公开(公告)号：WO2012155199A1

公开(公告)日：2012-11-22

申请号：PCT/AU2012/000538

申请日：2012-05-16

Applicant: BIONOMICS LIMITED ,  MERCK PATENT GMBH ,  HARVEY, Andrew ,  BOMBRUN, Agnes ,  COOKE, Rachel ,  JEANCLAUDE-ETTER, Isabelle ,  KUCHEL, Nathan ,  MOLETTE, Jerome ,  MOULD, Jorgen ,  PAUL, Dharam ,  SINGH, Rajinder ,  DONINI, Cristina ,  COLOVRAY, Veronique

Inventor： HARVEY, Andrew ,  BOMBRUN, Agnes ,  COOKE, Rachel ,  JEANCLAUDE-ETTER, Isabelle ,  KUCHEL, Nathan ,  MOLETTE, Jerome ,  MOULD, Jorgen ,  PAUL, Dharam ,  SINGH, Rajinder ,  DONINI, Cristina ,  COLOVRAY, Veronique

IPC: C07D213/16 ,  A61K31/50 ,  C07D213/89 ,  A61K31/165 ,  A61K31/505 ,  C07D231/12 ,  A61K31/351 ,  A61P37/06 ,  C07D233/56 ,  A61K31/415 ,  C07C233/06 ,  C07D237/08 ,  A61K31/4164 ,  C07D209/52 ,  C07D239/24 ,  A61K31/44 ,  C07D211/16 ,  C07D241/12 ,  A61K31/4402 ,  C07D211/26 ,  C07D309/14 ,  A61K31/4427 ,  C07D211/38 ,  C07D401/12 ,  A61K31/4436 ,  C07D213/61 ,  C07D405/12 ,  A61K31/445 ,  C07D213/64 ,  C07D411/12 ,  A61K31/454 ,  C07D213/70 ,  C07D413/12 ,  A61K31/4965

CPC classification number: C07D213/40 ,  C07C217/90 ,  C07D209/52 ,  C07D211/16 ,  C07D211/26 ,  C07D211/38 ,  C07D213/16 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/89 ,  C07D231/12 ,  C07D233/56 ,  C07D237/08 ,  C07D239/24 ,  C07D239/34 ,  C07D241/12 ,  C07D241/18 ,  C07D309/14 ,  C07D401/12 ,  C07D405/12 ,  C07D411/12 ,  C07D413/12 ,  C07D451/04

Abstract: The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

Abstract translation: 本发明涉及可用于调节细胞中钾通道活性的化合物，特别是在T细胞中发现的Kv1.3通道的活性。 本发明还涉及这些化合物在治疗或预防自身免疫性和炎性疾病，包括多发性硬化症中的用途，含有这些化合物的药物组合物及其制备方法。

公开(公告)号：WO2019218025A1

公开(公告)日：2019-11-21

申请号：PCT/AU2019/050472

申请日：2019-05-17

Applicant: BIONOMICS LIMITED

Inventor： HUFF, Belinda ,  HOLLIS, Courtney ,  TOOP, Hamish ,  KUCHEL, Nathan ,  MITCHELL, Lorna Helen ,  SINGH, Rajinder

IPC: C07D471/04 ,  C07D209/24 ,  C07D213/64 ,  C07D487/04 ,  A61K31/404 ,  A61K31/4412 ,  A61K31/437 ,  A61K31/5025 ,  A61P29/02

Abstract: The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.

公开(公告)号：WO2019218024A1

公开(公告)日：2019-11-21

申请号：PCT/AU2019/050471

申请日：2019-05-17

Applicant: BIONOMICS LIMITED

Inventor： HUFF, Belinda ,  HOLLIS, Courtney ,  TOOP, Hamish ,  KUCHEL, Nathan ,  MITCHELL, Lorna Helen ,  SINGH, Rajinder ,  AVERY, Thomas ,  MICHAUT-SIMON, Celine ,  CONTRERAS, Jean-Marie ,  MORICE, Christophe

IPC: C07D471/04 ,  C07D231/14 ,  C07D213/81 ,  C07D213/82 ,  C07D239/28 ,  C07D239/34 ,  C07D241/24 ,  C07D249/10 ,  C07D271/10 ,  C07D277/56 ,  A61P29/00 ,  A61K31/4245 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4965 ,  A61K31/519

Abstract: The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.

公开(公告)号：WO2019126842A1

公开(公告)日：2019-07-04

申请号：PCT/AU2018/051409

申请日：2018-12-24

Applicant: BIONOMICS LIMITED

Inventor： HOLLIS, Courtney ,  KUCHEL, Nathan ,  SINGH, Rajinder ,  HARVEY, Andrew ,  AVERY, Thomas ,  CHERY, Florence ,  CONTRERAS, Jean-Marie ,  GAY, Julie ,  JUNG, Laetitia ,  MICHAUT-SIMON, Celine ,  MORICE, Christophe ,  STEFFEN, Alexandre

IPC: C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  A61P29/02 ,  A61K31/41 ,  A61K31/4439

Abstract: The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.

公开(公告)号：WO2014172759A1

公开(公告)日：2014-10-30

申请号：PCT/AU2014/050021

申请日：2014-04-24

Applicant: BIONOMICS LIMITED

Inventor： HARVEY, Andrew ,  HUFF, Belinda ,  SINGH, Rajinder ,  KUCHEL, Nathan

IPC: C07D401/12 ,  C07D403/12 ,  C07D401/14 ,  A61K31/4427 ,  A61K31/506 ,  A61P25/28 ,  A61P29/00

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D403/12

Abstract: The present invention relates to chemical compounds useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (α7 nAChR).

Abstract translation: 本发明涉及可用于阳性调节α7烟碱乙酰胆碱受体（α7nAChR）的化合物。

公开(公告)号：WO2014036595A1

公开(公告)日：2014-03-13

申请号：PCT/AU2013/000991

申请日：2013-09-02

Applicant: BIONOMICS LIMITED

Inventor： HARVEY, Andrew ,  PAUL, Dharam ,  KUCHEL, Nathan ,  O'CONNOR, Sue

IPC: A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  C07D215/36 ,  C07D215/54 ,  C07D413/04

CPC classification number: A61K31/47 ,  A61K31/4709 ,  A61K31/5377 ,  C07D215/54

Abstract: The present disclosure relates to quinoline compounds of formula I, compositions comprising them and methods and uses for the treatment of central nervous system disorders, such as mood disorders (eg. depression), anxiety disorders, and neurodegenerative diseases. Additionally, the disclosure relates to methods of enhancing neurite outgrowth and the treatment of diseases/conditions associated with neurite outgrowth (eg. multiple sclerosis).

Abstract translation: 本公开内容涉及式I的喹啉化合物，包含它们的组合物以及用于治疗中枢神经系统疾病如情绪障碍（例如抑郁症），焦虑障碍和神经变性疾病的方法和用途。 此外，本公开涉及增强神经突生长和治疗与神经突生长（例如多发性硬化）相关的疾病/病症的方法。