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公开(公告)号：WO2017109654A1
公开(公告)日：2017-06-29
申请号：PCT/IB2016/057701
申请日：2016-12-16
Applicant: BASF SE , BASF (CHINA) COMPANY LIMITED
Inventor： PETZKE, Lutz , HEROLD, Andrea , FLECK, Christian , MARTY, Laurent , OEDMAN, Peter , DICKHAUT, Joachim , WEINGARTEN, Melanie , LUZHETSKY, Andriy , REBETS, Yuriy , SCRIMA, Andrea , SCHMELZ, Stefan
IPC: C12N15/113 , C12N15/31 , C12N15/63
CPC classification number: C12N15/63
Abstract: Provided are genetic systems for inducing or repressing gene expression. The polynucleotides and polypeptides suitable to built such systems, the microorganisms comprising such systems, and the methods using such systems in combination with pamamycin to modulate gene expression are also provided.
Abstract translation: 提供用于诱导或抑制基因表达的遗传系统。 还提供了适合于构建这样的系统的多核苷酸和多肽，包含这种系统的微生物以及使用这些系统与帕马霉素组合以调节基因表达的方法。
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公开(公告)号：WO2017103739A1
公开(公告)日：2017-06-22
申请号：PCT/IB2016/057403
申请日：2016-12-07
Applicant: BASF SE , BASF (CHINA) COMPANY LIMITED
Inventor： PETZKE, Lutz , HEROLD, Andrea , FLECK, Christian , DICKHAUT, Joachim , BRAKHAGE, Axel , VALIANTE, Vito , MATTERN, Derek J. , HORN, Fabian , GUTHKE, Reinhard , LINDE, Joerg , WALTHER, Grit
CPC classification number: C12N9/16 , C12N9/1025 , C12N15/52 , C12P17/181
Abstract: The invention provides polypeptides involved in the biosynthesis of austinoids, as well as recombinant microorganism for the production of austinoids.
Abstract translation: 本发明提供了涉及austinoids生物合成的多肽以及用于生产austinoids的重组微生物。
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公开(公告)号：WO2015092575A1
公开(公告)日：2015-06-25
申请号：PCT/IB2014/066284
申请日：2014-11-24
Applicant: BASF SE , BASF (CHINA) COMPANY LIMITED
Inventor： PETZKE, Lutz , HEROLD, Andrea , FLECK, Christian , TREIER-MARXEN, Katrin , ÖDMAN, Peter , DICKHAUT, Joachim , WEINGARTEN, Melanie , LUZHETSKY, Andriy , REBETS, Yuriy , BRÖTZ, Elke , MANDERSCHEID, Niko , MYRONOVSKYI, Maksym
CPC classification number: C12N15/52 , C07K14/36 , C12P17/181
Abstract: Provided are polynucleotides and polypeptides involved in the biosynthesis of pamamycin and pamamycin precursors as well as vectors and recombinant microorganisms comprising the polynucleotides and polypeptides. Also provided are methods for the production of pamamycins, in particular pamamycin 607 and pamamycin 621, and their precursors.
Abstract translation: 提供参与帕米霉素和帕米霉素前体的生物合成以及包含多核苷酸和多肽的载体和重组微生物的多核苷酸和多肽。 还提供了生产帕拉霉素，特别是帕米霉素607和帕米霉素621及其前体的方法。
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公开(公告)号：WO2018224939A1
公开(公告)日：2018-12-13
申请号：PCT/IB2018/053970
申请日：2018-06-04
Applicant: BASF SE , BASF (CHINA) COMPANY LIMITED
Inventor： PETZKE, Lutz , HEROLD, Andrea , LUZHETSKYY, Andriy , MYRONOVSKYI, Maksym , ROSENKRAENZER, Birgit , TOKOVENKO, Bogdan
Abstract: The invention pertains to the field of production of albucidin. It provides polynucleotides and polypeptides involved in the biosynthesis of albucidin as well as recombinant microorganisms comprising such polynucleotides and polypeptides. Also provided are methods for the production of albucidin.
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公开(公告)号：WO2017037629A1
公开(公告)日：2017-03-09
申请号：PCT/IB2016/055194
申请日：2016-08-31
Applicant: BASF SE , BASF (CHINA) COMPANY LIMITED
Inventor： PETZKE, Lutz , HEROLD, Andrea , FLECK, Christian , MARTY, Laurent , OEDMAN, Peter , DICKHAUT, Joachim , WEINGARTEN, Melanie , LUZHETSKY, Andriy , REBETS, Yuriy , MANDERSCHEID, Niko
CPC classification number: C12P17/181 , C12N15/52
Abstract: Provided are improved microorganisms for the biosynthesis of pamamycins. Also provided are methods for the production of pamamycins using these microorganisms.
Abstract translation: 提供了用于生物合成帕马霉素的改进的微生物。 还提供了使用这些微生物生产帕马霉素的方法。
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Patent Agency Ranking
公开(公告)号：WO2014030090A1
公开(公告)日：2014-02-27
申请号：PCT/IB2013/056519
申请日：2013-08-09
Applicant: BASF SE , BASF (CHINA) COMPANY LIMITED , BASF SCHWEIZ AG
Inventor： PETZKE, Lutz , HEROLD, Andrea , THUMMER, Robert , ZELDER, Oskar , CARLSON, Dale R. , PAULIK, Jill Marie , SEIFERT, Alexander
CPC classification number: C12N15/8274 , C12N9/0077 , C12Y114/15
Abstract: A method for metabolizing PPO-inhibiting herbicides, comprising contacting the PPO-inhibiting herbicide with a CytP450 monooxygenase, is provided. Transgenic plants comprising the CytP450 monooxygenase polypeptide of the invention, as well as methods for producing the same are provided. A method for controlling weeds, employing the CytP450 monooxygenase polypeptide of the invention, a method for producing a polypeptide with enhanced ability to metabolize PPO-inhibiting herbicide, and a method for screening for a microorganism capable of metabolizing PPO-inhibiting herbicide are also provided.
Abstract translation: 提供了一种用于代谢PPO抑制性除草剂的方法，其包括使PPO抑制性除草剂与CytP450单加氧酶接触。 提供了包含本发明的CytP450单加氧酶多肽的转基因植物及其制备方法。 还提供了使用本发明的CytP450单加氧酶多肽的方法，用于生产具有增强的抑制PPO的除草剂代谢能力的多肽的方法和用于筛选能够代谢PPO抑制性除草剂的微生物的方法。
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7.发明申请CORYNEFORM BACTERIA WITH FORMATE-THF-SYNTHETASE AND/OR GLYCINE CLEAVAGE ACTIVITY 审中-公开具有四氢呋喃 - 合成酶和/或甘氨酸清除活性的真菌细菌
公开(公告)号：WO2008101857A2
公开(公告)日：2008-08-28
申请号：PCT/EP2008/051795
申请日：2008-02-14
Applicant: BASF SE , YOCUM, R. Rogers , ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea , HAEFNER, Stefan , PATTERSON, Thomas A. , PERO, Janice G.
Inventor： ZELDER, Oskar , SCHRÖDER, Hartwig , KLOPPROGGE, Corinna , HEROLD, Andrea , HAEFNER, Stefan , PATTERSON, Thomas A. , PERO, Janice G.
Abstract: The present invention relates to microorganisms, in particular C. glutamicum in which the formation of N 5 , N 10 -methylene-THF is increased. The present invention also relates to the use of such microorganisms for producing methionine.
Abstract translation: 本发明涉及微生物，特别是谷氨酸棒杆菌，其中N 5，N 10 - 亚甲基-THF的形成增加。 本发明还涉及这种微生物用于产生甲硫氨酸的用途。
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公开(公告)号：WO2008080900A2
公开(公告)日：2008-07-10
申请号：PCT/EP2007/064471
申请日：2007-12-21
Applicant: BASF SE , ZELDER, Oskar , GRABARSE, Wolfgang , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , HAEFNER, Stefan , KNIETSCH, Anja , HEROLD, Andrea
Inventor： ZELDER, Oskar , GRABARSE, Wolfgang , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , HAEFNER, Stefan , KNIETSCH, Anja , HEROLD, Andrea
IPC: C07K14/43
CPC classification number: C12N9/0091 , C12P13/12
Abstract: The present invention relates to nulceotide sequences encoding enzymatically active cobalamin-methionine synthase and functional fragments thereof being modified in comparison to the respective wild-type enzyme such that said enzymes show reduced product inhibition by methionine. The present invention also relates to polypeptides being encoded by such nucleotide sequences and host cells comprising such nucleotide sequences. Furthermore, the present invention relates to methods for producing methionine in host organisms by making use of suchnucleotide sequences.
Abstract translation: 本发明涉及编码酶促活性钴胺素 - 甲硫氨酸合成酶的核糖核酸序列及其功能片段，其与相应的野生型酶相比被修饰，使得所述酶显示产品抑制蛋氨酸的产物减少。 本发明还涉及由该核苷酸序列编码的多肽和包含该核苷酸序列的宿主细胞。 此外，本发明涉及通过利用这种核苷酸序列在宿主生物体中产生甲硫氨酸的方法。
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公开(公告)号：WO2008049782A1
公开(公告)日：2008-05-02
申请号：PCT/EP2007/061152
申请日：2007-10-18
Applicant: BASF SE , HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , ZELDER, Oskar , JEONG, Weol Kyu
Inventor： HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , ZELDER, Oskar , JEONG, Weol Kyu
Abstract: The present invention relates to a method of increasing the amount of at least one polypeptide in the host cell by expressing a modified nucleotide sequence encoding for a polypeptide in a host cell with said modified.nucleotide sequence being derived from a different non-modified nucleotide sequence encoding for a polypeptide of identical amino acid sequence such that the codon usage of the modified nucleotide sequence is adjusted to the codon usage of abundant proteins in the host cell.
Abstract translation: 本发明涉及一种通过在宿主细胞中表达编码多肽的修饰的核苷酸序列来增加宿主细胞中至少一种多肽的量的方法，所述修饰的核苷酸序列衍生自不同的未修饰的核苷酸序列 编码相同氨基酸序列的多肽，使得修饰的核苷酸序列的密码子使用被调整为宿主细胞中丰富蛋白质的密码子使用。
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公开(公告)号：WO2008049781A1
公开(公告)日：2008-05-02
申请号：PCT/EP2007/061151
申请日：2007-10-18
Applicant: BASF SE , HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , ZELDER, Oskar , JEONG, Weol Kyu
Inventor： HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , ZELDER, Oskar , JEONG, Weol Kyu
IPC: C12N15/77
CPC classification number: C12N15/77
Abstract: The present invention is directed to a method of reducing the amount of at least one polypeptide in a host cell by expressing a nucleotide sequence encoding for the polypeptide in the host cell wherein the nucleotide sequence uses codons that are rarely used according to the codon usage of the host organism. Furthermore, the present invention relates to nucleotide sequences encoding for a polypeptide with a codon usage that has been adjusted to use codons that are only rarely used according to the codon usage of the host organism. The present invention further relates to the use of such sequences and methods for producing fine chemicals such as amino acids, sugars, lipids, oils, carbohydrates, vitamins, cofactors etc.
Abstract translation: 本发明涉及通过在宿主细胞中表达编码多肽的核苷酸序列来减少宿主细胞中至少一种多肽的量的方法，其中所述核苷酸序列使用根据密码子使用的密码子使用的密码子 宿主生物体。 此外，本发明涉及编码具有密码子用途的多肽的核苷酸序列，其已被调整为使用根据宿主生物的密码子使用很少使用的密码子。 本发明还涉及这样的序列和方法用于生产精细化学品如氨基酸，糖，脂质，油，碳水化合物，维生素，辅因子等的用途。
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