公开(公告)号：WO2010025224A1

公开(公告)日：2010-03-04

申请号：PCT/US2009/055156

申请日：2009-08-27

Applicant: TYCO HEALTHCARE GROUP LP ,  FINK, E., David ,  VITARIS, Ronald, F. ,  SHAH, Chirag, B. ,  MULLIGAN, Sharon, A. ,  DOWD, Brian ,  ORR, Scott

Inventor： FINK, E., David ,  VITARIS, Ronald, F. ,  SHAH, Chirag, B. ,  MULLIGAN, Sharon, A. ,  DOWD, Brian ,  ORR, Scott

IPC: B32B25/02 ,  D03D15/00 ,  D04H1/00

CPC classification number: D01F8/00 ,  A01N59/16 ,  A61L15/46 ,  A61L2300/104 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/61 ,  D01F1/103 ,  Y10T428/249921 ,  Y10T428/2933 ,  Y10T428/294 ,  Y10T428/2965 ,  Y10T428/2967 ,  Y10T428/2969 ,  A01N25/34

Abstract: An antimicrobial fiber is described including: an inner layer and an outer layer; wherein the inner layer and the outer layer comprise at least one of the following characteristics: (I) the inner layer and the outer layer comprise of different concentrations, or different release rates, of at least one antimicrobial agent; and (II) the inner layer and the outer layer comprise different antimicrobial agents. An alternative antimicrobial fiber includes an antimicrobial agent compounded or combined with a dissolvable substance to promote release or binding of the antimicrobial agent. Related articles are also described.

Abstract translation: 描述了一种抗微生物纤维，包括：内层和外层; 其中所述内层和所述外层包含以下特征中的至少一个：（I）所述内层和所述外层包含至少一种抗微生物剂的不同浓度或不同的释放速率; 和（II）内层和外层包含不同的抗微生物剂。 替代的抗微生物纤维包括与可溶解物质混合或组合以促进抗微生物剂的释放或结合的抗微生物剂。 还描述了相关文章。

公开(公告)号：WO2010025219A1

公开(公告)日：2010-03-04

申请号：PCT/US2009/055149

申请日：2009-08-27

Applicant: TYCO HEALTHCARE GROUP LP ,  SHAH, Chirag, B. ,  VITARIS, Ronald, F. ,  FINK, David, E ,  ORR, Scott ,  DOWD, Brian ,  TRANCHEMONTAGNE, Alain ,  WARD, Katherine ,  SWANIKER, Hansen ,  PATEL, Harish, A.

Inventor： SHAH, Chirag, B. ,  VITARIS, Ronald, F. ,  FINK, David, E ,  ORR, Scott ,  DOWD, Brian ,  TRANCHEMONTAGNE, Alain ,  WARD, Katherine ,  SWANIKER, Hansen ,  PATEL, Harish, A.

IPC: A01N25/00

CPC classification number: A01N25/00 ,  A01N25/34 ,  A61F13/0203 ,  A61F2013/0091 ,  A61L15/425 ,  A61L15/46 ,  A61L2300/206 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/608 ,  A01N33/12 ,  A01N47/44

Abstract: Articles may be formed including: at least one layer of foam, the foam layer and at least one antimicrobial agent associated with foam layer, the antimicrobial agent including PHMB, PEHMB, or derivatives thereof; at least one non-adherent layer disposed on at least a portion of the foam layer, the non-adherent layer being permeable to moisture; and a film disposed on at least another portion of the foam layer, the film being breathable to allow escape of moisture, but substantially impermeable to bacteria. Another article may include at least one layer of foam, the foam having pores of different sizes, at least some of the pores at least partially filled with at least one elutable antimicrobial agent, the pores of different sizes forming a gradient with the foam layer. Yet another article may include a foam matrix and a plurality of dissolvable members disposed with the foam matrix, at least one antimicrobial agents associated with the dissolvable members such that upon dissolution thereof the antimicrobial agent is eluted and pores or voids are created in the foam matrix. Wound dressings formed from the above articles are also described.

Abstract translation: 可以形成制品，包括：至少一层泡沫，泡沫层和与泡沫层相关的至少一种抗微生物剂，抗微生物剂包括PHMB，PEHMB或其衍生物; 设置在泡沫层的至少一部分上的至少一个非粘附层，非粘附层可渗透水分; 以及设置在泡沫层的至少另一部分上的膜，所述膜是透气的，以允许水分逸出，但是对细菌基本上不可渗透。 另一制品可以包括至少一层泡沫，泡沫具有不同尺寸的孔，至少部分至少部分填充有至少一种可消除的抗微生物剂的孔，不同尺寸的孔与泡沫层形成梯度。 另一种制品可以包括泡沫基质和与泡沫基体一起设置的多个可溶解构件，至少一种与可溶解构件相关联的抗微生物剂，使得在溶解时，抗微生物剂被洗脱，并且在泡沫基质中​​产生孔或空隙 。 还描述了由上述制品形成的伤口敷料。

公开(公告)号：WO2007120608A2

公开(公告)日：2007-10-25

申请号：PCT/US2007/008755

申请日：2007-04-11

Applicant: TYCO HEALTHCARE GROUP LP ,  PATEL, Harish A. ,  SWANIKER, Hansen ,  HEAGLE, David ,  WARD, Kate ,  TRANCHEMONTAGNE, Alain ,  FINK, E. David ,  VITARIS, Ronald F. ,  SHAH, Chirag B. ,  MULLIGAN, Sharon A. ,  DOWD, Brian ,  ORR, Scott

Inventor： PATEL, Harish A. ,  SWANIKER, Hansen ,  HEAGLE, David ,  WARD, Kate ,  TRANCHEMONTAGNE, Alain ,  FINK, E. David ,  VITARIS, Ronald F. ,  SHAH, Chirag B. ,  MULLIGAN, Sharon A. ,  DOWD, Brian ,  ORR, Scott

IPC: A61L15/16

CPC classification number: A61L15/46 ,  A61F13/00029 ,  A61F13/00063 ,  A61F2013/00463 ,  A61F2013/00472 ,  A61F2013/00608 ,  A61F2013/0091 ,  A61F2013/00927 ,  A61F2013/00936 ,  A61L15/18 ,  A61L15/20 ,  A61L2300/102 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/61

Abstract: A wound dressing includes one or more layers containing a first anti-microbial agent and at least one of: a chelating agent, and a second anti-microbial agent.

Abstract translation: 伤口敷料包括含有第一抗微生物剂和至少一种螯合剂和第二抗微生物剂的一层或多层。

公开(公告)号：WO0243786B1

公开(公告)日：2003-04-24

申请号：PCT/US0143719

申请日：2001-11-20

Applicant: MEDTRONIC AVE INC ,  TEDESCHI EUGENE ,  SHAH CHIRAG B

Inventor： TEDESCHI EUGENE ,  SHAH CHIRAG B

IPC: A61M31/00 ,  A61K33/00 ,  A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/00 ,  A61L31/10 ,  A61L31/16 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/16 ,  A61P13/08 ,  A61P31/04 ,  A61L27/18

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/606 ,  Y10S514/824 ,  C08L75/04

Abstract: Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medicaldevice coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidine, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.

Abstract translation: 提供了用于将一氧化氮输送到患者的血管组织以抑制或预防再狭窄或改善各种外科手术后的血管功能或与各种NO相关的病症有关的方法。 所公开的方法包括使涂覆有包含一氧化氮的涂层的医疗装置与多异氰酸酯的所述医疗装置上由反应形成的聚脲网络相接触并释放; 胺供体和/或羟基供体; 具有末端异氰酸酯基的异氰酸基硅烷加合物和与硅结合的至少一个可水解烷氧基; 和任选的选自聚环氧乙烷，聚乙烯吡咯烷，聚乙烯醇，聚乙二醇和聚丙烯酸的聚合物。

公开(公告)号：WO2010025227A1

公开(公告)日：2010-03-04

申请号：PCT/US2009/055161

申请日：2009-08-27

Applicant: TYCO HEALTHCARE GROUP LP ,  HEAGLE, David, G. ,  SHAH, Chirag, B. ,  VITARIS, Ronald, F. ,  FINK, E., David ,  MULLIGAN, Sharon, A. ,  DOWD, Brian

Inventor： HEAGLE, David, G. ,  SHAH, Chirag, B. ,  VITARIS, Ronald, F. ,  FINK, E., David ,  MULLIGAN, Sharon, A. ,  DOWD, Brian

IPC: C12Q1/18 ,  C12Q1/24

CPC classification number: A61L15/46 ,  A61F2013/00293 ,  A61L2300/206 ,  A61L2300/208 ,  A61L2300/404 ,  A61L2300/602

Abstract: A method of treating a substrate having a charge bias with at least one antimicrobial agent to modify the release properties of the antimicrobial agent with respect to the substrate, the method includes eliminating, mitigating, or modifying the charge bias of the substrate by applying at least one first agent to the substrate, and applying the at least one antimicrobial agent to the substrate. Related articles are also described.

Abstract translation: 一种用至少一种抗微生物剂处理具有电荷偏压的底物以改变抗微生物剂相对于底物的释放性质的方法，该方法包括通过至少施加至少应用来消除，减轻或改变基材的电荷偏压 一种基材的第一试剂，以及将至少一种抗微生物剂施用于基底。 还描述了相关文章。

公开(公告)号：WO2007120616A3

公开(公告)日：2008-11-20

申请号：PCT/US2007008771

申请日：2007-04-11

Applicant: TYCO HEALTHCARE ,  PATEL HARISH A ,  SWANIKER HANSEN ,  HEAGLE DAVID ,  WARD KATE ,  TRANCHEMONTAGNE ALAIN ,  FINK E DAVID ,  VITARIS RONALD F ,  SHAH CHIRAG B ,  MULLIGAN SHARON A ,  DOWD BRIAN ,  ORR SCOTT

Inventor： PATEL HARISH A ,  SWANIKER HANSEN ,  HEAGLE DAVID ,  WARD KATE ,  TRANCHEMONTAGNE ALAIN ,  FINK E DAVID ,  VITARIS RONALD F ,  SHAH CHIRAG B ,  MULLIGAN SHARON A ,  DOWD BRIAN ,  ORR SCOTT

IPC: A61K9/70 ,  A61L15/00

CPC classification number: A61L15/44 ,  A61F13/00029 ,  A61F13/00063 ,  A61F2013/00463 ,  A61F2013/00727 ,  A61F2013/0091 ,  A61L15/18 ,  A61L15/46 ,  A61L2300/102 ,  A61L2300/104 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/61

Abstract: A wound dressing includes one or more layers containing a first anti-microbial agent and/or at least one zinc-containing agent.

Abstract translation: 伤口敷料包括含有第一抗微生物剂和/或至少一种含锌剂的一层或多层。

公开(公告)号：WO2010024928A1

公开(公告)日：2010-03-04

申请号：PCT/US2009/004908

申请日：2009-08-28

Applicant: TYCO HEALTHCARE GROUP LP ,  VITARIS, Robert F. ,  PATEL, Harish A. ,  FINK, David E. ,  MULLIGAN, Sharon A. ,  DOWD, Brian ,  ORR, Scott ,  SHAH, Chirag B.

Inventor： VITARIS, Robert F. ,  PATEL, Harish A. ,  FINK, David E. ,  MULLIGAN, Sharon A. ,  DOWD, Brian ,  ORR, Scott ,  SHAH, Chirag B.

IPC: A61L15/16 ,  A61L15/44

CPC classification number: A61L15/46 ,  A61F13/00012 ,  A61F13/00063 ,  A61F13/0213 ,  A61F13/0226 ,  A61F13/0253 ,  A61F2013/00412 ,  A61F2013/00846 ,  A61F2013/0091 ,  A61L15/325 ,  A61L15/58 ,  A61L2300/114 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/608 ,  A61M35/00

Abstract: An article (10) includes a film layer (12); at least one layer of adhesive (13) on at least one side of the film layer; a patch or strip (14) comprising at least one antimicrobial agent, the patch or strip disposed on the same side of the film layer as the at least one layer of adhesive; and a relatively non-flexible sheet (16) releasably attached to the side of the film layer opposite to the patch or strip. Alternatively, an article (10') includes a film layer (28); a collagen layer (24); and a biodegradable hydrogel layer (26) comprising PHMB; wherein the biodegradable hydrogel layer comprising PHMB is disposed between the film layer and the collagen layer. Wound dressings (10, 10') comprising these articles are also described.

Abstract translation: 物品（10）包括膜层（12）; 在所述膜层的至少一侧上的至少一层粘合剂（13）; 包括至少一种抗微生物剂的贴片或条带（14），所述贴片或条带设置在与所述至少一层粘合剂的膜层相同的一侧上; 以及可释放地附接到膜片与贴片或条带相对的一侧的相对非柔性片材（16）。 或者，物品（10'）包括膜层（28）; 胶原层（24）; 和包含PHMB的可生物降解的水凝胶层（26） 其中包含PHMB的生物降解性水凝胶层设置在所述膜层和所述胶原层之间。 还描述了包括这些制品的伤口敷料（10,10'）。

公开(公告)号：WO2007120608A3

公开(公告)日：2008-03-27

申请号：PCT/US2007008755

申请日：2007-04-11

Applicant: TYCO HEALTHCARE ,  PATEL HARISH A ,  SWANIKER HANSEN ,  HEAGLE DAVID ,  WARD KATE ,  TRANCHEMONTAGNE ALAIN ,  FINK E DAVID ,  VITARIS RONALD F ,  SHAH CHIRAG B ,  MULLIGAN SHARON A ,  DOWD BRIAN ,  ORR SCOTT

Inventor： PATEL HARISH A ,  SWANIKER HANSEN ,  HEAGLE DAVID ,  WARD KATE ,  TRANCHEMONTAGNE ALAIN ,  FINK E DAVID ,  VITARIS RONALD F ,  SHAH CHIRAG B ,  MULLIGAN SHARON A ,  DOWD BRIAN ,  ORR SCOTT

IPC: A61L15/16

CPC classification number: A61L15/46 ,  A61F13/00029 ,  A61F13/00063 ,  A61F2013/00463 ,  A61F2013/00472 ,  A61F2013/00608 ,  A61F2013/0091 ,  A61F2013/00927 ,  A61F2013/00936 ,  A61L15/18 ,  A61L15/20 ,  A61L2300/102 ,  A61L2300/206 ,  A61L2300/404 ,  A61L2300/61

Abstract: A wound dressing includes one or more layers containing a first anti-microbial agent and at least one of: a chelating agent, and a second anti-microbial agent.

Abstract translation: 伤口敷料包括含有第一抗微生物剂和至少一种螯合剂和第二抗微生物剂的一层或多层。

公开(公告)号：WO0243786A3

公开(公告)日：2003-01-30

申请号：PCT/US0143719

申请日：2001-11-20

Applicant: MEDTRONIC AVE INC ,  TEDESCHI EUGENE ,  SHAH CHIRAG B

Inventor： TEDESCHI EUGENE ,  SHAH CHIRAG B

IPC: A61M31/00 ,  A61K33/00 ,  A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/00 ,  A61L31/10 ,  A61L31/16 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/16 ,  A61P13/08 ,  A61P31/04 ,  A61L27/18

CPC classification number: A61L31/16 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/114 ,  A61L2300/416 ,  A61L2300/606 ,  Y10S514/824 ,  C08L75/04

Abstract: Methods are provided for delivering nitric oxide to the vascular tissue of a patient to inhibit or prevent restenosis or improve vascular function following various surgical procedures or associated with various NO-related conditions. The disclosed methods comprise contacting the vascular tissue of a patient with a medicaldevice coated with a coating comprising nitric oxide associated with and releaseable from a polyurea network formed from the reaction on said medical device of a polyisocyanate; an amine donor and/or hydroxyl donor; an isocyanatosilane adduct having terminal isocyanate groups and at least one hydrolyzable alkoxy group bonded to silicon; and optionally a polymer selected from the group consisting of polyethylene oxide, polyvinyl pyrrolidine, polyvinyl alcohol, polyethylene glycol, and polyacrylic acid.

Abstract translation: 提供了将一氧化氮递送至患者的血管组织以抑制或预防再狭窄或在各种外科手术之后改善血管功能或与各种NO相关的病症相关的方法。 所公开的方法包括使患者的血管组织与涂覆有涂层的医疗装置接触，所述涂层包含一氧化氮，所述涂层包含与聚异氰酸酯在所述医疗装置上的反应形成的聚脲网络相连的聚脲网络; 胺供体和/或羟基供体; 具有末端异氰酸酯基和至少一个与硅键合的可水解烷氧基的异氰酸酯基硅烷加合物; 和任选的选自聚氧化乙烯，聚乙烯吡咯烷，聚乙烯醇，聚乙二醇和聚丙烯酸的聚合物。

公开(公告)号：WO0069504A9

公开(公告)日：2002-02-21

申请号：PCT/US0013119

申请日：2000-05-12

Applicant: BARD INC C R ,  GAMBALE RICHARD A ,  SHAH CHIRAG B ,  WEISER MICHAEL F ,  FORCUCCI STEPHEN J ,  FORDE SEAN

Inventor： GAMBALE RICHARD A ,  SHAH CHIRAG B ,  WEISER MICHAEL F ,  FORCUCCI STEPHEN J ,  FORDE SEAN

IPC: A61M36/04 ,  A61F2/00 ,  A61F2/02 ,  A61M31/00

CPC classification number: A61M37/0069 ,  A61F2/2493 ,  A61F2250/0067

Abstract: The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (2). Preferably the therapeutic substance is contained within a pellet form (14) that is deliverable into the interior of the device (2) after it has been implanted. In a preferred embodiment the implant device (2) comprises a flexible coiled spring body, the coils (4) of which have a diameter and spacing to contain the pellet (14) within the interior of the device (2). A cavity (18) provided by the interior of the device (2) permits blood to pool around the pellet (14) and mix with the therapeutic agent. In treatment of ischemic tissue such as the of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device (2) can help to provide an angiogenic effect. Several delivery systems have provided for delivering the implant and pellet (14) sequentially or simultaneously.

Abstract translation: 本发明提供了一种用于将治疗剂与植入装置（2）组合递送到组织中的系统。 优选地，治疗物质包含在颗粒形式（14）中，其在植入之后可输送到装置（2）的内部。 在优选实施例中，植入装置（2）包括柔性螺旋弹簧体，其线圈（4）具有直径和间距以在装置（2）的内部内容纳颗粒（14）。 由装置（2）的内部提供的空腔（18）允许血液围绕颗粒（14）聚集并与治疗剂混合。 在治疗缺血组织如心脏的心肌时，由植入装置（2）引起的组织的机械刺激有助于提供血管生成作用。 已经提供了几个递送系统来顺序地或同时地递送植入物和颗粒（14）。