公开(公告)号：WO2011117634A3

公开(公告)日：2012-03-15

申请号：PCT/GB2011050587

申请日：2011-03-23

Applicant: CADBURY UK LTD ,  CLARKE PETER ,  MARSHALL SARAH

Inventor： CLARKE PETER ,  MARSHALL SARAH

IPC: A23G3/00 ,  A23G3/54 ,  A23G4/00 ,  A23G4/20

CPC classification number: A23G3/54 ,  A23G1/54 ,  A23G3/364 ,  A23G3/545 ,  A23G4/12 ,  A23G4/20 ,  A23L27/70 ,  A23P30/25 ,  A23V2002/00 ,  A61K8/0216 ,  A61K9/0058 ,  A61K31/522 ,  A61K2800/244 ,  A61Q11/00

Abstract: The invention relates to a confectionery product comprising an extruded body portion, the body portion having a plurality of capillaries disposed therein, one or more of the capillaries being at least partially filled with a fill material which is a different material from that of the extruded body portion, the fill material and optionally the body portion comprising various active and/or reactive components. Some embodiments are designed to provide sequential release profiles. The invention also relates to a process for the manufacture of the same.

Abstract translation: 本发明涉及一种糖果产品，其包括挤压主体部分，主体部分具有多个设置在其中的毛细管，一个或多个毛细管至少部分地填充有填充材料，该填充材料是与挤出体的材料不同的材料 部分，填充材料和任选的主体部分包括各种有源和/或反应组分。 一些实施例被设计为提供顺序释放简档。 本发明还涉及其制造方法。

公开(公告)号：WO2011117638A3

公开(公告)日：2012-01-19

申请号：PCT/GB2011050591

申请日：2011-03-23

Applicant: CADBURY UK LTD ,  BINGLEY CAROLE ANN ,  BUFTON ANDREW ,  CLARKE PETER ,  MARSHALL SARAH ,  NORTON CLIVE RICHARD THOMAS ,  SAKANISHI HIDEKI ,  SUTARIA DEVANG

Inventor： BINGLEY CAROLE ANN ,  BUFTON ANDREW ,  CLARKE PETER ,  MARSHALL SARAH ,  NORTON CLIVE RICHARD THOMAS ,  SAKANISHI HIDEKI ,  SUTARIA DEVANG

IPC: A23G3/00 ,  A23G3/54 ,  A23G4/20

CPC classification number: A23G3/54 ,  A23G1/0056 ,  A23G1/52 ,  A23G1/54 ,  A23G3/0068 ,  A23G3/52 ,  A23G4/043 ,  A23G4/06 ,  A23G4/182 ,  A23G4/20

Abstract: The present invention relates to a confectionery product comprising an extruded body portion, the body portion being formed from a material which is liquid during extrusion and which has a plurality of capillaries disposed therein, the capillaries having an average width or diameter of no more than 3 millimetres. The invention also relates to a process of manufacturing the same.

Abstract translation: 本发明涉及一种糖果产品，其包括挤压主体部分，主体部分由在挤出期间为液体的材料形成，并且其中设置有多个毛细管，毛细管的平均宽度或直径不大于3 毫米。 本发明还涉及其制造方法。

公开(公告)号：WO2011117633A3

公开(公告)日：2012-01-12

申请号：PCT/GB2011050586

申请日：2011-03-23

Applicant: CADBURY UK LTD ,  CLARKE PETER ,  MARSHALL SARAH ,  NORTON CLIVE RICHARD THOMAS

Inventor： CLARKE PETER ,  MARSHALL SARAH ,  NORTON CLIVE RICHARD THOMAS

IPC: A23G3/00 ,  A21C9/06 ,  A21D13/00 ,  A23G3/20 ,  A23K1/00 ,  A23K1/18 ,  A23P1/12 ,  B29C44/58 ,  B29C47/00

CPC classification number: A21D13/0038 ,  A21D13/37 ,  A21D13/80 ,  A23G3/2015 ,  A23N17/005 ,  A23P30/20 ,  A23P30/25 ,  B29C47/0011 ,  B29C47/0014 ,  B29C47/003 ,  B29C47/0033 ,  B29C47/30 ,  B29C47/8805 ,  B29C47/8815 ,  B29C2947/92704 ,  B29C2947/92895 ,  B29K2105/251 ,  B29L2031/731

Abstract: The present invention relates to a consumable biscuit product comprising an extruded biscuit portion, the body portion being formed with one or more channels disposed therein, wherein the one or more channels contain a substance which is different from the substance of the body portion and wherein at least one of the channels does not extend along the full length of the body portion. The present invention also provides a method of production of the same.

Abstract translation: 本发明涉及一种消费性饼干产品，其包括挤出的饼干部分，主体部分形成有设置在其中的一个或多个通道，其中一个或多个通道包含不同于主体部分的物质的物质， 通道中的至少一个不沿身体部分的全长延伸。 本发明还提供了其制备方法。

公开(公告)号：WO2007134325A3

公开(公告)日：2008-04-03

申请号：PCT/US2007068977

申请日：2007-05-15

Applicant: INTROGEN THERAPEUTICS INC ,  ZHANG SHUYUAN ,  PHAM HAI ,  SONG PING ,  ZHENG MING ,  CLARKE PETER

Inventor： ZHANG SHUYUAN ,  PHAM HAI ,  SONG PING ,  ZHENG MING ,  CLARKE PETER

IPC: C12N15/861

CPC classification number: C12N15/86 ,  C12N2710/10343

Abstract: The present invention provides methods and compositions for recombinant protein production through replication-defective adenoviral vector infection of non-trans- complementation cell lines. Thus, this invention describes methods of heterologous protein production without an accompanied production of adenoviral vectors.

Abstract translation: 本发明提供了通过非反互补细胞系的复制缺陷型腺病毒载体感染重组蛋白质生产的方法和组合物。 因此，本发明描述了不伴随腺病毒载体产生的异源蛋白质生产的方法。

公开(公告)号：WO2006052302A3

公开(公告)日：2007-07-05

申请号：PCT/US2005026178

申请日：2005-07-22

Applicant: INTROGEN THERAPEUTICS INC ,  PHAM HAI ,  ZHANG SHUYUAN ,  CLARKE PETER

Inventor： PHAM HAI ,  ZHANG SHUYUAN ,  CLARKE PETER

IPC: C12N7/00 ,  A01N63/00 ,  A23J1/00 ,  C12N5/00 ,  C12Q1/68

CPC classification number: C12N15/86 ,  A61K48/00 ,  C12N7/00 ,  C12N15/1017 ,  C12N2710/10343 ,  C12N2710/10351 ,  C12Q1/70

Abstract: The present invention relates to improved methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.

Abstract translation: 本发明涉及用于产生腺病毒组合物的改进方法，其中宿主细胞在生物反应器中生长并通过大小分配纯化纯化以提供纯化的腺病毒组合物。

公开(公告)号：WO2005015344A3

公开(公告)日：2005-09-22

申请号：PCT/US2004020636

申请日：2004-06-28

Applicant: EXULT INC ,  ANDERSON GREG ,  CLARKE PETER ,  GROENESTIJN BERRY ,  JONES RICHARD ,  MONTGOMERY JIM ,  UNTERBERGER STEVE

Inventor： ANDERSON GREG ,  CLARKE PETER ,  GROENESTIJN BERRY ,  JONES RICHARD ,  MONTGOMERY JIM ,  UNTERBERGER STEVE

IPC: G06F20060101 ,  G06F17/60

CPC classification number: H04L41/5054 ,  G06Q10/10

Abstract: A system is provided for routing and managing service requests. A service request is received from a service requestor (100), and a determination (160) is made as to which of a plurality of service-providing nodes the service request should be transmitted. The service request is transmitted to the determined service-providing node. The service request may comprise one or more attributes describing the service request, and the determination as to which of the service-providing nodes the service request is transmitted may be based on the value of the one or more service request attributes (120). The service request may be divided into portions, each portion transmitted to a service-providing node. Information received from a service-providing node may enable an evaluation of whether and why a service request was not fulfilled.

Abstract translation: 提供了用于路由和管理服务请求的系统。 从服务请求者（100）接收到服务请求，并且确定（160）关于应该发送服务请求的多个服务提供节点中的哪一个。 服务请求被发送到确定的服务提供节点。 服务请求可以包括描述服务请求的一个或多个属性，并且关于服务请求被发送的服务提供节点中的哪一个的确定可以基于一个或多个服务请求属性（120）的值。 服务请求可以被划分为部分，每个部分被发送到服务提供节点。 从服务提供节点接收到的信息可以评估是否以及为什么不满足服务请求。

公开(公告)号：WO2008045601A2

公开(公告)日：2008-04-17

申请号：PCT/US2007071490

申请日：2007-06-18

Applicant: INTROGEN THERAPEUTICS INC ,  CLARKE PETER ,  WEAVER SCOTT ,  MOTIN VLADAMIR ,  CHOPRA ASHOK ,  PETERSON JOHN

Inventor： CLARKE PETER ,  WEAVER SCOTT ,  MOTIN VLADAMIR ,  CHOPRA ASHOK ,  PETERSON JOHN

IPC: C12N15/861 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145

CPC classification number: A61K39/12 ,  A61K39/00 ,  A61K39/0291 ,  A61K2039/5256 ,  C12N2710/10043 ,  C12N2770/36134

Abstract: Embodiments of the present invention include the construction and generation of a multi-use adenoviral vaccine platform applicable to biodefense, and emerging and re- emerging infectious diseases. Adenoviral vaccines of the invention will elicit an immune response against pathogenic organisms that cause such infectious diseases. In certain aspects of the invention, the pathogenic organisms include, but are not limited to EEEV and Y. pestis. Further embodiments of the invention include compositions and methods related to such adenoviral vaccines.

Abstract translation: 本发明的实施方案包括可应用于生物防御和新兴和新出现的感染性疾病的多用途腺病毒疫苗平台的构建和产生。 本发明的腺病毒疫苗将引起针对导致这种感染性疾病的致病生物体的免疫应答。 在本发明的某些方面，致病生物包括但不限于EEEV和鼠疫耶尔氏酵母。 本发明的其它实施方案包括与这种腺病毒疫苗相关的组合物和方法。

公开(公告)号：WO2006079014A2

公开(公告)日：2006-07-27

申请号：PCT/US2006002255

申请日：2006-01-20

Applicant: INTROGEN THERAPEUTICS INC ,  CLARKE PETER ,  CHADA SUNIL ,  MENANDER KERSTIN ,  SOBOL ROBERT ,  ZHANG SHUYUAN

Inventor： CLARKE PETER ,  CHADA SUNIL ,  MENANDER KERSTIN ,  SOBOL ROBERT ,  ZHANG SHUYUAN

IPC: A61K48/00 ,  C12N15/88

CPC classification number: C07K14/4746 ,  A61K8/606 ,  A61K9/0014 ,  A61K9/1272 ,  A61K48/005 ,  A61K48/0075 ,  A61Q11/00 ,  A61Q19/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2799/022 ,  C12N2830/008

Abstract: Compositions and methods for preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include a nucleic acid comprised in a solid or semi¬ solid formation or in a transdermal or transcutaneous delivery device are disclosed. Also disclosed are compositions of a nucleic acid capable of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include an adhesive. Compositions of a nucleic acid capable of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that include a nucleic acid uptake enhancer are also disclosed. Methods of preventing or inhibiting the growth of a hyperproliferative lesion in a subject that involve these therapeutic compositions and devices are also disclosed.

Abstract translation: 公开了用于预防或抑制包括固体或半固体形式中包含的核酸或者透皮或经皮递送装置中的核酸的受试者中过度增殖性损伤的生长的组合物和方法。 还公开了能够预防或抑制包括粘合剂的受试者中过度增殖性损伤的生长的核酸的组合物。 还公开了能够预防或抑制包括核酸摄取增强剂的受试者中过度增殖性损伤的生长的核酸的组合物。 还公开了预防或抑制涉及这些治疗组合物和装置的受试者中过度增殖性损伤的生长的方法。

公开(公告)号：WO2007059473A3

公开(公告)日：2007-11-01

申请号：PCT/US2006060847

申请日：2006-11-13

Applicant: INTROGEN THERAPEUTICS INC ,  ZHANG SHUYUAN ,  PHAM HAI ,  SONG PING ,  CLARKE PETER

Inventor： ZHANG SHUYUAN ,  PHAM HAI ,  SONG PING ,  CLARKE PETER

IPC: C12N7/02 ,  A61K48/00 ,  C12N15/861

CPC classification number: C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2710/10351

Abstract: The present invention relates to compositions comprising and methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.

Abstract translation: 本发明涉及组合物及其制备方法，其中宿主细胞在生物反应器中生长并通过大小分配纯化纯化以提供纯化的腺病毒组合物。