公开(公告)号：WO2013005168A2

公开(公告)日：2013-01-10

申请号：PCT/IB2012/053407

申请日：2012-07-04

申请人： LUPIN LIMITED ,  KULKARNI, Sanjeev, Anant ,  MADAN, Sachin ,  JANA, Nirmal, Kumar ,  TALE, Prashant, Vitthalrao ,  CHEEMALA, Narasimha, Murthy ,  MAHANGARE, Sachin, Jaysing ,  VIDHATE, Prashant, Popatrao ,  KULKARNI, Chaitanya, Prabhakar ,  PATEL, Sapana, Suresh ,  PATIL, Amolsing, Dattu ,  ZADE, Seema, Prabhakar ,  SHINDE, Rohan, Mahadev ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

发明人： KULKARNI, Sanjeev, Anant ,  MADAN, Sachin ,  JANA, Nirmal, Kumar ,  TALE, Prashant, Vitthalrao ,  CHEEMALA, Narasimha, Murthy ,  MAHANGARE, Sachin, Jaysing ,  VIDHATE, Prashant, Popatrao ,  KULKARNI, Chaitanya, Prabhakar ,  PATEL, Sapana, Suresh ,  PATIL, Amolsing, Dattu ,  ZADE, Seema, Prabhakar ,  SHINDE, Rohan, Mahadev ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： A61K31/4725

CPC分类号： C07D217/26 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/541 ,  C07C237/48 ,  C07D209/52 ,  C07D213/40 ,  C07D213/53 ,  C07D217/14 ,  C07D217/22 ,  C07D217/24 ,  C07D265/30 ,  C07D295/16 ,  C07D295/192 ,  C07D309/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D413/06 ,  C07D417/06 ,  C07D471/08 ,  C07D487/10 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

摘要： Compounds of Formula (I) along with processes for their preparation that are useful for treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

摘要翻译： 式（I）的化合物及其制备方法可用于治疗，控制和/或减轻与调节大麻素（CB）受体相关的疾病，病症，综合征或病症。 治疗，治疗和/或减轻与调节式（I）的大麻素（CB）受体相关的疾病，病症，综合征或病症的方法。

公开(公告)号：WO2015162538A1

公开(公告)日：2015-10-29

申请号：PCT/IB2015/052868

申请日：2015-04-20

申请人： LUPIN LIMITED

发明人： MADAN, Sachin ,  TALE, Prashant, Vitthalrao ,  ZADE, Seema, Prabhakar ,  PATIL, Amolsing, Dattu ,  KULKARNI, Sanjeev, Anant ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D213/78 ,  C07D311/16 ,  C07D311/24 ,  C07D215/48 ,  C07D215/56 ,  C07D333/60 ,  C07D239/34 ,  C07D239/74 ,  C07D263/32 ,  C07D263/58 ,  C07D277/68 ,  C07D209/42 ,  C07D213/30 ,  C07D307/85 ,  A61K31/343 ,  A61K31/381 ,  A61K31/352 ,  A61K31/517 ,  A61K31/47 ,  A61K31/404 ,  A61K31/423 ,  A61K31/428 ,  A61K31/42 ,  A61K31/505 ,  A61K31/4418 ,  A61P5/20 ,  A61P13/12

CPC分类号： C07D307/85 ,  C07D209/42 ,  C07D213/30 ,  C07D213/78 ,  C07D215/48 ,  C07D215/56 ,  C07D239/34 ,  C07D239/74 ,  C07D263/32 ,  C07D263/58 ,  C07D277/68 ,  C07D311/16 ,  C07D311/24 ,  C07D333/60

摘要： The invention relates to heterocyclic compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their pharmaceutical compositions for use in medicine for the treatment of diseases or disorders associated with the modulation of calcium sensing receptor modulators (CaSR), like e.g. hyperparathyroidism, chronic renal failure and chronic kidney disease and their complications.

摘要翻译： 本发明涉及式（I）的杂环化合物及其药学上可接受的盐，其中取代基如本文所述，及其用于治疗与钙感应受体调节剂调节相关的疾病或病症的医药组合物（ CaSR），例如 甲状旁腺功能亢进，慢性肾功能衰竭和慢性肾脏疾病及其并发症。

公开(公告)号：WO2012090179A3

公开(公告)日：2012-07-05

申请号：PCT/IB2011/056012

申请日：2011-12-29

申请人： LUPIN LIMITED ,  KULKARNI, Sanjeev, Anant ,  MADAN, Sachin ,  JANA, Nirmal, Kumar ,  MAHANGARE, Sachin, Jaysing ,  TALE, Prashant, Vitthalrao ,  ZADE, Seema, Prabhakar ,  PATIL, Amolsing, Dattu ,  CHEEMALA, Narasimha, Murthy ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

发明人： KULKARNI, Sanjeev, Anant ,  MADAN, Sachin ,  JANA, Nirmal, Kumar ,  MAHANGARE, Sachin, Jaysing ,  TALE, Prashant, Vitthalrao ,  ZADE, Seema, Prabhakar ,  PATIL, Amolsing, Dattu ,  CHEEMALA, Narasimha, Murthy ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： A61K31/4725 ,  A61K31/5377 ,  A61K31/541 ,  C07D217/26 ,  C07D401/12 ,  C07D405/12 ,  C07D491/08 ,  A61P29/00

摘要： Compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors. Methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of cannabinoid (CB) receptors of Formula (I).

公开(公告)号：WO2015022631A1

公开(公告)日：2015-02-19

申请号：PCT/IB2014/063867

申请日：2014-08-12

申请人： LUPIN LIMITED

发明人： MADAN, Sachin ,  TALE, Prashant, Vitthalrao ,  ZADE, Seema, Prabhakar ,  PATIL, Amolsing, Dattu ,  KULKARNI, Sanjeev, Anant ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D317/22 ,  C07C317/22 ,  C07C217/20 ,  C07C237/30 ,  A61K31/138 ,  A61P3/14

CPC分类号： C07C317/22 ,  C07C217/20 ,  C07C217/58 ,  C07C235/46 ,  C07C317/46 ,  C07C2601/02

摘要： The invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine for the treatment of diseases, disorders associated with the modulation of calcium sensing receptor modulators (Ca SR). The invention also relates to pharmaceutical compositions containing such compounds in treating diseases disorders associated with calcium sensing receptor modulators (Ca SR)channel modulators.

摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中取代基如本文所述，以及它们在医学中用于治疗与钙感应受体调节剂（Ca SR）的调节相关的疾病的用途。 本发明还涉及含有这些化合物治疗与钙感应受体调节剂（Ca SR）通道调节剂相关的疾病障碍的药物组合物。