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    COMPRESSED TABLETS
    7.
    发明申请
    COMPRESSED TABLETS 审中-公开
    压缩片

    公开(公告)号：WO2009114491A1

    公开(公告)日：2009-09-17

    申请号：PCT/US2009/036590

    申请日：2009-03-10

    Applicant: THE PROCTER & GAMBLE COMPANY ,  KHANOLKAR, Jayant, Eknath ,  HALLISSEY, Martin ,  KILPATRICK, Lynn, Eileen, Campbell

    Inventor： KHANOLKAR, Jayant, Eknath ,  HALLISSEY, Martin ,  KILPATRICK, Lynn, Eileen, Campbell

    IPC: A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A23L1/00 ,  A23L1/22

    CPC classification number: A61K9/0007 ,  A23G3/004 ,  A23G3/364 ,  A23G3/42 ,  A23G3/54 ,  A23P10/28 ,  A23V2002/00 ,  A61K9/0056 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/2077 ,  A61K9/209 ,  A61K31/045 ,  A23V2200/30

    Abstract: The invention provides a compressed tablet including a volatile active agent, preferably menthol, within a spray-dried granule further comprising a starch carrier and, optionally, a polyol granulating agent. The compressed tablet can be a two layer tablet comprising an effervescent layer and a non-effervescent layer with the spray-dried granule incorporated into the effervescent layer. The tablets herein are useful for providing decongestant benefits. The present invention further relates to the use of starch for increasing the rate of release of menthol from a compressed tablet. The use of starch as a carrier for the volatile active agent has been found to not only improve its rate of release from the tablet compared to other carriers, such as gum arabic, or compared to not using a carrier at all, but also to impart improved smoothness to the tablet when sucked.

    Abstract translation: 本发明提供一种包含挥发性活性剂，优选薄荷醇的压缩片剂，该喷雾干燥颗粒还包含淀粉载体和任选的多元醇造粒剂。 压缩片剂可以是包含泡腾层和非泡腾层的双层片剂，其中喷雾干燥颗粒并入泡腾层。 本文中的片剂可用于提供减充血剂益处。 本发明还涉及淀粉用于增加压缩片剂中薄荷醇释放速率的用途。 已经发现使用淀粉作为挥发性活性剂的载体不仅提高了与其它载体如阿拉伯树胶相比从片剂释放的速度，或者与根本不使用载体相比，而且与赋予 改善了吸入时片剂的平滑度。

    METHODS AND COMPOSITIONS OF SPHINGOLIPID FOR PREVENTING AND TREATING MICROBIAL INFECTIONS
    8.
    发明申请
    METHODS AND COMPOSITIONS OF SPHINGOLIPID FOR PREVENTING AND TREATING MICROBIAL INFECTIONS 审中-公开
    用于预防和治疗微生物感染的SPHINGOLIPID的方法和组合物

    公开(公告)号：WO2009104963A1

    公开(公告)日：2009-08-27

    申请号：PCT/NL2009/050075

    申请日：2009-02-19

    Applicant: INNOPACT B.V. ,  EKHART, Peter Frank

    Inventor： EKHART, Peter Frank

    IPC: A23J7/00 ,  A23L1/30 ,  A61K9/00 ,  A61K31/688 ,  A61K38/00 ,  C07K16/12

    CPC classification number: A61K31/688 ,  A23G3/364 ,  A23G4/12 ,  A23J7/00 ,  A23L33/115 ,  A23V2002/00 ,  A61K9/0056 ,  A61K31/133 ,  A61K38/1729 ,  A61K2300/00 ,  A23V2200/30

    Abstract: The present invention relates to controlled release composition for preventing and/or treating microbial infectionsin the oral cavity of a subject, said composition comprising a controlled delivery matrix which matrix has releasably associated therewith an amount of between 0.000009 and 5 wt% of a sphingolipid, wherein the composition provides a sphingolipid-release-profile in the oral cavity of a subject, wherein said release-profile is maintained for between 15 seconds and 24 hours and wherein said release-profile provides for a concentration of said sphingolipid in the saliva of said subject of between 20 µmole/L and 250 µmole/L.

    Abstract translation: 本发明涉及用于预防和/或治疗受试者口腔中的微生物感染的控释组合物，所述组合物包含受控递送基质，该基质可释放地与其相关联，其量为鞘脂的0.000009至5重量％，其中 所述组合物在受试者的口腔中提供鞘脂释放曲线，其中所述释放曲线保持在15秒和24小时之间，并且其中所述释放曲线提供所述受试者的唾液中所述神经鞘脂的浓度 在20μmole/ L和250μmole/ L之间。

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