公开(公告)号：WO2010096597A2

公开(公告)日：2010-08-26

申请号：PCT/US2010024637

申请日：2010-02-18

申请人： PERLMAN DANIEL

发明人： PERLMAN DANIEL

IPC分类号： A23D9/007

CPC分类号： A23D9/007 ,  A23D9/06

摘要： A fat-containing processed food composition is described that is suitable for human consumption, and that contains exogenously added microparticles of phenolic antioxidants dispersed but not dissolved in an antioxidant-protective edible oil/fat portion of the food composition. The oxidative stability of the phenolic antioxidants in the fat or oil portion of the food composition is substantially greater than when dissolved in an equal portion of water at pH 7.

摘要翻译： 描述了适用于人类消费的含脂肪加工食品组合物，其含有分散但未溶解在食品组合物的抗氧化保护性食用油/脂肪部分中的外来添加的酚类抗氧化剂微粒。 酚类抗氧化剂在食物组合物的脂肪或油部分中的氧化稳定性基本上大于当溶解在pH7的相等部分水中时的氧化稳定性。

公开(公告)号：WO0044237A2

公开(公告)日：2000-08-03

申请号：PCT/US0001597

申请日：2000-01-21

申请人： UNIV BRANDEIS ,  PERLMAN DANIEL ,  HAYES KENNETH C

发明人： PERLMAN DANIEL ,  HAYES KENNETH C

IPC分类号： A23C9/158 ,  A23C11/04 ,  A23C19/09 ,  A23L33/15 ,  A23C9/00

CPC分类号： A23C9/158 ,  A23C11/04 ,  A23C19/0921 ,  A23L33/15 ,  A23V2002/00 ,  A23V2250/5424 ,  A23V2250/712

摘要： A milk product including a level of at least 31IU vitamin E per serving of said product which can conveniently provide at least 100 IU of vitamin E per day to an individual ingesting the product. The vitamin E is uniformly microdispersed throughout the product, and ingestion of at least 100 IU of vitamin E per day in the product is sufficient to cause the fasting plasma vitamin E/cholesterol ratio in human subjects to be elevated at least 50 % above the basal fasting level of vitamin E measured in the same subjects consuming no vitamin E dietary supplements. A method for elevating the plasma vitamin E level at least 50 % in human subjects is also described. The method includes ingesting a milk product as described.

摘要翻译： 一种含有至少31IU维生素E的奶制品，每份所述产品每天可以方便地提供至少100IU的维生素E至摄取产品的个体。 维生素E在整个产品中均匀地微分散，并且每天在产品中摄入至少100IU的维生素E足以使人受试者的空腹血浆维生素E /胆固醇比例升高至基础以上至少50％ 维生素E的空腹水平在同一受试者中测量不消耗维生素E膳食补充剂。 还描述了在人受试者中提高血浆维生素E水平至少50％的方法。 该方法包括如上所述摄取牛奶制品。

公开(公告)号：WO2009045520A2

公开(公告)日：2009-04-09

申请号：PCT/US2008011481

申请日：2008-10-03

申请人： PERLMAN DANIEL

发明人： PERLMAN DANIEL

IPC分类号： A23L33/00 ,  A61K9/14 ,  A23L2/52 ,  A23L27/30 ,  A61K31/56 ,  A61P3/06

CPC分类号： A61K31/56 ,  A23L29/10 ,  A23L33/11 ,  A23V2002/00 ,  A23V2200/3262 ,  A23V2250/2136 ,  A23V2200/222

摘要： A water-dispersible dry-milled composition including phytosterol-surfactant conglomerate (PSC) particles which include a blend of dry microparticulate non- ester phytosterols and dry surfactant, e.g., dry binary surfactant is described. The composition further optionally includes one or more additional dry ingredients such as anti-caking agents, anti-foam agents, natural and artificial sweeteners, non-dairy creamers and flavoring agents.

摘要翻译： 描述了包括植物甾醇 - 表面活性剂聚集体（PSC）颗粒的水分散性干磨组合物，其包括干燥微粒非酯植物甾醇和干燥表面活性剂如干二元表面活性剂的混合物。 该组合物进一步任选地包含一种或多种额外的干成分，例如防结块剂，消泡剂，天然和人造甜味剂，非乳制奶精和调味剂。

公开(公告)号：WO2007025261A3

公开(公告)日：2007-10-04

申请号：PCT/US2006033589

申请日：2006-08-28

申请人： PERLMAN DANIEL

发明人： PERLMAN DANIEL

IPC分类号： A61K31/717 ,  A61K9/70

CPC分类号： A61K31/717 ,  A61K9/70 ,  A61L26/0023 ,  C08L1/00

摘要： A method and composition for reducing or eliminating stinging that may accompany application of topical solution of a skin-compatible polymeric material to a skin wound, abrasion, burn or other skin injury. The topical solution may contain one or more skin-irritating chemicals, such as diethyl ether, ethanol, ethyl acetate, methyl acetate, acetone, methyl ethyl ketone and combinations thereof. The method includes: (i) providing a composition that contains between 1% and 10% by weight of the skin-compatible polymeric material dissolved in a liquid medium suitable for human topical use in which the liquid medium includes less than 20% combined weight of skin-irritating chemicals, and at least 45% combined weight of at least one volatile solvent and/or volatile co-solvent, in which the molecules constituting this 45% combined weight portion of the liquid medium contain at least 5 carbon atoms, and the liquid medium has an initial boiling point at 1 atmosphere of greater than 35°C and less than 150°C, and causes little or no stinging when applied to a skin injury, and (ii) applying the composition to the skin of a patient at the site of the skin injury.

摘要翻译： 用于减少或消除可能伴随皮肤相容性聚合物材料的局部溶液应用于皮肤伤口，磨损，灼伤或其他皮肤损伤的刺痛的方法和组合物。 局部溶液可含有一种或多种皮肤刺激性化学物质，如乙醚，乙醇，乙酸乙酯，乙酸甲酯，丙酮，甲乙酮及其组合。 该方法包括：（i）提供一种组合物，其含有溶解在适用于人体局部应用的液体介质中的1重量％至10重量％的所述皮肤相容性聚合物材料，其中所述液体介质包含小于20重量％ 刺激皮肤的化学物质和至少45％的组合重量的至少一种挥发性溶剂和/或挥发性共溶剂，其中构成该液体介质的45重量％组合重量部分的分子含有至少5个碳原子，并且 液体培养基在1个大气压下的初始沸点大于35℃且小于150℃，并且当施用于皮肤损伤时引起很少或没有刺痛，和（ii）将所述组合物施用于患者的皮肤上 皮肤损伤的部位。

公开(公告)号：WO2012151387A2

公开(公告)日：2012-11-08

申请号：PCT/US2012036300

申请日：2012-05-03

申请人： UNIV BRANDEIS ,  PERLMAN DANIEL ,  HAYES KENNETH C ,  PRONCZUK ANDRZEJ ,  CHAABO FADI

发明人： PERLMAN DANIEL ,  HAYES KENNETH C ,  PRONCZUK ANDRZEJ ,  CHAABO FADI

IPC分类号： A23L1/035 ,  A23C9/152 ,  A23L1/30 ,  A23L2/52

CPC分类号： A23D9/013 ,  A23C9/152 ,  A23C11/103 ,  A23C2240/10 ,  A23D7/0053 ,  A23D7/011 ,  A23D9/007 ,  A23L23/00 ,  A23L27/60 ,  A23L29/10 ,  A23L33/11 ,  A23V2002/00 ,  A23V2200/222 ,  A23V2250/2136

摘要： The present invention relates to amphiphilic sterol- and fat-based particles, which can be dispersed in liquid foods and beverages such as milk. The compositions provided, when consumed, reduce low-density lipoprotein (LDL) and total plasma cholesterol (TC) levels.

摘要翻译： 本发明涉及可分散在液体食品和饮料如牛奶中的两亲甾醇和脂肪基颗粒。 当消耗时，提供的组合物降低低密度脂蛋白（LDL）和总血浆胆固醇（TC）水平。

公开(公告)号：WO2009111516A3

公开(公告)日：2009-12-17

申请号：PCT/US2009035940

申请日：2009-03-03

申请人： PERLMAN DANIEL

发明人： PERLMAN DANIEL

IPC分类号： A01N37/00 ,  A23L2/08 ,  A23L27/60 ,  A61K31/20

CPC分类号： A23C9/1528 ,  A23D7/003 ,  A23D7/0053 ,  A23V2002/00 ,  A23V2250/1882 ,  A23V2250/187 ,  A23V2250/1868 ,  A23V2250/202 ,  A23V2250/2042 ,  A23V2250/0604

摘要： A food or beverage composition suitable for human consumption includes an aqueous suspension such as cow's milk that has been supplemented and homogenized with an omega-3 fatty acid-containing supplementation oil, in which a supplementation oil includes a blend of an omega-3 fatty acid-containing enriching oil that has been combined and diluted with an oxidative stabilization oil, such as a low linoleic acid/high oleic acid-containing oxidative stabilization oil. As a result, the rate of oxidation of EPA/DHA fatty acids added to the aqueous suspension via the supplementation oil can be reduced substantially, e.g., at least two-fold or even much more compared to the rate of oxidation of an equal quantity of the same EPA/DHA fatty acid-containing enriching oil homogenized into the same aqueous suspension without having been first combined and diluted with the oxidative stabilization oil.

摘要翻译： 适合人类食用的食物或饮料组合物包括已经补充并用含ω-3脂肪酸的补充油均化的含水悬浮液，例如牛奶，其中补充油包括ω-3脂肪酸 - 含有用低亚油酸/高油酸氧化稳定油等氧化稳定油进行了组合稀释的富集油。 结果，通过补充油添加到含水悬浮液中的EPA / DHA脂肪酸的氧化速率可以显着降低，例如至少两倍或甚至远高于相等量的 将相同的含EPA / DHA脂肪酸的富集油均化成相同的含水悬浮液，而没有首先与氧化稳定油混合并稀释。

公开(公告)号：WO2011106618A8

公开(公告)日：2012-09-13

申请号：PCT/US2011026203

申请日：2011-02-25

申请人： UNIV BRANDEIS ,  PERLMAN DANIEL ,  HAYES KENNETH C

发明人： PERLMAN DANIEL ,  HAYES KENNETH C

IPC分类号： A23D7/00 ,  A23D9/00 ,  A23L1/29 ,  A23L1/30

CPC分类号： A23D7/001 ,  A23D7/003 ,  A23D9/00 ,  A23K20/158 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/20 ,  A61K31/201 ,  A61K45/06 ,  A61K2300/00 ,  A23V2250/1882 ,  A23V2200/3262 ,  A23V2250/186 ,  A23V2250/1872

摘要： Nutritional fat or oil-based compositions for increasing HDL cholesterol, decreasing total cholesterol (TC), LDL cholesterol and decreasing the LDL/HDL cholesterol ratio in human plasma are described. The compositions can advantageously include at least 10% of myristic acid and/or lauric acid in which at least 3% of said fatty acid composition is myristic acid and at least 3% is lauric acid; in some cases at least 1% by weight myristic acid and/or lauric acid is esterified at the sn-2 position in triglyceride molecules. The compositions also include between 5% and 40% by weight linoleic acid, and typically further include at least 10% by weight monounsaturated fatty acids and between 15% and 55% by weight total saturated fatty acids. The sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%. In desirable cases, the composition is substantially cholesterol-free. Also described are fat compositions and diets which are adapted to limit increases in blood triglycerides, total cholesterol, LDL, and VLDL, even in the presence of dietary cholesterol.

摘要翻译： 描述了用于增加HDL胆固醇，降低总胆固醇（TC），低密度脂蛋白胆固醇和降低人血浆中LDL / HDL胆固醇比例的营养脂肪或油基组合物。 组合物可以有利地包括至少10％的肉豆蔻酸和/或月桂酸，其中至少3％的所述脂肪酸组合物是肉豆蔻酸，并且至少3％是月桂酸; 在一些情况下，至少1重量％的肉豆蔻酸和/或月桂酸在甘油三酯分子的sn-2位被酯化。 组合物还包括5重量％至40重量％的亚油酸，并且通常还包括至少10重量％的单不饱和脂肪酸和15重量％至55重量％的总饱和脂肪酸。 饱和，单不饱和和多不饱和脂肪酸的重量百分比之和等于100％。 在期望的情况下，组合物基本上不含胆固醇。 还描述了脂肪组合物和饮食，其适于限制血液甘油三酯，总胆固醇，低密度脂蛋白和VLDL的增加，即使在膳食胆固醇的存在下。

公开(公告)号：WO2010027433A3

公开(公告)日：2010-05-14

申请号：PCT/US2009004860

申请日：2009-08-25

申请人： UNIV BRANDEIS ,  PERLMAN DANIEL ,  HAYES KENNETH C

发明人： PERLMAN DANIEL ,  HAYES KENNETH C

IPC分类号： A23D7/00

CPC分类号： C11C3/10 ,  A23D9/02 ,  A23L33/12

摘要： A nutritional fat or oil-based composition for increasing HDL cholesterol, decreasing LDL cholesterol and decreasing the LDL/HDL cholesterol ratio in human plasma is described. The composition can advantageously include at least 1 % by weight myristic acid esterified at the sn-2 position in triglyceride molecules, includes between 10% and 40% by weight linoleic acid, and further includes between 30% and 65% by weight oleic acid and between 15% and 40% by weight total saturated fatty acids. The ratio of sn-2 myristic acid to sn-2 palmitic acid is typically greater than 1 :1 and the sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%. In desirable cases, the composition is substantially cholesterol-free.

摘要翻译： 描述了用于增加人血浆中HDL胆固醇，降低LDL胆固醇和降低LDL / HDL胆固醇比的营养型油或脂基组合物。 所述组合物可以有利地包含在甘油三酯分子中在sn-2位酯化的至少1重量％的肉豆蔻酸，包含10重量％至40重量％的亚油酸，并且还包含30重量％至65重量％的油酸和 按重量计15％至40％的总饱和脂肪酸。 sn-2肉豆蔻酸与sn-2棕榈酸的比例通常大于1：1，饱和，单不饱和脂肪酸和多不饱和脂肪酸的重量百分比之和等于100％。 在理想的情况下，该组合物基本上不含胆固醇。

公开(公告)号：WO2008055250A3

公开(公告)日：2008-07-17

申请号：PCT/US2007083263

申请日：2007-10-31

申请人： UNIV BRANDEIS ,  PERLMAN DANIEL

发明人： PERLMAN DANIEL

IPC分类号： A23L27/00 ,  B01F3/12

CPC分类号： A23D9/00

摘要： An orally dispersible, substantially water-free edible oil-based gel composition for food use, that typically contains between 74% and 99% by weight triglyceride-based edible oil, up to 2.0% by weight hydrophilic microparticulate silicon dioxide, between 0.1% and 1.0% by weight of at least one edible polyol, less than 1% by weight water and less than 25% by weight of additional suspended solids. The polyol and the silicon dioxide have been fully dispersed in the oil-based composition to cause gelling of the edible oil. The composition commonly includes added flavoring agents and can include flavor enhancers.

摘要翻译： 用于食品用途的可口服分散的基本上无水的基于食用油的凝胶组合物通常含有基于甘油三酯的食用油74重量％至99重量％，亲水性微粒二氧化硅至多2.0重量％，以及0.1重量％ 1.0重量％的至少一种可食用多元醇，少于1重量％的水和少于25重量％的另外的悬浮固体。 多元醇和二氧化硅已经完全分散在油基组合物中以引起食用油的胶凝。 该组合物通常包括添加的调味剂并且可以包括风味增强剂。

公开(公告)号：WO2007030570A2

公开(公告)日：2007-03-15

申请号：PCT/US2006034776

申请日：2006-09-06

申请人： UNIV BRANDEIS ,  PERLMAN DANIEL ,  HAYES KENNETH ,  PRONCZUK ANDRZEJ

发明人： PERLMAN DANIEL ,  HAYES KENNETH ,  PRONCZUK ANDRZEJ

IPC分类号： A23D9/00

CPC分类号： A23D9/007 ,  A23L2/52 ,  A23L13/428 ,  A23L13/43 ,  A23L23/00 ,  A23L27/60 ,  A23L27/63 ,  A23L33/11 ,  A23L33/115 ,  A23L33/12 ,  A23V2002/00 ,  C11B5/0021 ,  C11B5/0085 ,  A23V2250/1882 ,  A23V2250/061 ,  A23V2250/5118 ,  A23V2250/5108 ,  A23V2250/70 ,  A23V2250/156 ,  A23V2250/54246

摘要： A nutritional supplement, prepared food product, or direct food additive for ingestion by mammals, and methods for preparing such products, are provided. Products of the invention comprise an oxidation-resistant fat-based composition substantially free of exogenous solubilizing and dispersing agents for phytosterols. The fat-based composition includes greater than 25% and less than 75% by weight of one or more triglyceride-based edible oil or fat, and greater than 25% and less than 75% by weight of one or more non-esterified phytosterols. The fat-based composition, when exposed to air, contains a reduced amount of oxidative by-products compared to a similar fat-based composition lacking non-esterified phytosterols. Also provided are methods for reducing plasma cholesterol in mammals, and methods for protecting plasma lipoproteins and cholesterol from oxidation by ingestion of products of the invention.

摘要翻译： 提供营养补充剂，制备的食品或哺乳动物摄入的直接食品添加剂，以及制备这些产品的方法。 本发明的产品包含基本上不含用于植物甾醇的外源增溶和分散剂的抗氧化脂肪基组合物。 基于脂肪的组合物包含大于25重量％且小于75重量％的一种或多种甘油三酯基食用油或脂肪，以及大于25重量％且小于75重量％的一种或多种非酯化植物甾醇。 基于脂肪的组合物当暴露于空气中时，与缺乏非酯化植物甾醇的类似的基于脂肪的组合物相比，含有减少量的氧化副产物。 还提供了用于降低哺乳动物血浆胆固醇的方法，以及通过摄入本发明的产品来保护血浆脂蛋白和胆固醇免于氧化的方法。