公开(公告)号：WO2007053386A2

公开(公告)日：2007-05-10

申请号：PCT/US2006/041590

申请日：2006-10-26

Applicant: JANSSEN PHARMACEUTICA N.V. ,  MANI, Neelakandha, S. ,  PALMER, David, C. ,  PANDIT, Chennagiri, R. ,  REYES, Mayra, B. ,  XIAO, Tong

Inventor： MANI, Neelakandha, S. ,  PALMER, David, C. ,  PANDIT, Chennagiri, R. ,  REYES, Mayra, B. ,  XIAO, Tong

IPC: C07D295/18

CPC classification number: C07D295/192

Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

Abstract translation: 本发明涉及用于制备环丙基 - 酰胺衍生物的新方法，其可用于治疗由组胺受体介导的病症和病症。

公开(公告)号：WO2007053386A3

公开(公告)日：2007-11-01

申请号：PCT/US2006041590

申请日：2006-10-26

Applicant: JANSSEN PHARMACEUTICA NV ,  MANI NEELAKANDHA S ,  PALMER DAVID C ,  PANDIT CHENNAGIRI R ,  REYES MAYRA B ,  XIAO TONG

Inventor： MANI NEELAKANDHA S ,  PALMER DAVID C ,  PANDIT CHENNAGIRI R ,  REYES MAYRA B ,  XIAO TONG

IPC: C07D295/18

CPC classification number: C07D295/192

Abstract: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.

Abstract translation: 本发明涉及用于制备环丙基 - 酰胺衍生物的新方法，其用于治疗由组胺受体介导的病症和病症。

公开(公告)号：WO0158869B1

公开(公告)日：2002-02-21

申请号：PCT/US0104131

申请日：2001-02-08

Applicant: SQUIBB BRISTOL MYERS CO ,  LEFTHERIS KATERINA ,  ZHAO RULIN ,  CHEN BANG CHI ,  KIENER PETER ,  WU HONG ,  PANDIT CHENNAGIRI R ,  WROBLESKI STEPHEN ,  CHEN PING ,  HYNES JOHN JR ,  LONGPHRE MALINDA ,  NORRIS DEREK J ,  SPERGEL STEVEN ,  TOKARSKI JOHN

Inventor： LEFTHERIS KATERINA ,  ZHAO RULIN ,  CHEN BANG-CHI ,  KIENER PETER ,  WU HONG ,  PANDIT CHENNAGIRI R ,  WROBLESKI STEPHEN ,  CHEN PING ,  HYNES JOHN JR ,  LONGPHRE MALINDA ,  NORRIS DEREK J ,  SPERGEL STEVEN ,  TOKARSKI JOHN

IPC: A61K31/40 ,  A61K31/404 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/433 ,  A61K31/4353 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/551 ,  A61K45/00 ,  A61P11/00 ,  A61P11/06 ,  C07D207/337 ,  C07D207/40 ,  C07D207/416 ,  C07D209/08 ,  C07D209/42 ,  C07D231/14 ,  C07D231/56 ,  C07D233/90 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D498/04 ,  C07D498/06 ,  C07D207/34 ,  C07D401/14 ,  C07D407/12

CPC classification number: C07D207/416 ,  A61K31/40 ,  A61K31/415 ,  A61K31/44 ,  C07D209/42 ,  C07D231/14 ,  C07D231/56 ,  C07D233/90 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/08

Abstract: Use of a compound for treating a respiratory disease in a mammal wherein the compound is a cannabinoid receptor modulator is disclosed. Compounds useful as cannabinoid receptor modulators for treating respiratory and non-respiratory leukocyte-activation associated diseases comprise compounds of formula (I), in which A and B are nitrogen or carbon, provided only one of A and B is nitrogen; and R1-R6 are as defined in the specification, wherein R2 with R5 may form a ring, and/or two R4 groups may form a six-membered aryl or heteroaryl ring, optionally having a substituent R6 forming a ring with R3.

Abstract translation: 公开了在化合物是大麻素受体调节剂的哺乳动物中用于治疗呼吸系统疾病的化合物的用途。 用作治疗呼吸道和非呼吸性白细胞活化相关疾病的大麻素受体调节剂的化合物包括式（I）化合物，其中A和B为氮或碳，只提供A和B之一为氮; 和R 1 -R 6如说明书中所定义，其中R 2与R 5可以形成环，和/或两个R 4基团可以形成六元芳基或杂芳基环，任选地具有与R 3形成环的取代基R 6。

公开(公告)号：WO2007143422A2

公开(公告)日：2007-12-13

申请号：PCT/US2007069723

申请日：2007-05-25

Applicant: JANSSEN PHARMACEUTICA NV ,  KEITH JOHN M ,  LETAVIC MICHAEL A ,  LY KIEV S ,  MANI NEELAKANDHA S ,  MILLS JOHN E ,  PANDIT CHENNAGIRI R ,  VILLANI FRANK J ,  ZHONG HUA

Inventor： KEITH JOHN M ,  LETAVIC MICHAEL A ,  LY KIEV S ,  MANI NEELAKANDHA S ,  MILLS JOHN E ,  PANDIT CHENNAGIRI R ,  VILLANI FRANK J ,  ZHONG HUA

IPC: C07D213/81 ,  A61K31/44 ,  A61P25/00

CPC classification number: C07D213/82 ,  C07D213/81 ,  C07D213/84 ,  C07D401/06

Abstract: Certain substituted pyridyl amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.

Abstract translation: 某些取代的吡啶酰胺化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。

公开(公告)号：WO2007053427A2

公开(公告)日：2007-05-10

申请号：PCT/US2006/041859

申请日：2006-10-26

Applicant: JANSSEN PHARMACEUTICA N.V. ,  PALMER, David C. ,  MANI, Neelakandha S. ,  PANDIT, Chennagiri R. ,  REYES, Mayra B. ,  XIAO, Tong

Inventor： MANI, Neelakandha S. ,  PANDIT, Chennagiri R. ,  REYES, Mayra B. ,  XIAO, Tong

IPC: C07D295/18 ,  C07D211/14 ,  C07D207/06

CPC classification number: C07D295/192 ,  C07D207/06 ,  C07D211/14 ,  C07D295/182 ,  C07D413/04

Abstract: The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.

Abstract translation: 本发明涉及用于制备取代的哌嗪基和二氮杂环庚烷苯甲酰胺的新方法，其可用于治疗由组胺受体介导的障碍和病症。

公开(公告)号：WO0158869A3

公开(公告)日：2002-01-24

申请号：PCT/US0104131

申请日：2001-02-08

Applicant: SQUIBB BRISTOL MYERS CO ,  LEFTHERIS KATERINA ,  ZHAO RULIN ,  CHEN BANG CHI ,  KIENER PETER ,  WU HONG ,  PANDIT CHENNAGIRI R ,  WROBLESKI STEPHEN ,  CHEN PING ,  HYNES JOHN JR ,  LONGPHRE MALINDA ,  NORRIS DEREK J ,  SPERGEL STEVEN ,  TOKARSKI JOHN

Inventor： LEFTHERIS KATERINA ,  ZHAO RULIN ,  CHEN BANG-CHI ,  KIENER PETER ,  WU HONG ,  PANDIT CHENNAGIRI R ,  WROBLESKI STEPHEN ,  CHEN PING ,  HYNES JOHN JR ,  LONGPHRE MALINDA ,  NORRIS DEREK J ,  SPERGEL STEVEN ,  TOKARSKI JOHN

IPC: A61K31/40 ,  A61K31/404 ,  A61K31/41 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/421 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/428 ,  A61K31/433 ,  A61K31/4353 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/551 ,  A61K45/00 ,  A61P11/00 ,  A61P11/06 ,  C07D207/337 ,  C07D207/40 ,  C07D207/416 ,  C07D209/08 ,  C07D209/42 ,  C07D231/14 ,  C07D231/56 ,  C07D233/90 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D453/02 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D498/04 ,  C07D498/06 ,  C07D207/34 ,  C07D401/14 ,  C07D407/12

CPC classification number: C07D207/416 ,  A61K31/40 ,  A61K31/415 ,  A61K31/44 ,  C07D209/42 ,  C07D231/14 ,  C07D231/56 ,  C07D233/90 ,  C07D257/04 ,  C07D263/32 ,  C07D271/06 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/08

Abstract: Use of a compound for treating a respiratory disease in a mammal wherein the compound is a cannabinoid receptor modulator is disclosed. Compounds useful as cannabinoid receptor modulators for treating respiratory and non-respiratory leukocyte-activation associated diseases comprise compounds of formula (I), in which A and B are nitrogen or carbon, provided only one of A and B is nitrogen; and R>1 6 2 5 4 6 3

Abstract translation: 公开了在化合物是大麻素受体调节剂的哺乳动物中用于治疗呼吸系统疾病的化合物的用途。 用作治疗呼吸道和非呼吸性白细胞活化相关疾病的大麻素受体调节剂的化合物包括式（I）化合物，其中A和B为氮或碳，只提供A和B之一为氮; 和R 1'-R 6如说明书中所定义，其中R> 2 可以形成环，和/或两个R 4基团可以形成六元芳基或杂芳基 环，任选地具有取代基R> 6 <形成具有R> 3的环。

公开(公告)号：WO2007143422A3

公开(公告)日：2007-12-13

申请号：PCT/US2007/069723

申请日：2007-05-25

Applicant: JANSSEN PHARMACEUTICA N.V. ,  KEITH, John M. ,  LETAVIC, Michael A. ,  LY, Kiev S. ,  MANI, Neelakandha S. ,  MILLS, John E. ,  PANDIT, Chennagiri R. ,  VILLANI, Frank J. ,  ZHONG, Hua

Inventor： KEITH, John M. ,  LETAVIC, Michael A. ,  LY, Kiev S. ,  MANI, Neelakandha S. ,  MILLS, John E. ,  PANDIT, Chennagiri R. ,  VILLANI, Frank J. ,  ZHONG, Hua

IPC: C07D213/81 ,  A61K31/44 ,  A61P25/00

Abstract: Pyridylamide compounds of Formula: (I); wherein R 1 is -C 1-4 alkyl or saturated monocyclic cycloalkyl; m is 1 or 2; X is N or CH; Y is N or CR 3 ; R a is -H, -Z-Ar, -CH 2 NR b R c , -CN, -CO 2 C 1-4 alkyl, -CO 2 H, or -CONR b R c ; where R b and R c are each independently -H or -C 1-4 alkyl; and R 2 is -H or -Z-Ar; with the proviso that one of X and Y is N and one of R a and R 2 is -Z-Ar; where Z is O or S; and Ar is a phenyl or monocyclic heteroaryl group unsubstituted or substituted with one, two, or three R 3 substituents; where each R 3 substituent is independently selected from the group consisting of: halo, -C 1-4 alkyl, -OH 1 -OC 1-4 alkyl, -SC 1-4 alkyl, -CN, -CONR d R e , and -NO 2 ; where R d and R e are each independently -H or -C 1-4 alkyl; are histamine H 3 receptor modulators useful in the treatment of histamine H 3 receptor-mediated1 diseases.

公开(公告)号：WO2007053427A3

公开(公告)日：2007-07-12

申请号：PCT/US2006041859

申请日：2006-10-26

Applicant: JANSSEN PHARMACEUTICA NV ,  PALMER DAVID C ,  MANI NEELAKANDHA S ,  PANDIT CHENNAGIRI R ,  REYES MAYRA B ,  XIAO TONG

Inventor： MANI NEELAKANDHA S ,  PANDIT CHENNAGIRI R ,  REYES MAYRA B ,  XIAO TONG

IPC: C07D295/18 ,  C07D207/06 ,  C07D211/14

CPC classification number: C07D295/192 ,  C07D207/06 ,  C07D211/14 ,  C07D295/182 ,  C07D413/04

Abstract: The present invention is directed to novel processes for the preparation of substituted piperazinyl and diazepanyl benzamides, useful for the treatment of disorders and conditions mediated by the histamine receptor.

Abstract translation: 本发明涉及用于制备用于治疗由组胺受体介导的病症和病症的取代哌嗪基和二氮杂苯甲酰基苯甲酰胺的新方法。

公开(公告)号：WO2005016897A1

公开(公告)日：2005-02-24

申请号：PCT/US2004/025154

申请日：2004-08-04

Applicant: JANSSEN PHARMACEUTICA, N.V. ,  DENG, Xiaohu ,  LIANG, Jimmy, T. ,  MANI, Neelakandha ,  PANDIT, Chennagiri, R.

Inventor： DENG, Xiaohu ,  LIANG, Jimmy, T. ,  MANI, Neelakandha ,  PANDIT, Chennagiri, R.

IPC: C07D241/42

CPC classification number: C04B35/632 ,  C07D241/42 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

Abstract: Certain methods that are useful in the preparation of amidophenyl-sulfonylamino-quinoxaline compounds CCK2 modulators of formula (I) are disclosed.

Abstract translation: 公开了可用于制备式（I）的氨基苯磺酰氨基 - 喹喔啉化合物CCK2调节剂的某些方法。