公开(公告)号：WO2013059442A3

公开(公告)日：2015-06-18

申请号：PCT/US2012060794

申请日：2012-10-18

Applicant: BAYLOR COLLEGE MEDICINE ,  SONG XIAO-TONG ,  LEWIS DOROTHY E ,  ZHU WEI

Inventor： SONG XIAO-TONG ,  LEWIS DOROTHY E ,  ZHU WEI

IPC: C12N15/113 ,  A61K31/7088 ,  A61K39/21

CPC classification number: C12N15/1137 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/541 ,  A61K2039/545 ,  A61K2039/55561 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2740/16134 ,  C12N2799/027 ,  C12Y102/01036

Abstract: A method and vaccine composition compressing a siRNA and/or a shRNA that targets a retinoic acid producing enzyme and an antigen. Silencing retinoic acid producing enzymes downregulates α4β7 expression on activated T and B cells. Immunization with a retinoic acid silencing mechanism greatly enhanced anti-HIV gp140 immune responses in the vaginal tract and periphery but not in the intestine, providing a unique strategy to redistribute anti-HIV mucosal immune responses on the front line of defense against HIV-1 with concomitant suppression of α4β7high CD4+ T cells.

Abstract translation: 压缩靶向视黄酸生成酶和抗原的siRNA和/或shRNA的方法和疫苗组合物。 沉默视黄酸生成酶下调活化的T细胞和B细胞上的α4β7表达。 用视黄酸沉默机制的免疫大大增强了阴道和周边但不在肠道中的抗HIV gp140免疫应答，提供了将抗HIV粘膜免疫应答重新分布在针对HIV-1的防线前端的独特策略， 伴随抑制α4β7高CD4 + T细胞。

公开(公告)号：WO2007053386A2

公开(公告)日：2007-05-10

申请号：PCT/US2006/041590

申请日：2006-10-26

Applicant: JANSSEN PHARMACEUTICA N.V. ,  MANI, Neelakandha, S. ,  PALMER, David, C. ,  PANDIT, Chennagiri, R. ,  REYES, Mayra, B. ,  XIAO, Tong

Inventor： MANI, Neelakandha, S. ,  PALMER, David, C. ,  PANDIT, Chennagiri, R. ,  REYES, Mayra, B. ,  XIAO, Tong

IPC: C07D295/18

CPC classification number: C07D295/192

Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

Abstract translation: 本发明涉及用于制备环丙基 - 酰胺衍生物的新方法，其可用于治疗由组胺受体介导的病症和病症。

公开(公告)号：WO2005077922A3

公开(公告)日：2006-01-26

申请号：PCT/US2005001917

申请日：2005-01-21

Applicant: JANSSEN PHARMACEUTICA NV ,  PALMER DAVID C ,  SORGI KIRK L ,  CESCO-CANCIAN SERGIO ,  XIAO TONG

Inventor： PALMER DAVID C ,  SORGI KIRK L ,  CESCO-CANCIAN SERGIO ,  XIAO TONG

IPC: C07D249/14 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  A61P35/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06 ,  C07D417/12

CPC classification number: C07D409/06 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D417/12

Abstract: The present invention is directed to a novel process for the preparation of substituted triazole compounds of formula: (I); wherein R1 and R2 are as defined in the claims, useful in the treating or ameliorating a selective kinase or dual-kinase mediated disorder. The process of the present invention preferentially produces the desired regioisomer of the substituted triazole compounds.

Abstract translation: 本发明涉及一种制备式（I）的取代三唑化合物的新方法; 其中R1和R2如权利要求中所定义，可用于治疗或改善选择性激酶或双重激酶介导的病症。 本发明的方法优选地产生所需的取代的三唑化合物的区域异构体。

公开(公告)号：WO2012047856A3

公开(公告)日：2012-06-07

申请号：PCT/US2011054726

申请日：2011-10-04

Applicant: INST HEPATITIS & VIRUS RES ,  XU XIAODONG ,  CUCONATI ANDREA ,  BLOCK TIMOTHY M ,  XIAO TONG

Inventor： XU XIAODONG ,  CUCONATI ANDREA ,  BLOCK TIMOTHY M ,  XIAO TONG

IPC: A61K31/519 ,  A01N43/90

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

Abstract: Pharmaceutical compositions of the invention comprise triazolopyrimidines useful for the treatment of hepatitis virus in a patient.

Abstract translation: 本发明的药物组合物包含可用于治疗患者中的肝炎病毒的三唑并嘧啶。

公开(公告)号：WO2009055516A1

公开(公告)日：2009-04-30

申请号：PCT/US2008/080854

申请日：2008-10-23

Applicant: JANSSEN PHARMACEUTICA, N.V. ,  PALMER, David, C. ,  CESCO-CANCIAN, Sergio ,  XIAO, Tong ,  SORGI, Kirk, L. ,  ROESSLER, Armin ,  VLADISLAVIC, Anita ,  FAESSLER, Roger

Inventor： PALMER, David, C. ,  CESCO-CANCIAN, Sergio ,  XIAO, Tong ,  SORGI, Kirk, L. ,  ROESSLER, Armin ,  VLADISLAVIC, Anita ,  FAESSLER, Roger

IPC: C07D209/42 ,  C07D307/14 ,  C07D307/68 ,  C07D307/85 ,  C07D309/04 ,  C07D309/14 ,  C07D311/58 ,  C07D311/92 ,  C07D313/08 ,  C07D333/36 ,  C07D333/70 ,  C07D335/02 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12

CPC classification number: C07D333/36 ,  C07D209/42 ,  C07D295/135 ,  C07D307/14 ,  C07D307/68 ,  C07D307/85 ,  C07D309/04 ,  C07D309/14 ,  C07D311/58 ,  C07D311/92 ,  C07D313/08 ,  C07D333/70 ,  C07D335/02 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12

Abstract: The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.

Abstract translation: 本发明涉及一种用于制备作为CCR2拮抗剂的苯基氨基取代的季盐化合物的环境影响降低的方法。

公开(公告)号：WO2007053386A3

公开(公告)日：2007-11-01

申请号：PCT/US2006041590

申请日：2006-10-26

Applicant: JANSSEN PHARMACEUTICA NV ,  MANI NEELAKANDHA S ,  PALMER DAVID C ,  PANDIT CHENNAGIRI R ,  REYES MAYRA B ,  XIAO TONG

Inventor： MANI NEELAKANDHA S ,  PALMER DAVID C ,  PANDIT CHENNAGIRI R ,  REYES MAYRA B ,  XIAO TONG

IPC: C07D295/18

CPC classification number: C07D295/192

Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

Abstract translation: 本发明涉及用于制备环丙基 - 酰胺衍生物的新方法，其用于治疗由组胺受体介导的病症和病症。

公开(公告)号：WO2013059442A2

公开(公告)日：2013-04-25

申请号：PCT/US2012/060794

申请日：2012-10-18

Applicant: BAYLOR COLLEGE OF MEDICINE ,  SONG, Xiao-tong ,  LEWIS, Dorothy, E. ,  ZHU, Wei

Inventor： SONG, Xiao-tong ,  LEWIS, Dorothy, E. ,  ZHU, Wei

IPC: A61K48/00

CPC classification number: C12N15/1137 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/541 ,  A61K2039/545 ,  A61K2039/55561 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2740/16134 ,  C12N2799/027 ,  C12Y102/01036

Abstract: A method and vaccine composition compressing a siRNA and/or a shRNA that targets a retinoic acid producing enzyme and an antigen. Silencing retinoic acid producing enzymes downregulates α4β7 expression on activated T and B cells. Immunization with a retinoic acid silencing mechanism greatly enhanced anti-HIV gp140 immune responses in the vaginal tract and periphery but not in the intestine, providing a unique strategy to redistribute anti-HIV mucosal immune responses on the front line of defense against HIV-1 with concomitant suppression of α4β7high CD4+ T cells.

Abstract translation: 压缩靶向视黄酸生成酶和抗原的siRNA和/或shRNA的方法和疫苗组合物。 沉默视黄酸生成酶下调活化的T和B细胞上的α4β7表达。 视网膜酸沉默机制的免疫大大增强了阴道和周边但不在肠道中的抗HIV gp140免疫应答，提供了独特的策略，以将抗HIV粘膜免疫应答重新分布在针对HIV-1的防线前端， 伴随抑制α4β7高CD4 + T细胞。

公开(公告)号：WO2012047856A2

公开(公告)日：2012-04-12

申请号：PCT/US2011/054726

申请日：2011-10-04

Applicant: INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH ,  XU, Xiaodong ,  CUCONATI, Andrea ,  BLOCK, Timothy, M. ,  XIAO, Tong

Inventor： XU, Xiaodong ,  CUCONATI, Andrea ,  BLOCK, Timothy, M. ,  XIAO, Tong

IPC: A61K31/519

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  A61K2300/00

Abstract: Pharmaceutical compositions of the invention comprise triazolopyrimidines useful for the treatment of hepatitis virus in a patient.

Abstract translation: 本发明的药物组合物包含用于治疗患者肝炎病毒的三唑并嘧啶。

公开(公告)号：WO2007053427A2

公开(公告)日：2007-05-10

申请号：PCT/US2006/041859

申请日：2006-10-26

Applicant: JANSSEN PHARMACEUTICA N.V. ,  PALMER, David C. ,  MANI, Neelakandha S. ,  PANDIT, Chennagiri R. ,  REYES, Mayra B. ,  XIAO, Tong

Inventor： MANI, Neelakandha S. ,  PANDIT, Chennagiri R. ,  REYES, Mayra B. ,  XIAO, Tong

IPC: C07D295/18 ,  C07D211/14 ,  C07D207/06

CPC classification number: C07D295/192 ,  C07D207/06 ,  C07D211/14 ,  C07D295/182 ,  C07D413/04

Abstract: The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.

Abstract translation: 本发明涉及用于制备取代的哌嗪基和二氮杂环庚烷苯甲酰胺的新方法，其可用于治疗由组胺受体介导的障碍和病症。

公开(公告)号：WO2005077922A2

公开(公告)日：2005-08-25

申请号：PCT/US2005/001917

申请日：2005-01-21

Applicant: JANSSEN PHARMACEUTICA, N.V. ,  PALMER, David, C. ,  SORGI, Kirk, L. ,  CESCO-CANCIAN, Sergio ,  XIAO, Tong

Inventor： PALMER, David, C. ,  SORGI, Kirk, L. ,  CESCO-CANCIAN, Sergio ,  XIAO, Tong

IPC: C07D249/00

CPC classification number: C07D409/06 ,  C07D249/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D417/12

Abstract: The present invention is directed to a novel process for the preparation of substituted triazole compounds, useful in the treating or ameliorating a selective kinase or dual-kinase mediated disorder. The process of the present invention preferentially produces the desired regioisomer of the substituted triazole compounds.

Abstract translation: 本发明涉及用于制备可用于治疗或改善选择性激酶或双重激酶介导的病症的取代的三唑化合物的新方法。 本发明的方法优选地产生所需的取代的三唑化合物的区域异构体。