公开(公告)号：WO2017037629A1

公开(公告)日：2017-03-09

申请号：PCT/IB2016/055194

申请日：2016-08-31

Applicant: BASF SE ,  BASF (CHINA) COMPANY LIMITED

Inventor： PETZKE, Lutz ,  HEROLD, Andrea ,  FLECK, Christian ,  MARTY, Laurent ,  OEDMAN, Peter ,  DICKHAUT, Joachim ,  WEINGARTEN, Melanie ,  LUZHETSKY, Andriy ,  REBETS, Yuriy ,  MANDERSCHEID, Niko

IPC: C12N1/20 ,  C12P1/04 ,  C12R1/465

CPC classification number: C12P17/181 ,  C12N15/52

Abstract: Provided are improved microorganisms for the biosynthesis of pamamycins. Also provided are methods for the production of pamamycins using these microorganisms.

Abstract translation: 提供了用于生物合成帕马霉素的改进的微生物。 还提供了使用这些微生物生产帕马霉素的方法。

公开(公告)号：WO2017109654A1

公开(公告)日：2017-06-29

申请号：PCT/IB2016/057701

申请日：2016-12-16

Applicant: BASF SE ,  BASF (CHINA) COMPANY LIMITED

Inventor： PETZKE, Lutz ,  HEROLD, Andrea ,  FLECK, Christian ,  MARTY, Laurent ,  OEDMAN, Peter ,  DICKHAUT, Joachim ,  WEINGARTEN, Melanie ,  LUZHETSKY, Andriy ,  REBETS, Yuriy ,  SCRIMA, Andrea ,  SCHMELZ, Stefan

IPC: C12N15/113 ,  C12N15/31 ,  C12N15/63

CPC classification number: C12N15/63

Abstract: Provided are genetic systems for inducing or repressing gene expression. The polynucleotides and polypeptides suitable to built such systems, the microorganisms comprising such systems, and the methods using such systems in combination with pamamycin to modulate gene expression are also provided.

Abstract translation: 提供用于诱导或抑制基因表达的遗传系统。 还提供了适合于构建这样的系统的多核苷酸和多肽，包含这种系统的微生物以及使用这些系统与帕马霉素组合以调节基因表达的方法。

公开(公告)号：WO2015092575A1

公开(公告)日：2015-06-25

申请号：PCT/IB2014/066284

申请日：2014-11-24

Applicant: BASF SE ,  BASF (CHINA) COMPANY LIMITED

Inventor： PETZKE, Lutz ,  HEROLD, Andrea ,  FLECK, Christian ,  TREIER-MARXEN, Katrin ,  ÖDMAN, Peter ,  DICKHAUT, Joachim ,  WEINGARTEN, Melanie ,  LUZHETSKY, Andriy ,  REBETS, Yuriy ,  BRÖTZ, Elke ,  MANDERSCHEID, Niko ,  MYRONOVSKYI, Maksym

IPC: C12N1/21 ,  C12N15/10 ,  C12N15/31 ,  C12N15/76 ,  C12P1/06 ,  C12Q1/04 ,  C12R1/47

CPC classification number: C12N15/52 ,  C07K14/36 ,  C12P17/181

Abstract: Provided are polynucleotides and polypeptides involved in the biosynthesis of pamamycin and pamamycin precursors as well as vectors and recombinant microorganisms comprising the polynucleotides and polypeptides. Also provided are methods for the production of pamamycins, in particular pamamycin 607 and pamamycin 621, and their precursors.

Abstract translation: 提供参与帕米霉素和帕米霉素前体的生物合成以及包含多核苷酸和多肽的载体和重组微生物的多核苷酸和多肽。 还提供了生产帕拉霉素，特别是帕米霉素607和帕米霉素621及其前体的方法。