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    USE OF 2,3,6-TRIMETHYL-2-CYCLOHEXEN-1-ONE AS AROMA INGREDIENT
    4.
    发明申请
    USE OF 2,3,6-TRIMETHYL-2-CYCLOHEXEN-1-ONE AS AROMA INGREDIENT 审中-公开

    公开(公告)号：WO2023285329A1

    公开(公告)日：2023-01-19

    申请号：PCT/EP2022/069210

    申请日：2022-07-11

    Applicant: BASF SE

    Inventor： WEINGARTEN, Melanie ,  SIEGEL, Wolfgang ,  PELZER, Ralf ,  BRU ROIG, Miriam ,  GARLICHS, Florian

    IPC: C11D3/50 ,  C07C45/67 ,  C07C49/603

    Abstract: The present invention relates to use of 2,3,6-Trimethyl-2-cyclohexen-1-one as aroma Ingredient. 2,3,6-Trimethyl-2-cyclohexen-1-one is used to impart an aroma impression which is reminiscent of animalic note, woody note, floral note, green note, minty note, dusty note, phenolic note, and/ or camphoraceous note to a composition and alsoenhancing and/or modifying the aroma of a composition. The present invention is further directed to an aroma composition comprising 2,3,6-Trimethyl-2-cyclohexen-1-one and (i) at least one aroma chemical different from the 2,3,6-Trimethyl-2-cyclohexen-1-one or (ii) at least one non-aroma chemical carrier, or (iii) both (i) and (ii).

    SYNTHESIS OF CHROMANOL DERIVATIVES
    5.
    发明申请
    SYNTHESIS OF CHROMANOL DERIVATIVES 审中-公开

    公开(公告)号：WO2020035604A1

    公开(公告)日：2020-02-20

    申请号：PCT/EP2019/072040

    申请日：2019-08-16

    Applicant: BASF SE

    Inventor： WEINGARTEN, Melanie ,  SIEGEL, Wolfgang ,  PUHL, Michael

    IPC: C07D311/58

    Abstract: The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula I wherein R 1 , R 2 and R 3 independently of each other are selected from hydrogen and methyl, R 4 is selected from C- 1 -C 6 -alkyl, and X is selected from C 1 -C 20 -alkyl and C 2 -C 20 -alkenyl.

    NOVEL PRODUCTION OF AROMA COMPOUNDS WITH IONYLIDENEETHANE SYNTHASES
    6.
    发明申请
    NOVEL PRODUCTION OF AROMA COMPOUNDS WITH IONYLIDENEETHANE SYNTHASES 审中-公开

    公开(公告)号：WO2023012111A2

    公开(公告)日：2023-02-09

    申请号：PCT/EP2022/071567

    申请日：2022-08-01

    Applicant: BASF SE

    Inventor： BREUER, Michael ,  WEINGARTEN, Melanie

    IPC: C12P5/00 ,  C12P7/26 ,  C12P23/00 ,  C12N9/88 ,  A23L27/20 ,  A61Q13/00 ,  C12N9/02

    Abstract: The present invention relates to the use of alpha-ionylideneethane as an aroma compound, and to the use of an alpha-ionylideneethane synthase in the production of one or more aroma compounds. The inventive method for preparing one or more aroma compounds comprises a) providing farnesyl diphosphate and an alpha-ionylideneethane synthase as defined herein, under conditions suitable for the alpha-ionylideneethane synthase to produce alpha-ionylideneethane, b) converting farnesyl diphosphate to alpha-ionylideneethane, in vitro or in a host cell, c) optionally, converting alpha-ionylideneethane to one or more further aroma compounds, d) isolating alpha-ionylideneethane and the optionally one or more further aroma compounds and, e) optionally, purifying alpha-ionylideneethane and the optionally one or more further aroma compounds. The invention pertains also to method for scenting a product, particularly for imparting and/or enhancing an odor or flavor, in which at least one alpha-ionylideneethane synthase is used. In addition, the invention provides an aroma compound or composition and/or fragrance composition and/or perfumed or fragranced product, comprising i) at least an alpha-ionylideneethane. Further encompassed by the invention is a perfumed or fragranced product comprising at least an alpha-ionylideneethane. The invention further relates to a method for producing alpha-ionone (4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one), comprising the steps in the following order: a) contacting farnesyl diphosphate with at least one alpha-ionylideneethane synthase, under conditions suitable to produce at least one alpha-ionylideneethane; b) producing the at least alpha-ionylideneethane; c) exposing the at least one alpha-ionylideneethane produced in step b) to conditions suitable for oxidative cleavage of alpha-ionylideneethane to produce alpha-ionone; and d) optionally, isolating the alpha-ionone produced in step c). The invention also relates to a host cell for producing alpha-ionone (4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one), wherein the host cell comprises farnesyl diphosphate and a heterologous nucleic acid encoding an alpha-ionylideneethane synthase, wherein the host cell is capable of oxidatively cleaving alpha-ionylideneethane to produce alpha-ionone. Finally, the invention relates to the use of a host cell comprising farnesyl diphosphate and a heterologous nucleic acid encoding an alpha-ionylideneethane synthase, for (i) producing alpha-ionylideneethane; (ii) producing alpha-ionone; (iii) producing vitamin A; (iv) converting alpha-ionylideneethane to alpha-ionone; (v) converting alpha-ionylideneethane to vitamin A; (vi) for heterologous reconstitution of a terpene or terpenoid; (vii) for producing an industrial product; (viii) a fermentative production system for producing a sesquiterpene.

    SYNTHESIS OF CHROMANOL DERIVATIVES
    8.
    发明申请
    SYNTHESIS OF CHROMANOL DERIVATIVES 审中-公开

    公开(公告)号：WO2020035600A1

    公开(公告)日：2020-02-20

    申请号：PCT/EP2019/072029

    申请日：2019-08-16

    Applicant: BASF SE

    Inventor： WEINGARTEN, Melanie ,  SIEGEL, Wolfgang ,  PUHL, Michael

    IPC: C07D311/58

    Abstract: The present invention relates to a process for the production of chromanol derivatives, more specifically to a process for preparing a compound of the general formula (I) wherein R 1 , R 2 and R 3 independently of each other are selected from hydrogen and methyl, R 4 is selected from hydrogen and C 1 -C 6 -alkanoyl, and X is selected from C 1 -C 20 -alkyl and C 2 -C 20 -alkenyl.

    2-(2,4,5-TRIMETHYLCYCLOHEX-2-EN-1-YL)ACETALDEHYDE AND DERIVATIVES AND THEIR USE AS AROMA CHEMICALS
    10.
    发明申请
    2-(2,4,5-TRIMETHYLCYCLOHEX-2-EN-1-YL)ACETALDEHYDE AND DERIVATIVES AND THEIR USE AS AROMA CHEMICALS 审中-公开

    公开(公告)号：WO2021005109A1

    公开(公告)日：2021-01-14

    申请号：PCT/EP2020/069251

    申请日：2020-07-08

    Applicant: BASF SE

    Inventor： WEINGARTEN, Melanie ,  SIEGEL, Wolfgang ,  WEYLAND, Silke ,  PELZER, Ralf

    IPC: C07C33/14 ,  C07C43/162 ,  C07C43/188 ,  C07C43/303 ,  C07C69/145 ,  C11B9/00 ,  C11D3/20 ,  C11D3/50 ,  A61Q5/02 ,  A61Q13/00 ,  A61Q19/00 ,  A61Q19/10 ,  A61K8/33 ,  A61K8/44

    Abstract: The present invention relates to 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde and derivatives thereof, to a process for preparing said compounds, to the use of 2-(2,4,5- trimethylcyclohex-2-en-1-yl)acetaldehyde or a specific derivative thereof or of mixtures of said compounds or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof as aroma chemicals; to the use of 2-(2,4,5-trimethylcyclohex-2- en-1-yl)acetaldehyde or a specific derivative thereof for modifying the scent character of a fragranced composition; to compositions containing 2-(2,4,5-trimethylcyclohex-2- en-1-yl)acetaldehyde or a specific derivative thereof or a mixture of said compounds or a stereoisomer thereof or a mixture of two or more stereoisomers thereof; and to a method of preparing a fragranced composition or for modifying the scent character of a fragranced composition, comprising incorporating 2-(2,4,5-trimethylcyclohex-2-en-1-yl)- acetaldehyde or a specific derivative thereof or a mixture of said compounds or a stereoisomer thereof or a mixture of two or more stereoisomers thereof into said composition.

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