,  A61L27/48 ,  A61N1/05

    Abstract: The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrate polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

    Abstract translation: 本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。 在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸且可进行生物分解的聚合物的生物分解聚合物相， 区域在体内成为纳米孔聚合物区域。 本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。 这些方法包括（a）提供包含稳定聚合物相和纳米级尺寸的崩解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。 在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗 在植入或插入医疗装置时在体内释放的药剂。

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